Cysteine and methionine metabolism

Source	ID	Pathway
KEGG	00270

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00005	Sulfate 14808-79-8	sulfuric acid	O₄S 96.063
YMDB00024	5-(methylsulfanyl)-2,3-dioxopentyl phosphate	{[5-(methylsulfanyl)-2,3-dioxopentyl]oxy}phosphonic acid	C₆H₁₁O₆PS 242.187
YMDB00034	L-aspartic 4-semialdehyde 15106-57-7	(2S)-2-amino-4-oxobutanoic acid	C₄H₇NO₃ 117.1033
YMDB00040	5-Methylthioribose 1-phosphate 72843-83-5	{[(3R,4S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxy}phosphonic acid	C₆H₁₃O₇PS 260.202
YMDB00046	L-Cysteine 52-90-4	(2R)-2-amino-3-sulfanylpropanoic acid	C₃H₇NO₂S 121.158
YMDB00062	Methanethiol 74-93-1	methanethiol	CH₄S 48.107
YMDB00071	2-Ketobutyric acid 600-18-0	2-oxobutanoic acid	C₄H₆O₃ 102.0886
YMDB00076	DL-O-Phosphoserine 17885-08-4	2-amino-3-(phosphonooxy)propanoic acid	C₃H₈NO₆P 185.0725
YMDB00104	L-Homoserine 672-15-1	(2S)-2-amino-4-hydroxybutanoic acid	C₄H₉NO₃ 119.1192
YMDB00112	L-Serine 56-45-1	(2S)-2-amino-3-hydroxypropanoic acid	C₃H₇NO₃ 105.0926
YMDB00113	4-Phospho-L-aspartic acid 22138-53-0	(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid	C₄H₈NO₇P 213.0826
YMDB00114	Sulfite 14265-45-3	sulfurous acid	O₃S 80.063
YMDB00129	5-Methylthioribulose 1-phosphate 86316-83-8	{[(3R,4S)-3,4-dihydroxy-5-(methylsulfanyl)-2-oxopentyl]oxy}phosphonic acid	C₆H₁₃O₇PS 260.202
YMDB00130	S-Adenosylmethioninamine 22365-13-5	{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium	C₁₄H₂₃N₆O₃S 355.436
YMDB00154	L-Alanine 56-41-7	(2S)-2-aminopropanoic acid	C₃H₇NO₂ 89.0932
YMDB00158	O-Acetyl-L-homoserine 7540-67-2	(2S)-4-(acetyloxy)-2-aminobutanoic acid	C₆H₁₁NO₄ 161.1558
YMDB00160	Glutathione 70-18-8	(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid	C₁₀H₁₇N₃O₆S 307.323
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00178	5'-Methylthioadenosine 2457-80-9	(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol	C₁₁H₁₅N₅O₃S 297.334
YMDB00185	1,2-Dihydroxy-3-keto-5-methylthiopentene 746507-19-7	(1Z)-1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one	C₆H₁₀O₃S 162.207
YMDB00198	S-Adenosylhomocysteine 979-92-0	(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid	C₁₄H₂₀N₆O₅S 384.411
YMDB00245	L-Cystathionine 56-88-2	(2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid	C₇H₁₄N₂O₄S 222.262
YMDB00297	S-Adenosylmethionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00303	Thiosulfate 14383-50-7	sulfanesulfonic acid	O₃S₂ 112.128
YMDB00318	L-Methionine 63-68-3	(2S)-2-amino-4-(methylsulfanyl)butanoic acid	C₅H₁₁NO₂S 149.211
YMDB00421	4-Methylthio-2-oxobutanoate 583-92-6	4-(methylsulfanyl)-2-oxobutanoic acid	C₅H₈O₃S 148.18
YMDB00438	S-Adenosyl-L-methionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00520	L-Homocysteine 6027-13-0	(2S)-2-amino-4-sulfanylbutanoic acid	C₄H₉NO₂S 135.185
YMDB00652	O-acetyl-L-serine 5147-00-2	(2S)-3-(acetyloxy)-2-aminopropanoic acid	C₅H₉NO₄ 147.1293
YMDB00653	Hydrogen sulfide 7783-06-4	hydrogen sulfide	H₂S 34.081
YMDB00690	L-cysteinylglycine 70-18-8	2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acid	C₅H₁₀N₂O₃S 178.21
YMDB00761	O-Phospho-L-serine 407-41-0	(2S)-2-amino-3-(phosphonooxy)propanoic acid	C₃H₈NO₆P 185.0725
YMDB00861	Cystine 56-89-3	(2R)-2-amino-3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}propanoic acid	C₆H₁₂N₂O₄S₂ 240.3
YMDB00886	L-Cystine 56-89-3	(2R)-2-amino-3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}propanoic acid	C₆H₁₂N₂O₄S₂ 240.3
YMDB00896	L-Aspartic acid 56-84-8	(2S)-2-aminobutanedioic acid	C₄H₇NO₄ 133.1027
YMDB00913	D-Cysteine 921-01-7	(2S)-2-amino-3-sulfanylpropanoic acid	C₃H₇NO₂S 121.158
YMDB00917	O-Succinyl-L-homoserine 1492-23-5	(2S)-2-amino-4-[(3-carboxypropanoyl)oxy]butanoic acid	C₈H₁₃NO₆ 219.1919
YMDB00961	S-Methyl-5-thio-alpha-D-ribose 1-phosphate	{[(2R,3R,4S,5S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxy}phosphonic acid	C₆H₁₃O₇PS 260.202
YMDB00980	(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium 22365-13-5	{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium	C₁₄H₂₃N₆O₃S 355.436
YMDB01011	2-oxobutanoate 600-18-0		C₄H₅O₃ 101.0807
YMDB01022	L-aspartate 4-semialdehyde 15106-57-7		C₄H₆NO₃ 116.0953
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541
YMDB01067	4-phospho-L-aspartate 22138-53-0		C₄H₅NO₇P 210.0588
YMDB01335	Ethoxy ethene 109-92-2	ethoxyethene	C₄H₈O 72.1057

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P32626	UTR4 YEL038W	Enolase-phosphatase E1	Enzyme	5-(methylsulfanyl)-2,3-dioxopentyl phosphate Glycerol 3-phosphate 1,2-Dihydroxy-3-keto-5-methylthiopentene Glycerol Formic acid 4-Methylthio-2-oxobutanoate glycolic acid Phosphoglycolic acid hydron water phosphate glycerol 1-phosphate glycerol 2-phosphate
P47095	MDE1 YJR024C	Methylthioribulose-1-phosphate dehydratase	Enzyme	5-(methylsulfanyl)-2,3-dioxopentyl phosphate 5-Methylthioribulose 1-phosphate water
P13663	HOM2 YDR158W	Aspartate-semialdehyde dehydrogenase	Enzyme	L-aspartic 4-semialdehyde 4-Phospho-L-aspartic acid NADPH NADP hydron phosphate
P36088	YKL069W	Free methionine-R-sulfoxide reductase	Enzyme	L-methionine (R)-S-oxide L-Methionine
Q06489	MRI1 YPR118W	Methylthioribose-1-phosphate isomerase	Enzyme	5-Methylthioribose 1-phosphate 5-Methylthioribulose 1-phosphate
P08465	MET2 YNL277W	Homoserine O-acetyltransferase	Enzyme	Coenzyme A L-Homoserine O-Acetyl-L-homoserine Acetyl-CoA Acetylhomoserine
P53206	YGR012W	Putative cysteine synthase	Enzyme	L-Cysteine Acetic acid Sulfide O-acetyl-L-serine Hydrogen sulfide hydron 2-Aminoacrylic acid
Q04533	YML082W	Putative cystathionine gamma-synthase YML082W	Enzyme	L-Cysteine Acetic acid 2-Ketobutyric acid O-Acetyl-L-homoserine L-Cystathionine Succinic acid Ammonium hydron water O-Succinyl-L-homoserine
P06106	MET17 YLR303W	Protein MET17	Enzyme	L-Cysteine Acetic acid Methanethiol Sulfide O-Acetyl-L-homoserine L-Methionine Homocysteine L-Homocysteine O-acetyl-L-serine Hydrogen sulfide hydron Acetylhomoserine
P31373	CYS3 YAL012W	Cystathionine gamma-lyase	Enzyme	L-Cysteine 2-Ketobutyric acid Ammonia Pyruvic acid L-Cystathionine Ammonium Hydrogen sulfide hydron water Selenomethionine Se-Methylselenocysteine 2-aminoprop-2-enoate methylselenol
Q12198	YLL058W	Putative cystathionine gamma-synthase YLL058W	Enzyme	L-Cysteine L-Cystathionine Succinic acid O-Succinyl-L-homoserine
P47164	STR2 YJR130C	Cystathionine gamma-synthase	Enzyme	L-Cysteine Acetic acid O-Acetyl-L-homoserine L-Cystathionine Succinic acid hydron O-Succinyl-L-homoserine Selenocysteine Selenocystathionine Acetylhomoserine
P39954	SAH1 YER043C	Adenosylhomocysteinase	Enzyme	Adenosine S-Adenosylhomocysteine Homocysteine L-Homocysteine water
P05694	MET6 YER091C	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	Enzyme	Tetrahydropteroyltri-L-glutamate 5-Methyltetrahydrofolic acid L-Methionine 5-Methyltetrahydropteroyltri-L-glutamate Homocysteine 5,6,7,8-Tetrahydrofolic acid 5-Methyltetrahydropteroyltri-L-glutamic acid Tetrahydropteroyltri-L-glutamic acid L-Homocysteine hydron Selenomethionine Selenohomocysteine
P0CF21	SDL1 YIL167W	L-serine dehydratase	Enzyme	Ammonia L-Serine Pyruvic acid
P53101	STR3 YGL184C	Cystathionine beta-lyase	Enzyme	Ammonia Pyruvic acid L-Cystathionine Homocysteine Ammonium L-Homocysteine water Selenohomocysteine Selenocystathionine
P43623	IRC7 YFR055W	Putative cystathionine beta-lyase	Enzyme	Ammonia Pyruvic acid L-Cystathionine Homocysteine Ammonium L-Homocysteine water Selenohomocysteine Selenocystathionine
P10659	SAM1 YLR180W	S-adenosylmethionine synthase 1	Enzyme	Adenosine triphosphate Pyrophosphate S-Adenosylmethionine L-Methionine S-Adenosyl-L-methionine water phosphate
P10869	HOM3 YER052C	Aspartokinase	Enzyme	L-aspartic 4-semialdehyde L-Homoserine Adenosine triphosphate 4-Phospho-L-aspartic acid NADPH NADP hydron L-Aspartic acid ADP
P32582	CYS4 YGR155W	Cystathionine beta-synthase	Enzyme	L-Serine L-Cystathionine Homocysteine L-Homocysteine water
P38840	ARO9 YHR137W	Aromatic amino acid aminotransferase 2	Enzyme	2-Ketobutyric acid L-Tryptophan Oxoglutaric acid L-Alanine 3-(indol-3-yl)pyruvic acid Pyruvic acid L-Glutamic acid L-Phenylalanine L-Methionine L-Tyrosine 4-Methylthio-2-oxobutanoate keto-phenylpyruvic acid (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate
P53090	ARO8 YGL202W	Aromatic amino acid aminotransferase 1	Enzyme	L-Tryptophan Oxoadipic acid Oxoglutaric acid 3-(indol-3-yl)pyruvic acid L-Glutamic acid L-Phenylalanine L-Tyrosine keto-phenylpyruvic acid (4-hydroxyphenyl)pyruvic acid L-2-aminoadipate 3-(indol-3-yl)pyruvate
Q12455	SPE4 YLR146C	Spermine synthase	Enzyme	S-Adenosylmethioninamine 5'-Methylthioadenosine Spermine Spermidine hydron
Q12074	SPE3 YPR069C	Spermidine synthase	Enzyme	S-Adenosylmethioninamine Putrescine 5'-Methylthioadenosine Spermidine hydron
P21182	SPE2 YOL052C	S-adenosylmethionine decarboxylase proenzyme	Enzyme	S-Adenosylmethioninamine S-Adenosylmethionine S-Adenosyl-L-methionine hydron Carbon dioxide (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium
Q01802	AAT1 YKL106W	Aspartate aminotransferase, mitochondrial	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
P23542	AAT2 YLR027C	Aspartate aminotransferase, cytoplasmic	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
Q12525	MHT1 YLL062C	Homocysteine S-methyltransferase 1	Enzyme	S-Adenosylhomocysteine L-Methionine S-Methyl-L-methionine Homocysteine S-Adenosyl-L-methionine L-Homocysteine hydron
Q08985	SAM4 YPL273W	Homocysteine S-methyltransferase 2	Enzyme	S-Adenosylhomocysteine L-Methionine S-Methyl-L-methionine Homocysteine S-Adenosyl-L-methionine L-Homocysteine hydron
P31116	HOM6 YJR139C	Homoserine dehydrogenase	Enzyme	L-aspartic 4-semialdehyde L-Homoserine NAD NADH NAD(+) NADPH NADP hydron
P19358	SAM2 YDR502C	S-adenosylmethionine synthase 2	Enzyme	Adenosine triphosphate Pyrophosphate S-Adenosylmethionine L-Methionine S-Adenosyl-L-methionine water phosphate