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Identification
YMDB IDYMDB00982
Nameno
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionNitric oxide, also known as NO or EDRF, belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'. Nitric oxide is an extremely weak basic (essentially neutral) compound (based on its pKa). Nitric oxide exists in all living species, ranging from bacteria to humans.
Structure
Thumb
Synonyms
  • Mononitrogen monoxide
  • Nitric oxide
  • Nitrogen monoxide
  • Nitrogen oxide
  • nitrogen protoxide
  • Nitrosyl hydride
  • Nitrosyl radical
  • Nitroxide radical
  • Nitroxyl
  • (NO)(.)
  • [NO]
  • EDRF
  • Endothelium-derived relaxing factor
  • Monoxido de nitrogeno
  • Monoxyde d'azote
  • Nitrogen monooxide
  • Nitrosyl
  • NO
  • (.)NO
  • NO(.)
  • Oxido de nitrogeno(II)
  • Oxido nitrico
  • Oxyde azotique
  • Oxyde nitrique
  • Stickstoff(II)-oxid
  • Stickstoffmonoxid
  • INOmax
  • Endogenous nitrate vasodilator
  • Monoxide, nitrogen
  • Nitric oxide, endothelium derived
  • Nitric oxide, endothelium-derived
  • Monoxide, mononitrogen
  • Vasodilator, endogenous nitrate
  • Endothelium-derived nitric oxide
  • Nitrate vasodilator, endogenous
  • Oxide, nitric
CAS number10102-43-9
WeightAverage: 30.0061
Monoisotopic: 29.997988627
InChI KeyMWUXSHHQAYIFBG-UHFFFAOYSA-N
InChIInChI=1S/NO/c1-2
IUPAC Namenitroso
Traditional IUPAC Namenitric oxide
Chemical FormulaNO
SMILESN#[O]
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassOther non-metal organides
Sub ClassOther non-metal oxides
Direct ParentOther non-metal oxides
Alternative Parents
Substituents
  • Other non-metal oxide
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
StateGas
Charge0
Melting point-163.6 °C
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
logP-0.35ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m³·mol⁻¹ChemAxon
Polarizability1.69 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular LocationsNot Available
Organoleptic PropertiesNot Available
SMPDB Pathways
Nitrogen metabolismPW002504 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Arginine and proline metabolismec00330 Map00330
Nitrogen metabolismec00910 Map00910
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-9000000000-d182bfca83d886821e6dJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-8a2dd9da1fc114d013b3JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-8a2dd9da1fc114d013b3JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-8a2dd9da1fc114d013b3JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-9000000000-e998110984a05853a05dJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-e998110984a05853a05dJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-e998110984a05853a05dJSpectraViewer
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Gardner, P. R. (2005). "Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases." J Inorg Biochem 99:247-266.15598505
Synthesis Reference:Morabito, Paul; Heicklen, Julian. Disproportionation to combination ratios of alkoxy radicals with nitric oxide. Journal of Physical Chemistry (1985), 89(13), 2914-16.
External Links:
ResourceLink
CHEBI ID16480
HMDB IDHMDB03378
Pubchem Compound ID945
Kegg IDC00533
ChemSpider ID127983
FOODB IDNot Available
WikipediaNitric_oxide
BioCyc IDNITRIC-OXIDE

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity
Gene Name:
YHB1
Uniprot ID:
P39676
Molecular weight:
44646.0
Reactions
2 NO + 2 O(2) + NAD(P)H → 2 NO(3)(-) + NAD(P)(+).