Nicotinate and nicotinamide metabolism

Source	ID	Pathway
KEGG	00760

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00007	Quinolinic acid 89-00-9	pyridine-2,3-dicarboxylic acid	C₇H₅NO₄ 167.1189
YMDB00101	Fumaric acid 110-17-8	(2E)-but-2-enedioic acid	C₄H₄O₄ 116.0722
YMDB00103	Nicotinamide riboside 1341-23-7	3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅N₂O₅ 255.2472
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00138	Nicotinamide ribotide 1094-61-7	3-carbamoyl-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅N₂O₈P 334.2192
YMDB00157	Nicotinate D-ribonucleoside	3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₄NO₆ 256.232
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00193	Nicotinic acid mononucleotide 321-02-8	3-carboxy-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonatooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-2,3-dihydro-1λ⁵-pyridin-1-ylium	C₁₁H₁₆NO₉P 337.2198
YMDB00224	Nicotinic acid 59-67-6	pyridine-3-carboxylic acid	C₆H₅NO₂ 123.1094
YMDB00236	Succinic acid semialdehyde 692-29-5	4-oxobutanoic acid	C₄H₆O₃ 102.0886
YMDB00274	Niacinamide 98-92-0	pyridine-3-carboxamide	C₆H₆N₂O 122.1246
YMDB00306	deamido-NAD(+)	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carboxy-1lambda5-pyridin-1-ylium	C₂₁H₂₇N₆O₁₅P₂ 665.4178
YMDB00322	Dihydroxyacetone phosphate 57-04-5	(3-hydroxy-2-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00348	1-Methylnicotinamide 3106-60-3	3-carbamoyl-1-methylpyridin-1-ium	C₇H₉N₂O 137.1592
YMDB00412	NAD(+) 53-84-9		C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00596	Iminoaspartic acid 79067-61-1	2-iminobutanedioic acid	C₄H₅NO₄ 131.0868
YMDB00741	nicotinic acid D-ribonucleotide	3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅NO₉P 336.2119
YMDB00857	propionic acid 79-09-4	propanoic acid	C₃H₆O₂ 74.0785
YMDB00896	L-Aspartic acid 56-84-8	(2S)-2-aminobutanedioic acid	C₄H₇NO₄ 133.1027
YMDB00992	succinate semialdehyde 692-29-5		C₄H₆O₃ 102.0886
YMDB01007	nicotinate 59-67-6		C₆H₄NO₂ 122.1015
YMDB01038	fumarate(2-) 110-17-8		C₄H₂O₄ 114.0563
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P38795	QNS1 YHR074W	Glutamine-dependent NAD(+) synthetase	Enzyme	L-Glutamine Adenosine monophosphate Adenosine triphosphate NAD Pyrophosphate L-Glutamic acid deamido-NAD(+) NAD(+) Ammonium hydron water
Q05788	PNP1 YLR209C	Purine nucleoside phosphorylase	Enzyme	Purine Adenosine Ribose 1-phosphate Uracil Xanthine 2'-Deoxyadenosine 2'-Deoxyguanosine Thymidine 2'-Deoxyuridine Guanosine Inosine xanthosine Hypoxanthine 2'-Deoxyinosine 2-deoxy-D-ribofuranose 1-phosphate Guanine 9H-xanthine Thymine Adenine phosphate
P25353	NPP1 YCR026C	Ectonucleotide pyrophosphatase/phosphodiesterase 1	Enzyme	Uridine 5'-monophosphate Guanosine monophosphate Glucose 1-phosphate D-Mannose 1-phosphate UDP-D-glucose water
P39997	NPP2 YEL016C	Ectonucleotide pyrophosphatase/phosphodiesterase 2	Enzyme	Uridine 5'-monophosphate Guanosine monophosphate Glucose 1-phosphate D-Mannose 1-phosphate UDP-D-glucose water
P43619	BNA6 YFR047C	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	Enzyme	Quinolinic acid Nicotinic acid mononucleotide Pyrophosphate Phosphoribosyl pyrophosphate nicotinic acid D-ribonucleotide hydron Carbon dioxide
P53184	PNC1 YGL037C	Nicotinamidase	Enzyme	Ammonia Nicotinic acid Niacinamide Ammonium water Pyrazinecarboxamide
P53164	NPY1 YGL067W	NADH pyrophosphatase	Enzyme	Adenosine monophosphate NAD Nicotinamide ribotide NAD(+) hydron water
P53915	NRK1 YNL129W	Nicotinamide riboside kinase	Enzyme	Nicotinamide riboside Adenosine triphosphate Nicotinamide ribotide Nicotinate D-ribonucleoside Nicotinic acid mononucleotide nicotinic acid D-ribonucleotide hydron ADP
P53204	NMA2 YGR010W	Nicotinamide-nucleotide adenylyltransferase 2	Enzyme	Adenosine triphosphate NAD Nicotinamide ribotide Nicotinic acid mononucleotide Pyrophosphate deamido-NAD(+) NAD(+) nicotinic acid D-ribonucleotide hydron
Q06178	NMA1 YLR328W	Nicotinamide-nucleotide adenylyltransferase 1	Enzyme	Adenosine triphosphate NAD Nicotinamide ribotide Nicotinic acid mononucleotide Pyrophosphate deamido-NAD(+) NAD(+) nicotinic acid D-ribonucleotide hydron
P21373	UTR1 YJR049C	NAD(+) kinase	Enzyme	Adenosine triphosphate NAD NADH NAD(+) NADPH NADP hydron ADP
P39683	NPT1 YOR209C	Nicotinate phosphoribosyltransferase	Enzyme	Adenosine triphosphate Nicotinic acid mononucleotide Pyrophosphate Nicotinic acid Phosphoribosyl pyrophosphate nicotinic acid D-ribonucleotide hydron water phosphate ADP
Q05874	NNT1 YLR285W	Putative nicotinamide N-methyltransferase	Enzyme	S-Adenosylhomocysteine Niacinamide S-Adenosylmethionine 1-Methylnicotinamide S-Adenosyl-L-methionine