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Identification
YMDB IDYMDB11447
Name1-MLCL(0:0/10:0/10:0/20:1(13Z))
SpeciesSaccharomyces cerevisiae
StrainBrewer's yeast
Description1-MLCL(0:0/10:0/10:0/20:1(13Z)) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 1-MLCL(0:0/10:0/10:0/20:1(13Z)) contains one chain of at the C1 position, two chains of decanoic acid at the C2 and C3 positions, one chain of (13Z-eicosenoyl) at the C4 position. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter­mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Structure
Thumb
SynonymsNot Available
CAS numberNot Available
WeightAverage: 1001.223
Monoisotopic: 1000.601710943
InChI KeyWBIIJHKZYAELHT-AFDHZSLMSA-N
InChIInChI=1S/C49H94O16P2/c1-4-7-10-13-16-17-18-19-20-21-22-23-24-25-28-31-34-37-49(54)65-46(41-59-47(52)35-32-29-26-14-11-8-5-2)43-63-67(57,58)61-40-44(51)39-60-66(55,56)62-42-45(38-50)64-48(53)36-33-30-27-15-12-9-6-3/h17-18,44-46,50-51H,4-16,19-43H2,1-3H3,(H,55,56)(H,57,58)/b18-17-/t44-,45+,46+/m0/s1
IUPAC Name[(2R)-3-(decanoyloxy)-2-[(13Z)-icos-13-enoyloxy]propoxy][(2S)-3-({[(2R)-2-(decanoyloxy)-3-hydroxypropoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropoxy]phosphinic acid
Traditional IUPAC Name(2R)-3-(decanoyloxy)-2-[(13Z)-icos-13-enoyloxy]propoxy((2S)-3-{[(2R)-2-(decanoyloxy)-3-hydroxypropoxy(hydroxy)phosphoryl]oxy}-2-hydroxypropoxy)phosphinic acid
Chemical FormulaC49H94O16P2
SMILES[H][C@](O)(COP(O)(=O)OC[C@@]([H])(CO)OC(=O)CCCCCCCCC)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCC
Chemical Taxonomy
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.00084 g/LALOGPS
logP7.3ALOGPS
logP12.87ChemAxon
logS-6.1ALOGPS
pKa (Strongest Acidic)1.59ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area230.88 ŲChemAxon
Rotatable Bond Count53ChemAxon
Refractivity260.82 m³·mol⁻¹ChemAxon
Polarizability113.66 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Mitochondrion membrane
Organoleptic PropertiesNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(10:0/10:0/20:1(13Z)/22:0)PW003649 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/20:1(13Z)/22:1(11Z))PW003650 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/20:1(13Z)/22:1(9Z))PW003651 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/20:1(13Z)/24:0)PW003652 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/20:1(13Z)/24:1(11Z))PW003653 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB Reactions
CL(10:0/10:0/20:1(13Z)/22:0)1-MLCL(0:0/10:0/10:0/20:1(13Z))
CL(10:0/10:0/20:1(13Z)/22:1(11Z))1-MLCL(0:0/10:0/10:0/20:1(13Z))
CL(10:0/10:0/20:1(13Z)/22:1(9Z))1-MLCL(0:0/10:0/10:0/20:1(13Z))
CL(10:0/10:0/20:1(13Z)/24:0)1-MLCL(0:0/10:0/10:0/20:1(13Z))
CL(10:0/10:0/20:1(13Z)/24:1(11Z))1-MLCL(0:0/10:0/10:0/20:1(13Z))
KEGG ReactionsNot Available
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-003u-4785067198-4f5b931e1aaed45bee0fJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0563-1592235234-ef0ecc75002c8308b79bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-004i-4393023002-256c59deac8396796ebbJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0592-1917214356-a01523ac5424b65193f0JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9414211111-78abaa3baac3ec4e37c7JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9233000000-c4a06fa79c7f72cc1f01JSpectraViewer
References
References:
  • Baile MG, Lu YW, Claypool SM. (2014). "The topology and regulation of cardiolipin biosynthesis and remodeling in yeast." Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1.24184646
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI IDNot Available
HMDB IDNot Available
Pubchem Compound IDNot Available
Kegg IDNot Available
ChemSpider IDNot Available
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDNot Available