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Identification
YMDB IDYMDB00961
NameS-Methyl-5-thio-alpha-D-ribose 1-phosphate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionS-Methyl-5-thio-alpha-D-ribose 1-phosphate, also known as S-methyl-5-thio-D-ribose 1-phosphoric acid or 5-S-methyl-1-O-phosphono-5-thio-a-D-ribofuranose, belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms. S-Methyl-5-thio-alpha-D-ribose 1-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). S-Methyl-5-thio-alpha-D-ribose 1-phosphate exists in both E. coli (prokaryote) and yeast (eukaryote).
Structure
Thumb
Synonyms
  • 5-methylthio-d-ribose 1-phosphate
  • 5-S-methyl-1-O-phosphono-5-thio-alpha-D-ribofuranose
  • S-Methyl-5-thio-5-deoxy-D-ribose 1-phosphate
  • S-Methyl-5-thio-alpha-D-ribose 1-phosphate
  • S-Methyl-5-thio-D-ribose 1-phosphate
  • s5-methyl-5-thio-d-ribose 1-phosphate
  • 5-S-Methyl-1-O-phosphono-5-thio-a-D-ribofuranose
  • 5-S-Methyl-1-O-phosphono-5-thio-α-D-ribofuranose
  • S-Methyl-5-thio-5-deoxy-D-ribose 1-phosphoric acid
  • S-Methyl-5-thio-D-ribose 1-phosphoric acid
  • S-Methyl-5-thio-a-D-ribose 1-phosphate
  • S-Methyl-5-thio-a-D-ribose 1-phosphoric acid
  • S-Methyl-5-thio-alpha-D-ribose 1-phosphoric acid
  • S-Methyl-5-thio-α-D-ribose 1-phosphate
  • S-Methyl-5-thio-α-D-ribose 1-phosphoric acid
CAS numberNot Available
WeightAverage: 260.202
Monoisotopic: 260.011959972
InChI KeyJTFITTQBRJDSTL-KVTDHHQDSA-N
InChIInChI=1S/C6H13O7PS/c1-15-2-3-4(7)5(8)6(12-3)13-14(9,10)11/h3-8H,2H2,1H3,(H2,9,10,11)/t3-,4-,5-,6-/m1/s1
IUPAC Name{[(2R,3R,4S,5S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxy}phosphonic acid
Traditional IUPAC Name[(2R,3R,4S,5S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxyphosphonic acid
Chemical FormulaC6H13O7PS
SMILESCSC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O
Chemical Taxonomy
Description belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentPentoses
Alternative Parents
Substituents
  • Pentose monosaccharide
  • Monoalkyl phosphate
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Tetrahydrofuran
  • 1,2-diol
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Dialkylthioether
  • Sulfenyl compound
  • Thioether
  • Organic oxide
  • Alcohol
  • Hydrocarbon derivative
  • Organosulfur compound
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility28.7 g/LALOGPS
logP-1.2ALOGPS
logP-0.94ChemAxon
logS-0.96ALOGPS
pKa (Strongest Acidic)1.16ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area116.45 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity51.67 m³·mol⁻¹ChemAxon
Polarizability22.39 ųChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Cytoplasm
Organoleptic PropertiesNot Available
SMPDB PathwaysNot Available
KEGG Pathways
Cysteine and methionine metabolismec00270 Map00270
SMPDB ReactionsNot Available
KEGG Reactions
phosphate + 5'-MethylthioadenosineS-Methyl-5-thio-alpha-D-ribose 1-phosphate + Adenine
S-Methyl-5-thio-alpha-D-ribose 1-phosphate5-Methylthioribulose 1-phosphate
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Subhi, A. L., Diegelman, P., Porter, C. W., Tang, B., Lu, Z. J., Markham, G. D., Kruger, W. D. (2003). "Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites." J Biol Chem 278:49868-49873.14506228
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI ID27859
HMDB IDHMDB00963
Pubchem Compound ID45266677
Kegg IDC04188
ChemSpider ID10160733
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDCPD-444

Enzymes

General function:
Involved in catalytic activity
Specific function:
Seems to be implicated in the regulation of the expression of the ADH2 gene
Gene Name:
MEU1
Uniprot ID:
Q07938
Molecular weight:
37856.30078
Reactions
S-methyl-5'-thioadenosine + phosphate → adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate