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Glycine, serine and threonine metabolism

SourceIDPathway
KEGG00260 Map00260

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00016Glycine
56-40-6
2-aminoacetic acidC2H5NO2
75.0666
Thumb
YMDB00033Glyoxylic acid
298-12-4
2-oxoacetic acidC2H2O3
74.0355
Thumb
YMDB00034L-aspartic 4-semialdehyde
15106-57-7
(2S)-2-amino-4-oxobutanoic acidC4H7NO3
117.1033
Thumb
YMDB000421,3-Diaminopropane
109-76-2
propane-1,3-diamineC3H10N2
74.1249
Thumb
YMDB00046L-Cysteine
52-90-4
(2R)-2-amino-3-sulfanylpropanoic acidC3H7NO2S
121.158
Thumb
YMDB000712-Ketobutyric acid
600-18-0
2-oxobutanoic acidC4H6O3
102.0886
Thumb
YMDB00076DL-O-Phosphoserine
17885-08-4
2-amino-3-(phosphonooxy)propanoic acidC3H8NO6P
185.0725
Thumb
YMDB000835-Aminolevulinic acid
106-60-5
5-amino-4-oxopentanoic acidC5H9NO3
131.1299
Thumb
YMDB00091Ammonia
7664-41-7
ammoniaH3N
17.0305
Thumb
YMDB00104L-Homoserine
672-15-1
(2S)-2-amino-4-hydroxybutanoic acidC4H9NO3
119.1192
Thumb
YMDB00112L-Serine
56-45-1
(2S)-2-amino-3-hydroxypropanoic acidC3H7NO3
105.0926
Thumb
YMDB001134-Phospho-L-aspartic acid
22138-53-0
(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acidC4H8NO7P
213.0826
Thumb
YMDB00126L-Tryptophan
73-22-3
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acidC11H12N2O2
204.2252
Thumb
YMDB00139Tetrahydrofolic acid
135-16-0
2-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB00170Pyruvaldehyde
78-98-8
2-oxopropanalC3H4O2
72.0627
Thumb
YMDB00175Pyruvic acid
127-17-3
2-oxopropanoic acidC3H4O3
88.0621
Thumb
YMDB00214L-Threonine
72-19-5
(2S,3R)-2-amino-3-hydroxybutanoic acidC4H9NO3
119.1192
Thumb
YMDB00227Choline
62-49-7
(2-hydroxyethyl)trimethylazaniumC5H14NO
104.1708
Thumb
YMDB00245L-Cystathionine
56-88-2
(2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acidC7H14N2O4S
222.262
Thumb
YMDB00258O-Phosphohomoserine
4210-66-6
(2S)-2-amino-4-(phosphonooxy)butanoic acidC4H10NO6P
199.0991
Thumb
YMDB002605,10-Methylene-THF
31690-11-6
2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB00284D-Serine
312-84-5
(2R)-2-amino-3-hydroxypropanoic acidC3H7NO3
105.0926
Thumb
YMDB00295L-Allothreonine
24830-94-2
(2S,3S)-2-amino-3-hydroxybutanoic acidC4H9NO3
119.1192
Thumb
YMDB00393Phosphohydroxypyruvic acid
3913-50-6
2-oxo-3-(phosphonooxy)propanoic acidC3H5O7P
184.0414
Thumb
YMDB004835,6,7,8-Tetrahydrofolic acid
135-16-0
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB00695L-2-amino-3-oxobutanoic acid(2S)-2-amino-3-oxobutanoic acidC4H7NO3
117.1033
Thumb
YMDB007563-phospho-D-glyceric acid
820-11-1
(2R)-2-hydroxy-3-(phosphonooxy)propanoic acidC3H7O7P
186.0572
Thumb
YMDB00761O-Phospho-L-serine
407-41-0
(2S)-2-amino-3-(phosphonooxy)propanoic acidC3H8NO6P
185.0725
Thumb
YMDB00848(6R)-5,10-methylenetetrahydrofolic acid
3432-99-3
(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB00892Aminoacetone
298-08-8
1-aminopropan-2-oneC3H7NO
73.0938
Thumb
YMDB00896L-Aspartic acid
56-84-8
(2S)-2-aminobutanedioic acidC4H7NO4
133.1027
Thumb
YMDB00912Carbon dioxide
124-38-9
methanedioneCO2
44.0095
Thumb
YMDB010112-oxobutanoate
600-18-0
C4H5O3
101.0807
Thumb
YMDB01022L-aspartate 4-semialdehyde
15106-57-7
C4H6NO3
116.0953
Thumb
YMDB01027L-2-amino-3-oxobutanoateC4H6NO3
116.0953
Thumb
YMDB01033Glyoxylate
298-12-4
C2HO3
73.0275
Thumb
YMDB01053pyruvate
127-17-3
C3H3O3
87.0541
Thumb
YMDB010674-phospho-L-aspartate
22138-53-0
C4H5NO7P
210.0588
Thumb
YMDB010685-aminolevulinate
106-60-5
C5H8NO3
130.1219
Thumb
YMDB01251PS(16:0/16:0)
3036-82-6
(2S)-2-amino-3-({[(2R)-2,3-bis(hexadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acidC38H74NO10P
735.981
Thumb
YMDB01257PS(18:0/18:1(9Z))(2S)-2-amino-3-({hydroxy[(2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(octadecanoyloxy)propoxy]phosphoryl}oxy)propanoic acidC42H80NO10P
790.073
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P49095GCV2
YMR189W
Glycine dehydrogenase [decarboxylating], mitochondrialEnzyme
P37291SHM2
YLR058C
Serine hydroxymethyltransferase, cytosolicEnzyme
P37292SHM1
YBR263W
Serine hydroxymethyltransferase, mitochondrialEnzyme
P37303GLY1
YEL046C
Low specificity L-threonine aldolaseEnzyme
P09950HEM1
YDR232W
5-aminolevulinate synthase, mitochondrialEnzyme
P43567AGX1
YFL030W
Alanine--glyoxylate aminotransferase 1Enzyme
P09624LPD1
YFL018C
Dihydrolipoyl dehydrogenase, mitochondrialEnzyme
P07246ADH3
YMR083W
Alcohol dehydrogenase 3, mitochondrialEnzyme
P00330ADH1
YOL086C
Alcohol dehydrogenase 1Enzyme
P10127ADH4
YGL256W
Alcohol dehydrogenase 4Enzyme
P38113ADH5
YBR145W
Alcohol dehydrogenase 5Enzyme
P00331ADH2
YMR303C
Alcohol dehydrogenase 2Enzyme
P13663HOM2
YDR158W
Aspartate-semialdehyde dehydrogenaseEnzyme
P31373CYS3
YAL012W
Cystathionine gamma-lyaseEnzyme
P40510SER33
YIL074C
D-3-phosphoglycerate dehydrogenase 2Enzyme
P00927ILV1
YER086W
Threonine dehydratase, mitochondrialEnzyme
P25379CHA1
YCL064C
Catabolic L-serine/threonine dehydrataseEnzyme
P33330SER1
YOR184W
Phosphoserine aminotransferaseEnzyme
P48015GCV1
YDR019C
Aminomethyltransferase, mitochondrialEnzyme
P0CF21SDL1
YIL167W
L-serine dehydrataseEnzyme
P17423THR1
YHR025W
Homoserine kinaseEnzyme
P10869HOM3
YER052C
AspartokinaseEnzyme
P08456CHO1
YER026C
CDP-diacylglycerol--serine O-phosphatidyltransferaseEnzyme
P42941SER2
YGR208W
Phosphoserine phosphataseEnzyme
P32582CYS4
YGR155W
Cystathionine beta-synthaseEnzyme
P00931TRP5
YGL026C
Tryptophan synthaseEnzyme
P16120THR4
YCR053W
Threonine synthaseEnzyme
P31116HOM6
YJR139C
Homoserine dehydrogenaseEnzyme
P40054SER3
YER081W
D-3-phosphoglycerate dehydrogenase 1Enzyme
P53095DSD1
YGL196W
D-serine dehydrataseEnzyme