Canmetcon
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Lysine degradation

SourceIDPathway
KEGG00310 Map00310

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00016Glycine
56-40-6
2-aminoacetic acidC2H5NO2
75.0666
Thumb
YMDB00019Saccharopine
997-68-2
(2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acidC11H20N2O6
276.2863
Thumb
YMDB00142Oxoadipic acid
3184-35-8
2-oxohexanedioic acidC6H8O5
160.1247
Thumb
YMDB00305Aminoadipic acid
542-32-5
C6H11NO4
161.1558
Thumb
YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
Thumb
YMDB00330L-Lysine
56-87-1
(2S)-2,6-diaminohexanoic acidC6H14N2O2
146.1876
Thumb
YMDB00529acetoacetyl-CoA
1420-36-6
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC25H40N7O18P3S
851.607
Thumb
YMDB00721L-Allysine
1962-83-0
(2S)-2-amino-6-oxohexanoic acidC6H11NO3
145.1564
Thumb
YMDB00999L-2-aminoadipate
542-32-5
(2S)-2-aminohexanedioic acidC6H11NO4
161.1558
Thumb
YMDB01338Piperidine
535-75-1
piperidineC5H11N
85.1475
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P38998LYS1
YIR034C
Saccharopine dehydrogenase [NAD+, L-lysine-forming]Enzyme
P38999LYS9
YNR050C
Saccharopine dehydrogenase [NADP+, L-glutamate-forming]Enzyme
P46367ALD4
YOR374W
Potassium-activated aldehyde dehydrogenase, mitochondrialEnzyme
P54115ALD6
YPL061W
Magnesium-activated aldehyde dehydrogenase, cytosolicEnzyme
P19262KGD2
YDR148C
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialEnzyme
P41338ERG10
YPL028W
Acetyl-CoA acetyltransferaseEnzyme
P07702LYS2
YBR115C
L-aminoadipate-semialdehyde dehydrogenaseEnzyme
P22281ALD1
Aldehyde dehydrogenase 1, mitochondrialEnzyme
P20967KGD1
YIL125W
2-oxoglutarate dehydrogenase, mitochondrialEnzyme
P38818CTM1
YHR109W
Cytochrome c lysine N-methyltransferase 1Enzyme
Q04089DOT1
YDR440W
Histone-lysine N-methyltransferase, H3 lysine-79 specificEnzyme
P46995SET2
YJL168C
Histone-lysine N-methyltransferase, H3 lysine-36 specificEnzyme
P38827SET1
YHR119W
Histone-lysine N-methyltransferase, H3 lysine-4 specificEnzyme