Lysine biosynthesis

SourceIDPathway
KEGG00300 Map00300

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00019Saccharopine
997-68-2
(2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acidC11H20N2O6
276.2863
Thumb
YMDB00034L-aspartic 4-semialdehyde
15106-57-7
(2S)-2-amino-4-oxobutanoic acidC4H7NO3
117.1033
Thumb
YMDB00096(2R)-Homocitric acid
3562-74-1
(2R)-2-hydroxybutane-1,2,4-tricarboxylic acidC7H10O7
206.1501
Thumb
YMDB00104L-Homoserine
672-15-1
(2S)-2-amino-4-hydroxybutanoic acidC4H9NO3
119.1192
Thumb
YMDB001134-Phospho-L-aspartic acid
22138-53-0
(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acidC4H8NO7P
213.0826
Thumb
YMDB00142Oxoadipic acid
3184-35-8
2-oxohexanedioic acidC6H8O5
160.1247
Thumb
YMDB00144Homoisocitric acid(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acidC7H10O7
206.1501
Thumb
YMDB00153Oxoglutaric acid
328-50-7
2-oxopentanedioic acidC5H6O5
146.0981
Thumb
YMDB00269but-1-ene-1,2,4-tricarboxylic acid(1Z)-but-1-ene-1,2,4-tricarboxylic acidC7H8O6
188.1348
Thumb
YMDB00305Aminoadipic acid
542-32-5
C6H11NO4
161.1558
Thumb
YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
Thumb
YMDB00330L-Lysine
56-87-1
(2S)-2,6-diaminohexanoic acidC6H14N2O2
146.1876
Thumb
YMDB007052-Oxaloglutaric acid1-oxobutane-1,2,4-tricarboxylic acidC7H8O7
204.1342
Thumb
YMDB00721L-Allysine
1962-83-0
(2S)-2-amino-6-oxohexanoic acidC6H11NO3
145.1564
Thumb
YMDB00896L-Aspartic acid
56-84-8
(2S)-2-aminobutanedioic acidC4H7NO4
133.1027
Thumb
YMDB00999L-2-aminoadipate
542-32-5
(2S)-2-aminohexanedioic acidC6H11NO4
161.1558
Thumb
YMDB01022L-aspartate 4-semialdehyde
15106-57-7
C4H6NO3
116.0953
Thumb
YMDB010674-phospho-L-aspartate
22138-53-0
C4H5NO7P
210.0588
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P38998LYS1
YIR034C
Saccharopine dehydrogenase [NAD+, L-lysine-forming]Enzyme
P38999LYS9
YNR050C
Saccharopine dehydrogenase [NADP+, L-glutamate-forming]Enzyme
P18544ARG8
YOL140W
Acetylornithine aminotransferase, mitochondrialEnzyme
P13663HOM2
YDR158W
Aspartate-semialdehyde dehydrogenaseEnzyme
Q12122LYS21
YDL131W
Homocitrate synthase, mitochondrialEnzyme
P48570LYS20
YDL182W
Homocitrate synthase, cytosolic isozymeEnzyme
P07702LYS2
YBR115C
L-aminoadipate-semialdehyde dehydrogenaseEnzyme
P10869HOM3
YER052C
AspartokinaseEnzyme
P40495LYS12
YIL094C
Homoisocitrate dehydrogenase, mitochondrialEnzyme
P38840ARO9
YHR137W
Aromatic amino acid aminotransferase 2Enzyme
P53090ARO8
YGL202W
Aromatic amino acid aminotransferase 1Enzyme
P49367LYS4
YDR234W
Homoaconitase, mitochondrialEnzyme
P31116HOM6
YJR139C
Homoserine dehydrogenaseEnzyme