{"ymdb_id":"YMDB01633","created_at":"2011-08-31T03:30:25.000Z","updated_at":"2016-09-08T18:36:55.000Z","name":"Acetyllysine","cas":null,"state":"Solid","melting_point":"250","description":"Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. The acetylation of lysine residues in proteins is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"17752","hmdb_id":"HMDB00206","kegg_id":"C02727","pubchem_id":"92907","cs_id":"167134","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-6-amino-2-acetamidohexanoic acid","traditional_iupac":"nα-acetyllysine","logp":"-3.154849831228551","pka":"15.916998108448613","alogps_solubility":"1.61e+01 g/l","alogps_logp":"-2.54","alogps_logs":"-1.07","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"6","polar_surface_area":"92.41999999999999","refractivity":"47.2533","polarizability":"19.961306276615304","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"10.205475361447382","pka_strongest_acidic":"3.8943963051732786","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["6-amino-L-2-Acetamidohexanoate","6-amino-L-2-Acetamidohexanoic acid","Acetyllysine","N-a-Acetyl-L-lysine","N-a-Acetyllysine","N-Acetyl poly-L-lysine","N-Acetyl polylysine","N-Acetyl-L-lysine","N-alpha-Acetyl-L-lysine","N2-Acetyl-L-lysine","N2-Acetyllysine"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":19889834,"citation":"Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). \"Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.\" Mol Biol Cell 21:198-211."}],"proteins":[]}