{"ymdb_id":"YMDB16129","created_at":"2016-09-12T18:13:13.000Z","updated_at":"2016-10-17T22:34:41.000Z","name":"Coenzyme Q10","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2-[(2E,6E,10E,14E,18E,22E,26Z,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione","traditional_iupac":"ubisemiquinone","logp":"17.156128291","pka":null,"alogps_solubility":"1.93e-04 g/l","alogps_logp":"9.94","alogps_logs":"-6.65","acceptor_count":"4","donor_count":"0","rotatable_bond_count":"31","polar_surface_area":"52.60000000000001","refractivity":"286.60519999999997","polarizability":"111.4334393116442","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.718903581971888","pka_strongest_acidic":null,"bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-26T17:56:42.000Z","updated_at":"2011-05-26T17:56:42.000Z","name":"Fumarate reductase","uniprot_id":"P32614","uniprot_name":"FRDS_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":470,"molecular_weight":"50843.69922","theoretical_pi":"6.26","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2498,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm","altext":"Succinate + NAD(+) = fumarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"U18779","genbank_protein_id":"603632","gene_card_id":null,"chromosome_location":null,"locus":"YEL047C","synonyms":["FAD-dependent oxidoreductase FRDS","NADH","NADH-dependent fumarate reductase"],"enzyme_classes":["1.3.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTCTCTCTCTCCCGTTGTTGTTATTGGAACCGGTTTGGCCGGGCTGGCTGCTGCCAATGAATTGGTTAACAAGTATAACATCCCTGTAACCATCCTCGAAAAGGCTTCCTCGATCGGTGGGAACTCTATCAAGGCCTCCAGTGGTATTAACGGTGCTTGCACCGAGACTCAACGTCACTTCCACATCGAGGACTCCCCACGCTTATTTGAAGATGACACCATCAAGTCTGCTAAAGGTAAAGGTGTCCAAGAATTAATGGCTAAGTTGGCCAATGATTCTCCCCTGGCTATTGAATGGTTGAAAAACGAATTTGATTTGAAATTGGACCTATTGGCTCAATTGGGTGGCCACTCTGTGGCAAGAACTCACAGATCGTCTGGGAAGTTGCCTCCAGGTTTCGAAATTGTTTCTGCCTTATCTAACAATTTGAAGAAATTAGCTGAGACTAAACCAGAGTTAGTTAAGATTAACTTAGACAGTAAAGTCGTAGACATCCATGAAAAGGATGGCTCCATTTCTGCTGTAGTGTACGAGGACAAGAATGGCGAAAAGCACATGGTGAGTGCTAACGATGTCGTTTTTTGTTCTGGAGGGTTTGGCTTTTCTAAGGAAATGCTTAAAGAATACGCACCCGAACTGGTGAACTTGCCAACAACAAACGGGCAACAAACAACTGGTGATGGTCAAAGGCTTCTGCAGAAGTTAGGCGCTGATCTGATTGACATGGACCAAATTCAAGTTCATCCAACTGGGTTCATTGATCCAAATGACCGTAGCTCAAGCTGGAAATTCTTGGCTGCCGAATCCTTAAGAGGTCTTGGTGGTATCCTATTAAACCCTATTACCGGTAGAAGATTTGTCAACGAATTGACCACAAGAGATGTAGTCACTGCAGCTATTCAAAAGGTTTGTCCTCAAGAGGATAACAGAGCACTATTGGTTATGGGCGAAAAAATGTACACAGATTTGAAGAATAATTTAGATTTTTACATGTTCAAGAAACTTGTACAGAAATTGACATTATCTCAAGTTGTTTCTGAATATAATTTACCAATCACTGTCGCCCAATTATGCGAGGAATTGCAAACATACTCTTCCTTCACTACCAAGGCTGATCCGTTGGGACGTACCGTTATTCTCAACGAATTTGGCTCTGACGTTACTCCAGAAACTGTGGTTTTTATTGGTGAAGTAACACCGGTTGTCCATTTCACCATGGGTGGTGCTAGAATCAATGTCAAGGCTCAAGTCATTGGCAAGAACGACGAAAGGCTACTAAAAGGCCTGTACGCGGCCGGTGAAGTTTCTGGCGGTGTTCATGGCGCCAATAGGTTGGGTGGTTCAAGTTTGTTAGAATGCGTTGTCTTTGGGAGAACCGCAGCTGAATCTATTGCCAATGACCGCAAGTAA","protein_sequence":"MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"}]}