{"ymdb_id":"YMDB00914","created_at":"2011-05-29T19:04:46.000Z","updated_at":"2016-10-18T17:11:41.000Z","name":"ADP","cas":"58-64-0","state":"Solid","melting_point":"","description":"Adenosine diphosphate (ADP) is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"Golgi;mitochondrion;endoplasmic reticulum;peroxisome;nucleus;vacuole;cytoplasm","synthesis_reference":"Yamagata, Yukio.  Prebiotic formation of ADP and ATP from AMP, calcium phosphates and cyanate in aqueous solution.    Origins of Life and Evolution of the Biosphere  (1999),  29(5),  511-520. ","chebi_id":"16761","hmdb_id":"HMDB01341","kegg_id":"C00008","pubchem_id":"6022","cs_id":"5800","foodb_id":null,"wikipedia_link":"Adenosine_diphosphate","biocyc_id":"ADP","iupac":"[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid","traditional_iupac":"adenosine-diphosphate","logp":"-4.711847208485645","pka":"3.1362480842882006","alogps_solubility":"3.27e+00 g/l","alogps_logp":"-1.65","alogps_logs":"-2.12","acceptor_count":"12","donor_count":"6","rotatable_bond_count":"6","polar_surface_area":"232.59999999999994","refractivity":"84.94139999999997","polarizability":"34.23829042406093","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"3.998359170782524","pka_strongest_acidic":"1.768740258002925","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["adenosindiphosphorsaeure","adenosine 5'-pyrophosphate","adenosine diphosphate","adenosine pyrophosphate","adenosine-5-diphosphate","adenosine-5'-diphosphate","adenosine-diphosphate","adp"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Biotin Biosynthesis","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Fructose Metabolism","kegg_map_id":null},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Glycerol metabolism","kegg_map_id":null},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Glycolysis I","kegg_map_id":null},{"name":"Inositol Metabolism","kegg_map_id":null},{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Leloir Pathway","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria 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","concentration":"420.0","concentration_units":"\u0026#181;M","error":"110.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts and glucose","concentration":"1400.0","concentration_units":"\u0026#181;M","error":"800.0"},{"growth_media":"Minimal medium supplemented with ammonia salts and (glucose or galactose)","concentration":"950.0","concentration_units":"\u0026#181;M","error":"350.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"320.0","concentration_units":"\u0026#181;M","error":"20.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"530.0","concentration_units":"\u0026#181;M","error":"100.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"530.0","concentration_units":"\u0026#181;M","error":"140.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"1100.0","concentration_units":"\u0026#181;M","error":"300.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":11135551,"citation":"Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M. C., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., Westerhoff, H. V., van Dam, K., Oliver, S. G. (2001). \"A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.\" Nat Biotechnol 19:45-50."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":5092557,"citation":"Leibach, T. K., Spiess, G. I., Neudecker, T. J., Peschke, G. J., Puchwein, G., Hartmann, G. R. (1971). \"Purification and properties of adenosine kinase from dried brewer's yeast.\" Hoppe Seylers Z Physiol Chem 352:328-344."},{"pubmed_id":10383756,"citation":"Llorente, B., Fairhead, C., Dujon, B. (1999). \"Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway.\" Mol Microbiol 32:1140-1152."},{"pubmed_id":6394965,"citation":"Entian, K. D., Kopetzki, E., Frohlich, K. U., Mecke, D. (1984). \"Cloning of hexokinase isoenzyme PI from Saccharomyces cerevisiae: PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts.\" Mol Gen Genet 198:50-54."},{"pubmed_id":15978040,"citation":"Shi, F., Kawai, S., Mori, S., Kono, E., Murata, K. (2005). \"Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae.\" FEBS J 272:3337-3349."},{"pubmed_id":9506987,"citation":"Kim, K. H., Voelker, D. R., Flocco, M. T., Carman, G. M. (1998). \"Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae.\" J Biol Chem 273:6844-6852."},{"pubmed_id":10409709,"citation":"Gao, X. D., Kaigorodov, V., Jigami, Y. (1999). \"YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae.\" J Biol Chem 274:21450-21456."},{"pubmed_id":11956213,"citation":"Dubois, E., Scherens, B., Vierendeels, F., Ho, M. M., Messenguy, F., Shears, S. B. (2002). \"In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.\" J Biol Chem 277:23755-23763."},{"pubmed_id":9624177,"citation":"Homma, K., Terui, S., Minemura, M., Qadota, H., Anraku, Y., Kanaho, Y., Ohya, Y. (1998). \"Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis.\" J Biol Chem 273:15779-15786."},{"pubmed_id":6355828,"citation":"Larimer, F. W., Morse, C. C., Beck, A. K., Cole, K. W., Gaertner, F. H. (1983). \"Isolation of the ARO1 cluster gene of Saccharomyces cerevisiae.\" Mol Cell Biol 3:1609-1614."},{"pubmed_id":2556364,"citation":"Plateau, P., Fromant, M., Schmitter, J. M., Buhler, J. M., Blanquet, S. (1989). \"Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.\" J Bacteriol 171:6437-6445."},{"pubmed_id":9874242,"citation":"Przybyla-Zawislak, B., Dennis, R. A., Zakharkin, S. O., McCammon, M. T. (1998). \"Genes of succinyl-CoA ligase from Saccharomyces cerevisiae.\" Eur J Biochem 258:736-743."},{"pubmed_id":9611819,"citation":"ter Schure, E. G., Sillje, H. H., Vermeulen, E. E., Kalhorn, J. W., Verkleij, A. J., Boonstra, J., Verrips, C. T. (1998). \"Repression of nitrogen catabolic genes by ammonia and glutamine in nitrogen-limited continuous cultures of Saccharomyces cerevisiae.\" Microbiology 144 ( Pt 5):1451-1462."},{"pubmed_id":10960485,"citation":"Ives, E. B., Nichols, J., Wente, S. R., York, J. D. (2000). \"Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases.\" J Biol Chem 275:36575-36583."},{"pubmed_id":1654509,"citation":"Korch, C., Mountain, H. A., Bystrom, A. S. (1991). \"Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae.\" Mol Gen Genet 229:96-108."},{"pubmed_id":6357942,"citation":"Maitra, P. K., Lobo, Z. (1983). \"Genetics of yeast glucokinase.\" Genetics 105:501-515."},{"pubmed_id":11731153,"citation":"Bayly, A. M., Berglez, J. M., Patel, O., Castelli, L. A., Hankins, E. G., Coloe, P., Hopkins Sibley, C., Macreadie, I. G. (2001). \"Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae.\" FEMS Microbiol Lett 204:387-390."},{"pubmed_id":6185493,"citation":"Burke, R. L., Tekamp-Olson, P., Najarian, R. (1983). \"The isolation, characterization, and sequence of the pyruvate kinase gene of Saccharomyces cerevisiae.\" J Biol Chem 258:2193-2201."},{"pubmed_id":15137942,"citation":"Bieganowski, P., Brenner, C. (2004). \"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.\" Cell 117:495-502."},{"pubmed_id":9729482,"citation":"Rebbeor, J. F., Connolly, G. C., Dumont, M. E., Ballatori, N. (1998). \"ATP-dependent transport of reduced glutathione in yeast secretory vesicles.\" Biochem J 334 ( Pt 3):723-729."},{"pubmed_id":17382260,"citation":"Strahl, T., Thorner, J. (2007). \"Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.\" Biochim Biophys Acta 1771:353-404."},{"pubmed_id":8973190,"citation":"Huo, X., Viola, R. E. (1996). \"Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli.\" Biochemistry 35:16180-16185."},{"pubmed_id":10799479,"citation":"Cherest, H., Thomas, D., Surdin-Kerjan, Y. (2000). \"Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.\" J Biol Chem 275:14056-14063."},{"pubmed_id":3007939,"citation":"Heinisch, J. (1986). \"Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast.\" Mol Gen Genet 202:75-82."},{"pubmed_id":14761959,"citation":"Hoja, U., Marthol, S., Hofmann, J., Stegner, S., Schulz, R., Meier, S., Greiner, E., Schweizer, E. (2004). \"HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae.\" J Biol Chem 279:21779-21786."},{"pubmed_id":14562095,"citation":"Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). \"Global analysis of protein localization in budding yeast.\" Nature 425:686-691."},{"pubmed_id":12361950,"citation":"Han, G. S., Audhya, A., Markley, D. J., Emr, S. D., Carman, G. M. (2002). \"The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity.\" J Biol Chem 277:47709-47718."},{"pubmed_id":10329685,"citation":"Kim, K., Kim, K. H., Storey, M. K., Voelker, D. R., Carman, G. M. (1999). \"Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase.\" J Biol Chem 274:14857-14866."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."}],"proteins":[{"created_at":"2011-05-24T19:11:36.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Adenosine kinase","uniprot_id":"P47143","uniprot_name":"ADK_YEAST","enzyme":true,"transporter":false,"gene_name":"ADO1","num_residues":340,"molecular_weight":"36372.0","theoretical_pi":"4.77","general_function":"Involved in adenosine kinase activity","specific_function":"ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle","reactions":[{"id":1270,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2242,"direction":"\u003e","locations":null,"altext":"ATP + adenosine = ADP + AMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558082","genbank_protein_id":"45270054","gene_card_id":"ADO1","chromosome_location":"chromosome 10","locus":"YJR105W","synonyms":[],"enzyme_classes":["2.7.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Function","description":" nucleoside kinase activity"},{"category":"Function","description":" adenosine kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular biosynthetic process"},{"category":"Process","description":" heterocycle biosynthetic process"},{"category":"Process","description":" purine salvage"},{"category":"Process","description":" purine ribonucleoside salvage"}],"pfams":[{"name":"PfkB","identifier":"PF00294"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGACCGCACCATTGGTAGTATTGGGTAACCCACTTTTAGATTTCCAAGCCGACGTCACGGCTGAATACCTGGCCAAGTATTCTCTAAAGGAAAACGACGCAATTTTGGTCGATGCCAAATCAGGCGATGCTAAGATGGCTATTTTTGACGAGCTCTTACAGATGCCAGAAACAAAGCTTGTTGCAGGTGGTGCTGCTCAAAACACTGCTAGAGGGGCAGCATACGTTTTGGGCGCCGGCCAGGTGGTGTACTTCGGTTCCGTCGGTAAGGACAAGTTCAGCGAGAGATTGCTTAACGAAAACGAAAAAGCTGGTGTCAAGTCTATGTACCAAGTTCAAAATGATATTGGTACCGGTAAGTGTGCCGCATTAATCACTGGCCATAACCGGTCCTTGGTCACTGACTTGGGTGCTGCCAATTTCTTTACTCCAGACCACTTGGACAAGCATTGGGACTTGGTCGAAGCAGCTAAGCTCTTCTACATCGGTGGTTTCCACTTGACCGTGTCTCCAGACGCTATCGTTAAGTTGGGCCAACATGCTAAAGAGAACAGCAAACCTTTCGTGTTGAACTTTAGTGCTCCTTTCATTCCTCATGTCTTCAAAGACGCATTGGCCAGAGTTTTGCCTTATGCTACCGTCATCATCGCTAACGAATCGGAGGCCGAAGCCTTTTGCGACGCCTTCCAATTAGACTGTGCCAACACTGATTTGGAAGCTATTGCTCAAAGAATTGTCAAGGACTCTCCAGTTGAAAAGACTGTCATCTTCACCCACGGTGTCGAACCAACAGTGGTCGTGTCCTCCAAGGGTACCAGCACATATCCAGTCAAACCTTTGGACTCTTCTAAGATCGTCGACACCAACGGTGCTGGTGACGCCTTCGCTGGTGGCTTTATGGCTGGGTTGACTAAAGGTGAAGATTTGGAAACCTCTATTGACATGGGTCAATGGCTAGCTGCTTTGTCTATTCAAGAAGTTGGTCCCTCTTACCCTTCCGAAAAAATATCTTACTCTAAATAG","protein_sequence":"MTAPLVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDAKMAIFDELLQMPETKLVAGGAAQNTARGAAYVLGAGQVVYFGSVGKDKFSERLLNENEKAGVKSMYQVQNDIGTGKCAALITGHNRSLVTDLGAANFFTPDHLDKHWDLVEAAKLFYIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPFIPHVFKDALARVLPYATVIIANESEAEAFCDAFQLDCANTDLEAIAQRIVKDSPVEKTVIFTHGVEPTVVVSSKGTSTYPVKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAALSIQEVGPSYPSEKISYSK"},{"created_at":"2011-05-24T19:21:34.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Phosphoribosylformylglycinamidine synthase","uniprot_id":"P38972","uniprot_name":"PUR4_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE6","num_residues":1358,"molecular_weight":"148904.0","theoretical_pi":"4.92","general_function":"Involved in catalytic activity","specific_function":"ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate","reactions":[{"id":1889,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2248,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z72846","genbank_protein_id":"1323079","gene_card_id":"ADE6","chromosome_location":"chromosome 7","locus":"YGR061C","synonyms":["FGAM synthase","FGAMS","Formylglycinamide ribotide amidotransferase","FGARAT","Formylglycinamide ribotide synthetase"],"enzyme_classes":["6.3.5.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" phosphoribosylformylglycinamidine synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"}],"pfams":[{"name":"AIRS","identifier":"PF00586"},{"name":"AIRS_C","identifier":"PF02769"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGACTGATTATATTTTGCCGGGTCCCAAGGCCTTATCTCAGTTCAGAGTCGATAATCTAATTAAAGATATAAACTCCTATACAAACAGTACTTCTGTCATCAATGAATTGCGTTCGTGTTACATTCACTATGTCAACGGCATCGCTCAAAATTTGTCTGAACAGGACACTAAATTGCTAGAAGTTTTGTTGACTTACGATTCTGCTTTAGATATTGCTAACGATCCATTAGCAAGACAATTAAACGATGCTGTCGCTAATAATTTACCCAGTTCAGCTCTTGGCGAAGACACATATTTGATTAGAGTTGTTCCTAGATCAGGCACTATCTCTCCTTGGTCTTCCAAGGCTACTAATATTGCTCATGTATGCGGGCTACAAGACAAAGTTCAACGTATTGAAAGAGGTTTAGCCTTACTCATAAAGACTGTTCCAGGTTTCCCTCTTTTGGAAAATCTAAATGATATTTCATTGAAGTGTGTCTACGATAGGATGACACAACAATTATATCTGACCGAACCACCAAATACGATGAGTATTTTCACACATGAAGAGCCAAAGCCATTAGTTCACGTTCCTTTAACTCCTAAGGACACTAAACAGTCTCCAAAGGATATTTTATCCAAAGCTAATACGGAATTGGGTTTAGCTCTAGATAGTGGAGAAATGGAATATTTGATTCATGCATTCGTCGAAACTATGAAAAGAGATCCTACTGATGTTGAGTTATTTATGTTCGCTCAAGTTAATTCTGAACATTGTCGTCACAAGATCTTCAATGCTGATTGGACCATTGATGGAATAAAACAACAATTCACCTTGTTTCAAATGATTAGAAATACCCATAAATTAAACCCAGAATATACTATTAGCGCCTATTCTGATAATGCAGCCGTTTTGGATAGTGAAAATGATGCCTTTTTCTTTGCACCAAATTCAACTACAAAGGAATGGACCTCTACAAAGGAAAGAATTCCATTACTTATCAAAGTCGAAACTCACAACCATCCAACAGCCGTGTCTCCTTTCCCAGGTGCTGCTACAGGTTCTGGTGGTGAAATCAGAGACGAGGGTGCTACAGGCAGAGGTTCCAAGACTAAGTGTGGTTTGAGTGGATTCTCTGTCAGCGACCTTTTGATACCAGGTAATGAACAACCTTGGGAGTTGAATATTGGTAAGCCTTACCATATTGCATCTGCATTAGATATTATGATTGAGGCTCCTTTGGGTTCAGCTGCATTTAACAATGAGTTTGGTAGACCTTGTATAAACGGTTACTTCAGAACTTTAACTACAAAGGTTTTGAATCACCAAGGGAAGGAGGAAATCAGAGGGTTCCACAAGCCAATTATGATTGCGGGTGGTTTCGGTACTGTTAGACCTCAATTTGCTTTGAAGAACACCCCAATAACTCCAGGCTCTTGTTTAATTGTACTTGGTGGTCAATCTATGCTGATTGGTTTAGGTGGTGGTGCTGCTTCTTCTGTAGCTTCCGGTGAAGGTTCCGCCGATTTGGATTTTGCTTCTGTACAAAGAGGGAACCCCGAAATGGAACGTCGTTGCCAACAAGTGATTGACGCTTGTGTTGCCTTAGGTAACAATAATCCTATCCAATCTATTCACGATGTTGGTGCTGGTGGGTTATCCAACGCTTTGCCAGAATTGGTTCATGACAATGACTTGGGTGCTAAATTCGATATTAGAAAGGTCCTCTCCTTAGAACCTGGTATGTCACCAATGGAAATTTGGTGTAATGAATCACAAGAACGTTATGTTCTTGGTGTTTCTCCTCAAGACTTATCCATTTTCGAGGAAATCTGTAAGAGAGAAAGAGCACCATTTGCTGTCGTCGGTCACGCAACCGCTGAACAAAAATTGATTGTAGAAGATCCTCTTTTGAAAACAACTCCAATTGATTTAGAAATGCCAATTTTATTTGGTAAGCCTCCAAAGATGTCAAGAGAAACCATAACTGAAGCACTAAATCTACCAGAGGCAAATTTGAGCGAAATTCCTTCCCTACAAGATGCTATTCAAAGAGTTCTAAACTTACCATCTGTTGGCTCAAAGTCATTTTTGATTACTATTGGTGACAGATCCGTCACAGGTCTAATTGATAGGGATCAATTTGTTGGTCCTTGGCAAGTACCTGTTGCGGATGTCGGTGTTACCGGTACCTCTTTGGGTGAGACAATAATTTCCACAGGTGAAGCCATGGCTATGGGTGAAAAACCAGTTAACGCCCTAATCTCCGCATCTGCTTCCGCTAAATTATCTGTGGCAGAATCTTTATTGAACATATTCGCTGCTGATGTGAAATCTTTAAATCATATCAAGCTATCTGCTAACTGGATGTCTCCAGCCTCTCATCAAGGTGAGGGTTCTAAGTTATATGAAGCCGTTCAAGCATTAGGTCTGGATTTATGTCCTGCATTAGGTGTTGCTATCCCTGTTGGTAAGGATTCCATGTCCATGAAGATGAAATGGGATGATAAGGAAGTTACTGCACCATTGTCATTGAATATCACAGCATTTGCACCAGTTTTCAACACTAGTAAAACGTGGACTCCATTGCTAAATAGAAACACAGATGATTCTGTCCTTGTCTTGGTTGATCTATCAGCTAAACAAGAGACTAAGTCACTAGGTGCCTCTGCTTTGTTGCAAGTTTACAACCAAGTTGGTAACAAGTCGCCTACTGTGTATGATAACGCCATTTTGAAGGGTTTCTTGGAAAGTTTAATCCAATTGCATCAACAAAAGGAGGATATAGTGCTTGCCTACCATGATAGGTCTGATGGTGGTCTACTAATCACTTTACTGGAAATGGCATTTGCTTCCAGATGCGGCTTAGAAATCAACATTGACGGTGGAGACCTAGAAAGTCAATTAACAAACCTATTCAATGAAGAATTAGGTGCAGTATTCCAGATTTCTGCTAAGAACTTGAGCAAGTTCGAAAAAATCTTGAACGAGAACGGAGTTGCTAAAGAATATATTTCTATTGTTGGTAAGCCATCCTTCCAAAGCCAGGAAATCAAGATTATTAACTCCACAACAAATGATGTAATTTACGCCAATTCGAGATCTGAATTGGAGCAAACTTGGAGTAAGACATCTTACGAAATGCAGAAATTGAGAGACAATCCAAAAACAGCCGAAGAAGAGTTTGCCAGTATCACGGACGATAGAGATCCCGGTTTGCAGTATGCCCTAACATACAACCCAGCCGATGATATGAAGATCGGATTAGAATTATCCAGTCAAAGGCCAAAGGTTGCTATCTTAAGAGAGCAAGGTGTGAACGGTCAAATGGAAATGGCATGGTGCTTCCAACAAGCTGGATTCAACTCAGTGGATGTCACTATGACAGATTTGCTAGAAGGTAGGTTCCATTTGGATGACTTCATCGGTCTTGCCGCATGTGGTGGTTTCTCTTATGGTGATGTCTTAGGTGCAGGTGCGGGTTGGGCTAAATCCGTATTGTATCACGAAGGTGTGCGCTCGCAATTTTCTAAGTTCTTCAATGAAAGACAAGATACATTTGCTTTTGGTGCTTGTAATGGTTGTCAATTCTTGAGTAGATTAAAAGATATCATACCCGGGTGTGAAAACTGGCCAAGTTTCGAAAGAAATGTTAGTGAACAATATGAAGCCCGTGTATGTATGGTGCAAATATCTCAAGAAAAGGACAATTCTAGCGAGGAATCTGTTTTCTTGAATGGCATGGCAGGATCCAAATTGCCAATTGCTGTCGCACATGGTGAAGGTAAAGCAACATTTTCTAAAAGCGCTGAACAACTGGAAAAGTTCGAAAAGGATGGTTTATGTTGTATAAGGTATGTGGACAACTACGGTAACGTCACCGAAAGGTTCCCCTTCAACCCCAATGGGTCGACCAATGGTATTGCCGGTATCAAGTCACCAAATGGTAGAGTGCTTGCCATGATGCCACATCCTGAAAGAGTTTGCAGATTGGAGGCCAATTCCTGGTATCCAGAGGGCAAATACGAAGAGTGGGGTGGATACGGTCCATGGATTAGATTATTCAGATCTGCCAGAAGATGGGTCGGTTGA","protein_sequence":"MTDYILPGPKALSQFRVDNLIKDINSYTNSTSVINELRSCYIHYVNGIAQNLSEQDTKLLEVLLTYDSALDIANDPLARQLNDAVANNLPSSALGEDTYLIRVVPRSGTISPWSSKATNIAHVCGLQDKVQRIERGLALLIKTVPGFPLLENLNDISLKCVYDRMTQQLYLTEPPNTMSIFTHEEPKPLVHVPLTPKDTKQSPKDILSKANTELGLALDSGEMEYLIHAFVETMKRDPTDVELFMFAQVNSEHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVLDSENDAFFFAPNSTTKEWTSTKERIPLLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQPWELNIGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGFHKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSVASGEGSADLDFASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNALPELVHDNDLGAKFDIRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAEQKLIVEDPLLKTTPIDLEMPILFGKPPKMSRETITEALNLPEANLSEIPSLQDAIQRVLNLPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQALGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSLNITAFAPVFNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINIDGGDLESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTTNDVIYANSRSELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDMKIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDIIPGCENWPSFERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYVDNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWVG"},{"created_at":"2011-05-24T19:26:20.000Z","updated_at":"2011-05-29T05:06:11.000Z","name":"Carbamoyl-phosphate synthase arginine-specific small chain","uniprot_id":"P07258","uniprot_name":"CARA_YEAST","enzyme":true,"transporter":false,"gene_name":"CPA1","num_residues":411,"molecular_weight":"45361.19922","theoretical_pi":"7.32","general_function":"Involved in catalytic activity","specific_function":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate","reactions":[{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"K02132","genbank_protein_id":"171305","gene_card_id":"CPA1","chromosome_location":"chromosome 15","locus":"YOR303W","synonyms":["CPS-A","Arginine-specific carbamoyl-phosphate synthetase, glutamine chain"],"enzyme_classes":["6.3.5.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CPSase_sm_chain","identifier":"PF00988"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGTCCTCCGCTGCAACAAAAGCTACTTTCTGTATTCAAAATGGTCCTTCCTTTGAAGGTATATCTTTTGGTGCAAACAAATCTGTTGCTGGTGAAACAGTTTTCACTACTTCTCTGGTTGGTTACCCAGAGTCCATGACTGATCCTTCCTACCGTGGTCAGATATTAGTCTTCACGCAACCCTTGATTGGTAACTACGGTGTCCCATCCGGCGAAGCCCGCGATGAATACAATTTACTGAAGTATTTTGAATCTCCGCATATACATGTGGTCGGCATCGTTGTCGCTGAATATGCTTATCAATATTCGCATTGGACCGCTGTTGAATCTCTGGCACAATGGTGTCAGAGAGAAGGTGTTGCTGCTATTACTGGCGTAGACACCCGTGAACTAGTGCAATACTTGAGGGAACAAGGTTCTTCTTTGGGCCGTATTACGTTGGCTGATCATGACCCTGTCCCCTACGTGAATCCCATGAAAACTAACTTGGTTGCTCAAGTCACCACAAAAAAGCCTTTCCACGTCTCTGCCTTACCTGGGAAGGCTAAGGCAAATGTGGCTCTTATTGACTGTGGTGTTAAAGAAAACATTATCAGATGCCTAGTCAAAAGAGGTGCCAATGTAACTGTTTTCCCCTATGATTACAGAATTCAAGATGTTGCTTCTGAATTCGACGGTATTTTCTTATCCAATGGACCAGGCAACCCAGAACTATGCCAAGCTACAATTTCCAACGTCAGGGAATTACTAAATAACCCTGTTTATGACTGTATCCCTATTTTTGGGATTTGTCTAGGCCATCAACTCTTGGCTCTGGCCTCCGGTGCCTCTACTCACAAATTGAAATATGGTAATAGGGCTCACAACATCCCTGCCATGGATTTGACTACCGGCCAGTGCCACATTACATCTCAAAATCATGGCTATGCAGTTGATCCTGAGACCCTACCAAAGGACCAATGGAAACCTTATTTTGTTAATTTAAACGACAAATCAAACGAAGGCATGATACACCTTCAAAGACCCATATTTTCTACCCAATTTCACCCAGAGGCAAAAGGTGGTCCCTTAGACACAGCTATTCTTTTTGACAAATTCTTCGATAATATAGAAAAATACCAATTACAATCTCAGGCAAAAAGTTCAATCTCACTAAAAGTAACATACAGTACCGATAAATCGAGATTGCAGAGTATAAATGTTACTAAGTTGGCCAAGGAAAGAGTGTTGTTCTAA","protein_sequence":"MSSAATKATFCIQNGPSFEGISFGANKSVAGETVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSGEARDEYNLLKYFESPHIHVVGIVVAEYAYQYSHWTAVESLAQWCQREGVAAITGVDTRELVQYLREQGSSLGRITLADHDPVPYVNPMKTNLVAQVTTKKPFHVSALPGKAKANVALIDCGVKENIIRCLVKRGANVTVFPYDYRIQDVASEFDGIFLSNGPGNPELCQATISNVRELLNNPVYDCIPIFGICLGHQLLALASGASTHKLKYGNRAHNIPAMDLTTGQCHITSQNHGYAVDPETLPKDQWKPYFVNLNDKSNEGMIHLQRPIFSTQFHPEAKGGPLDTAILFDKFFDNIEKYQLQSQAKSSISLKVTYSTDKSRLQSINVTKLAKERVLF"},{"created_at":"2011-05-24T19:28:29.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Protein URA1","uniprot_id":"P07259","uniprot_name":"PYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"URA2","num_residues":2214,"molecular_weight":"245124.0","theoretical_pi":"5.64","general_function":"Involved in carboxyl- or carbamoyltransferase activity","specific_function":"This protein is a \"fusion\" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)","reactions":[{"id":1332,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1365,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2256,"direction":"\u003e","locations":null,"altext":"Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3739,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006264","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14249,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006733","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M27174","genbank_protein_id":"173146","gene_card_id":"URA2","chromosome_location":"chromosome 10","locus":"YJL130C","synonyms":["Glutamine-dependent carbamoyl-phosphate synthase","Aspartate carbamoyltransferase"],"enzyme_classes":["6.3.5.5","2.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" aspartate carbamoyltransferase activity"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" carboxyl- or carbamoyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CPSase_sm_chain","identifier":"PF00988"},{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"CPSase_L_D3","identifier":"PF02787"},{"name":"MGS","identifier":"PF02142"},{"name":"OTCace","identifier":"PF00185"},{"name":"OTCace_N","identifier":"PF02729"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGGCCACTATTGCTCCCACTGCTCCAATCACCCCTCCAATGGAATCTACGGGTGACCGTCTGGTTACGTTGGAACTTAAGGACGGCACGGTCTTACAAGGTTATTCATTTGGTGCTGAGAAATCCGTCGCTGGTGAATTAGTTTTCCAAACTGGTATGGTTGGTTATCCTGAATCTGTGACCGATCCATCTTATGAAGGCCAGATCTTAGTCATCACTTACCCATTGGTAGGCAATTATGGTGTCCCAGATATGCACTTGAGAGATGAATTGGTCGAAGAATTGCCAAGATATTTTGAAAGTAATAGAATCCATATTGCCGGTTTAGTTATTTCTCACTATACCGACGAGTACTCTCATTATCTTGCTAAATCTTCCTTAGGTAAATGGTTACAAAATGAAGGGATCCCAGCTGTTTATGGTGTTGATACAAGATCATTGACCAAGCATTTGAGAGATGCAGGTTCAATGTTGGGTAGGTTGTCTTTGGAAAAAAGCGGCTCTGACAGAACCATCTCCAGATCTTCCTCTTGGAGAAGTGCGTTTGATGTTCCTGAATGGGTGGATCCAAATGTTCAAAACCTAGTTTCTAAGGTCTCCATCAATGAACCTAAATTGTACGTTCCTCCAGCAGACAATAAGCACATCGAATTGCAAACCGGACCCGATGGTAAAGTTTTAAGGATTCTAGCCATTGACGTGGGTATGAAATACAATCAAATTCGTTGTTTTATCAAAAGGGGTGTAGAATTGAAAGTTGTTCCATGGAACTACGATTTCACTAAAGAAGATTATGATGGTCTGTTTATTTCAAATGGTCCAGGTGATCCATCTGTTCTAGATGATCTATCTCAAAGATTGTCAAATGTCCTGGAGGCTAAAAAGACGCCAGTATTCGGTATTTGTCTCGGTCATCAATTGATAGCAAGAGCTGCCGGTGCATCCACCCTAAAACTAAAATTTGGTAACCGTGGTCATAACATACCTTGTACATCAACTATAAGTGGTCGTTGTTACATAACATCTCAAAACCATGGGTTCGCTGTGGATGTTGACACTCTAACTTCCGGATGGAAGCCATTGTTTGTTAACGCGAATGATGACTCTAACGAAGGTATCTATCATTCTGAATTACCTTATTTTTCCGTCCAATTCCATCCAGAATCCACACCTGGCCCAAGAGATACAGAATTCTTGTTTGACGTTTTTATCCAAGCAGTTAAAGAATTCAAGTATACACAAGTGTTGAAACCAATCGCTTTCCCAGGTGGCCTATTAGAGGATAACGTTAAGGCACACCCTAGAATCGAAGCGAAGAAGGTTCTAGTTCTCGGTTCTGGTGGTTTGTCCATCGGTCAAGCTGGTGAATTTGACTACTCTGGTTCTCAAGCCATCAAAGCTTTGAAAGAAGAAGGTATCTATACAATTTTAATTAATCCAAACATTGCTACCATCCAAACTTCGAAAGGGTTGGCTGATAAGGTTTATTTTGTTCCTGTTACTGCAGAGTTCGTGAGAAAAGTTATTTTACATGAAAGGCCGGACGCCATTTATGTGACATTTGGTGGACAAACTGCTTTATCTGTTGGTATAGCCATGAAAGATGAATTTGAGGCGTTAGGAGTTAAAGTATTGGGTACTCCAATCGATACTATTATTACCACGGAAGACCGTGAACTCTTCAGTAATGCCATTGACGAAATTAATGAAAAATGTGCGAAATCTCAAGCTGCTAATTCAGTGGACGAGGCATTGGCCGCTGTCAAGGAGATCGGTTTCCCAGTTATTGTACGTGCTGCATATGCATTGGGAGGTTTAGGTTCCGGTTTCGCTAATAATGAAAAAGAATTGGTTGATCTATGTAATGTTGCATTTTCATCCTCACCTCAAGTTTTAGTCGAGAAATCTATGAAAGGTTGGAAAGAAGTCGAATATGAAGTTGTTCGTGATGCTTTTGACAACTGTATTACTGTTTGTAATATGGAAAATTTTGATCCACTAGGTATTCACACCGGTGATTCCATCGTTGTAGCCCCATCTCAAACTTTATCTGATGAAGATTACAATATGTTAAGAACTACTGCTGTTAATGTTATTAGACACTTAGGTGTTGTTGGTGAATGTAATATCCAATATGCTTTAAATCCCGTTTCTAAGGATTATTGCATCATTGAAGTTAATGCGCGTTTGTCACGTTCCTCTGCTTTAGCTTCTAAGGCTACTGGTTACCCATTGGCCTACACTGCGGCTAAGTTAGGTTTGAATATCCCATTAAATGAAGTTAAGAATTCCGTCACAAAATCCACATGTGCTTGTTTTGAACCTTCTCTAGACTACTGTGTTGTCAAAATGCCAAGATGGGATTTGAAGAAGTTCACCAGAGTTTCTACCGAATTATCTTCATCAATGAAATCTGTTGGTGAAGTTATGAGCATCGGTAGAACCTTCGAAGAAGCTATTCAAAAAGCTATCAGATCCACAGAATATGCTAACCTCGGATTCAATGAGACAGATCTAGATATCGACATTGATTACGAGTTGAACAACCCTACGGATATGCGTGTCTTCGCCATTGCAAATGCTTTTGCTAAGAAGGGATATTCTGTTGATAAAGTCTGGGAAATGACTAGAATTGATAAGTGGTTTTTAAACAAACTGCACGATTTGGTCCAATTTGCTGAGAAAATTAGTTCATTTGGTACTAAAGAGGAATTACCTTCCTTAGTTTTAAGACAGGCTAAGCAGTTAGGTTTTGATGACAGACAGATTGCAAGATTTTTGGATTCCAACGAAGTTGCCATCCGTAGATTAAGAAAAGAATATGGAATTACACCATTTGTCAAACAAATTGATACAGTTGCCGCTGAATTCCCCGCTTACACGAACTATTTATACATGACATACAATGCTGACTCACACGATTTATCCTTTGATGACCACGGTGTTATGGTCTTGGGTTCTGGTGTTTACCGTATCGGTTCTTCTGTCGAATTTGATTGGTGTGCTGTTACTGCAGTTAGAACATTACGTGCCAACAATATCAAAACTATCATGGTCAACTATAATCCAGAAACTGTTTCCACAGATTATGATGAGGCTGATAGACTATACTTTGAAACCATCAACCTTGAAAGAGTTTTGGATATTTACGAGATTGAAAACTCAAGCGGTGTTGTCGTATCAATGGGTGGTCAAACTTCCAACAACATCGCCATGACTTTACATCGTGAAAATGTAAAGATTCTTGGTACATCCCCTGACATGATTGATTCTGCTGAAAACCGTTACAAGTTCTCTCGTATGTTGGATCAAATTGGTGTTGACCAACCAGCTTGGAAAGAATTGACATCCATGGACGAAGCTGAATCTTTTGCCGAAAAGGTGGGTTATCCAGTTTTGGTACGTCCATCTTATGTGTTATCCGGTGCCGCCATGAATACTGTTTATTCTAAAAACGATTTGGAATCCTACTTAAACCAAGCCGTCGAAGTTTCACGTGATTATCCTGTTGTTATCACTAAATATATTGAAAACGCAAAGGAGATTGAAATGGATGCAGTTGCAAGAAATGGTGAATTGGTTATGCATGTTGTCTCTGAGCATGTTGAAAATGCAGGTGTCCACTCGGGTGATGCAACATTAATCGTTCCACCTCAAGATTTGGCTCCTGAAACTGTGGATAGAATTGTTGTCGCCACTGCTAAAATTGGTAAGGCTTTGAAAATTACAGGTCCATACAACATCCAATTCATTGCAAAGGACAATGAAATCAAGGTCATAGAATGTAATGTTCGTGCTTCGAGATCTTTCCCATTCATTTCAAAGGTTGTTGGCGTCAATCTGATTGAATTGGCAACAAAGGCCATAATGGGTTTGCCTTTGACGCCTTATCCTGTTGAAAAATTACCAGATGATTATGTCGCCGTTAAAGTACCACAATTCTCTTTCCCACGTTTAGCAGGAGCTGATCCAGTCTTAGGTGTTGAAATGGCCTCTACTGGTGAAGTCGCTACTTTTGGCCACTCGAAGTATGAAGCATACTTAAAGTCTTTGTTGGCAACCGGCTTCAAACTTCCAAAGAAGAATATTTTATTGTCTATTGGTTCTTACAAGGAAAAACAAGAATTGCTTTCTTCCGTACAAAAACTATACAACATGGGATATAAATTATTTGCAACATCAGGTACTGCTGACTTTTTATCTGAACATGGTATTGCCGTCCAATATCTGGAGGTTTTAAACAAGGATGATGATGATCAAAAATCAGAATACTCACTTACTCAACATTTGGCTAATAATGAAATTGACCTTTACATCAACTTGCCTTCTGCCAACAGGTTCCGTCGTCCTGCATCCTATGTTTCAAAGGGGTATAAAACACGTCGTTTGGCTGTCGATTATTCGGTTCCGTTGGTTACTAACGTTAAATGTGCAAAATTGTTGATTGAAGCCATTTCAAGAAATATCACTTTAGATGTTTCTGAACGTGATGCACAAACTTCCCACAGAACTATTACCTTACCTGGTTTAATCAATATCGCAACTTATGTTCCGAATGCATCCCATGTTATCAAAGGCCCAGCTGAACTGAAGGAGACCACACGTCTATTTTTGGAATCCGGTTTTACATACTGTCAATTGATGCCCAGATCCATCAGCGGACCTGTTATTACTGACGTTGCATCCTTGAAGGCCGCAAACTCTGTTTCCCAAGATTCATCTTACACTGACTTTTCTTTCACTATTGCTGGTACAGCACACAATGCTCATAGTGTTACGCAATCTGCTAGCAAAGTGACAGCATTGTTTTTGCCCCTACGTGAATTAAAGAACAAGATCACAGCAGTAGCTGAACTTCTGAATCAGTGGCCAACTGAAAAGCAAGTGATTGCAGAAGCTAAAACTGCAGATTTGGCATCGGTTTTATTGTTAACCTCCCTTCAAAACAGATCTATTCACATTACTGGTGTTTCGAATAAGGAAGATTTAGCTTTGATCATGACGGTCAAGGCAAAAGACCCTAGAGTGACTTGTGATGTCAATATTTATTCTTTGTTTATTGCCCAAGATGACTATCCGGAGGCAGTTTTCTTGCCTACTAAGGAAGATCAAGAGTTTTTCTGGAACAACCTTGATAGTATCGATGCTTTCTCTGTCGGTGCTCTTCCTGTCGCCTTGGCAAATGTCACAGGTAACAAGGTTGATGTTGGTATGGGTATCAAAGATTCATTACCACTATTGTTGGCTGCTGTTGAAGAAGGTAAATTAACCATTGATGATATCGTCCTTCGTCTGCATGACAATCCCGCTAAAATTTTCAACATCCCTACTCAGGACTCAGTTGTCGAAATTGATTTGGATTATTCTTTCAGACGTAATAAGAGATGGTCACCATTCAACAAAGATATGAACGGTGGTATTGAGCGTGTTGTCTATAATGGCGAAACATTAGTTTTGAGCGGTGAATTAGTTTCACCAGGCGCCAAAGGAAAATGCATTGTTAATCCAAGTCCAGCTTCCATAACTGCTTCCGCAGAGCTCCAATCTACTAGTGCTAAAAGAAGGTTCTCGATCACGGAAGAAGCAATCGCTGATAATTTAGATGCCGCGGAGGATGCAATTCCAGAACAGCCTTTGGAACAAAAATTGATGTCTTCAAGGCCACCAAGAGAACTTGTTGCTCCAGGCGCCATCCAGAATTTGATCCGTAGTAACAATCCATTCCGCGGAAGACATATATTGTCTATCAAACAATTCAAACGTTCTGATTTCCATGTGTTGTTTGCTGTTGCACAAGAACTAAGGGCACGTGTCGCAAGAGAAGGTGTCTTAGATTTAATGAAAGGCCACGTTATTACTACAATTTTCTTTGAACCATCTACTCGTACTTGTTCTTCATTCATTGCTGCTATGGAACGTTTGGGTGGTAGAATTGTAAATGTTAATCCATTGGTGTCTTCTGTCAAGAAAGGTGAAACCCTTCAAGATACTATCAGAACTTTGGCTTGTTACAGTGATGCCATTGTCATGCGTCATTCAGAAGAAATGTCTGTTCATATCGCCGCTAAATATTCTCCTGTTCCAATTATTAATGGTGGTAATGGTTCTCGCGAGCATCCTACGCAGGCCTTCTTGGATTTGTTTACGATTCGTGAAGAAATCGGTACTGTTAATGGTATTACTGTTACTTTCATGGGTGATCTCAAACATGGTAGAACCGTACATTCATTGTGTCGTTTGTTAATGCACTATCAAGTCAGAATTAATCTTGTTTCTCCTCCGGAATTGAGGTTACCAGAAGGATTAAGAGAAGAGCTAAGAAAAGCTGGCTTACTTGGTGTTGAGAGCATTGAATTAACCCCTCATATCATCTCAAAGACCGATGTTCTGTATTGTACAAGGGTCCAAGAAGAAAGATTCAATAGCCCTGAAGAATATGCACGTCTGAAGGATACTTATATCGTGGACAACAAGATCTTGGCACACGCCAAAGAAAATATGGCTATCATGCATCCATTGCCTCGTGTAAATGAAATCAAAGAGGAAGTGGACTACGATCATCGTGCTGCTTACTTCAGACAAATGAAGTATGGTTTGTTCGTCAGAATGGCTTTGTTGGCCATGGTCATGGGTGTTGATATGTGA","protein_sequence":"MATIAPTAPITPPMESTGDRLVTLELKDGTVLQGYSFGAEKSVAGELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYGVPDMHLRDELVEELPRYFESNRIHIAGLVISHYTDEYSHYLRKSSLGKWLQNEGIPAVYGVDTRSLTKHLRDAGSMLGRLSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVPPADNKHIELQTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGPGDPSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTISGRCYITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPGPRDTEFLFDVFIQAVKEFKYTQVLKPIAFPGGLLEDNVKAHPRIEAKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTEDRELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKELVDLCNVAFSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDIDIDYELNNPTDMRVFAIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVLRQAKQLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADSHDLSFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETINLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRMLDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQAVEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDLAPETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNLIELATKAIMGLPLTPYPVEKLPDDYVAVKVPQFSFPRLAGADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKKNILLSIGSYKEKQELLSSVQKLYNMGYKLFATSGTADFLSEHGIAVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLPSANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISRNITLDVSERDAQTSHRTITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRELKNKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAKDPRVTCDVNIYSLFIAQDDYPEAVFLPTKEDQEFFWNNLDSIDAFSVGALPVALANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDLDYSFRRNKRWSPFNKDMNGGIERVVYNGETLVLSGELVSPGAKGKCIVNPSPASITASAELQSTSAKRRFSITEEAIADNLDAAEDAIPEQPLEQKLMSSRPPRELVAPGAIQNLIRSNNPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQVRINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEYARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALLAMVMGVDM"},{"created_at":"2011-05-24T19:29:59.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial","uniprot_id":"Q03557","uniprot_name":"GATH_YEAST","enzyme":true,"transporter":false,"gene_name":"HER2","num_residues":464,"molecular_weight":"50918.0","theoretical_pi":"8.84","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling","reactions":[{"id":1319,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X80836","genbank_protein_id":"530350","gene_card_id":"HER2","chromosome_location":"chromosome 13","locus":"YMR293C","synonyms":["Glu-ADT subunit A","HMG2-induced ER-remodeling protein 2","Loss of respiratory capacity protein 6"],"enzyme_classes":["6.3.5.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Amidase","identifier":"PF01425"}],"pathways":[],"gene_sequence":"ATGCCACTGAAACGCTCCTTAAAAGAATCAATCGAAAGATTATCTAGTTTTCAATCAAAATATAATATTTTCACTAGTATCAATCCATCTCCTTATTCAATCACAAATAAAAAAGGTACAAAAGAAACATTGACAGGTTGCGTTGCCAGTATCAAGGATAATATAGTTACAAAAGATTTTCCAACCACATGTGCCTCACATATACTTGAGAATTTCAAGTCTCCCTTCGATGCAACAGTAGTGAAACTATTAAAACAGGCAGGAGTGCATATCTTAGGCAAGACAAATTTAGATGAATTTGGAATGGGTTCTGGGGGAGTACATTCAATAAGAGGGCCCGTAATTAACCCTTTATATCCTCATGAGGACAAGAAGATCATGGGAGGTTCATCGTCTGGAGCCGCTGCAAGCGTTGCTTGCGATCTAGTCGATTTTGCCTTGGGAACAGATACTGGTGGCTCCGTTAGGCTCCCCGCATGCTATGGATCTGTTTTAGGATTCAAGCCGTCCTATGGACGGTTGTCAAGATTTGGCGTAATAGCGTATTCTCAATCTTTAGACACTGTTGGCATACTTAGCAAAAAGATAAACGTCTTGCGAAAAGTATTTCATACGCTCGATAAATATGACATGAAAGATCCCACTTCCTTAAGTGTGGAATTGCGTGAATTGATAGAAGGGAATAAAAAGGTTAGGAGACCTTTAAAGGTAGGAATTGTAAAGGAATTTAGCCATGAAAGTATGCCCATTGGGTTCCACAGATTATATTTATCCTTACTAGAAAAGCTGATAAATTTAGGGCTTGAAATATACCCTGTATCCATTCCATCTGTAAAAAACTGTTTACCGATTTATTATACGCTATCACCCGCTGAAGCGGCTTCCAATTTATCAAGGTATGATGGTATCAGATATGGATACAGAGATTCAGAACTCGATATAAAAGACGGTATTTTATTCGCACCTACTAGGTCCAAATTCGGAACAGAAGTTAAGAATAGAATCATTCTAGGTAATTATAATCTTTGTTCAGATGCATTTAAGAACAATTTTATTAAGGCAGAAAAGCTACGAGTTAATTTGATCGATGAATTTGACGGGATCTTCAGATTTCCAAATGTTTTAACTAATTCTAAGGGAAATCCAGACGGCCTAGATCTACTGATAGTTCCCACATCGTCCAAGCTTCCTGGATCCATAAGGGACTTCGAAGAAGAGGAAGCCAAATCTCCGGCTAACTCGTATATAAACGATGTCTTTACTGTCCCAATGTCATTGGCTGGACTACCAAGTTTATCAATGCCTTTAAAAGAGAAGACCCCGATTGGCTTACAGGTAGTAGGTCAATATGGTGATGATTCCACTGTGTTAGATTTTGTCGAGTCAATATCATAA","protein_sequence":"MPLKRSLKESIERLSSFQSKYNIFTSINPSPYSITNKKGTKETLTGCVASIKDNIVTKDFPTTCASHILENFKSPFDATVVKLLKQAGVHILGKTNLDEFGMGSGGVHSIRGPVINPLYPHEDKKIMGGSSSGAAASVACDLVDFALGTDTGGSVRLPACYGSVLGFKPSYGRLSRFGVIAYSQSLDTVGILSKKINVLRKVFHTLDKYDMKDPTSLSVELRELIEGNKKVRRPLKVGIVKEFSHESMPIGFHRLYLSLLEKLINLGLEIYPVSIPSVKNCLPIYYTLSPAEAASNLSRYDGIRYGYRDSELDIKDGILFAPTRSKFGTEVKNRIILGNYNLCSDAFKNNFIKAEKLRVNLIDEFDGIFRFPNVLTNSKGNPDGLDLLIVPTSSKLPGSIRDFEEEEAKSPANSYINDVFTVPMSLAGLPSLSMPLKEKTPIGLQVVGQYGDDSTVLDFVESIS"},{"created_at":"2011-05-24T19:30:54.000Z","updated_at":"2011-05-29T05:06:11.000Z","name":"Carbamoyl-phosphate synthase arginine-specific large chain","uniprot_id":"P03965","uniprot_name":"CARB_YEAST","enzyme":true,"transporter":false,"gene_name":"CPA2","num_residues":1118,"molecular_weight":"123914.0","theoretical_pi":"4.95","general_function":"Involved in ATP binding","specific_function":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate","reactions":[{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"K01178","genbank_protein_id":"171310","gene_card_id":"CPA2","chromosome_location":"chromosome 10","locus":"YJR109C","synonyms":["Arginine-specific carbamoyl-phosphate synthetase, ammonia chain"],"enzyme_classes":["6.3.5.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"CPSase_L_D3","identifier":"PF02787"},{"name":"MGS","identifier":"PF02142"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGACATCGATTTATACATCAACAGAGCCTACGAATTCTGCTTTTACTACCGAGGACTACAAACCTCAATTAGTTGAAGGAGTAAATTCTGTACTTGTCATTGGATCAGGAGGGCTCTCTATTGGTCAAGCTGGTGAATTCGATTACAGTGGTTCTCAAGCTATCAAAGCTCTGAAGGAAGATAACAAGTTTACTATATTGGTTAACCCAAATATCGCTACTAACCAGACTTCTCATTCCCTGGCGGACAAGATTTATTACTTGCCCGTTACACCAGAATACATCACATATATCATTGAACTTGAAAGGCCGGATGCTATACTTTTAACCTTCGGTGGTCAAACAGGTCTAAATTGTGGGGTGGCTCTGGATGAATCTGGTGTTTTGGCTAAATACAACGTCAAAGTTTTAGGTACTCCTATCAAAACTTTGATCACTTCTGAAGATAGGGATCTTTTCGCATCTGCGTTAAAGGATATCAACATTCCCATCGCAGAATCATTTGCTTGTGAAACCGTGGATGAAGCTTTGGAGGCTGCTGAAAGGGTCAAATACCCAGTTATTGTCAGATCTGCATACGCTTTGGGTGGGTTAGGCTCAGGTTTCGCTAACAATGCAAGTGAAATGAAGGAACTTGCCGCACAGTCCTTGTCGTTGGCCCCACAAATTCTTGTTGAAAAATCTTTGAAAGGTTGGAAAGAAGTTGAATATGAAGTGGTCAGAGATAGGGTTGGTAACTGTATTACAGTATGTAATATGGAAAATTTCGACCCACTTGGTGTTCATACTGGTGATTCTATGGTTTTTGCTCCTTCGCAGACCCTATCAGATGAAGAGTTTCATATGTTAAGATCCGCCGCAATTAAAATCATTAGACACCTTGGTGTTATTGGTGAATGTAATGTCCAATACGCTTTGCAACCTGATGGGCTAGACTATAGAGTTATTGAAGTGAACGCACGTTTATCTCGTTCCTCTGCATTGGCGTCTAAGGCCACTGGTTATCCCTTAGCATACACTGCCGCCAAAATTGGGCTAGGCTATACTTTGCCAGAATTGCCAAACCCAATCACAAAAACTACAGTGGCTAACTTTGAGCCATCTTTGGATTATATTGTGGCAAAAATACCTAAGTGGGATCTTTCTAAGTTCCAATACGTGGACAGATCCATTGGTTCCTCTATGAAATCAGTTGGAGAAGTTATGGCTATTGGTAGAAACTATGAAGAAGCCTTTCAAAAAGCATTAAGACAGGTGGATCCATCATTATTGGGATTCCAAGGTTCTACTGAATTCGGCGATCAACTTGATGAAGCCTTGAGAACTCCAACTGATAGAAGAGTCCTTGCCATTGGTCAGGCCTTAATCCATGAAAACTATACTGTTGAGAGAGTTAATGAATTGAGTAAAATTGATAAATGGTTTCTTTACAAGTGCATGAACATTGTTAATATCTATAAAGAGCTTGAATCAGTTAAATCTTTAAGTGACTTGAGTAAAGATCTCTTGCAGAGAGCCAAGAAATTAGGGTTTTCAGATAAGCAGATTGCGGTTACTATAAATAAACACGCCTCCACAAACATTAACGAACTGGAAATCAGAAGTTTAAGAAAAACGTTAGGTATAATCCCTTTTGTCAAGAGAATCGATACTTTGGCCGCAGAATTTCCAGCACAAACCAATTATTTGTATACCACTTACAATGCTACAAAGAACGATGTGGAGTTCAACGAAAATGGTATGCTGGTTTTAGGCTCTGGTGTCTATCGTATTGGTTCATCTGTAGAATTTGATTGGTGTGCCGTGAACACCGCGAAGACATTAAGAGATCAAGGCAAGAAAACTATCATGATAAATTATAACCCAGAAACAGTTTCCACAGATTTCGATGAAGTTGATAGATTATACTTTGAAGAATTATCGTATGAAAGAGTGATGGACATTTATGAGTTGGAGCAATCTGAGGGTTGCATTATTTCTGTCGGTGGTCAATTACCTCAAAACATTGCCTTGAAACTTTACGATAACGGCTGTAATATAATGGGTACCAATCCAAACGATATTGATAGAGCTGAGAACAGACACAAATTCTCATCTATTTTGGATTCTATTGATGTTGACCAACCTGAATGGAGTGAATTAACATCAGTAGAAGAAGCAAAATTATTTGCTTCTAAAGTTAACTACCCTGTGTTGATTCGTCCCTCATATGTTCTTTCCGGTGCGGCAATGAGTGTTGTTAATAATGAGGAGGAACTGAAGGCTAAATTAACTTTGGCATCTGACGTTTCTCCAGACCATCCAGTCGTCATGTCTAAATTTATTGAAGGTGCTCAAGAAATTGATGTGGACGCCGTTGCTTATAATGGTAATGTCTTGGTACATGCCATTTCCGAGCATGTTGAAAATGCGGGTGTGCACTCCGGTGATGCTTCTTTAGTCTTACCGCCACAACATCTTTCTGACGATGTGAAGATTGCCCTAAAAGACATTGCTGATAAGGTCGCAAAAGCTTGGAAGATCACTGGCCCCTTCAATATGCAAATCATCAAGGATGGGGAGCATACATTGAAAGTGATTGAATGTAACATTAGAGCTTCTAGATCATTTCCATTCGTTTCAAAAGTTTTAGGCGTTAATTTTATTGAAATTGCTGTCAAGGCATTTTTGGGCGGTGACATTGTACCAAAACCTGTTGATTTGATGCTCAACAAAAAGTACGACTATGTTGCTACTAAAGTTCCTCAATTTTCCTTTACAAGGTTGGCTGGTGCAGATCCTTTCTTAGGGGTTGAAATGGCATCAACTGGTGAAGTTGCTTCATTTGGTAGAGATTTAATTGAAAGCTATTGGACTGCTATTCAAAGTACCATGAACTTCCATGTACCACTACCTCCAAGTGGTATATTATTTGGAGGTGATACATCTCGAGAATACTTGGGCCAAGTGGCTTCCATAGTGGCCACTATTGGTTACAGAATATACACAACTAATGAGACCACTAAAACGTATCTACAGGAACACATCAAAGAAAAGAACGCAAAGGTTTCTTTGATTAAATTTCCAAAGAATGATAAGAGAAAATTGCGTGAACTATTTCAAGAATATGACATAAAAGCTGTTTTCAATTTAGCCTCCAAGAGAGCTGAGAGCACTGACGATGTTGACTATATTATGAGAAGGAATGCTATTGATTTTGCTATCCCATTGTTCAATGAACCTCAAACGGCTTTGTTATTTGCAAAGTGTTTGAAGGCAAAAATTGCAGAAAAGATCAAAATTTTGGAATCTCATGACGTTATAGTTCCACCAGAAGTCCGTTCCTGGGATGAATTTATTGGTTTCAAAGCATATTGA","protein_sequence":"MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLAIGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKVPQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLRELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKIAEKIKILESHDVIVPPEVRSWDEFIGFKAY"},{"created_at":"2011-05-24T19:31:37.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"CTP synthase 1","uniprot_id":"P28274","uniprot_name":"URA7_YEAST","enzyme":true,"transporter":false,"gene_name":"URA7","num_residues":579,"molecular_weight":"64709.80078","theoretical_pi":"5.91","general_function":"Involved in CTP synthase activity","specific_function":"Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen","reactions":[{"id":1416,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1417,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2258,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + UTP + NH(3) = ADP + phosphate + CTP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X53995","genbank_protein_id":"440583","gene_card_id":"URA7","chromosome_location":"chromosome 2","locus":"YBL039C","synonyms":["CTP synthetase 1","UTP--ammonia ligase 1"],"enzyme_classes":["6.3.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" CTP synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CTP_synth_N","identifier":"PF06418"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGAAGTACGTTGTTGTTTCAGGTGGTGTCATTTCGGGTATCGGTAAAGGTGTTCTTGCATCTTCAACTGGTATGCTAATGAAAACCCTCGGTTTAAAGGTTACGTCAATTAAAATTGACCCTTATATGAACATTGATGCAGGTACTATGTCTCCTTTGGAACATGGTGAATGTTTCGTGCTTGACGACGGTGGTGAAACAGATTTGGACTTGGGTAACTACGAGAGATACCTTGGAGTTACTTTGACTAAAGATCATAACATTACTACTGGTAAAATATACTCGCACGTTATTGCTAAGGAAAGAAAAGGTGACTATTTAGGCAAAACCGTGCAAATTGTCCCTCATTTGACCAACGCTATCCAAGATTGGATTGAGCGCGTGGCCAAAATTCCTGTAGATGACACCGGTATGGAACCAGATGTTTGTATCATTGAATTGGGTGGGACAGTTGGTGACATTGAAAGTGCTCCTTTTGTGGAGGCACTAAGACAATTCCAATTTAAAGTTGGAAAGGAAAATTTTGCCTTGATACACGTTTCTCTAGTTCCTGTCATCCACGGTGAACAAAAAACTAAGCCAACTCAAGCTGCCATCAAAGGTTTGAGGTCTCTTGGTTTAGTTCCAGATATGATCGCCTGTAGATGTAGTGAAACTTTGGATAAACCAACAATCGATAAGATTGCCATGTTTTGTCATGTGGGGCCTGAACAGGTGGTTAACGTTCACGATGTTAATTCTACTTATCACGTCCCATTGTTGCTACTGGAACAAAAGATGATTGATTACTTACACGCCAGATTAAAGTTAGATGAAATATCACTTACAGAAGAAGAAAAACAAAGAGGCCTGGAATTATTGTCTAAATGGAAGGCCACAACAGGTAACTTCGATGAATCCATGGAAACAGTGAAGATTCGTTTGGTTGGGAAATACACCAACTTGAAAGATTCTTATCTATCAGTGATAAAAGCATTGGAACATTCATCCATGAAGTGTCGTCGTAAGTTAGACATTAAATGGGTGGAAGCTACTGATTTGGAACCTGAAGCACAAGAAAGCAACAAAACTAAATTTCATGAAGCATGGAACATGGTCAGTACCGCAGACGGTATCTTAATCCCCGGTGGTTTTGGTGTTAGAGGTACTGAAGGTATGGTTTTGGCTGCTAGATGGGCTCGTGAAAATCACATTCCATTCTTAGGGGTTTGCCTGGGTTTACAAATTGCCACCATTGAATTTACACGTAGTTCGTTGGGAAGAAAAGACAGTCATTCGGCAGAATTTTATCCAGACATTGATGAAAAAAATCACGTTGTCGTTTTCATGCCTGAAATTGACAAGGAAACCATGGGGGGCTCAATGAGATTAGGTTTGAGACCAACATTTTTCCAAAATGAAACTGAATGGAGTCAAATCAAGAAGTTATACGGTGACGTCTCCGAAGTCCATGAAAGACACCGTCACCGTTACGAAATCAATCCAAAGATGGTTGATGAATTGGAAAACAACGGGTTGATCTTTGTAGGTAAGGACGACACTGGAAAGCGTTGTGAGATTTTGGAATTAAAGAATCACCCATACTATATTGCTACTCAATATCACCCAGAATACACATCAAAGGTCTTAGATCCATCCAAACCATTTTTGGGTTTAGTTGCTGCTTCCGCTGGTATCCTTCAAGATGTCATTGAAGGTAAGTACGATCTTGAGGCCGGCGAAAACAAATTCAACTTTTAA","protein_sequence":"MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQDWIERVAKIPVDDTGMEPDVCIIELGGTVGDIESAPFVEALRQFQFKVGKENFALIHVSLVPVIHGEQKTKPTQAAIKGLRSLGLVPDMIACRCSETLDKPTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLEQKMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDESMETVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLDIKWVEATDLEPEAQESNKTKFHEAWNMVSTADGILIPGGFGVRGTEGMVLAARWARENHIPFLGVCLGLQIATIEFTRSVLGRKDSHSAEFYPDIDEKNHVVVFMPEIDKETMGGSMRLGLRPTFFQNETEWSQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGKDDTGKRCEILELKNHPYYIATQYHPEYTSKVLDPSKPFLGLVAASAGILQDVIEGKYDLEAGENKFNF"},{"created_at":"2011-05-24T19:32:21.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamine synthetase","uniprot_id":"P32288","uniprot_name":"GLNA_YEAST","enzyme":true,"transporter":false,"gene_name":"GLN1","num_residues":370,"molecular_weight":"41705.60156","theoretical_pi":"6.29","general_function":"Involved in glutamate-ammonia ligase activity","specific_function":"ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine","reactions":[{"id":1579,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2259,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.","export":false,"pw_reaction_id":null,"source":null},{"id":14887,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007078","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z68111","genbank_protein_id":"1072403","gene_card_id":"GLN1","chromosome_location":"chromosome 16","locus":"YPR035W","synonyms":["GS","Glutamate--ammonia ligase"],"enzyme_classes":["6.3.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-ammonia (or amide) ligase activity"},{"category":"Function","description":" ammonia ligase activity"},{"category":"Function","description":" glutamate-ammonia ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" glutamine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Gln-synt_C","identifier":"PF00120"},{"name":"Gln-synt_N","identifier":"PF03951"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"}],"gene_sequence":"ATGGCTGAAGCAAGCATCGAAAAGACTCAAATTTTACAAAAATATCTAGAACTGGACCAAAGAGGTAGAATAATTGCCGAATACGTTTGGATCGATGGTACTGGTAACTTACGTTCCAAAGGTAGAACTTTGAAGAAGAGAATCACATCCATTGACCAATTGCCAGAATGGAACTTCGACGGTTCTTCTACCAACCAAGCGCCAGGCCACGACTCTGACATCTATTTGAAACCCGTTGCTTACTACCCAGATCCCTTCAGGAGAGGTGACAACATTGTTGTCTTGGCCGCATGTTACAACAATGACGGTACTCCAAACAAGTTCAACCACAGACACGAAGCTGCCAAGCTATTTGCTGCTCATAAGGATGAAGAAATCTGGTTTGGTCTAGAACAAGAATACACTCTATTTGACATGTATGACGATGTTTACGGATGGCCAAAGGGTGGGTACCCAGCTCCACAAGGTCCTTACTACTGTGGTGTTGGTGCCGGTAAGGTTTATGCCAGAGACATGATCGAAGCTCACTACAGAGCTTGTTTGTATGCCGGATTAGAAATTTCTGGTATTAACGCTGAAGTCATGCCATCTCAATGGGAATTCCAAGTCGGTCCATGTACCGGTATTGACATGGGTGACCAATTATGGATGGCCAGATACTTTTTGCACAGAGTGGCAGAAGAGTTTGGTATCAAGATCTCATTCCATCCAAAGCCATTGAAGGGTGACTGGAACGGTGCCGGTTGTCACGCTAACGTTTCCACCAAGGAAATGAGACAACCAGGTGGTACGAAATACATCGAACAAGCCATCGAGAAGTTATCCAAGAGACACGCTGAACACATTAAGTTGTACGGTAGCGATAACGACATGAGATTAACTGGTAGACATGAAACCGCTTCCATGACTGCCTTTTCTTCTGGTGTCGCCAACAGAGGTAGCTCAATTAGAATCCCAAGATCCGTCGCCAAGGAAGGTTACGGTTACTTTGAAGACCGTAGACCAGCTTCCAACATCGACCCATACTTGGTTACAGGTATCATGTGTGAAACTGTTTGCGGTGCTATTGACAATGCTGACATGACGAAGGAATTTGAAAGAGAATCTTCATAA","protein_sequence":"MAEASIEKTQILQKYLELDQRGRIIAEYVWIDGTGNLRSKGRTLKKRITSIDQLPEWNFDGSSTNQAPGHDSDIYLKPVAYYPDPFRRGDNIVVLAACYNNDGTPNKFNHRHEAAKLFAAHKDEEIWFGLEQEYTLFDMYDDVYGWPKGGYPAPQGPYYCGVGAGKVYARDMIEAHYRACLYAGLEISGINAEVMPSQWEFQVGPCTGIDMGDQLWMARYFLHRVAEEFGIKISFHPKPLKGDWNGAGCHANVSTKEMRQPGGTKYIEQAIEKLSKRHAEHIKLYGSDNDMRLTGRHETASMTAFSSGVANRGSSIRIPRSVAKEGYGYFEDRRPASNIDPYLVTGIMCETVCGAIDNADMTKEFERESS"},{"created_at":"2011-05-24T19:33:54.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial","uniprot_id":"P33893","uniprot_name":"GATB_YEAST","enzyme":true,"transporter":false,"gene_name":"PET112","num_residues":541,"molecular_weight":"61842.19922","theoretical_pi":"7.8","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)","reactions":[{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"L22072","genbank_protein_id":"347493","gene_card_id":"PET112","chromosome_location":"chromosome 2","locus":"YBL080C","synonyms":["Glu-ADT subunit B","Cytochrome oxidase assembly factor PET112"],"enzyme_classes":["6.3.5.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GatB_N","identifier":"PF02934"},{"name":"GatB_Yqey","identifier":"PF02637"}],"pathways":[],"gene_sequence":"ATGTTGCGGCTTGCACGTTTTTATTCTTTGGCCAGAACCAAAGCCATACATAGTCACGGTGCACCCTTCAGGCCGGAATATGCATTGAAGTGTGGATTGGAGATTCATACGCAATTGAACACCAAAAACAAGCTTTTTTCACAATCAACGAATAGCGCCACATCTCTAGTGGATGCACCAAACCATCATACTAGTTATTATGACATAGCTCTACCGGGAACGCAGCCGGTTTTGAATCTGGAAGCAATCTTGTTTGCCATGAAACTATCCTTGGCACTGGGTTCTCAAGTGAATAGCATATCTCAGTTTGATAGGAAGCATTATTTTTATGGAGATCAACCTCAAGGCTATCAACTGACGCAGCACTACAGGCCGTTTGCTCGGGGTGGGAAGATCAATCTGTCGAAGGAATTGGATGATATCGATGAATCAGCCAAGGAAATCGGTATCTTACAGTTGCAGATAGAGCAGGACACGGGGAAGTCACACTATACAGAGACAGATAAAGACGTTATTACTTTGGTTGATTTAAATAGGTCGAACGTCCCGCTTATCGAATTGGTAACTAAACCAGATTTCAGTGATATTAAACAGGTTAGAGCGTTTATTAAAAAATATCAGAATTTGGTACGTCATTTGCACATTTCCTCTGGGGACCTGGAAACGGGCGCCATGCGAGTGGACGTTAACCTCTCAATTAATGAATATGCACGCGTTGAGTTGAAGAATTTACCCAATACTAGTTCCATCATCAATGCAATCAAGTACGAATATCAGCGGCAAGTTGAGTTGATTTCTGTGGGTGACACTAGCTCACTGATGGAGCCAGAAACAAGGGGCTGGACAGGCTCATCAACGGTGAAGTTGAGAAGCAAAGAAACCACGATCGATTACAGGTACATGCCTGATCCAGAATTGCCGTATATCAACCTCGCACCAGACGTTATCAGTGGTGTGAGAGGGTTGATGCCCCAATTACCGGACGATATAATGAGAATTCTTATGAAGAAACCCTATCAATTATCATTGAAGGACGCCAAGATTCTGACTTATAATAGTAACCAAAACGATATGTACAATCATGAGGCGTTGAGATCGTACTACTTAGACACCTTCCGTGAATTTTCCAAGCTTGCTGGTGAACGTAGTAACGCGAAATTACCTACGAATTGGATAATCCATGAATTCTTGGGAGATTTGAACAAGCTACAAATTCCATTGGCCAAAGCAAAAGAAATTTTGCCTCCTCCGGTTTTCGCCCAGTTTTTGAAGTTATTGCATGAAGAGGTTATATCCGCAACTAGTGGTAAAATGTTACTGTTTCACATATTGGAAAATTTCGAGCAGAGTAACTGCCAAGATTTGTCTATTCCAGATTTTTCAAAACTAATCGAGAAATTTGAATTGCATGCGATTAATCAGGTCGACCCTCAAGAATTGATGGATCTCTGTAATGATGTCATTGCACAGCACACAGATGACACTTTTATACGGAACCTGGTTACTGGTAAAAAGAAGTCCTCTTTAAAATTCCTAATTGGACAAGGAATGAGACGAAGCCAGGGACGTATAAAGGCAAACGAATTCGAGAAAAAATTCAAAGAGATCTTAAATATTCAATGGTAA","protein_sequence":"MLRLARFYSLARTKAIHSHGAPFRPEYALKCGLEIHTQLNTKNKLFSQSTNSATSLVDAPNHHTSYYDIALPGTQPVLNLEAILFAMKLSLALGSQVNSISQFDRKHYFYGDQPQGYQLTQHYRPFARGGKINLSKELDDIDESAKEIGILQLQIEQDTGKSHYTETDKDVITLVDLNRSNVPLIELVTKPDFSDIKQVRAFIKKYQNLVRHLHISSGDLETGAMRVDVNLSINEYARVELKNLPNTSSIINAIKYEYQRQVELISVGDTSSLMEPETRGWTGSSTVKLRSKETTIDYRYMPDPELPYINLAPDVISGVRGLMPQLPDDIMRILMKKPYQLSLKDAKILTYNSNQNDMYNHEALRSYYLDTFREFSKLAGERSNAKLPTNWIIHEFLGDLNKLQIPLAKAKEILAPPVFAQFLKLLHEEVISATSGKMLLFHILENFEQSNCQDLSIPDFSKLIEKFELHAINQVDPQELMDLCNDVIAQHTDDTFIRNLVTGKKKSSLKFLIGQGMRRSQGRIKANEFEKKFKEILNIQW"},{"created_at":"2011-05-24T19:40:55.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"CTP synthase 2","uniprot_id":"P38627","uniprot_name":"URA8_YEAST","enzyme":true,"transporter":false,"gene_name":"URA8","num_residues":564,"molecular_weight":"63055.69922","theoretical_pi":"6.0","general_function":"Involved in CTP synthase activity","specific_function":"Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis","reactions":[{"id":1416,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1417,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2258,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + UTP + NH(3) = ADP + phosphate + CTP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49603","genbank_protein_id":"1015810","gene_card_id":"URA8","chromosome_location":"chromosome 10","locus":"YJR103W","synonyms":["CTP synthetase 2","UTP--ammonia ligase 2"],"enzyme_classes":["6.3.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" CTP synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CTP_synth_N","identifier":"PF06418"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGAAATACGTTGTTGTTTCTGGTGGTGTTATCTCAGGTATTGGTAAGGGTGTTTTAGCGTCCTCTACAGGGATGCTACTGAAAACCCTCGGCCTAAAGGTTACTTCCATCAAGATTGACCCATATATGAATATTGACGCCGGGACGATGTCTCCCTTGGAACATGGTGAGTGTTTTGTACTTGATGATGGTGGGGAAACGGACTTGGATCTCGGTAATTACGAGCGGTACCTCGGTATTACCTTAAGCAGGGACCACAACATCACCACCGGTAAGATATACTCCCACGTAATTTCCAGAGAAAGGAGAGGTGATTATTTAGGTAAGACAGTTCAAATTGTTCCTCATTTGACTAACGCAATTCAGGATTGGATTCAACGTGTTTCAAAAATTCCAGTGGATGACACAGGATTAGAACCAGACGTCTGTATCATCGAGTTAGGTGGTACGGTCGGTGACATTGAGAGTGCGCCCTTCGTGGAAGCATTACGACAATTTCAGTTCGAAGTTGGAAGAGAGAATTTCGCCCTGATCCATGTTTCACTTGTGCCCGTCATTCATGGTGAACAGAAGACGAAACCCACCCAAGCAGCAATCAAAGATTTAAGGTCATTAGGGCTTATTCCCGATATGATTGCCTGCAGATGCAGCGAAGAACTTAACAGGAGCACTATTGACAAGATTGCCATGTTTTGCCATGTGGGGCCGGAGCAAGTGGTCAACGTTCATGATGTTAACTCCACGTACCACGTTCCCTTATTGCTGCTAAAGCAACATATGATCGACTACCTCCATTCAAGGTTGAAATTAGGTGAAGTGCCTCTAACCTTGGAAGACAAGGAAAGAGGGTCTCAATTATTGACTAACTGGGAAAACATGACCAAAAACCTAGATGATTCTGATGATGTTGTCAAGATTGCTCTTGTGGGAAAATACACTAATTTGAAGGATTCCTACCTATCTGTGACCAAATCCTTAGAACACGCAAGCATGAAGTGCCGTCGTCAGCTAGAAATCCTCTGGGTAGAGGCAAGTAACCTAGAGCCCGAAACTCAAGAGGTGGACAAGAACAAGTTCCACGATTCATGGAATAAGCTCAGTTCCGCCGACGGAATTTTGGTTCCTGGTGGATTTGGCACGAGAGGTATTGAAGGTATGATTCTTGCTGCCAAATGGGCCCGTGAATCCGGTGTTCCCTTTCTTGGTGTCTGTCTTGGATTACAAGTTGCCGCTATCGAGTTCGCCCGCAATGTGATAGGCCGCCCAAACAGCAGTTCTACAGAATTTTTGGACGAGACACTACTAGCTCCTGAAGACCAAGTAGTCATATACATGCCCGAGATCGACAAGGAACACATGGGTGGCACGATGAGATTGGGTTTGAGGCCTACCATTTTCCAACCGAACTCAGAATGGAGCAACATAAGGAAGCTTTATGGTGAAGTTAATGAGGTGCATGAGAGACATCGTCATCGCTATGAGATAAACCCGAAAATAGTGAATGATATGGAGTCTCGTGGCTTTATTTTTGTTGGTAAGGACGAGACGGGCCAGCGTTGCGAAATATTCGAATTGAAAGGCCATCCATACTACGTGGGCACTCAATACCATCCAGAGTATACATCGAAGGTGCTGGAACCATCAAGACCGTTTTGGGGGCTTGTGGCCGCAGCTCCGGCACACTTGGTGAAGTGA","protein_sequence":"MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTVGDIESAPFVEALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLIPDMIACRCSEELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYLSVTKSLEHASMKCRRQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPGGFGTRGIEGMILAAKWARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDQVVIYMPEIDKEHMGGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGFIFVGKDETGQRCEIFELKGHPYYVGTQYHPEYTSKVLEPSRPFWGLVAAAPAHLVK"},{"created_at":"2011-05-24T19:42:23.000Z","updated_at":"2011-05-24T19:42:23.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial","uniprot_id":"P53260","uniprot_name":"GATF_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":183,"molecular_weight":"20786.80078","theoretical_pi":"10.15","general_function":"Involved in ATP binding","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)","reactions":[{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558325","genbank_protein_id":"45270540","gene_card_id":null,"chromosome_location":null,"locus":"YGR102C","synonyms":["Glu-ADT subunit F","gatF"],"enzyme_classes":["6.3.5.-"],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGTACAAAACATGGCGTCTATGCGGAACACATACAGTGGGTGGGTTATGCCATGATGGAAGTCATCGGTTCGTATCTACGGGAGGGGCAAAGATTGGTAAAAAATTTGAAAATATGAATCAAATAAGGGATTATTTATCAAGACCTGTATGGTCCGTCCACGAATATTTAGGCATAAACACTAAAGAGGAAAAACTAGAGCCACCGTCTGCTGAAGCTGTAAAAAAATTGTTGCGGTTATCAGGTCTTCCCTTGGAAGGAGCAGATATTAAAGAAATTCAAATGCGACTTGCCAAGCAATTATCATTCATCAACAAACTCCATAACATACCTGTCGAAGGTGAAAAGCACACCAAGGAATATGATGCTCGGTTGGTGCAAAGAAATACGAAACAGCTGAACTACACAAAGCTACTTGAAGGCATCAGCCACCAAAAGCAGGATGCTGAGCTAGGAGAAGTTAGCGGATCTTGGAAAGCAACTGGACTTGCCGCGGAATCCAAAAATGCATATTTTGTTGTCAAAGAGGGACTACTCAAAAACAGGAAGTAA","protein_sequence":"MYKTWRLCRTHTVGGLCHDGSHRFVSTGGAKIGKKFENMNQIRDYLSRPVWSVHEYLGINTKEEKLEPPSAEAVKKLLRLSGLPLEGADIKEIQMRLAKQLSFINKLHNIPVEGEKHTKEYDARLVQRNTKQLNYTKLLEGISHQKQDAELGEVSGSWKATGLAAESKNAYFVVKEGLLKNRK"},{"created_at":"2011-05-24T19:43:43.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Urea amidolyase","uniprot_id":"P32528","uniprot_name":"DUR1_YEAST","enzyme":true,"transporter":false,"gene_name":"DUR1","num_residues":1835,"molecular_weight":"201830.0","theoretical_pi":"5.3","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Hydrolysis of urea to ammonia and CO(2)","reactions":[{"id":1312,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2035,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2266,"direction":"\u003e","locations":null,"altext":"ATP + urea + HCO(3)(-) = ADP + phosphate + urea-1-carboxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":2267,"direction":"\u003e","locations":null,"altext":"Urea-1-carboxylate + H(2)O = 2 CO(2) + 2 NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M64926","genbank_protein_id":"173122","gene_card_id":"DUR1","chromosome_location":null,"locus":"YBR208C","synonyms":["Urea carboxylase","Allophanate hydrolase"],"enzyme_classes":["6.3.4.6","3.5.1.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Amidase","identifier":"PF01425"},{"name":"AHS1","identifier":"PF02682"},{"name":"AHS2","identifier":"PF02626"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGACAGTTAGTTCCGATACAACTGCTGAAATATCGTTAGGTTGGTCAATCCAAGACTGGATTGATTTCCACAAGTCATCAAGCTCCCAGGCTTCACTAAGGCTTCTTGAATCACTACTAGACTCTCAAAATGTTGCGCCAGTCGATAATGCGTGGATATCGCTAATTTCAAAGGAAAATTTACTGCACCAATTCCAAATTTTAAAGAGCAGAGAAAATAAAGAAACTCTACCTCTCTACGGTGTCCCTATTGCTGTTAAGGACAACATCGACGTTAGAGGTCTACGCACCACCGCTGCATGTCCATCCTTTGCATATGAGCCTTCCAAAGACTCTAAAGTAGTAGAACTACTAAGAAATGCAGGTGCAATAATCGTGGGTAAGACAAACTTGGACCAATTTGCCACAGGATTAGTCGGCACACGGTCTCCATATGGGAAAACACCTTGCGCTTTTAGCAAAGAGCATGTATCTGGTGGTTCCTCCGCTGGGTCAGCATCGGTGGTCGCCAGAGGTATCGTACCAATTGCATTGGGTACTGATACAGCAGGTTCTGGTAGAGTCCCAGCCGCCTTGAACAACCTGATTGGCCTAAAGCCAACAAAGGGCGTCTTTTCCTGTCAAGGTGTAGTTCCCGCTTGTAAATCTTTAGACTGCGTCTCCATCTTTGCATTAAACCTAAGTGATGCTGAACGCTGCTTCCGCATCATGTGCCAGCCAGATCCTGATAATGATGAATATTCTAGACCCTATGTTTCCAACCCAAAGAAAAATTTTTCAAGCAATGTAACGATTGCTATTCCTAAAAATATCCCATGGTATGGTGAAACCAAGAATCCTGTACTGTTTTCCAATGCTGTCGAAAATCTATCAAGAACGGGCGCTAACGTCATAGAAATTGATTTTGAGCCTCTTTTAGAGTTAGCTCGCTGTTTATACGAAGGTACTTGGGTGGCCGAGCGTTATCAAGCTATTCAATCGTTTTTGGACAGTAAACCACCAAAGGAATCTTTGGACCCTACTGTTATTTCAATTATAGAAGGGGCCAAGAAATACAGTGCAGTAGACTGCTTCAGTTTTGAATACAAAAGACAAGGCATCTTGCAAAAAGTGAGACGACTTCTCGAATCAGTCGATGTCTTGTGTGTGCCCACATGTCCCTTAAATCCTACTATGCAACAAGTTGCGGATGAACCAGTCCTAGTCAATTCAAGACAAGGCACATGGACTAATTTTGTCAACTTGGCAGATTTGGCAGCCCTTGCTGTTCCCGCAGGGTTCCGAGACGATGGTTTGCCAAATGGTATTACTTTAATCGGTAAAAAATTCACAGATTACGCACTATTAGAGTTGGCTAACCGCTATTTCCAAAATATGTTCCCCAACGGTTCCAGAACATACGGTACTTTTACCTCTTCTTCAGTAAAGCCAGCAAACGATCAATTAGTGGGACCAGACTATGACCCATCTACGTCCATAAAATTGGCTGTTGTCGGTGCACATCTTAAGGGTCTGCCTCTACATTGGCAATTGGAAAAGGTCAATGCAACATATTTATGTACAACAAAAACATCAAAAGCTTACCAGCTTTTTGCTTTGCCCAAAAATGGACCAGTTTTAAAACCTGGTTTGAGAAGAGTTCAAGATAGCAATGGCTCTCAAATCGAATTAGAAGTGTACAGTGTTCCAAAAGAACTGTTCGGTGCTTTTATTTCCATGGTTCCTGAACCATTGGGAATAGGTTCAGTGGAGTTAGAATCTGGTGAATGGATCAAATCCTTTATTTGTGAAGAATCTGGTTACAAAGCCAAAGGTACAGTTGATATCACAAAGTATGGTGGATTTAGAGCATATTTTGAAATGTTGAAGAAAAAAGAGTCCCAAAAGAAGAAGTTATTTGATACCGTGTTAATTGCCAATAGAGGTGAAATTGCCGTTCGTATTATCAAGACATTAAAAAAATTGGGTATTAGATCAGTTGCAGTTTATTCCGACCCTGATAAATATTCTCAACACGTTACTGATGCAGATGTTTCTGTACCCCTTCATGGCACAACCGCAGCCCAAACTTATTTAGACATGAATAAGATCATAGATGCCGCTAAGCAAACTAATGCACAGGCCATTATTCCTGGTTATGGTTTCTTGTCGGAAAATGCGGATTTTTCTGATGCGTGCACCAGTGCTGGCATTACCTTTGTTGGTCCTTCGGGAGATATTATCAGAGGTTTAGGGTTAAAACATTCTGCTAGACAGATTGCACAGAAGGCTGGCGTTCCTCTAGTGCCAGGCTCTTTGCTTATCACATCAGTTGAAGAGGCTAAGAAAGTCGCAGCGGAATTGGAATACCCAGTTATGGTGAAGTCAACTGCTGGTGGCGGTGGTATTGGTTTGCAGAAAGTCGATTCTGAAGAGGACATCGAGCATATTTTTGAGACTGTGAAACATCAAGGTGAAACATTTTTCGGTGACGCTGGTGTATTTCTGAAACGGTTTATCGAAAATGCCAGGCATGTTGAAGTCCAACTTATGGGAGATGGTTTTGGTAAGGCCATTGCTTTGGGCGAACGTGATTGTTCTTTACAGCGTCGTAACCAAAAAGTTATCGAAGAAACTCCTGCACCAAATTTGCCAGAAAAGACGAGGTTGGCGTTAAGAAAGGCAGCTGAAAGTTTGGGATCTTTATTGAATTACAAGTGTGCTGGTACGGTTGAATTTATTTACGATGAGAAAAAGGACGAGTTTTACTTTTTAGAAGTTAATACAAGATTACAAGTTGAACATCCAATAACAGAAATGGTTACAGGGTTAGACTTGGTCGAGTGGATGATCAGGATTGCCGCTAATGATGCACCTGATTTTGATTCTACAAAGGTAGAAGTCAATGGGGTTTCAATGGAGGCACGTTTATATGCTGAAAATCCATTGAAAAATTTCAGACCTTCTCCAGGTTTACTTGTCGATGTGAAATTTCCTGATTGGGCAAGAGTGGATACTTGGGTTAAGAAAGGTACTAATATTTCTCCCGAATATGATCCAACATTGGCCAAAATTATCGTTCATGGGAAAGACCGTGATGATGCAATTTCCAAGTTAAATCAAGCGTTAGAAGAAACAAAAGTTTACGGATGTATTACTAACATTGACTACCTGAAGTCTATCATTACCAGTGATTTCTTTGCTAAAGCAAAAGTTTCTACAAACATTTTGAACTCTTATCAATATGAGCCTACCGCCATCGAAATTACTTTGCCCGGTGCACACACTAGTATTCAGGATTACCCCGGTAGAGTTGGGTACTGGAGAATTGGTGTTCCGCCCTCTGGTCCAATGGACGCATATTCGTTTAGATTGGCGAACAGAATTGTTGGTAATGACTACAGGACTCCTGCCATTGAAGTAACGTTGACTGGTCCATCCATCGTTTTCCATTGTGAAACTGTCATTGCCATTACTGGTGGTACCGCTCTATGTACATTAGACGGCCAAGAAATTCCCCAACACAAACCGGTCGAAGTTAAGAGGGGATCTACTTTATCCATTGGCAAGTTGACAAGCGGCTGTAGAGCATACTTAGGTATCAGGGGTGGCATTGATGTGCCTAAATACTTGGGCTCTTATTCTACTTTCACTCTAGGAAATGTCGGTGGATACAATGGAAGGGTGCTAAAACTTGGAGACGTACTATTCTTACCAAGCAATGAAGAAAATAAATCAGTTGAGTGCCTTCCACAGAATATTCCTCAATCATTAATTCCTCAAATTTCCGAAACTAAGGAATGGAGAATTGGTGTAACATGTGGTCCCCATGGGTCTCCAGATTTTTTTAAACCTGAGTCCATCGAAGAATTTTTCAGTGAGAAGTGGAAGGTTCATTACAACTCCAATAGATTTGGTGTCCGTTTGATTGGACCTAAACCTAAGTGGGCAAGAAGTAATGGTGGTGAAGGTGGTATGCATCCTTCAAACACTCACGATTACGTTTATTCTCTGGGTGCAATTAATTTCACGGGTGATGAGCCAGTTATTATTACTTGCGATGGTCCTTCCTTAGGTGGTTTTGTGTGTCAAGCTGTTGTCCCAGAAGCAGAACTGTGGAAGGTTGGACAGGTTAAACCCGGTGATTCCATTCAGTTTGTGCCACTTTCTTACGAAAGCTCGAGATCCTTAAAGGAATCTCAGGAAGTTGCAATTAAATCATTGGATGGTACTAAGTTAAGGCGCTTAGACTCTGTTTCAATTTTACCATCATTCGAAACGCCTATTCTTGCACAAATGGAAAAAGTGAATGAGCTTTCACCAAAGGTTGTATACAGACAAGCAGGTGATCGTTATGTTTTGGTGGAATACGGTGATAATGAAATGAATTTTAATATTTCCTATAGAATTGAATGCCTGATCTCCCTTGTGAAAAAGAATAAGACTATTGGTATTGTTGAAATGTCCCAAGGTGTTAGATCTGTGTTGATAGAATTTGATGGTTACAAAGTCACTCAAAAAGAATTGCTTAAAGTATTGGTGGCATATGAAACAGAAATCCAGTTTGATGAAAATTGGAAGATAACTTCTAATATAATAAGATTACCGATGGCTTTCGAAGACTCGAAGACTTTGGCATGTGTTCAAAGGTATCAAGAAACAATTCGTTCGTCTGCTCCATGGTTGCCAAATAACGTTGATTTCATTGCCAATGTAAATGGAATTTCAAGGAATGAAGTTTATGATATGTTGTATTCTGCCAGATTTATGGTTTTAGGTTTAGGTGATGTCTTCCTAGGGTCGCCTTGTGCTGTTCCATTAGATCCTCGTCACAGATTTTTGGGAAGCAAGTACAACCCAAGTAGAACATATACAGAAAGAGGTGCAGTCGGTATTGGCGGTATGTATATGTGCATATATGCTGCTAACAGTCCTGGTGGGTACCAATTAGTGGGTAGAACAATACCAATTTGGGACAAACTATGTCTGGCCGCATCTTCTGAGGTTCCGTGGTTGATGAACCCATTTGACCAAGTCGAATTTTACCCAGTTTCTGAAGAAGATTTGGATAAAATGACTGAAGATTGTGATAATGGTGTTTATAAAGTCAATATCGAAAAGAGTGTTTTTGATCATCAAGAATACTTGAGATGGATCAACGCAAACAAAGATTCCATCACAGCATTCCAGGAGGGCCAGCTTGGTGAAAGAGCAGAGGAATTTGCCAAATTGATTCAAAATGCAAACTCTGAACTAAAAGAAAGTGTCACAGTCAAACCTGACGAGGAAGAAGACTTCCCAGAAGGTGCAGAAATTGTATATTCTGAGTATTCTGGGCGTTTTTGGAAATCCATAGCATCTGTTGGAGATGTTATTGAAGCAGGTCAAGGGCTACTAATTATTGAAGCCATGAAAGCGGAAATGATTATATCCGCTCCTAAATCGGGTAAGATTATCAAGATTTGCCATGGCAATGGTGATATGGTTGATTCTGGTGACATAGTGGCCGTCATAGAGACATTGGCATGA","protein_sequence":"MTVSSDTTAEISLGWSIQDWIDFHKSSSSQASLRLLESLLDSQNVAPVDNAWISLISKENLLHQFQILKSRENKETLPLYGVPIAVKDNIDVRGLPTTAACPSFAYEPSKDSKVVELLRNAGAIIVGKTNLDQFATGLVGTRSPYGKTPCAFSKEHVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGVFSCQGVVPACKSLDCVSIFALNLSDAERCFRIMCQPDPDNDEYSRPYVSNPLKKFSSNVTIAIPKNIPWYGETKNPVLFSNAVENLSRTGANVIEIDFEPLLELARCLYEGTWVAERYQAIQSFLDSKPPKESLDPTVISIIEGAKKYSAVDCFSFEYKRQGILQKVRRLLESVDVLCVPTCPLNPTMQQVADEPVLVNSRQGTWTNFVNLADLAALAVPAGFRDDGLPNGITLIGKKFTDYALLELANRYFQNIFPNGSRTYGTFTSSSVKPANDQLVGPDYDPSTSIKLAVVGAHLKGLPLHWQLEKVNATYLCTTKTSKAYQLFALPKNGPVLKPGLRRVQDSNGSQIELEVYSVPKELFGAFISMVPEPLGIGSVELESGEWIKSFICEESGYKAKGTVDITKYGGFRAYFEMLKKKESQKKKLFDTVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVSVPLHGTTAAQTYLDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSARQIAQKAGVPLVPGSLLITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIFETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETPAPNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLDLVEWMIRIAANDAPDFDSTKVEVNGVSMEARLYAENPLKNFRPSPGLLVDVKFPDWARVDTWVKKGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKVSTNILNSYQYEPTAIEITLPGAHTSIQDYPGRVGYWRIGVPPSGPMDAYSFRLANRIVGNDYRTPAIEVTLTGPSIVFHCETVIAITGGTALCTLDGQEIPQHKPVEVKRGSTLSIGKLTSGCRAYLGIRGGIDVPKYLGSYSTFTLGNVGGYNGRVLKLGDVLFLPSNEENKSVECLPQNIPQSLIPQISETKEWRIGVTCGPHGSPDFFKPESIEEFFSEKWKVHYNSNRFGVRLIGPKPKWARSNGGEGGMHPSNTHDYVYSLGAINFTGDEPVIITCDGPSLGGFVCQAVVPEAELWKVGQVKPGDSIQFVPLSYESSRSLKESQDVAIKSLDGTKLRRLDSVSILPSFETPILAQMEKVNELSPKVVYRQAGDRYVLVEYGDNEMNFNISYRIECLISLVKKNKTIGIVEMSQGVRSVLIEFDGYKVTQKELLKVLVAYETEIQFDENWKITSNIIRLPMAFEDSKTLACVQRYQETIRSSAPWLPNNVDFIANVNGISRNEVYDMLYSARFMVLGLGDVFLGSPCAVPLDPRHRFLGSKYNPSRTYTERGAVGIGGMYMCIYAANSPGGYQLVGRTIPIWDKLCLAASSEVPWLMNPFDQVEFYPVSEEDLDKMTEDCDNGVYKVNIEKSVFDHQEYLRWINANKDSITAFQEGQLGERAEEFAKLIQNANSELKESVTVKPDEEEDFPEGAEIVYSEYSGRFWKSIASVGDVIEAGQGLLIIEAMKAEMIISAPKSGKIIKICHGNGDMVDSGDIVAVIETLA"},{"created_at":"2011-05-24T19:45:53.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Galactokinase","uniprot_id":"P04385","uniprot_name":"GAL1_YEAST","enzyme":true,"transporter":false,"gene_name":"GAL1","num_residues":528,"molecular_weight":"57943.80078","theoretical_pi":"6.72","general_function":"Involved in galactokinase activity","specific_function":"ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate","reactions":[{"id":1558,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2270,"direction":"\u003e","locations":null,"altext":"ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3835,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006359","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01609","genbank_protein_id":"171567","gene_card_id":"GAL1","chromosome_location":"chromosome 2","locus":"YBR020W","synonyms":["Galactose kinase"],"enzyme_classes":["2.7.1.6"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" galactokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" carbohydrate phosphorylation"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" galactose metabolic process"},{"category":"Process","description":" phosphorus metabolic process"}],"pfams":[{"name":"GalKase_gal_bdg","identifier":"PF10509"},{"name":"GHMP_kinases_C","identifier":"PF08544"},{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGACTAAATCTCATTCAGAAGAAGTGATTGTACCTGAGTTCAATTCTAGCGCAAAGGAATTACCAAGACCATTGGCCGAAAAGTGCCCGAGCATAATTAAGAAATTTATAAGCGCTTATGATGCTAAACCGGATTTTGTTGCTAGATCGCCTGGTAGAGTCAATCTAATTGGTGAACATATTGATTATTGTGACTTCTCGGTTTTACCTTTAGCTATTGATTTTGATATGCTTTGCGCCGTCAAAGTTTTGAACGAGAAAAATCCATCCATTACCTTAATAAATGCTGATCCCAAATTTGCTCAAAGGAAGTTCGATTTGCCGTTGGACGGTTCTTATGTCACAATTGATCCTTCTGTGTCGGACTGGTCTAATTACTTTAAATGTGGTCTCCATGTTGCTCACTCTTTTCTAAAGAAACTTGCACCGGAAAGGTTTGCCAGTGCTCCTCTGGCCGGGCTGCAAGTCTTCTGTGAGGGTGATATACCAACTGGCAGTGGATTGTCTTCTTCGGCCGCATTCATTTGTGCCGTTGCTTTAGCTGTTGTTAAAGCGAATATGGGCCCTGGTTATCATATGTCCAAGCAAAATTTAATGCGTATCACGGTCGTTGCAGACATTATGTTGGTGTTAACAATGGCGGTATGGATCAGGCTGCCTCTGTTTGCGGTGAGGAAGATCATGCTCTATACGTTGAGTTCAAACGCAGTTGAGGCTACCCCGTTTAAATTTCCGCAATTAAAAAACCATGAAATTAGCTTTGTTATTGCGAACACCCTTGTTGTATCTAACAAGTTTGAAACCGCCCCAACCAACTATAATTTAAGAGTGGTAGAAGTCACTACAGCTGCAAATGTTTTAGCTGCCACGTACGGTGTTGTTTTACCTTCTGGAAAAGAAGGATCGAGCACGAATAAAGGTAATCTAAGAGATTTCATGAACGTTTATTATGCCAGATATCACAACATTTCCACACCCTGGAACGGCGATATTGAATCCGGCATCGAACGGTTAACAAAGATGCTAGTATTAGTTGAAGAGTCTCTCGCCAATAAGAAACAGGGCTTTAGTGTTGACGATGTCGCACAATCCTTGAATTGTTCTCGCGAAGAATTCACAAGAGACTACTTAACAACATCTCCAGTGAGATTTCAAGTCTTAAAGCTATATCAGAGGGCTAAGCATGTGTATTCTGAATCTTTAAGAGTCTTGAAGGCTGTGAAATTAATGACTACCGCGAGCTTTACTGCCGACGAAGACTTTTTCAAGCAATTTGGTGTCTTGATGAACGAGTCTCAAGCTTCTTGCGATAAACTTTACGAATGTTCTTGTCCAGAGATTGACAAAATTTGTTCCATTGCTTTGTCAAATGGATCATATGGTTCCCGTTTGACTGGAGCTGGCTGGGGTGGTTGTACTGTTCACTTGGTTCCAGGGGGCCCAAATAACGGCAACATAGAAAAGGTAAAAGAAGCCCTTGCCAATGAGTTCTACAAGGTCAAGTACCCTAAGATCACTGATGCTGAGCTAGAAAATGCTATCATCGTCTCTAAACCAGCATTGGGCAGCTGTCTATATGAATTATAA","protein_sequence":"MTKSHSEEVIVPEFNSSAKELPRPLAEKCPSIIKKFISAYDAKPDFVARSPGRVNLIGEHIDYCDFSVLPLAIDFDMLCAVKVLNEKNPSITLINADPKFAQRKFDLPLDGSYVTIDPSVSDWSNYFKCGLHVAHSFLKKLAPERFASAPLAGLQVFCEGDVPTGSGLSSSAAFICAVALAVVKANMGPGYHMSKQNLMRITVVAEHYVGVNNGGMDQAASVCGEEDHALYVEFKPQLKATPFKFPQLKNHEISFVIANTLVVSNKFETAPTNYNLRVVEVTTAANVLAATYGVVLLSGKEGSSTNKGNLRDFMNVYYARYHNISTPWNGDIESGIERLTKMLVLVEESLANKKQGFSVDDVAQSLNCSREEFTRDYLTTSPVRFQVLKLYQRAKHVYSESLRVLKAVKLMTTASFTADEDFFKQFGALMNESQASCDKLYECSCPEIDKICSIALSNGSYGSRLTGAGWGGCTVHLVPGGPNGNIEKVKEALANEFYKVKYPKITDAELENAIIVSKPALGSCLYEL"},{"created_at":"2011-05-24T19:49:46.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Protein APA1","uniprot_id":"P16550","uniprot_name":"APA1_YEAST","enzyme":true,"transporter":false,"gene_name":"APA1","num_residues":321,"molecular_weight":"36492.19922","theoretical_pi":"4.66","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP","reactions":[{"id":1339,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1340,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1991,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2274,"direction":"\u003e","locations":null,"altext":"ADP + sulfate = phosphate + adenylyl sulfate.","export":false,"pw_reaction_id":null,"source":null},{"id":2275,"direction":"\u003e","locations":null,"altext":"Adenylylsulfate + ATP = P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M31791","genbank_protein_id":"171064","gene_card_id":"APA1","chromosome_location":"chromosome 3","locus":"YCL050C","synonyms":["5',5'''-P-1,P-4-tetraphosphate phosphorylase","ATP adenylyltransferase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP,A phosphorylase","AP-4-A phosphorylase","ADP-sulfurylase"],"enzyme_classes":["2.7.7.53","2.7.7.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAGTATCCCCGCTGACATTGCATCTTTAATTAGTGACAAGTACAAAAGTGCCTTCGATAATGGTAACTTAAAATTTATCCAGACTGAAACAACGAAAACAAAGGACCCAAAAACCAGCATGCCATACTTGATTAGTCACATGCCAAGTCTGATCGAAAAGCCAGAGCGTGGCCAAACTCCAGAAGGAGAGGATCCACTAGGCAAACCTGAGGAAGAATTAACGGTTATCCCAGAATTTGGTGGTGCCGATAACAAAGCGTATAAATTGCTATTAAACAAATTCCCTGTAATCCCTGAACACACTTTATTGGTAACTAACGAATACCAACATCAAACTGATGCCTTGACCCCAACCGATTTATTGACTGCTTATAAGTTGCTGTGTGCCTTGGACAATGAAGAATCCGACAAGAGACACATGGTCTTTTACAATTCTGGTCCAGCCAGTGGTTCTTCATTGGACCACAAACATTTGCAAATTCTGCAAATGCCTGAAAAGTTCGTCACTTTCCAAGATAGACTATGTAATGGTAAAGAACATTTCCTACCAACTTTCAATACTGAACCTTTGCAAGATGCTAAAGTCTCGTTCGCTCATTTTGTCTTGCCAATGCCGGAGTCTGAAGAAACTGTTGATGAAGACCTATTAGCTATGTGTTACATCTCCATATTGCAAAGAGCTTTGACCTTTTTCCAGGACTGGTTGAACGAAAATCCAGAACTAAAGAAATCCTACAATCTTATGTTAACCAAGGAATGGATCTGTGTCGTTCCACGCTCGAAGGCCTTTTCTGATGAAATGAAGATAGGTTTCAACTCCACAGGTTATTGTGGTATGATCTTAACCAAAAATGATGAAGTTTTCTCCAAGATTACTGAAAAACCTGAATTGATTAACGATATCTTATTGGAATGTGGTTTCCCAAACACTTCTGGTCAAAAACCAAACGAATACAACTATTGA","protein_sequence":"MSIPADIASLISDKYKSAFDNGNLKFIQTETTKTKDPKTSMPYLISHMPSLIEKPERGQTPEGEDPLGKPEEELTVIPEFGGADNKAYKLLLNKFPVIPEHTLLVTNEYQHQTDALTPTDLLTAYKLLCALDNEESDKRHMVFYNSGPASGSSLDHKHLQILQMPEKFVTFQDRLCNGKEHFLPTFNTEPLQDAKVSFAHFVLPMPESEETVDEDLLAMCYISILQRALTFFQDWLNENPELKKSYNLMLTKEWICVVPRSKAFSDEMKIGFNSTGYCGMILTKNDEVFSKITEKPELINDILLECGFPNTSGQKPNEYNY"},{"created_at":"2011-05-24T19:50:13.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Inositol polyphosphate multikinase","uniprot_id":"P07250","uniprot_name":"IPMK_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG82","num_residues":355,"molecular_weight":"40352.5","theoretical_pi":"4.33","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity","reactions":[{"id":1661,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1662,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1663,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1664,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2276,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2277,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14818,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007006","source":"Smpdb"},{"id":14819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007031","source":"Smpdb"},{"id":14820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007032","source":"Smpdb"},{"id":14821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007033","source":"Smpdb"},{"id":14822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007034","source":"Smpdb"},{"id":14823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007035","source":"Smpdb"},{"id":14824,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007036","source":"Smpdb"},{"id":14825,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007037","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X05328","genbank_protein_id":"3376","gene_card_id":"ARG82","chromosome_location":"chromosome 4","locus":"YDR173C","synonyms":["IPMK","Arginine metabolism regulation protein III"],"enzyme_classes":["2.7.1.151"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGGATACGGTAAACAATTATAGGGTTTTAGAGCATAAAGCTGCTGGCCACGACGGTACTCTAACAGACGGTGATGGATTGCTCATCTTTAAACCGGCCTTTCCGCAGGAACTGGAATTCTACAAAGCCATACAAGTGAGAGATGTGAGTCGAAGAAAGTCTTCGGCTGATGGAGATGCTCCCTTGTGCTCTTGGATGCCCACGTATCTTGGAGTCTTGAATGAAGGGGCAAAAATCGAGCAAAGTGGCGATGCTGCGCTTCTGAAGATAGATGAGCGGTTAAGTGATTCCACTGATAATCTTGATTCAATACCTGTAAAGTCTGAGAAGTCCAAGCAATACCTCGTTTTAGAAAATCTACTATATGGATTTAGTAAACCTAATATACTTGATATAAAATTAGGCAAAACTTTGTATGATTCGAAGGCATCATTGGAAAAAAGAGAGAGAATGAAAAGAGTCAGTGAGACGACGACTTCAGGATCTTTGGGTTTCAGGATATGTGGCATGAAAATACAGAAAAATCCCTCTGTGCTGAATCAGCTTTCGCTCGAATATTACGAAGAAGAAGCAGACAGTGATTATATCTTTATAAACAAATTGTATGGTCGTTCAAGAACCGATCAAAATGTTTCAGATGCAATTGAACTTTATTTTAACAATCCTCATCTGTCGGATGCGAGAAAGCATCAACTGAAGAAAACATTTTTGAAAAGATTGCAGTTGTTTTATAATACTATGCTAGAAGAAGAAGTTAGAATGATATCAAGTAGTCTTTTGTTTATTTACGAAGGAGACCCGGAGCGATGGGAATTACTAAATGATGTTGACAAACTTATGCGAGATGATTTTATAGACGATGATGACGACGATGATGATAATGATGATGATGATGATGATGATGCCGAGGGAAGCAGCGAAGGACCAAAGGACAAAAAAACAACTGGTTCTTTGAGTTCCATGTCACTAATAGATTTTGCACATTCTGAAATAACGCCGGGGAAGGGTTATGATGAAAACGTGATTGAAGGAGTTGAAACCTTGCTAGATATTTTTATGAAATTCTAG","protein_sequence":"MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF"},{"created_at":"2011-05-24T19:54:26.000Z","updated_at":"2011-07-22T17:54:40.000Z","name":"Ethanolamine 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Also exhibits choline kinase activity but its preferred substrate is ethanolamine","reactions":[{"id":1479,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2280,"direction":"\u003e","locations":null,"altext":"ATP + ethanolamine = ADP + O-phosphoethanolamine.","export":false,"pw_reaction_id":null,"source":null},{"id":14801,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006996","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z50046","genbank_protein_id":"899397","gene_card_id":"EKI1","chromosome_location":"chromosome 4","locus":"YDR147W","synonyms":["EK"],"enzyme_classes":["2.7.1.82"],"go_classes":[],"pfams":[{"name":"Choline_kin_N","identifier":"PF04428"},{"name":"Choline_kinase","identifier":"PF01633"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGTACACCAATTATTCACTTACAAGCAGTGACGCAATGCCCCGAACTTACTTGGTCGGCACAGCCTCACCAGAAATGTCTAAGAAAAAGCGCCAGTCTGCAAATTGTGACAAGCCAACGAGGAGGGTGATCCACATCATCGATACTAATGAGCACTCAGAAGTCGACTTGAAAAATGAACTGCCAATAACATGCACGAATGAAGACGGTGAGATGACATCAAGCTCATGGACTTCACAAACCGCTAATGATTTTCTCAAACTGGCATACGTAAACGCGAAATTAGACCCGTCTTTGCCATCTCAATATTTCAAACAAGATATCATAAATGTTTTACAAAGCTTGGAGATTCCTGGATGGTCTGTGCCCGGCTCTAAAGAATCCTCGTTGAATAAGAATTTATTAACTTTGACACAAATCAAGGGGGCCCTTACAAATGTTATTTATAAGATTCACTATCCAAACTTACCCCCTTTACTGATGAGAATTTTTGGTGATAGCATAGATTCTGTAATTGATAGAGAGTATGAATTAAAGGTTATTGCGAGATTATCATTTTATGATTTAGGACCCAAACTAGAAGGGTTTTTTGAAAATGGCAGATTTGAAAAATACATTGAGGGTTCGAGGACATCTACTCAAGCCGACTTTATAGATCGGGATACTTCAATAAAAATTGCTAAAAAATTGAAAGAGTTGCATTGTACTGTTCCATTAACGCATAAAGAAATAACGGATCAACCGTCATGCTGGACAACCTTTGATCAGTGGATCAAATTAATAGACTCGCATAAAGAGTGGGTTTCCAATAATGTAAATATAAGTGAAAATTTACGCTGTTCAAGTTGGAATTTTTTTTTAAAGAGTTTCAAAAATTATAAGCGTTGGTTGTATAATGATTCTGCTTTTACCTCAAAATTATTAAGAGAGGATGATAAAGATAGTATGATAAATTCTGGGCTAAAAATGGTATTTTGCCATAACGACTTACAGCATGGTAATTTACTTTTTAAAAGTAAGGGTAAGGATGACATCTCAGTGGGCGATTTAACAATTATTGACTTTGAGTACGCAGGCCCTAACCCCGTTGTATTTGATTTATCAAATCATTTGAATGAATGGATGCAAGACTATAATGATGTGCAGTCTTTCAAGTCTCATATTGATAAGTATCCAAAAGAAGAAGATATTTTAGTTTTTGCACAAAGTTATATAAATCACATGAATGAGAACCATGTCAAAATTGCTTCTCAAGAGGTTAGGATTCTTTACAATCTAATCATCGAATGGAGGCCTTGTACACAATTATTCTGGTGCCTTTGGGCTCTTTTGCAAAGCGGAAGGCTACCACAACGACCACTGATAGAAGGTGAAAAACTAATGAGCGAAAAGGCTGGACTAGGTGATGAAACGCACCTTATGGAGCACAAAAATAAAGAGAATGGAAAATACGATTGTTCTGAAGATGATTCGTTCAACTATTTAGGATTTTGTAAAGAAAAAATGTCTGTCTTTTGGGGCGATTTAATTACATTGGGAGTTATCGACAAAGACTGCCCAGATATTGGAAAAACAGATTACTTAGACACTAAACTTATTTTTTAA","protein_sequence":"MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF"},{"created_at":"2011-05-24T19:54:50.000Z","updated_at":"2011-07-22T17:54:40.000Z","name":"Choline kinase","uniprot_id":"P20485","uniprot_name":"KICH_YEAST","enzyme":true,"transporter":false,"gene_name":"CKI1","num_residues":582,"molecular_weight":"66316.0","theoretical_pi":"5.34","general_function":"Involved in phosphotransferase activity, alcohol group as acceptor","specific_function":"Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline","reactions":[{"id":1383,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1479,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2281,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + choline = ADP + O-phosphocholine.","export":false,"pw_reaction_id":null,"source":null},{"id":14813,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007000","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692779","genbank_protein_id":"51013009","gene_card_id":"CKI1","chromosome_location":"chromosome 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2","uniprot_id":"Q12471","uniprot_name":"6P22_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK27","num_residues":397,"molecular_weight":"45317.10156","theoretical_pi":"5.4","general_function":"Involved in catalytic activity","specific_function":"Synthesis of fructose 2,6-bisphosphate","reactions":[{"id":1223,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006336","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X90861","genbank_protein_id":"1085116","gene_card_id":"PFK27","chromosome_location":"chromosome 15","locus":"YOL136C","synonyms":["6PF-2-K 2","Phosphofructokinase 2 II"],"enzyme_classes":["2.7.1.105"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGTGGTTCTTCCGATTCAGACTCTCACGATGGATATTTGACTTCCGAATATAATTCCTCGAATTCTCTTTTTTCACTTAACACCGGTAACAGCTATTCAAGCGCATCTCTCGACAGAGCCACTTTAGATTGTCAAGATTCTGTTTTTTTCGATAATCACAAAAGTTCACTGCTGTCTACAGAGGTCCCAAGGTTTATTTCTAACGACCCGTTACACTTACCCATTACACTGAATTACAAAAGAGATAATGCAGACCCTACGTATACAAATGGAAAAGTTAACAAGTTTATGATTGTTTTGATTGGGCTACCAGCTACTGGGAAGTCTACCATTTCTTCTCATTTAATTCAATGTTTGAAGAACAATCCACTAACTAATTCATTACGCTGTAAAGTTTTTAATGCTGGTAAGATAAGAAGGCAAATCAGTTGTGCTACCATTTCAAAGCCTTTGCTTTTGTCGAATACATCTTCGGAAGACTTATTTAATCCGAAAAATAACGATAAAAAGGAAACGTATGCCAGGATCACTTTGCAAAAGTTGTTTCACGAAATCAACAACGATGAATGTGACGTGGGAATCTTCGACGCCACAAATTCGACCATCGAAAGAAGAAGATTTATATTTGAGGAGGTTTGTTCGTTCAATACAGATGAGCTTTCTAGTTTCAATTTGGTGCCCATAATCTTACAGGTGTCATGTTTTAACAGAAGCTTTATCAAATACAATATCCACAATAAATCGTTTAATGAAGACTACTTAGACAAACCTTATGAACTTGCCATCAAAGATTTTGCAAAGAGATTAAAACATTACTATTCGCAGTTTACACCTTTCTCCCTTGATGAGTTCAATCAAATCCATCGATATATCAGCCAACATGAAGAAATCGATACGAGCTTATTTTTCTTCAATGTTATCAATGCGGGCGTCGTTGAGCCACATTCTTTAAATCAAAGTCATTACCCTTCGACCTGTGGCAAGCAAATTAGGGACACCATTATGGTTATTGAAAATTTCATCAATCACTATTCTCAGATGTTTGGTTTTGAATACATCGAAGCTGTTAAATTGTTTTTTGAAAGTTTTGGAAATAGCTCAGAGGAAACTTTAACTACACTAGACTCTGTTGTTAATGATAAATTTTTTGATGATTTGCAGAGCCTAATTGAAAGCAACGGATTTGCTTGA","protein_sequence":"MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCLKNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQKLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSFIKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDTSLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLFFESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA"},{"created_at":"2011-05-24T19:57:09.000Z","updated_at":"2011-05-24T19:57:09.000Z","name":"Putative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W","uniprot_id":"Q06137","uniprot_name":"YL345_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":509,"molecular_weight":"58385.19922","theoretical_pi":"6.4","general_function":"Involved in catalytic activity","specific_function":"Synthesis and degradation of fructose 2,6-bisphosphate","reactions":[{"id":2283,"direction":"\u003e","locations":"Cytoplasm","altext":"Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19028","genbank_protein_id":"609382","gene_card_id":null,"chromosome_location":null,"locus":"YLR345W","synonyms":["6-phosphofructo-2-kinase","Fructose-2,6-bisphosphatase"],"enzyme_classes":["2.7.1.105","3.1.3.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"},{"name":"PGAM","identifier":"PF00300"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"}],"gene_sequence":"ATGCCAAATGTGCTTTCTGATGATGAAGAGCTCCTTAATGGACTAGGAAGTGAGATTATGAAACCCTCTAGACAAGGTAACCATATGGCAAGGACCGTCAAAAGGTGGGTAAATAAAGAACGTGCTACCACAGCCGATCTGAAAAATGTTAATATTGATGGAGTTCATGGACCGGTAAATACCGAAAGTTATATATCACCAGGACAGCTTTACTCCACTGACTCGGGCAATTTATTTCATGCTGGAAGAATCCTTGTCGTTCTAGTCGGTCTTCCAGCAACATCAAAGACACTATTGTCAGTAGCGATTACAAGATATACAAGATGGTTAGGAGTTAGGACGAAATCGTTCCATTTTTCAGAATATAAAGAATCAGCTAAAAATATACCCTCAGACTATTTTTGCGTAGTGCCAACGTCAAAAGAAGGTGTAGCGTTTGTTGAAAAGCTTCGCATGCAGATGTTGAATGATATACTGGCATTTTTCAACGACTTGTCAGGTCAGCTGGCCATTTATGATGCCCTAAACATCCGTAAAATTGACAGAAAGAATTTGGAGACAACGTTTTCTGAAATTGGAGTTAAAGTACTCTTCATAGAATCAATCGTGTCTGATCAAGAAATCATGAATAGAAACATAGCTCTTGCACTGGAGTCGAACGATTACAAGGGACTTTCAACTGATGAAGCCATTGACGAATATATGAGACGTTTATCAGTGAACGAACCATACTATGAAATGATGACACATGACGAAGAATTATCGTACATTAAATATATAAATTTGGGAAAGCAGATAATTGTGAAAGATAACATACATGGTTATTTGGTCAACAAAATAGTATTTTTCTTAATGAATTTGAGGCAGAAAAAGGGGTGTGTATATTTTGCTCGCTGTGGCACCAGCGATAAAGACAACTACATACATGATGAGGAACTAAACGAGGAGGGAATCCATTACTCTCAAGTTCTCAAGGATTTTGTCCTCCAACGAATTAAACAGAAGAGACAGGCCAAAAAAAATTCGGATTCCTTAGTCGAAGTAATAGATGGAAGTCATGATGAAGATTTGAAGACTTCCTTGATAGTTTGGACAGGTCCCAGGAAAAGAACCCACGATACTGCACTCTTTTTTTCAAAAGAAGGTATTAAAGTTCAGCAACGGTCAGAGTTGAGACAGTTGAACCCAGGAAGTATTGCTGATCTTACTGATCAACAGATAATGGACAAATTTCCATCAGAATATAAAGAATCATTAAAAGACCCATATCATTTTCGATTCCCTAGGGCGGAATCTTACCATGACTTAGCCGTTCGTATGGAACCTTTACTATTAGAAATGGAGCATACGAGCAAGGACATTCTCATCATTGCACATGAGTCAACATTAAGAGTATTATATGGCTATTTAATGGCTTGCACCTGCGTAGAGTTACCAAATCTAAATTTCACAAGAGACAAATTAGTTGAAATTTCATTCAGCCCTTTCTGTAATACTGTAGAGTTACTGAACATTCCTTTAACTAGCTAA","protein_sequence":"MPNVLSDDEELLNGLGSEIMKPSRQGNHMARTVKRWVNKERATTADLKNVNIDGVHGPVNTESYISPGQLYSTDSGNLFHAGRILVVLVGLPATSKTLLSVAITRYTRWLGVRTKSFHFSEYKESAKNIPSDYFCVVPTSKEGVAFVEKLRMQMLNDILAFFNDLSGQLAIYDALNIRKIDRKNLETTFSEIGVKVLFIESIVSDQEIMNRNIALALESNDYKGLSTDEAIDEYMRRLSVNEPYYEMMTHDEELSYIKYINLGKQIIVKDNIHGYLVNKIVFFLMNLRQKKGCVYFARCGTSDKDNYIHDEELNEEGIHYSQVLKDFVLQRIKQKRQAKKNSDSLVEVIDGSHDEDLKTSLIVWTGPRKRTHDTALFFSKEGIKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHTSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCNTVELLNIPLTS"},{"created_at":"2011-05-24T19:57:42.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"6-phosphofructo-2-kinase 1","uniprot_id":"P40433","uniprot_name":"6P21_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK26","num_residues":827,"molecular_weight":"93416.20313","theoretical_pi":"9.02","general_function":"Involved in catalytic activity","specific_function":"Synthesis of fructose 2,6-bisphosphate","reactions":[{"id":1223,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006336","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692819","genbank_protein_id":"51013089","gene_card_id":"PFK26","chromosome_location":"chromosome 9","locus":"YIL107C","synonyms":["6PF-2-K 1","Phosphofructokinase 2 I"],"enzyme_classes":["2.7.1.105"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"},{"name":"PGAM","identifier":"PF00300"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTCAAACCAGTAGACTTCTCTGAAACATCTCCTGTGCCGCCTGATATTGATCTTGCTCCTACACAATCTCCACACCATGTGGCACCTAGTCAAGACTCCAGTTATGATCTTTTATCCCGGAGTTCCGATGATAAAATTGATGCTGAAAAGGGTCCGCATGATGAATTATCTAAGCACTTACCACTTTTTCAGAAAAGACCTTTGAGCGATACTCCTATATCGAGCAATTGGAACTCTCCTGGAATCACTGAAGAAAATACACCTTCTGACTCTCCTGAAAATAGCGCTACTAATTTGAAATCGCTACATCGATTGCATATTAACGACGAAACGCAACTAAAAAATGCTAAAATTCCCACAAACGATACTACTGACTACATGCCTCCTTCAGATGGAGCAAATGAGGTAACTCGGATTGATTTGAAAGACATTAAATCACCTACGAGACACCATAAAAGAAGACCTACCACCATCGATGTTCCTGGTTTAACAAAGTCTAAAACATCTCCAGATGGTCTCATATCAAAGGAAGATAGTGGATCAAAGTTAGTGATTGTCATGGTCGGACTGCCAGCTACGGGAAAGTCATTTATTACAAATAAATTATCCAGATTTTTAAATTATTCTTTATACTATTGTAAAGTGTTTAATGTCGGTAACACTAGAAGGAAGTTTGCTAAGGAGCATGGCCTAAAGGACCAGGATTCAAAGTTTTTCGAGCCGAAAAACGCCGACTCTACTAGGTTGAGAGACAAATGGGCCATGGATACTCTGGATGAATTGCTAGATTATTTATTAGAAGGTTCAGGATCTGTGGGAATTTTTGATGCTACAAATACCTCTCGTGAAAGAAGAAAAAACGTTCTGGCTAGAATCAGAAAGAGAAGTCCTCATTTGAAGGTTTTATTTTTAGAATCTGTTTGTTCGGATCATGCACTGGTACAGAAAAATATTAGACTCAAATTATTTGGTCCAGATTACAAAGGTAAAGATCCTGAAAGCTCTTTAAAAGATTTTAAAAGTCGCCTGGCAAACTACTTGAAAGCCTATGAACCAATTGAGGATGACGAAAATTTGCAGTACATCAAAATGATAGATGTGGGAAAGAAAGTCATCGCATACAATATTCAAGGGTTTTTAGCTTCGCAGACGGTATATTATTTATTAAATTTCAATTTGGCTGACAGACAAATTTGGATAACGAGAAGTGGCGAGAGCGAAGATAATGTTAGTGGCCGTATAGGCGGAAATTCCCATTTGACTCCTCGTGGTCTAAGATTTGCTAAAAGTCTACCAAAATTCATTGCCAGACAGAGAGAAATATTTTATCAAAATCTCATGCAACAAAAAAAGAATAATGAAAATACAGATGGGAACATTTATAATGACTTTTTCGTTTGGACCAGCATGCGTGCTAGGACTATAGGGACTGCTCAATATTTCAACGAAGATGATTATCCTATCAAACAAATGAAAATGTTAGATGAGTTAAGTGCAGGTGATTATGATGGTATGACATATCCAGAAATTAAAAACAACTTTCCTGAAGAATTCGAAAAAAGACAGAAAGATAAGTTGAGATACAGATACCCTGGTATTGGCGGTGAATCGTATATGGACGTTATTAATAGACTCAGACCTGTTATCACAGAACTAGAAAGAATCGAGGATAACGTTCTTATTATTACACACCGGGTGGTGGCAAGAGCCTTATTGGGTTATTTTATGAACTTGAGTATGGGTATTATTGCCAATTTGGATGTCCCATTACATTGTGTATATTGCCTAGAACCAAAACCATATGGAATCACTTGGTCATTATGGGAGTATGATGAAGCATCGGATTCATTTTCTAAGGTCCCACAAACGGACTTGAATACCACCAGAGTAAAGGAGGTTGGCCTTGTTTATAATGAAAGAAGATATTCTGTTATACCAACAGCTCCGCCAAGTGCAAGAAGCAGCTTTGCAAGTGACTTTTTGTCAAGAAAAAGATCTAATCCTACTTCTGCATCTTCATCCCAGAGTGAATTATCAGAACAACCCAAGAATAGCGTTAGTGCTCAAACTGGCAGCAATAATACCACTCTCATTGGGAGCAACTTTAACATCAAGAATGAAAATGGTGATTCGAGAATACCATTATCTGCACCACTTATGGCCACTAATACTTCTAATAACATCTTAGATGGTGGAGGTACCTCAATTTCGATACATCGTCCCAGGGTTGTTCCAAATCAAAACAACGTGAATCCCCTTTTGGCTAACAACAATAAAGCGGCTTCTAATGTACCTAATGTAAAGAAGTCAGCGGCTACACCAAGGCAAATTTTTGAAATAGATAAAGTGGACGAAAAGTTATCCATGTTGAAAAATAAAAGTTTTCTATTACATGGAAAGGATTATCCTAATAATGCTGATAATAATGACAACGAAGATATAAGGGCAAAAACCATGAATCGCAGCCAAAGTCACGTTTAA","protein_sequence":"MFKPVDFSETSPVPPDIDLAPTQSPHHVAPSQDSSYDLLSRSSDDKIDAEKGPHDELSKHLPLFQKRPLSDTPISSNWNSPGITEENTPSDSPENSATNLKSLHRLHINDETQLKNAKIPTNDTTDYMPPSDGANEVTRIDLKDIKSPTRHHKRRPTTIDVPGLTKSKTSPDGLISKEDSGSKLVIVMVGLPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFAKEHGLKDQDSKFFEPKNADSTRLRDKWAMDTLDELLDYLLEGSGSVGIFDATNTSRERRKNVLARIRKRSPHLKVLFLESVCSDHALVQKNIRLKLFGPDYKGKDPESSLKDFKSRLANYLKAYEPIEDDENLQYIKMIDVGKKVIAYNIQGFLASQTVYYLLNFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFYQNLMQQKKNNENTDGNIYNDFFVWTSMRARTIGTAQYFNEDDYPIKQMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGIGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEVGLVYNERRYSVIPTAPPSARSSFASDFLSRKRSNPTSASSSQSELSEQPKNSVSAQTGSNNTTLIGSNFNIKNENGDSRIPLSAPLMATNTSNNILDGGGTSISIHRPRVVPNQNNVNPLLANNNKAASNVPNVKKSAATPRQIFEIDKVDEKLSMLKNKSFLLHGKDYPNNADNNDNEDIRAKTMNRSQSHV"},{"created_at":"2011-05-24T20:00:21.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Inositol hexakisphosphate kinase 1","uniprot_id":"Q12494","uniprot_name":"KCS1_YEAST","enzyme":true,"transporter":false,"gene_name":"KCS1","num_residues":1050,"molecular_weight":"119549.0","theoretical_pi":"6.78","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance","reactions":[{"id":1199,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1215,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1226,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1469,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1667,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"S81651","genbank_protein_id":"1478442","gene_card_id":"KCS1","chromosome_location":"chromosome 4","locus":"YDR017C","synonyms":["InsP6 kinase 1","InsP6 kinase KCS1","PKC1 suppressor protein 1"],"enzyme_classes":["2.7.4.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[],"gene_sequence":"ATGGATACCTCTCACGAAATTCATGATAAAATACCCGATACATTAAGAGAGCAGCAGCAGCATTTGCGCCAAAAAGAGTCGGAAGGGTGCATAACAACATTGAAAGATCTTAATGTACCTGAGACGAAGAAACTTTCCTCCGTCTTACATGGCAGAAAGGCGAGTACATATTTAAGAATTTTTAGAGATGATGAATGTTTAGCCGATAACAACAATGGTGTAGATAGCAATAATGGCGGGTCCGTGACATGCGCGGACAAAATAACAAGGTCAGAAGCAACTCCCAAATCGGTACCAGAAGGACTACAAGTTTCTGAAAAAAAGAATAACCCAGATACTTTGTCCTCTTCATTGTCAAGTTTCATTTTATCTAACCACGAGGAGCCGGCAATTAAGCCCAATAAACACGTGGCGCATAGAAATAATATTACTGAGACAGGTCAAGGCTCTGGTGAGGATATCGCAAAACAACAATCACACCAACCACAGGTGTTACACCACCAGACTTCTTTAAAGCCAATTCAGAATGTTGATGAGGGATGTATTTCGCCTAAGTCCACTTATCAGGAGAGCTTACATGGAATATCGGAGGACTTAACGTTAAAGCCTGTTTCTTCTGCAACATACTATCCTCACAAAAGTAAAGCAGATTCTGGTTATGAAGAAAAGGATAAAATGGAAAATGATATTGATACTATTCAGCCTGCCACCATAAATTGTGCCTCTGGTATAGCGACACTTCCTAGTTCATATAACCGACATACTTTCAAAGTTAAGACATATTCAACTTTATCACAATCCCTAAGGCAAGAAAACGTCAACAATCGTAGTAACGAAAAAAAACCTCAACAGTTTGTGCCACATAGCGAATCAATTAAAGAAAAACCCAATACGTTTGAACAAGATAAAGAAGGCGAGCAAGCGGACGAAGAAGAGGATGAAGGTGATAATGAACATAGGGAATATCCCCTAGCAGTTGAACTAAAACCATTTACGAATAGAGTTGGAGGTCACACTGCAATATTCAGATTTTCGAAGAGAGCGGTTTGTAAGGCTCTAGTGAATAGAGAAAACAGGTGGTATGAGAATATAGAGCTGTGCCATAAAGAATTATTGCAATTCATGCCACGTTATATTGGTGTCCTGAATGTTAGGCAACATTTTCAGTCAAAAGATGACTTTTTAAGCGATTTGGATCAAGAAAACAACGGTAAAAATGATACCAGTAATGAAAACAAAGACATAGAAGTCAATCATAACAATAACGACGATATTGCGCTTAATACAGAACCCACGGGGACCCCCTTAACACACATACATTCCTTCCCCTTGGAACATTCGTCGAGACAAGTACTTGAAAAAGAGCATCCTGAAATTGAGTCTGTCCATCCACACGTGAAAAGATCACTGTCAAGTTCCAACCAACCTTCCTTGTTGCCCGAGGTTGTATTAAATGATAACAGGCATATTATACCGGAATCTCTGTGGTACAAATATTCCGATTCTCCAAACTCGGCACCGAATGATTCGTACTTTTCGTCCTCCTCTTCTCATAACTCATGTTCGTTCGGTGAGCGTGGCAATACAAATAAATTAAAAAGACGCGATTCTGGGTCCACCATGATCAATACTGAATTGAAGAACCTAGTCATAAGGGAAGTATTTGCACCGAAATGTTTTAGAAGGAAAAGAAACTCTAATACGACTACAATGGGAAACCATAATGCGCGTTTGGGTTCCAGTCCATCTTTTTTAACACAAAAATCAAGAGCCTCGTCCCATGATGCATCGAATACGTCTATGAAGACTCTTGGTGATTCATCGTCACAAGCGAGTTTACAGATGGATGACTCGAAAGTCAATCCGAATTTGCAGGATCCTTTCTTGAAAAAATCGCTTCATGAAAAAATATCTAATGCTTTAGATGGCTCGCATTCAGTAATGGATTTGAAGCAATTCCACAAAAACGAACAAATAAAACATAAAAACTCTTTCTGCAACTCTTTATCACCCATTCTCACTGCAACCAATTCTAGAGATGATGGCGAATTTGCCACCTCCCCGAATTATATCAGCAACGCACAAGATGGTGTTTTTGATATGGATGAAGATACGGGAAACGAAACTATAAATATGGATAACCACGGCTGCCATCTTGACTCTGGTAAAAACATGATTATAAAGTCATTGGCGTATAATGTTTCAAATGACTATAGTCATCATGATATTGAATCAATTACGTTTGAGGAGACGTCCCACACCATTGTTTCAAAATTTATCTTATTGGAAGATTTGACAAGAAACATGAACAAGCCTTGTGCACTGGATCTAAAGATGGGGACAAGACAATATGGCGTAGACGCCAAAAGAGCCAAGCAACTGTCACAGCGTGCAAAGTGTTTAAAGACCACTTCTAGGCGTTTAGGCGTTAGAATCTGCGGATTAAAGGTTTGGAACAAAGATTATTATATCACAAGAGATAAATACTTTGGTAGAAGGGTTAAGGTTGGTTGGCAATTTGCTAGGGTACTTGCACGTTTTTTGTATGATGGTAAGACCATTGAAAGTTTAATCAGGCAAATTCCAAGGTTGATCAAGCAACTAGATACTTTGTATTCTGAAATTTTTAATTTGAAAGGTTACAGGCTATATGGCGCGTCTTTATTACTAATGTACGATGGAGATGCTAATAAATCAAATTCTAAAAGGAAAAAAGCTGCTAATGTTAAAGTCAACTTGATCGATTTTGCACGTTGTGTTACTAAAGAAGATGCAATGGAATGTATGGATAAATTTCGTATACCCCCAAAATCGCCAAATATAGAAGATAAAGGGTTCTTACGAGGTGTGAAGAGCTTGAGGTTTTATCTGTTATTAATCTGGAATTATCTGACTTCTGATATGCCGTTAATTTTCGATGAAGTAGAGATGAATGATATGATTAGCGAAGAAGCAGATTCGAATAGTTTCACCTCCGCCACCGGTTCGAAAATCAACTTCAACAGTAAGTGGGATTGGTTAGATGAATTTGACAAAGAAGACGAAGAAATGTATAATGATCCAAATAGTAAACTAAGACAAAAATGGAGAAAATACGAGCTTATTTTCGACGCTGAACCAAGATACAATGACGATGCTCAAGTTAGTGATTGA","protein_sequence":"MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD"},{"created_at":"2011-05-24T20:01:03.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase","uniprot_id":"Q06685","uniprot_name":"VIP1_YEAST","enzyme":true,"transporter":false,"gene_name":"VIP1","num_residues":1146,"molecular_weight":"129754.0","theoretical_pi":"9.01","general_function":"Involved in acid phosphatase activity","specific_function":"Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth","reactions":[{"id":1198,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1221,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1222,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1225,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null},{"id":2291,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton","altext":"ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Cytoplasm, cytoskeleton","genbank_gene_id":"U20162","genbank_protein_id":"632676","gene_card_id":"VIP1","chromosome_location":"chromosome 12","locus":"YLR410W","synonyms":["InsP6 and PP-IP5 kinase"],"enzyme_classes":["2.7.4.21","2.7.4.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"},{"name":"RimK","identifier":"PF08443"}],"pathways":[],"gene_sequence":"ATGAGTGGGATAAAGAAGGAACCGATTGAATCTGATGAGGTTCCTCAACAAGAGACAAAAAATAACTTACCTAGTGCACCTTCTGAGATGTCACCCCTTTTCCTAAACAAAAACACACAGAAGGCTATGCAATCTATTGCACCAATATTGGAGGGTTTCAGTCCTAAGACGTCAGCTAGCGAAAATATGTCTTTGAAATTGCCACCTCCCGGTATTCAAGATGATCACAGTGAAGAGAATCTCACCGTGCATGATACTCTGCAAAGAACCATAAGCACTGCACTAGGAAACGGAAACAACACCAATACAGTTACAACTTCCGGTTTAAAAAAGGCAGACAGTGAATCAAAGTCAGAAGCTGATCCTGAGGGGCTCAGCAATTCTAACATAGTCAATGATGCAGATAACATAAATTCCATCTCCAAGACCGGATCGCCCCATTTACCTCAAGGAACAATGGACGCTGAGCAGACTAACATGGGAACTAACTCTGTACCTACTTCATCAGCTTCTTCACGCAAATCCTCGACTAGTCATCCCAAACCTAGGCTACCCAAGGTAGGGAAGATTGGGGTATGTGCAATGGATGCAAAAGTCCTTTCAAAGCCAATGAGACACATTTTGAATCGTTTAATTGAACATGGTGAATTTGAAACTGTCATTTTTGGAGATAAGGTGATTCTAGATGAAAGAATAGAGAATTGGCCAACTTGCGACTTTTTGATATCTTTCTTTTCTTCAGGATTTCCCCTAGATAAAGCAATTAAATACGTCAAGTTACGCAAGCCTTTCATTATCAATGATTTAATAATGCAAAAGATTTTGTGGGACAGGAGATTATGTCTACAAGTATTAGAAGCCTACAACGTTCCAACACCTCCTAGACTGGAAATCAGTAGAGATGGTGGTCCCCGTGCCAACGAAGAATTAAGGGCAAAATTACGTGAGCATGGCGTAGAAGTTAAACCCGTTGAAGAACCGGAATGGAAAATGGTTGATGATGATACTTTAGAAGTTGATGGGAAAACCATGACTAAGCCCTTTGTTGAAAAGCCCGTTGATGGTGAAGACCACAACATTTATATATACTATCATTCTAAGAACGGAGGAGGCGGTCGTCGTCTATTCCGTAAAGTTGGTAACAAGTCTTCTGAGTTTGATCCTACTTTGGTTCATCCTCGTACGGAGGGGTCTTACATTTATGAGCAGTTTATGGATACCGATAATTTCGAAGATGTGAAGGCTTATACGATTGGTGAGAACTTTTGTCACGCTGAAACTAGGAAATCACCTGTGGTTGATGGTATAGTTAGAAGAAATACTCATGGTAAAGAAGTTAGATATATTACTGAGTTATCAGACGAAGAGAAAACCATTGCTGGGAAAGTTTCCAAAGCTTTTTCACAAATGATCTGTGGTTTCGATTTGCTTCGCGTTTCTGGTAAAAGTTACGTCATTGATGTTAACGGATTTTCTTTTGTAAAGGATAACAAAGCTTACTATGATTCATGCGCCAATATATTGAGAAGTACCTTCATTGAAGCCAAAAAGAAGATGGATATGGAAAAGAAGAATCTGCCCATTATTCGTGAAGAAAAGGAACAAAAGTGGGTATTCAAAGGACTGGCTATCATTATCCGTCACGCGGACAGAACACCAAAACAGAAATTCAAACATTCATTCACTTCGCCTATTTTTATATCGTTACTAAAAGGTCACAAAGAAGAAGTTGTCATTCGGAATGTAAATGATTTAAAGATTGTTCTTCAGGCCTTAAGAATTGCGTTAGATGAAAAAGCAGGAAATCCAGCTAAAATTAAAGTGTTAGCAAACGCTCTAGAAAAGAAACTGAATTTTCCCGGTACGAAAATACAATTGAAACCGGTTTTAAATAAAGAGAACGAAGTGGAAAAAGTTCAGTTTATTTTGAAATGGGGTGGTGAACCCACTCATTCTGCCAAATATCAGGCTACGGAACTCGGAGAGCAAATGAGACAAGATTTTGACCTATTGAATAAGAGCATTCTACAAAACATCAAGATATTTTCATCGTCTGAGAGACGTGTTCTTCATACGGCGCAGTACTGGACCAGAGCTCTTTTTGGGGCCGATGAATTAGGTAGCGATGAAATCAGTATTAGAAAGGATCTTTTAGATGACAGTAATGCCGCCAAAGATTTAATGGATAAGGTGAAAAAGAAGTTGAAGCCACTTTTAAGAGAGGGTAAGGAAGCTCCCCCACAATTTGCCTGGCCTTCAAAGATGCCGGAGCCATATTTAGTCATAAAGCGAGTGGTTGAATTGATGAATTACCATAAAAAAATTATGGATAACAACTTTGCTAAAAAGGATGTCAACTCGATGCAAACAAGATGGTGTACTTCTGAAGATCCTAGTTTGTTTAAGGAAAGGTGGGATAAACTTTTCAAAGAATTCAATAATGCTGAAAAAGTCGATCCTTCTAAAATTTCTGAATTGTATGATACTATGAAGTATGATGCTCTTCACAACAGGCAGTTCCTAGAGAACATATTTGACCCGGGTCTTCCAAATGAAGCTATCGCCGATGAACTCGGCAGTCATTCTTTAGTTGACCGATACCCAATTAACGTTCTCGCCAAAAATAATTTTAAGATAATAGACAGTCATAGCATGAACAATTCTGGAAAGAACAGTAGTAATAGTGTTGGGTCGTTAGGATGGGTTCTGGAAAGCGGAAAAACATCTACAGCAAGAAACCCCAAATCTTCTTCTCAATTCGATGAGCCACGCTTTATGCAGTTGCGGGAGCTGTATAAGCTGGCCAAAGTATTGTTTGATTTTATCTGCCCCAAAGAATATGGTATTTCAGATGCAGAGAAACTGGATATCGGTTTGTTAACTTCGTTGCCTTTGGCAAAGCAAATACTAAATGATATAGGAGACATGAAAAATAGAGAAACTCCAGCTTGTGTTGCGTACTTCACCAAAGAGTCCCATATTTACACTCTATTGAATATCATATACGAATCTGGTATTCCAATGAGAATCGCTAGAAATGCTTTACCAGAACTAGACTACTTGTCGCAGATCACTTTTGAACTTTATGAGAGTACGGATGCTTCTGGTCAAAAATCGCATTCCATTAGACTAAAAATGTCTCCTGGGTGTCATACTCAAGATCCGTTAGATGTTCAATTAGATGACAGGCATTATATTAGTTGTATTCCAAAGATTTCCCTGACGAAGCATTTGGATATGGACTATGTTCAACAGAAATTGAGAAACAAATTTACCAGGGTCATTATGCCTCCGAAATTTACACCAGTAAACATTACGAGCCCCAACTTGAGTTTCCAGAAACGCAAAACCAGAAGAAAGTCGGTATCTGTTGAGAAGTTGAAACGTCCTGCCTCGTCCGGATCTTCATCATCTACCTCCGTTAACAAGACATTAGATTAG","protein_sequence":"MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSASENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEADPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFETVIFGDKVILDERIENWPTCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSPVVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKDNKAYYDSCANILRSTFIEAKKKMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPKQKFKHSFTSPIFISLLKGHKEEVVIRNVNDLKIVLQALRIALDEKAGNPAKIKVLANALEKKLNFPGTKIQLKPVLNKENEVEKVQFILKWGGEPTHSAKYQATELGEQMRQDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKEFNNAEKVDPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDIGDMKNRETPACVAYFTKESHIYTLLNIIYESGIPMRIARNALPELDYLSQITFELYESTDASGQKSHSIRLKMSPGCHTQDPLDVQLDDRHYISCIPKISLTKHLDMDYVQQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASSGSSSSTSVNKTLD"},{"created_at":"2011-05-24T20:05:04.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Glutathione synthetase","uniprot_id":"Q08220","uniprot_name":"GSHB_YEAST","enzyme":true,"transporter":false,"gene_name":"GSH2","num_residues":491,"molecular_weight":"55814.69922","theoretical_pi":"5.32","general_function":"Involved in ATP binding","specific_function":"ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione","reactions":[{"id":1585,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2297,"direction":"\u003e","locations":null,"altext":"ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.","export":false,"pw_reaction_id":null,"source":null},{"id":3830,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006355","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1M0W","cellular_location":null,"genbank_gene_id":"AY723864","genbank_protein_id":"51830516","gene_card_id":"GSH2","chromosome_location":"chromosome 15","locus":"YOL049W","synonyms":["GSH synthetase","GSH-S","Glutathione synthase"],"enzyme_classes":["6.3.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" glutathione synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"},{"category":"Process","description":" glutathione biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GSH_synth_ATP","identifier":"PF03917"},{"name":"GSH_synthase","identifier":"PF03199"}],"pathways":[{"name":"Glutathione 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purine biosynthetic protein ADE5,7","uniprot_id":"P07244","uniprot_name":"PUR2_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE5","num_residues":802,"molecular_weight":"86067.39844","theoretical_pi":"4.89","general_function":"Involved in catalytic activity","specific_function":"ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide","reactions":[{"id":1885,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1891,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2304,"direction":"\u003e","locations":null,"altext":"ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2305,"direction":"\u003e","locations":null,"altext":"ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X04337","genbank_protein_id":"3335","gene_card_id":"ADE5","chromosome_location":null,"locus":"YGL234W","synonyms":["Phosphoribosylamine--glycine ligase","Glycinamide ribonucleotide synthetase","GARS","Phosphoribosylglycinamide synthetase","Phosphoribosylformylglycinamidine cyclo-ligase","AIR synthase","AIRS","Phosphoribosyl-aminoimidazole synthetase"],"enzyme_classes":["6.3.4.13","6.3.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen 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metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGCTCAACATTCTCGTTTTAGGAAACGGTGCAAGAGAACACGTTCTTGTCACCAAGCTGGCTCAGTCACCCACCGTGGGTAAGATCTATGTCGCTCCAGGTAATGGAGGGACCGCAACCATGGATCCTTCGCGTGTGATAAACTGGGATATTACGCCAGATGTCGCCAATTTTGCTCGTTTGCAGTCGATGGCTGTGGAACATAAGATCAACTTGGTCGTTCCTGGTCCAGAATTACCTCTAGTCAACGGCATCACCTCCGTGTTCCATAGCGTTGGTATTCCCGTTTTTGGACCTTCCGTCAAAGCCGCTCAGTTGGAAGCTTCCAAGGCTTTCTCCAAGAGATTTATGTCAAAACACAATATTCCAACCGCGTCTTATGATGTCTTCACTAATCCAGAAGAAGCCATTTCATTCTTGCAAGCTCATACTGACAAAGCTTTTGTCATCAAGGCCGACGGGATCGCTGCTGGGAAAGGTGTTATTATCCCATCTAGCATCGACGAGTCCGTCCAAGCTATCAAGGACATAATGGTCACCAAGCAATTCGGTGAAGAAGCGGGCAAGCAGGTTGTGATAGAACAATTCTTGGAAGGTGATGAAATCTCTCTACTCACCATTGTTGACGGGTACTCTCACTTCAATCTCCCCGTCGCACAAGATCACAAGAGGATCTTTGATGGCGACAAGGGCTTGAACACCGGTGGGATGGGTGCCTATGCCCCCGCTCCTGTGGCCACACCATCTTTGTTGAAGACCATAGATTCACAGATTGTGAAGCCTACGATTGATGGGATGAGACGTGATGGTATGCCCTTTGTTGGTGTGCTGTTCACCGGGATGATTTTGGTGAAGGATTCTAAGACAAATCAACTTGTTCCCGAAGTGTTAGAATATAATGTCAGATTCGGTGACCCAGAGACACAGGCTGTTTTGAGTTTACTTGATGATCAAACCGATTTGGCGCAAGTGTTTTTGGCTGCTGCTGAACATCGTTTGGATTCCGTAAACATAGGAATCGATGACACAAGATCTGCCGTTACTGTCGTAGTGGCTGCAGGTGGTTATCCTGAATCATACGCCAAAGGTGACAAAATTACCTTGGATACCGATAAATTACCTCCACATACACAAATCTTCCAAGCAGGTACCAAATACGATTCCGCCACCGATTCTTTATTGACCAATGGTGGTAGAGTTCTTTCTGTGACCTCCACTGCTCAGGACTTGAGAACAGCAGTAGATACAGTATATGAAGCCGTCAAATGCGTCCATTTCCAAAATTCTTACTACAGAAAGGACATCGCATACCGTGCGTTCCAAAACTCAGAATCATCAAAAGTTGCCATCACATACGCAGACTCAGGTGTCTCTGTTGATAATGGTAACAATCTCGTACAAACTATCAAAGAAATGGTCAGATCCACAAGAAGGCCAGGTGCAGACTCTGATATTGGTGGTTTTGGTGGTTTATTCGATTTGGCTCAAGCAGGTTTCCGTCAAAACGAAGATACCTTACTAGTAGGTGCTACAGATGGTGTCGGTACTAAATTAATCATTGCCCAAGAGACCGGGATTCATAATACTGTCGGTATTGACCTGGTGGCCATGAATGTTAACGATTTGGTGGTACAAGGTGCTGAGCCTCTATTCTTTTTGGACTACTTTGCCACTGGTGCTCTTGACATTCAAGTTGCCTCTGATTTTGTGTCCGGTGTTGCTAATGGTTGTATTCAAAGTGGTTGTGCTCTTGTGGGTGGTGAAACTTCGGAAATGCCCGGTATGTATCCACCCGGCCACTACGATACTAATGGTACCGCTGTTGGTGCTGTATTAAGACAAGATATCTTGCCCAAGATAAATGAAATGGCCGCAGGAGATGTTCTTCTGGGTCTCGCCTCTAGCGGTGTTCATTCTAATGGTTTCTCTTTGGTTAGAAAAATTATTCAACATGTAGCATTACCATGGGACGCTCCATGTCCATGGGATGAATCTAAGACGTTAGGTGAAGGTATTCTTGAACCAACAAAAATTTACGTCAAGCAATTATTGCCATCAATTAGACAAAGACTACTACTAGGTTTAGCTCATATAACAGGTGGTGGTTTAGTAGAGAATATCCCAAGAGCTATTCCAGACCACCTACAGGCCCGCGTTGATATGTCAACCTGGGAAGTACCCCGTGTCTTCAAATGGTTTGGTCAAGCAGGTAATGTTCCACACGATGACATTTTAAGAACCTTCAACATGGGTGTTGGTATGGTTTTGATTGTCAAGAGAGAAAACGTCAAGGCTGTTTGTGATTCATTGACTGAAGAAGGTGAAATTATTTGGGAGCTTGGTTCTTTGCAAGAAAGACCAAAGGATGCTCCCGGTTGTGTGATTGAAAACGGAACTAAGCTTTACTAA","protein_sequence":"MLNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPDVANFARLQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIPTASYDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGGMGAYAPAPVATPSLLKTIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLVPEVLEYNVRFGDPETQAVLSLLDDQTDLAQVFLAAAEHRLDSVNIGIDDTRSAVTVVVAAGGYPESYAKGDKITLDTDKLPPHTQIFQAGTKYDSATDSLLTNGGRVLSVTSTAQDLRTAVDTVYEAVKCVHFQNSYYRKDIAYRAFQNSESSKVAITYADSGVSVDNGNNLVQTIKEMVRSTRRPGADSDIGGFGGLFDLAQAGFRQNEDTLLVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMAAGDVLLGLASSGVHSNGFSLVRKIIQHVALPWDAPCPWDESKTLGEGILEPTKIYVKQLLPSIRQRLLLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKRENVKAVCDSLTEEGEIIWELGSLQERPKDAPGCVIENGTKLY"},{"created_at":"2011-05-24T20:16:09.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Dihydroxyacetone kinase 2","uniprot_id":"P43550","uniprot_name":"DAK2_YEAST","enzyme":true,"transporter":false,"gene_name":"DAK2","num_residues":591,"molecular_weight":"62134.0","theoretical_pi":"5.67","general_function":"Involved in glycerone kinase activity","specific_function":"ATP + glycerone = ADP + glycerone phosphate","reactions":[{"id":1465,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2308,"direction":"\u003e","locations":"","altext":"ATP + glycerone = ADP + glycerone phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3899,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006416","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836702","gene_card_id":"DAK2","chromosome_location":"chromosome 6","locus":"YFL053W","synonyms":["DHA kinase 2","Glycerone kinase 2"],"enzyme_classes":["2.7.1.29"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" glycerone kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"}],"pfams":[{"name":"Dak1","identifier":"PF02733"},{"name":"Dak2","identifier":"PF02734"}],"pathways":[{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Glycerol 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kinase 1","uniprot_id":"P54838","uniprot_name":"DAK1_YEAST","enzyme":true,"transporter":false,"gene_name":"DAK1","num_residues":584,"molecular_weight":"62206.10156","theoretical_pi":"5.05","general_function":"Involved in glycerone kinase activity","specific_function":"ATP + glycerone = ADP + glycerone phosphate","reactions":[{"id":1465,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2308,"direction":"\u003e","locations":"","altext":"ATP + glycerone = ADP + glycerone phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z38114","genbank_protein_id":"558404","gene_card_id":"DAK1","chromosome_location":"chromosome 13","locus":"YML070W","synonyms":["DHA kinase 1","Glycerone kinase 1"],"enzyme_classes":["2.7.1.29"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" glycerone kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"}],"pfams":[{"name":"Dak1","identifier":"PF02733"},{"name":"Dak2","identifier":"PF02734"}],"pathways":[{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Methane 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of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside 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process"}],"pfams":[{"name":"Cation_ATPase_C","identifier":"PF00689"},{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGGGCGAAGGAACTACTAAGGAAAACAATAATGCAGAATTCAATGCTTATCACACGCTGACTGCAGAAGAAGCCGCTGAATTCATAGGCACAAGTCTAACTGAAGGTTTGACCCAAGATGAGTTCGTCCACAGATTGAAAACAGTGGGTGAGAACACATTGGGTGATGACACTAAAATTGATTACAAGGCAATGGTCCTCCATCAGGTATGTAATGCCATGATCATGGTCCTTCTAATATCCATGATAATCTCGTTTGCCATGCATGATTGGATTACTGGTGGCGTTATTTCTTTTGTTATCGCGGTCAATGTGCTCATTGGCCTAGTTCAAGAATATAAGGCTACCAAGACAATGAACTCTTTGAAAAACTTGAGCTCTCCCAATGCTCATGTTATTAGGAACGGGAAAAGTGAGACTATAAACTCAAAAGATGTGGTTCCAGGTGATATTTGTCTGGTGAAGGTCGGTGATACTATTCCTGCTGATTTGCGTTTAATTGAAACTAAGAATTTTGATACTGATGAATCACTACTGACCGGTGAATCTTTGCCTGTCTCCAAAGACGCCAACTTAGTGTTTGGAAAAGAAGAAGAAACCTCCGTGGGTGATCGTTTGAATTTAGCATTTTCTTCATCCGCCGTTGTCAAGGGAAGAGCCAAGGGTATTGTCATCAAGACAGCTTTGAATAGTGAAATTGGTAAAATTGCAAAATCTCTACAAGGTGATTCAGGTCTCATTTCCCGCGATCCTAGTAAGTCGTGGTTACAGAATACATGGATATCTACAAAGAAAGTTACTGGTGCATTTTTAGGTACAAATGTCGGTACGCCCCTGCACAGGAAACTGTCTAAGTTGGCGGTATTGCTTTTCTGGATTGCCGTACTTTTTGCTATCATCGTCATGGCCTCTCAAAAGTTTGACGTAGATAAAAGGGTAGCTATCTATGCCATTTGTGTGGCCCTATCCATGATTCCCTCTTCATTAGTCGTTGTCTTGACCATCACCATGTCTGTTGGGGCTGCTGTTATGGTTTCTAGAAACGTTATTGTAAGAAAATTAGATTCTCTGGAAGCTTTAGGTGCCGTTAACGATATCTGTTCTGACAAGACCGGTACTCTTACACAGGGTAAAATGTTAGCGAGGCAAATTTGGATCCCTCGCTTTGGTACCATAACTATCTCGAATTCTGATGACCCCTTTAATCCCAATGAGGGCAACGTGAGTTTGATTCCAAGGTTTTCACCTTACGAATATTCTCATAATGAGGATGGTGACGTTGGTATTCTCCAGAATTTCAAGGATCGCCTATACGAAAAAGATTTACCAGAAGATATTGACATGGATCTATTTCAAAAATGGCTCGAAACCGCCACTTTGGCTAACATTGCTACTGTTTTCAAAGATGACGCAACTGACTGTTGGAAAGCTCATGGTGACCCAACAGAAATTGCGATTCAAGTGTTTGCTACTAAGATGGACTTGCCTCACAATGCCCTTACCGGTGAGAAATCGACTAATCAAAGTAATGAGAATGACCAATCCTCTCTTTCACAACACAATGAGAAGCCTGGCAGTGCACAATTCGAACATATTGCTGAATTCCCATTCGACTCAACTGTGAAGCGAATGTCATCTGTCTACTACAACAATCACAACGAAACATATAATATTTATGGCAAGGGTGCTTTCGAAAGCATCATCAGTTGTTGCAGTTCTTGGTATGGTAAGGATGGTGTAAAAATCACACCATTGACCGATTGTGATGTCGAAACGATAAGGAAAAATGTTTACAGTCTATCAAATGAGGGTTTAAGAGTCTTGGGTTTTGCCTCCAAATCTTTCACTAAAGATCAAGTGAATGACGATCAATTGAAAAACATTACTTCAAACAGGGCCACCGCAGAAAGTGATTTAGTTTTCCTAGGGTTGATTGGTATTTACGATCCACCCAGAAATGAGACTGCCGGTGCAGTCAAGAAGTTTCACCAAGCTGGTATTAACGTTCATATGTTAACTGGGGACTTTGTGGGTACAGCAAAGGCTATCGCTCAGGAGGTTGGCATCTTACCCACCAATTTGTACCATTACTCCCAAGAGATTGTTGACAGTATGGTCATGACCGGATCTCAGTTTGACGGACTAAGTGAGGAGGAAGTGGACGATTTGCCCGTCTTACCTTTAGTTATTGCACGTTGCTCTCCGCAGACTAAGGTGAGAATGATCGAAGCTTTACACCGTAGGAAGAAGTTCTGCACAATGACAGGTGACGGTGTTAACGATTCTCCATCTCTAAAAATGGCCAATGTTGGTATTGCAATGGGTATTAATGGTTCAGATGTTTCCAAAGAAGCGTCTGATATTGTTCTAAGCGATGACAATTTTGCTTCTATTTTGAATGCTGTCGAAGAAGGTCGTAGGATGACGGATAACATTCAGAAGTTTGTCCTACAATTATTGGCAGAAAATGTTGCTCAGGCTTTGTATTTGATCATTGGTTTAGTATTCAGAGATGAGAACGGAAAATCAGTATTTCCCTTATCACCAGTGGAAGTATTGTGGATTATTGTCGTCACCTCTTGTTTTCCTGCTATGGGGCTAGGTCTAGAAAAGGCTGCTCCAGATTTGATGGATAGACCTCCTCATGATTCAGAGGTTGGTATTTTCACGTGGGAGGTTATTATAGATACATTTGCATATGGGATTATAATGACAGGGTCCTGTATGGCTTCATTTACTGGATCACTGTATGGAATAAATAGTGGTAGATTGGGGCACGATTGTGATGGCACCTATAACAGCAGTTGTCGTGATGTTTATAGATCACGTTCTGCGGCTTTCGCAACCATGACGTGGTGCGCTTTGATTCTGGCTTGGGAAGTGGTTGACATGAGAAGATCCTTTTTCAGAATGCATCCAGACACTGACAGCCCAGTCAAGGAATTTTTCAGAAGCATTTGGGGAAACCAGTTTTTGTTCTGGTCAATCATTTTTGGATTTGTGTCAGCCTTCCCCGTCGTCTATATTCCGGTTATTAATGATAAAGTGTTTTTGCATAAACCAATTGGTGCTGAATGGGGTCTCGCCATTGCATTCACAATTGCATTCTGGATAGGTGCTGAACTTTACAAGTGTGGAAAGAGGCGCTATTTCAAAACTCAGAGAGCGCACAACCCGGAGAATGATTTGGAGAGTAACAATAAGCGCGATCCATTCGAAGCGTATAGTACTTCTACTACAATCCATACAGAAGTTAATATTGGTATTAAACAATGA","protein_sequence":"MGEGTTKENNNAEFNAYHTLTAEEAAEFIGTSLTEGLTQDEFVHRLKTVGENTLGDDTKIDYKAMVLHQVCNAMIMVLLISMIISFAMHDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCTMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNPENDLESNNKRDPFEAYSTSTTIHTEVNIGIKQ"},{"created_at":"2011-05-24T20:21:04.000Z","updated_at":"2011-06-04T23:10:36.000Z","name":"Sodium transport ATPase 5","uniprot_id":"Q12691","uniprot_name":"ATN5_YEAST","enzyme":false,"transporter":true,"gene_name":"ENA5","num_residues":1091,"molecular_weight":"120295.0","theoretical_pi":"5.19","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance","reactions":[{"id":2311,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein","altext":"ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"64-84;91-111;283-303;313-333;816-836;849-869;886-906;944-964;992-1012;1022-1042","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z74334","genbank_protein_id":"1431486","gene_card_id":"ENA5","chromosome_location":"chromosome 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of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cation_ATPase_C","identifier":"PF00689"},{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGAGCGAGGGAACTGTCAAAGAAAACAATAATGAAGAATTCAATGCTTATCACACATTGACTACAGAAGAAGCCGCTGAATTTATAGGCACAAGTCTGACTGAAGGTCTTACTCAAGATGAGTCCCTCCGCAGACTGAAAGCAGTGGGAGAGAACACATTGGGTGATGATACCAAAATTGACTATAAAGCAATGGTCCTCCATCAGGTATGTAATGCAATGATTATGGTCTTGGTAATATCCATGGCGATCTCTTTCGCTGTGCGCGACTGGATTACTGGTGGCGTTATTTCTTTTGTTATCGCGGTCAATGTGCTCATTGGCCTAGTTCAAGAATATAAGGCTACCAAGACAATGAACTCTTTGAAAAACTTGAGCTCTCCCAATGCTCATGTTATTAGGAACGGGAAAAGTGAGACTATAAACTCAAAAGATGTGGTTCCAGGTGATATTTGTCTGGTGAAGGTCGGTGATACTATTCCTGCTGATTTGCGTTTAATTGAAACTAAGAATTTTGATACTGATGAATCACTACTGACCGGTGAATCTTTGCCTGTCTCCAAAGACGCCAACTTAGTGTTTGGAAAAGAAGAAGAAACCTCCGTGGGTGATCGTTTGAATTTAGCATTTTCTTCATCCGCCGTTGTCAAGGGAAGAGCCAAGGGTATTGTCATCAAGACAGCTTTGAATAGTGAAATTGGTAAAATTGCAAAATCTCTACAAGGTGATTCAGGTCTCATTTCCCGCGATCCTAGTAAGTCGTGGTTACAGAATACATGGATATCTACAAAGAAAGTTACTGGTGCATTTTTAGGTACAAATGTCGGTACGCCCCTGCACAGGAAACTGTCTAAGTTGGCGGTATTGCTTTTCTGGATTGCCGTACTTTTTGCTATCATCGTCATGGCCTCTCAAAAGTTTGACGTAGATAAAAGGGTAGCTATCTATGCCATTTGTGTGGCCCTATCCATGATTCCCTCTTCATTAGTCGTTGTCTTGACCATCACCATGTCTGTTGGGGCTGCTGTTATGGTTTCTAGAAACGTTATTGTAAGAAAATTAGATTCTCTGGAAGCTTTAGGTGCCGTTAACGATATCTGTTCTGACAAGACCGGTACTCTTACACAGGGTAAAATGTTAGCGAGGCAAATTTGGATCCCTCGCTTTGGTACCATAACTATCTCGAATTCTGATGACCCCTTTAATCCCAATGAGGGCAACGTGAGTTTGATTCCAAGGTTTTCACCTTACGAATATTCTCATAATGAGGATGGTGACGTTGGTATTCTCCAGAATTTCAAGGATCGCCTATACGAAAAAGATTTACCAGAAGATATTGACATGGATCTATTTCAAAAATGGCTCGAAACCGCCACTTTGGCTAACATTGCTACTGTTTTCAAAGATGACGCAACTGACTGTTGGAAAGCTCATGGTGACCCAACAGAAATTGCGATTCAAGTGTTTGCTACTAAGATGGACTTGCCTCACAATGCCCTTACCGGTGAGAAATCGACTAATCAAAGTAATGAGAATGACCAATCCTCTCTTTCACAACACAATGAGAAGCCTGGCAGTGCACAATTCGAACATATTGCTGAATTCCCATTCGACTCAACTGTGAAGCGAATGTCATCTGTCTACTACAACAATCACAACGAAACATATAATATTTATGGCAAGGGTGCTTTCGAAAGCATCATCAGTTGTTGCAGTTCTTGGTATGGTAAGGATGGTGTAAAAATCACACCATTGACCGATTGTGATGTCGAAACGATAAGGAAAAATGTTTACAGTCTATCAAATGAGGGTTTAAGAGTCTTGGGTTTTGCCTCCAAATCTTTCACTAAAGATCAAGTGAATGACGATCAATTGAAAAACATTACTTCAAACAGGGCCACCGCAGAAAGTGATTTAGTTTTCCTAGGGTTGATTGGTATTTACGATCCACCCAGAAATGAGACTGCCGGTGCAGTCAAGAAGTTTCACCAAGCTGGTATTAACGTTCATATGTTAACTGGGGACTTTGTGGGTACAGCAAAGGCTATCGCTCAGGAGGTTGGCATCTTACCCACCAATTTGTACCATTACTCCCAAGAGATTGTTGACAGTATGGTCATGACCGGATCTCAGTTTGACGGACTAAGTGAGGAGGAAGTGGACGATTTGCCCGTCTTACCTTTAGTTATTGCACGTTGCTCTCCGCAGACTAAGGTGAGAATGATCGAAGCTTTACACCGTAGGAAGAAGTTCTGCGCAATGACAGGTGACGGTGTTAACGATTCTCCATCTCTAAAAATGGCCAATGTTGGTATTGCAATGGGTATTAATGGTTCAGATGTTTCCAAAGAAGCGTCTGATATTGTTCTAAGCGATGACAATTTTGCTTCTATTTTGAATGCTGTCGAAGAAGGTCGTAGGATGACGGATAACATTCAGAAGTTTGTCCTACAATTATTGGCAGAAAATGTTGCTCAGGCTTTGTATTTGATCATTGGTTTAGTATTCAGAGATGAGAACGGAAAATCAGTATTTCCCTTATCACCAGTGGAAGTATTGTGGATTATTGTCGTCACCTCTTGTTTTCCTGCTATGGGGCTAGGTCTAGAAAAGGCTGCTCCAGATTTGATGGATAGACCTCCTAATGATTCAGAGGTTGGTATTTTCACATGGGAGGTTATTATAGATACATTTGCATATGGGATTATAATGACAGGGTCCTGTATGGCTTCATTTACTGGATCACTGTATGGAATAAATAGTGGTAGATTGGGGCACGATTGTGATGGCACCTATAACAGCAGTTGTCGTGATGTTTATAGATCACGTTCTGCGGCTTTCGCAACTATGACGTGGTGCGCTTTGATTCTGGCTTGGGAAGTGGTTGACATGAGAAGATCTTTTTTCAGAATGCATCCAGACACTGACAGCCCAGTCAAGGAATTTTTCAGAAGTATTTGGGGAAACCAGTTTTTGTTCTGGTCAATCATTTTTGGATTTGTGTCAGCCTTCCCCGTCGTCTATATTCCGGTTATTAATGATAAAGTGTTTTTGCATAAACCAATTGGTGCTGAATGGGGTCTCGCCATTGCATTCACAATTGCATTCTGGATAGGTGCTGAACTTTACAAGTGTGGAAAGAGGCGCTATTTCAAAACTCAGAGAGCTCACAATTCGGAAAACGATTTGGAGCGAAGCAGTAAACACGATCCATTTGAAGCGTATAGCACATCCACAACCCTTCAAAGCGAAATTAATATCAGTGTCAAGCATTAA","protein_sequence":"MSEGTVKENNNEEFNAYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISMAISFAVRDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPNDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNSENDLERSSKHDPFEAYSTSTTLQSEINISVKH"},{"created_at":"2011-05-24T20:22:24.000Z","updated_at":"2011-06-04T23:11:17.000Z","name":"Sodium transport ATPase 2","uniprot_id":"Q01896","uniprot_name":"ATN2_YEAST","enzyme":false,"transporter":true,"gene_name":"ENA2","num_residues":1091,"molecular_weight":"120316.0","theoretical_pi":"5.19","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance","reactions":[{"id":2311,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein","altext":"ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"64-84;91-111;283-303;313-333;816-836;849-869;886-906;944-964;992-1012;1022-1042","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"U24069","genbank_protein_id":"790261","gene_card_id":"ENA2","chromosome_location":"chromosome 4","locus":"YDR039C","synonyms":[],"enzyme_classes":["3.6.3.7"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cation_ATPase_C","identifier":"PF00689"},{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGGGCGAAGGAACTACTAAGGAAAACAATAATGCAGAATTCAATGCTTATCACACGCTGACTGCAGAAGAAGCCGCTGAATTCATAGGCACAAGTCTAACTGAAGGTTTGACCCAAGATGAGTTCGTCCACAGATTGAAAACAGTGGGTGAGAACACATTGGGTGATGACACTAAAATTGATTACAAGGCAATGGTCCTCCATCAGGTATGTAATGCCATGATCATGGTCCTTCTAATATCCATGATAATCTCGTTTGCCATGCATGATTGGATTACTGGTGGCGTTATTTCTTTTGTTATCGCGGTCAATGTGCTCATTGGCCTAGTTCAAGAATATAAGGCTACCAAGACAATGAACTCTTTGAAAAACTTGAGCTCTCCCAATGCTCATGTTATTAGGAACGGGAAAAGTGAGACTATAAACTCAAAAGATGTGGTTCCAGGTGATATTTGTCTGGTGAAGGTCGGTGATACTATTCCTGCTGATTTGCGTTTAATTGAAACTAAGAATTTTGATACTGATGAATCACTACTGACCGGTGAATCTTTGCCTGTCTCCAAAGACGCCAACTTAGTGTTTGGAAAAGAAGAAGAAACCTCCGTGGGTGATCGTTTGAATTTAGCATTTTCTTCATCCGCCGTTGTCAAGGGAAGAGCCAAGGGTATTGTCATCAAGACAGCTTTGAATAGTGAAATTGGTAAAATTGCAAAATCTCTACAAGGTGATTCAGGTCTCATTTCCCGCGATCCTAGTAAGTCGTGGTTACAGAATACATGGATATCTACAAAGAAAGTTACTGGTGCATTTTTAGGTACAAATGTCGGTACGCCCCTGCACAGGAAACTGTCTAAGTTGGCGGTATTGCTTTTCTGGATTGCCGTACTTTTTGCTATCATCGTCATGGCCTCTCAAAAGTTTGACGTAGATAAAAGGGTAGCTATCTATGCCATTTGTGTGGCCCTATCCATGATTCCCTCTTCATTAGTCGTTGTCTTGACCATCACCATGTCTGTTGGGGCTGCTGTTATGGTTTCTAGAAACGTTATTGTAAGAAAATTAGATTCTCTGGAAGCTTTAGGTGCCGTTAACGATATCTGTTCTGACAAGACCGGTACTCTTACACAGGGTAAAATGTTAGCGAGGCAAATTTGGATCCCTCGCTTTGGTACCATAACTATCTCGAATTCTGATGACCCCTTTAATCCCAATGAGGGCAACGTGAGTTTGATTCCAAGGTTTTCACCTTACGAATATTCTCATAATGAGGATGGTGACGTTGGTATTCTCCAGAATTTCAAGGATCGCCTATACGAAAAAGATTTACCAGAAGATATTGACATGGATCTATTTCAAAAATGGCTCGAAACCGCCACTTTGGCTAACATTGCTACTGTTTTCAAAGATGACGCAACTGACTGTTGGAAAGCTCATGGTGACCCAACAGAAATTGCGATTCAAGTGTTTGCTACTAAGATGGACTTGCCTCACAATGCCCTTACCGGTGAGAAATCGACTAATCAAAGTAATGAGAATGACCAATCCTCTCTTTCACAACACAATGAGAAGCCTGGCAGTGCACAATTCGAACATATTGCTGAATTCCCATTCGACTCAACTGTGAAGCGAATGTCATCTGTCTACTACAACAATCACAACGAAACATATAATATTTATGGCAAGGGTGCTTTCGAAAGCATCATCAGTTGTTGCAGTTCTTGGTATGGTAAGGATGGTGTAAAAATCACACCATTGACCGATTGTGATGTCGAAACGATAAGGAAAAATGTTTACAGTCTATCAAATGAGGGTTTAAGAGTCTTGGGTTTTGCCTCCAAATCTTTCACTAAAGATCAAGTGAATGACGATCAATTGAAAAACATTACTTCAAACAGGGCCACCGCAGAAAGTGATTTAGTTTTCCTAGGGTTGATTGGTATTTACGATCCACCCAGAAATGAGACTGCCGGTGCAGTCAAGAAGTTTCACCAAGCTGGTATTAACGTTCATATGTTAACTGGGGACTTTGTGGGTACAGCAAAGGCTATCGCTCAGGAGGTTGGCATCTTACCCACCAATTTGTACCATTACTCCCAAGAGATTGTTGACAGTATGGTCATGACCGGATCTCAGTTTGACGGACTAAGTGAGGAGGAAGTGGACGATTTGCCCGTCTTACCTTTAGTTATTGCACGTTGCTCTCCGCAGACTAAGGTGAGAATGATCGAAGCTTTACACCGTAGGAAGAAGTTCTGCACAATGACAGGTGACGGTGTTAACGATTCTCCATCTCTAAAAATGGCCAATGTTGGTATTGCAATGGGTATTAATGGTTCAGATGTTTCCAAAGAAGCGTCTGATATTGTTCTAAGCGATGACAATTTTGCTTCTATTTTGAATGCTGTCGAAGAAGGTCGTAGGATGACGGATAACATTCAGAAGTTTGTCCTACAATTATTGGCAGAAAATGTTGCTCAGGCTTTGTATTTGATCATTGGTTTAGTATTCAGAGATGAGAACGGAAAATCAGTATTTCCCTTATCACCAGTGGAAGTATTGTGGATTATTGTCGTCACCTCTTGTTTTCCTGCTATGGGGCTAGGTCTAGAAAAGGCTGCTCCAGATTTGATGGATAGACCTCCTCATGATTCAGAGGTTGGTATTTTCACGTGGGAGGTTATTATAGATACATTTGCATATGGGATTATAATGACAGGGTCCTGTATGGCTTCATTTACTGGATCACTGTATGGAATAAATAGTGGTAGATTGGGGCACGATTGTGATGGCACCTATAACAGCAGTTGTCGTGATGTTTATAGATCACGTTCTGCGGCTTTCGCAACCATGACGTGGTGCGCTTTGATTCTGGCTTGGGAAGTGGTTGACATGAGAAGATCCTTTTTCAGAATGCATCCAGACACTGACAGCCCAGTCAAGGAATTTTTCAGAAGCATTTGGGGAAACCAGTTTTTGTTCTGGTCAATCATTTTTGGATTTGTGTCAGCCTTCCCCGTCGTCTATATTCCGGTTATTAATGATAAAGTGTTTTTGCATAAACCAATTGGTGCTGAATGGGGTCTCGCCATTGCATTCACAATTGCATTCTGGATAGGTGCTGAACTTTACAAGTGTGGAAAGAGGCGCTATTTCAAAACTCAGAGAGCGCACAACCCGGAGAATGATTTGGAGAGTAACAATAAGCGCGATCCATTCGAAGCGTATAGTACTTCTACTACAATCCATACAGAAGTTAATATTGGTATTAAACAATGA","protein_sequence":"MSEGTVKENNNEEFNAYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISMAISFAVRDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNPENDLESNNKRDPFEAYSTSTTIHTEVNIGIKQ"},{"created_at":"2011-05-24T20:47:22.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"Pentafunctional AROM polypeptide","uniprot_id":"P08566","uniprot_name":"ARO1_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO1","num_residues":1588,"molecular_weight":"174754.0","theoretical_pi":"6.22","general_function":"Involved in 3-dehydroquinate dehydratase activity","specific_function":"The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis","reactions":[{"id":1162,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1163,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1187,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1965,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1966,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2343,"direction":"\u003e","locations":"Cytoplasm","altext":"3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2344,"direction":"\u003e","locations":"Cytoplasm","altext":"3-dehydroquinate = 3-dehydroshikimate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2345,"direction":"\u003e","locations":"Cytoplasm","altext":"Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2346,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + shikimate = ADP + shikimate 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2347,"direction":"\u003e","locations":"Cytoplasm","altext":"Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X06077","genbank_protein_id":"3381","gene_card_id":"ARO1","chromosome_location":"chromosome 4","locus":"YDR127W","synonyms":["3-dehydroquinate synthase","3-phosphoshikimate 1-carboxyvinyltransferase","5-enolpyruvylshikimate-3-phosphate synthase","EPSP synthase","EPSPS","Shikimate kinase","3-dehydroquinate dehydratase","3-dehydroquinase","Shikimate dehydrogenase"],"enzyme_classes":["4.2.3.4","2.5.1.19","2.7.1.71","4.2.1.10","1.1.1.25"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" shikimate kinase activity"},{"category":"Function","description":" shikimate 5-dehydrogenase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" 3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" carbon-oxygen lyase activity, acting on phosphates"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" 3-dehydroquinate synthase activity"},{"category":"Function","description":" 3-dehydroquinate dehydratase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"}],"pfams":[{"name":"DHQ_synthase","identifier":"PF01761"},{"name":"DHquinase_I","identifier":"PF01487"},{"name":"EPSP_synthase","identifier":"PF00275"},{"name":"Shikimate_DH","identifier":"PF01488"},{"name":"Shikimate_dh_N","identifier":"PF08501"},{"name":"SKI","identifier":"PF01202"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan 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NFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTSSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE"},{"created_at":"2011-05-24T21:16:20.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Succinyl-CoA 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acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" succinate-CoA ligase activity"},{"category":"Function","description":" succinate-CoA ligase (ADP-forming) activity"},{"category":"Function","description":" ATP citrate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CoA_binding","identifier":"PF02629"},{"name":"Ligase_CoA","identifier":"PF00549"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTAAGATCTACCGTTTCAAAAGCTTCTCTCAAAATTTGTCGTCACTTTCACAGAGAATCTATTCCTTACGATAAGACGATCAAAAATTTGCTGCTTCCCAAGGACACCAAGGTGATCTTTCAGGGGTTCACAGGTAAACAAGGTACTTTTCATGCCAGCATCTCTCAAGAATATGGTACAAATGTTGTGGGTGGTACGAACCCAAAAAAGGCGGGTCAAACACATTTAGGCCAACCTGTCTTTGCCTCTGTGAAGGACGCGATTAAGGAGACTGGAGCCACTGCCAGTGCCATCTTTGTTCCTCCACCGATCGCAGCTGCTGCCATTAAAGAATCTATTGAAGCTGAAATTCCGTTAGCTGTATGTATCACTGAAGGTATTCCTCAACATGACATGTTATACATTGCAGAAATGTTGCAGACACAAGATAAAACAAGATTAGTTGGGCCCAACTGCCCTGGTATCATTAACCCAGCAACAAAGGTAAGAATTGGTATCCAGCCCCCAAAAATTTTTCAAGCTGGTAAAATCGGTATTATTTCCAGATCGGGAACTTTGACATACGAAGCTGTTCAGCAAACTACAAAAACTGACCTTGGTCAATCACTGGTTATTGGTATGGGTGGTGATGCTTTTCCCGGTACTGATTTTATTGACGCCTTGAAATTATTTCTAGAAGATGAAACTACAGAAGGTATTATTATGTTAGGTGAAATAGGTGGTAAGGCCGAAATCGAAGCTGCTCAATTTCTCAAAGAATACAACTTTAGCAGGAGTAAGCCGATGCCGGTGGCATCTTTCATCGCAGGAACTGTTGCTGGTCAAATGAAAGGTGTTAGAATGGGTCACTCCGGTGCAATTGTAGAAGGATCTGGAACTGATGCAGAATCCAAAAAACAAGCTTTGAGAGATGTTGGTGTTGCCGTCGTTGAATCTCCAGGTTACTTAGGTCAAGCTTTACTGGATCAATTTGCCAAATTTAAATGA","protein_sequence":"MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK"},{"created_at":"2011-05-24T21:43:59.000Z","updated_at":"2011-05-27T15:00:58.000Z","name":"Dephospho-CoA kinase CAB5","uniprot_id":"Q03941","uniprot_name":"CAB5_YEAST","enzyme":true,"transporter":false,"gene_name":"CAB5","num_residues":241,"molecular_weight":"27339.5","theoretical_pi":"8.81","general_function":"Involved in dephospho-CoA kinase activity","specific_function":"Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A","reactions":[{"id":2394,"direction":"\u003e","locations":"Endoplasmic reticulum. Mitochondrion. Nucleus.","altext":"ATP + 3'-dephospho-CoA = ADP + CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3771,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006293","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum. Mitochondrion. Nucleus.","genbank_gene_id":"AY557679","genbank_protein_id":"45269251","gene_card_id":"CAB5","chromosome_location":"chromosome 4","locus":"YDR196C","synonyms":["DPCK","Dephosphocoenzyme A kinase"],"enzyme_classes":["2.7.1.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" dephospho-CoA kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" coenzyme A biosynthetic process"}],"pfams":[{"name":"CoaE","identifier":"PF01121"}],"pathways":[{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"beta-Alanine 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ligase [ADP-forming] subunit beta, mitochondrial","uniprot_id":"P53312","uniprot_name":"SUCB_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC2","num_residues":427,"molecular_weight":"46900.30078","theoretical_pi":"7.56","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73029","genbank_protein_id":"1323442","gene_card_id":"LSC2","chromosome_location":"chromosome 7","locus":"YGR244C","synonyms":["Succinyl-CoA synthetase beta chain","SCS-beta"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ligase_CoA","identifier":"PF00549"},{"name":"ATP-grasp_2","identifier":"PF08442"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTACTCAAGAAAATCCTTATCCCTAATTTCAAAGTGTGGGCAATTAAGCAGGCTAAACGCGCAAGCTGCTTTACAAGCAAGGAGACACTTGTCAATTCATGAATACAGGTCAGCTCAGTTATTGAGGGAATACGGTATTGGTACTCCAGAAGGATTTCCAGCGTTCACTCCCGAAGAGGCTTTCGAAGCAGCCAAGAAATTAAACACTAACAAACTGGTCATCAAGGCGCAGGCATTGACCGGAGGTAGAGGTAAAGGTCACTTCGACACCGGTTACAAAAGCGGTGTTCACATGATCGAAAGTCCTCAGCAGGCAGAGGATGTTGCAAAAGAAATGCTCAATCATAACCTGATTACTAAACAGACGGGAATAGCGGGGAAGCCAGTATCTGCTGTATATATAGTGAAAAGAGTAGATACAAAGCATGAAGCTTATTTATCTATTCTAATGGACAGACAAACCAAGAAACCGATGATCATTGCGTCCAGTCAAGGTGGTATGAATATTGAAGAGGTGGCTGAGAGAACCCCAGATGCTATAAAGAAATTTTCAATTGAAACTTCAAAGGGATTGAGCCCACAAATGGCCAAGGATGTTGCCAAGAGTCTCGGTTTCAGTCCCGATGCACAAGACGAGGCAGCAAAAGCTGTTTCCAATTTGTATAAAATATTCATGGAAAGGGATGCTACACAAGTGGAGATTAACCCTTTGAGTGAAATTGAACATGATCCAACCCACAAAATCATGTGTACAGACGCCAAATTTGGGTTTGATGATAACGCATCATTCAGACAGGAAAAGATATATTCCTGGAGGGACTTATCACAAGAAGATCCTGATGAAGTTAAGGCAAAGAAGTATGATTTGAATTTTGTTAAGTTGAAGGGTAACATTGGATGTTTAGTCAATGGTGCTGGTTTGGCTATGGCTACTATGGATGTCATCAAATTAAATGGAGGCGATCCTGCGAACTTTTTGGATTGTGGTGGTGGTGCCACCCCTGAGACCATCAAACAAGGTTTCGAATTGATCTTATCCAATAAGAACGTAGATGCAATTTTCGTCAATATTTTCGGCGGTATCGTAAGATGTGACTATGTTGCCCTGGGGCTGGTAGAAGCCGCCAGAGAACTAGAAGTTAGGGTCCCCATTGTGGCACGTTTGCAAGGTACCAAAGTAGAAGAAGGCCGCGACATTATCAATAAGTCAGGCGTGAAGATTTATTCGTTTGATGAATTAGATCCTGCTGCTAAAAAGGTCGTTGAATTGACCCAAAATTAA","protein_sequence":"MYSRKSLSLISKCGQLSRLNAQAALQARRHLSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGHFDTGYKSGVHMIESPQQAEDVAKEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDPTHKIMCTDAKFGFDDNASFRQEKIYSWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN"},{"created_at":"2011-05-26T16:32:02.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Glutamate--cysteine ligase","uniprot_id":"P32477","uniprot_name":"GSH1_YEAST","enzyme":true,"transporter":false,"gene_name":"GSH1","num_residues":678,"molecular_weight":"78252.89844","theoretical_pi":"6.22","general_function":"Involved in glutamate-cysteine ligase activity","specific_function":"ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine","reactions":[{"id":1560,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2425,"direction":"\u003e","locations":null,"altext":"ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.","export":false,"pw_reaction_id":null,"source":null},{"id":3829,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006346","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D90220","genbank_protein_id":"218429","gene_card_id":"GSH1","chromosome_location":"chromosome 10","locus":"YJL101C","synonyms":["Gamma-ECS","GCS","Gamma-glutamylcysteine synthetase"],"enzyme_classes":["6.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" glutamate-cysteine ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"},{"category":"Process","description":" glutathione biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GCS","identifier":"PF03074"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGGACTCTTAGCTTTGGGCACGCCTTTGCAGTGGTTTGAGTCTAGGACGTACAATGAACACATAAGGGATGAAGGTATCGAGCAGTTGTTGTATATTTTCCAAGCTGCTGGTAAAAGAGACAATGACCCTCTTTTTTGGGGAGACGAGCTTGAGTACATGGTTGTAGATTTTGATGATAAGGAGAGAAATTCTATGCTCGACGTTTGCCATGACAAGATACTCACTGAGCTTAATATGGAGGATTCGTCCCTTTGTGAGGCTAACGATGTGAGTTTTCACCCTGAGTATGGCCGGTATATGTTAGAGGCAACACCAGCTTCTCCATATTTGAATTACGTGGGTAGTTACGTTGAGGTTAACATGCAAAAAAGACGTGCCATTGCAGAATATAAGCTATCTGAATATGCGAGACAAGATAGTAAAAATAACTTGCATGTGGGCTCCAGGTCTGTCCCTTTGACGCTGACTGTCTTCCCGAGGATGGGATGCCCCGACTTTATTAACATTAAGGATCCGTGGAATCATAAAAATGCCGCTTCCAGGTCTCTGTTTTTACCCGATGAAGTCATTAACAGACATGTCAGGTTTCCTAACTTGACAGCATCCATCAGGACCAGGCGTGGTGAAAAAGTTTGCATGAATGTTCCCATGTATAAAGATATAGCTACTCCAGAAACGGATGACTCCATCTACGATCGAGATTGGTTTTTACCAGAAGACAAAGAGGCGAAACTGGCTTCCAAACCGGGTTTCATTTATATGGATTCCATGGGTTTTGGCATGGGCTGTTCGTGCTTACAAGTGACCTTTCAGGCACCCAATATCAACAAGGCACGTTACCTGTACGATGCATTAGTGAATTTTGCACCTATAATGCTAGCCTTCTCTGCCGCTGCGCCTGCTTTTAAAGGTTGGCTAGCCGACCAAGATGTTCGTTGGAATGTGATATCTGGTGCGGTGGACGACCGTACTCCGAAGGAAAGAGGTGTTGCGCCATTACTACCCAAATACAACAAGAACGGATTTGGAGGCATTGCCAAAGACGTACAAGATAAAGTCCTTGAAATACCAAAGTCAAGATATAGTTCGGTTGATCTTTTCTTGGGTGGGTCGAAATTTTTCAATAGGACTTATAACGACACAAATGTACCTATTAATGAAAAAGTATTAGGACGACTACTAGAGAATGATAAGGCGCCACTGGACTATGATCTTGCTAAACATTTTGCGCATCTCTACATAAGAGATCCAGTATCTACATTCGAAGAACTGTTGAATCAGGACAACAAAACGTCTTCAAATCACTTTGAAAACATCCAAAGTACAAATTGGCAGACATTACGTTTTAAACCCCCCACACAACAAGCAACCCCGGACAAAAAGGATTCTCCTGGTTGGAGAGTGGAATTCAGACCATTTGAAGTGCAACTATTAGATTTTGAGAACGCTGCGTATTCCGTGCTCATATACTTGATTGTCGATAGCATTTTGACCTTTTCCGATAATATTAACGCATATATTCATATGTCCAAAGTATGGGAAAATATGAAGATAGCCCATCACAGAGATGCTATCCTATTTGAAAAATTTCATTGGAAAAAATCATTTCGCAACGACACCGATGTGGAAACTGAAGATTATTCTATAAGCGAGATTTTCCATAATCCAGAGAATGGTATATTTCCTCAATTTGTTACGCCAATCCTATGCCAAAAAGGGTTTGTAACCAAAGATTGGAAAGAATTAAAGCATTCTTCCAAACACGAGAGACTATACTATTATTTAAAGCTAATTTCTGATAGAGCAAGCGGTGAATTGCCAACAACAGCAAAATTCTTTAGAAATTTTGTACTACAACATCCAGATTACAAACATGATTCAAAAATTTCAAAGTCGATCAATTATGATTTGCTTTCTACGTGTGATAGACTTACCCATTTAGACGATTCAAAAGGTGAATTGACATCCTTTTTAGGAGCTGAAATTGCAGAATATGTAAAAAAAAATAAGCCTTCAATAGAAAGCAAATGTTAA","protein_sequence":"MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDPLFWGDELEYMVVDFDDKERNSMLDVCHDKILTELNMEDSSLCEANDVSFHPEYGRYMLEATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRSVPLTLTVFPRMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPMYKDIATPETDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNINKARYLYDALVNFAPIMLAFSAAAPAFKGWLADQDVRWNVISGAVDDRTPKERGVAPLLPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFNRTYNDTNVPINEKVLGRLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRFKPPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYLIVDSILTFSDNINAYIHMSKVWENMKIAHHRDAILFEKFHWKKSFRNDTDVETEDYSISEIFHNPENGIFPQFVTPILCQKGFVTKDWKELKHSSKHERLYYYLKLISDRASGELPTTAKFFRNFVLQHPDYKHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIESKC"},{"created_at":"2011-05-26T16:34:45.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Protein ARG5,6, mitochondrial","uniprot_id":"Q01217","uniprot_name":"ARG56_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG5","num_residues":863,"molecular_weight":"94868.39844","theoretical_pi":"8.45","general_function":"Involved in acetylglutamate kinase activity","specific_function":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH","reactions":[{"id":1244,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1752,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2427,"direction":"\u003e","locations":"Mitochondrion","altext":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2428,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18813","genbank_protein_id":"603305","gene_card_id":"ARG5","chromosome_location":null,"locus":"YER069W","synonyms":["N-acetyl-gamma-glutamyl-phosphate reductase","N-acetyl-glutamate semialdehyde dehydrogenase","NAGSA dehydrogenase","Acetylglutamate kinase","N-acetyl-L-glutamate 5-phosphotransferase","NAG kinase","AGK"],"enzyme_classes":["1.2.1.38","2.7.2.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" mitochondrion"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein dimerization activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" N-acetyl-gamma-glutamyl-phosphate reductase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" acetylglutamate kinase activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Semialdhyde_dh","identifier":"PF01118"},{"name":"Semialdhyde_dhC","identifier":"PF02774"},{"name":"DUF619","identifier":"PF04768"},{"name":"AA_kinase","identifier":"PF00696"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGCCATCTGCTAGCTTACTCGTCTCGACAAAGAGACTTAACGCTTCCAAATTCCAAAAATTTGTGTCTTCATTAAACAAATCCACCATAGCAGGATTTGCATCTGTACCCTTGAGAGCTCCACCATCCGTTGCATTTACGAGAAAGAAAGTCGGATACTCAAAGAGGTATGTTTCATCTACTAACGGCTTTTCAGCTACTAGATCCACTGTGATCCAACTGTTGAACAATATCAGCACAAAAAGAGAGGTTGAACAATATTTGAAATATTTCACTTCCGTCTCACAACAACAATTTGCTGTGATCAAGGTGGGTGGTGCCATTATCAGCGACAATCTACACGAACTCGCTTCCTGCTTGGCATTTTTGTATCATGTTGGTCTATATCCAATAGTTTTACATGGTACCGGTCCTCAGGTTAATGGAAGGCTAGAAGCGCAGGGAATTGAGCCAGACTATATTGATGGTATTAGAATCACGGATGAGCACACAATGGCCGTAGTTAGAAAATGTTTTTTGGAACAAAATCTTAAGCTAGTTACTGCATTAGAACAGCTAGGGGTCCGTGCAAGACCCATTACTTCTGGTGTTTTTACTGCTGACTATTTGGATAAGGACAAATACAAGCTAGTGGGCAATATTAAAAGTGTCACAAAAGAGCCAATTGAAGCATCTATTAAGGCAGGTGCCCTACCAATCTTGACCTCTTTAGCCGAAACTGCTTCTGGTCAAATGTTGAACGTCAACGCCGACGTAGCTGCTGGTGAATTAGCCCGTGTTTTTGAGCCTTTGAAGATCGTTTACCTGAATGAGAAAGGGGGTATTATCAATGGCTCCACGGGAGAAAAAATTTCGATGATCAATTTGGATGAAGAGTATGACGATTTAATGAAGCAAAGTTGGGTGAAGTATGGTACCAAATTAAAAATTAGAGAAATTAAAGAGCTTTTGGACTATCTTCCTCGTTCTTCTTCAGTTGCAATCATTAACGTTCAAGATCTACAAAAAGAACTGTTCACTGATTCTGGTGCGGGTACTATGATCAGGAGAGGTTACAAATTAGTGAAGAGATCCTCCATTGGCGAATTTCCATCCGCTGATGCTCTAAGAAAAGCTCTTCAAAGGGACGCTGGCATTAGTTCCGGTAAAGAATCTGTTGCTTCTTATTTAAGATATTTGGAAAACTCTGATTTTGTCTCTTATGCTGATGAACCTCTTGAAGCAGTGGCCATTGTAAAGAAAGATACGAACGTTCCCACACTAGACAAATTTGTCTGTTCTGACGCAGCCTGGTTGAATAACGTCACAGATAATGTATTCAATGTTTTGCGCCGTGATTTTCCTGCTTTACAATGGGTAGTCAGTGAAAATGATGCTAACATTGCATGGCATTTTGATAAGTCTCAAGGTTCATATCTAAAAGGCGGAAAAGTTTTGTTCTGGTATGGTATCGATGATATAAATACAATATCCGAGCTCGTTGAAAATTTTGTGAAGTCGTGTGACACTGCTTCTACCCTCAACTCATCAGCAAGTAGTGGAGTATTTGCTAACAAAAAATCAGCTAGGTCGTACTCAACTAGATCCACTCCTCGTCCCGAGGGAGTTAACACCAACCCTGGTCGTGTCGCGCTTATTGGTGCTAGAGGTTACACAGGTAAAAATTTGGTATCTTTGATCAACGGCCACCCATATTTAGAAGTGGCCCATGTTTCTTCTCGTGAATTGAAAGGTCAAAAGTTGCAAGATTATACAAAATCCGAAATTATATATGAAAGTTTGCAAATACAGGATATTAGGAAACTGGAAGAACAAAATGCTGTGGACTTTTGGGTTATGGCATTACCCAACAAAGTCTGTGAACCTTTCGTTGAGACAATCCAAAGTGTTCATGGTAAGTCTAAAATTATTGATCTGTCCGCTGATCACAGGTTTGTATCAGAATCAGACTGGGCTTACGGTTTGCCAGAATTGAATGATAGAGCAAAAATTGCAAACGCTGCCAAAATTGCTAATCCCGGTTGTTATGCTACTGGTTCGCAATTAACTATTTCTCCGTTAACAAAGTATATCAATGGTCTTCCAACTGTGTTTGGTGTTTCAGGGTATTCAGGCGCGGGGACGAAGCCTTCTCCAAAAAACGATCCCAAATTCTTGAACAATAACTTAATTCCTTACGCTTTAAGTGATCATATACACGAACGCGAAATCTCAGCTCGCATTGGGCACAATGTTGCATTCATGCCCCATGTTGGGCAGTGGTTTCAAGGTATCTCTTTGACCGTCTCTATTCCAATAAAAAAAGGTTCCTTGTCTATTGATGAGATCAGGAAATTATACAGAAATTTTTACGAAGACGAAAAGCTAGTACATGTCATCGATGATATCCCACTGGTTAAAGATATTGAGGGCACCCATGGTGTAGTTATTGGTGGTTTCAAGCTGAATGATGCTGAAGATCGTGTAGTTGTTTGCGCAACCATCGATAACTTACTTAAAGGCGCCGCTACTCAATGTCTGCAAAATATTAATCTTGCTATGGGTTATGGAGAGTATGCTGGTATCCCTGAAAATAAAATTATTGGTGTCTGA","protein_sequence":"MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV"},{"created_at":"2011-05-26T16:37:26.000Z","updated_at":"2011-05-26T16:37:26.000Z","name":"Putative uridine kinase YDR020C","uniprot_id":"Q12084","uniprot_name":"YD020_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":232,"molecular_weight":"26594.80078","theoretical_pi":"4.57","general_function":"Involved in ATP binding","specific_function":"ATP + uridine = ADP + UMP","reactions":[{"id":2433,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + uridine = ADP + UMP.","export":false,"pw_reaction_id":null,"source":null},{"id":2434,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + cytidine = ADP + CMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY558571","genbank_protein_id":"45271032","gene_card_id":null,"chromosome_location":null,"locus":"YDR020C","synonyms":[],"enzyme_classes":["2.7.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGGACAGAAAAGCTGTCGAAGAAAAAAGAATTGTTATTTCTATCGGTGGAGGGCATGCTACTGGTGTTGGAGCAATTGCACTGGATTTACAAAATACTTTCAAAAGCCTATATAACTCTATCAATATAAGGGTAATAAACCTAGATAATATGATAGAAGGGAACATCAAGAGCTACAATAATAACGACTATGATTTTGATAATATCCTTAATTTGGTATATGAAAAGCACGCTGTAACTTCTCAAAATGACATGATTCAACATGATTACGAGGACCCGATAGATTTGATAATAGTATGTGGCTGTTATGCGCTATACGATAAACGCATCAACGAAATATCTCAATTAAAGGTATTCTTGGATAGTGATGCAGATAAAAGATTAATTAGTCTAATCAAGAAGAAGAACGTAGGGAGCAATGAACAACTAGCCCAGTTGATCACTGAGTATATGGACCATCTGCGCCCGGAGATGCAACAATATATAGAGCCCACTAGAACTTTTGCAGATTTGATCATTCCTTCTACAAATGAAAATCTAGGGCGCGCAGTCCTCGTGGACGGTATAGTTAAAGCAATCGAAGATACCAAAAGCCAAATAGAAGGCAACAATACGAACAACAAAATACGCCCACGTTTATGGGATTTCGAAGCTGAAACAATGGACTTGGAGAAAGATAGATATTACGATCTGTCATGA","protein_sequence":"MDRKAVEEKRIVISIGGGHATGVGAIALDLQNTFKSLYNSINIRVINLDNMIEGNIKSYNNNDYDFDNILNLVYEKHAVTSQNDMIQHDYEDPIDLIIVCGCYALYDKRINEISQLKVFLDSDADKRLISLIKKKNVGSNEQLAQLITEYMDHLRPEMQQYIEPTRTFADLIIPSTNENLGRAVLVDGIVKAIEDTKSQIEGNNTNNKIRPRLWDFEAETMDLEKDRYYDLS"},{"created_at":"2011-05-26T16:38:22.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Golgi apyrase","uniprot_id":"P40009","uniprot_name":"YND1_YEAST","enzyme":true,"transporter":false,"gene_name":"YND1","num_residues":630,"molecular_weight":"71851.20313","theoretical_pi":"6.18","general_function":"Involved in hydrolase activity","specific_function":"Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis","reactions":[{"id":1341,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1618,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1782,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1784,"direction":"\u003e","locations":"Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1785,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2043,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2435,"direction":"\u003e","locations":"Golgi apparatus. Membrane; Single-pass membrane protein (Potential)","altext":"ATP + 2 H(2)O = AMP + 2 phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"501-517","pdb_id":null,"cellular_location":"Golgi apparatus. Membrane; Single-pass membrane protein (Potential)","genbank_gene_id":"AF203695","genbank_protein_id":"6573161","gene_card_id":"YND1","chromosome_location":"chromosome 5","locus":"YER005W","synonyms":["ATP-diphosphatase","ATP-diphosphohydrolase","Adenosine diphosphatase","ADPase","Golgi nucleoside diphosphatase","Yeast nucleoside diphosphatase 1"],"enzyme_classes":["3.6.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"GDA1_CD39","identifier":"PF01150"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGCTCATAGAAAACACTAATGATCGGTTTGGTATCGTCATAGATGCAGGGTCTTCGGGTTCGAGAATCCATGTGTTTAAGTGGCAGGACACGGAATCGCTTCTTCATGCAACAAACCAGGACTCACAGTCCATATTACAATCAGTACCTCATATTCATCAAGAAAAAGACTGGACTTTTAAGCTGAATCCAGGCTTGTCGAGTTTTGAAAAAAAACCTCAAGATGCGTACAAATCTCACATCAAGCCGTTACTAGATTTTGCTAAGAATATTATCCCTGAATCACATTGGTCGAGTTGTCCCGTTTTTATTCAAGCAACCGCGGGCATGCGCCTTTTACCTCAAGACATACAATCTTCCATTTTGGATGGTTTGTGTCAGGGGCTCAAACACCCTGCAGAATTTTTGGTTGAGGATTGCTCAGCACAAATTCAAGTCATTGATGGTGAAACCGAAGGTTTATATGGCTGGCTTGGCTTAAACTATCTATATGGACACTTTAATGACTATAATCCAGAGGTCTCTGACCATTTTACATTTGGGTTTATGGACATGGGCGGTGCCTCTACTCAGATTGCGTTTGCACCGCATGATTCAGGAGAAATAGCTAGACATAGAGATGACATCGCCACCATCTTCTTGAGGAGTGTTAACGGAGATTTGCAGAAATGGGACGTTTTTGTTAGTACGTGGTTAGGGTTTGGTGCCAATCAGGCTAGAAGAAGGTACTTGGCTCAGTTGATCAATACCCTTCCAGAAAACACAAATGATTACGAAAATGATGACTTCTCTACAAGGAACTTGAATGATCCATGTATGCCGCGAGGAAGCAGCACGGATTTTGAATTTAAAGATACCATATTTCACATCGCGGGTTCTGGGAATTACGAACAATGTACAAAATCTATTTATCCGTTACTTTTAAAGAACATGCCTTGTGATGACGAGCCGTGCTTGTTTAATGGTGTTCATGCTCCTCGAATAGACTTTGCCAATGACAAATTTATAGGTACTTCTGAGTACTGGTACACTGCCAACGACGTATTCAAACTTGGGGGCGAATACAACTTTGACAAATTTAGCAAAAGCCTAAGGGAGTTTTGCAATTCCAATTGGACGCAAATATTAGCGAACAGTGATAAAGGCGTGTATAATTCTATTCCGGAGAATTTTTTGAAAGATGCATGCTTTAAGGGCAATTGGGTCCTTAATATACTTCATGAAGGGTTTGATATGCCTCGAATAGATGTCGACGCAGAAAATGTCAATGACAGGCCCTTATTTCAAAGTGTGGAAAAAGTCGAAGAACGAGAGTTATCGTGGACACTAGGCAGAATTTTACTTTATGCCTCAGGTAGCATATTGGCAGGTAATGATGACTTCATGGTGGGTATTGCGCCCAGTGAAAGAAGAACTAAGCTCACTGGTAAGAAATTCATACCTGGCAAGTTACTGGAGTCTGATCAACTACGCAAGCAAAGTTCCAGCCTTTCTAATAAAGGATTTTTGATGTGGTTCGCAATTATTTGTTGCATATTTTACTTGATCTTTCATAGGTCACACATAATCAGAAGACGTTTTTCCGGTCTGTACAACATTACCAAGGACTTTAAGACAGGCATAAGGAGAAGGTTGAAATTTCTAAGGAGATCAGATCCATTTTCCAGATTGGAGGAAGGTGAACTTGGAACAGACGTAGATGGCTTCAAAGATGTGTACAGGATGAAGAGTAGCAGTATGTTTGATCTTGGTAAGAGTTCAGCCACAATGCAAAGGGAGCACGAACCACAAAGGACAGCAAGTCAGTCCGCTAATCTCGCTCCGTCAAACTTACGACCTGCGTTTTCTATGGCTGATTTTTCCAAATTTAAGGACAGTAGGCTATATGAT","protein_sequence":"MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD"},{"created_at":"2011-05-26T16:39:20.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Uridylate kinase","uniprot_id":"P15700","uniprot_name":"UMPK_YEAST","enzyme":true,"transporter":false,"gene_name":"URA6","num_residues":204,"molecular_weight":"22933.0","theoretical_pi":"6.53","general_function":"Involved in ATP binding","specific_function":"Furnishes the cell with pyrimidines. Accepts UMP, and dUMP as phosphate acceptors with high activity; to a lesser extent, it can also use IMP, GMP, dGMP, 5-iodo-dUMP, XMP, and dTMP as substrates. ATP and dATP are the best phosphate donors; can use GTP, dGTP, dCTP, and dTTP to some degree (30-50%)","reactions":[{"id":2033,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2039,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2436,"direction":"\u003e","locations":"Cytoplasm. Nucleus.","altext":"ATP + UMP = ADP + UDP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1UKZ","cellular_location":"Cytoplasm. Nucleus.","genbank_gene_id":"AY558074","genbank_protein_id":"45270038","gene_card_id":"URA6","chromosome_location":"chromosome 11","locus":"YKL024C","synonyms":["UK","Uridine monophosphate kinase","UMP kinase"],"enzyme_classes":["2.7.4.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"}],"pathways":[],"gene_sequence":"ATGACAGCTGCCACTACATCACAGCCAGCTTTCTCGCCTGACCAAGTTTCCGTGATCTTCGTTCTAGGAGGACCCGGTGCAGGCAAGGGTACTCAGTGTGAAAAACTAGTTAAGGACTATTCATTTGTCCATTTGTCAGCCGGAGACCTTCTACGTGCTGAGCAGGGCAGAGCAGGTTCCCAATATGGGGAATTGATCAAGAACTGCATCAAAGAGGGCCAGATTGTCCCTCAAGAGATTACTTTGGCGCTTTTACGCAACGCTATTTCCGATAACGTCAAGGCGAACAAGCATAAGTTCTTAATTGACGGATTTCCTAGGAAGATGGATCAAGCCATTTCCTTTGAAAGAGACATCGTTGAAAGCAAATTCATCCTGTTCTTTGACTGCCCTGAAGATATCATGTTAGAGAGACTATTGGAGCGTGGCAAGACCAGTGGTAGAAGCGATGACAACATTGAGTCCATTAAGAAGAGATTTAACACTTTCAAGGAGACTAGTATGCCCGTCATCGAGTACTTTGAAACCAAATCGAAAGTCGTCCGTGTTCGTTGCGACAGATCCGTCGAAGATGTGTACAAAGACGTCCAAGACGCTATCCGTGATAGCTTATAG","protein_sequence":"MTAATTSQPAFSPDQVSVIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKHKFLIDGFPRKMDQAISFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIRDSL"},{"created_at":"2011-05-26T16:41:01.000Z","updated_at":"2011-07-22T17:54:33.000Z","name":"Uridine kinase","uniprot_id":"P27515","uniprot_name":"URK1_YEAST","enzyme":true,"transporter":false,"gene_name":"URK1","num_residues":501,"molecular_weight":"56295.5","theoretical_pi":"7.8","general_function":"Involved in ATP binding","specific_function":"Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway","reactions":[{"id":1425,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2037,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2038,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2433,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + uridine = ADP + UMP.","export":false,"pw_reaction_id":null,"source":null},{"id":2434,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + cytidine = ADP + CMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X53998","genbank_protein_id":"4773","gene_card_id":"URK1","chromosome_location":"chromosome 14","locus":"YNR012W","synonyms":["Uridine monophosphokinase"],"enzyme_classes":["2.7.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTCCCATCGTATAGCACCTTCCAAAGAACGATCTTCATCATTTATTTCAATTTTAGACGATGAAACAAGAGACACATTGAAAGCTAATGCAGTCATGGATGGTGAAGTAGATGTCAAAAAAACAAAAGGAAAAAGCTCTCGGTATATCCCACCATGGACAACTCCATATATAATAGGTATAGGTGGTGCTTCAGGTTCAGGCAAGACAAGCGTTGCTGCTAAGATTGTGTCGTCAATTAATGTTCCCTGGACAGTATTAATATCTTTGGATAACTTTTACAATCCATTAGGCCCAGAGGACAGAGCCAGAGCCTTTAAAAATGAATACGATTTCGACGAGCCAAATGCCATCAACTTAGATTTGGCATATAAGTGCATTTTGAACTTAAAGGAGGGCAAAAGGACAAATATCCCAGTTTATAGCTTCGTCCACCACAATAGAGTTCCTGATAAAAATATAGTCATATACGGGGCCAGTGTGGTAGTTATCGAAGGGATCTACGCCCTTTACGATCGCCGATTGCTGGATTTGATGGACTTGAAAATTTATGTTGACGCTGATTTGGATGTCTGCTTAGCAAGAAGATTGTCGAGAGATATAGTTTCCAGAGGGAGAGATTTGGATGGTTGTATTCAACAATGGGAGAAATTTGTGAAACCAAATGCGGTAAAGTTTGTGAAACCAACAATGAAGAATGCAGATGCTATCATTCCATCGATGAGTGATAATGCTACAGCGGTAAATTTAATCATTAACCACATCAAGTCAAAACTGGAACTAAAATCAAATGAACACTTAAGAGAGCTAATCAAATTGGGCTCTTCTCCTTCACAAGATGTGCTTAATCGTAACATAATTCATGAATTGCCGCCCACCAACCAAGTTCTTTCGCTGCATACTATGCTTCTAAATAAAAATCTAAATTGCGCGGACTTTGTTTTCTACTTTGACAGGTTAGCAACAATTTTGTTATCATGGGCACTTGATGACATTCCTGTAGCACATACGAACATAATTACACCTGGTGAGCATACCATGGAAAACGTTATTGCCTGTCAATTCGATCAAGTTACAGCTGTTAATATTATTCGATCTGGCGATTGTTTTATGAAGTCTTTGAGAAAGACGATCCCCAATATCACAATTGGTAAATTGTTGATTCAGTCCGATTCACAAACTGGGGAACCTCAACTGCATTGCGAATTTTTACCCCCAAATATAGAAAAGTTTGGCAAGGTTTTCTTAATGGAAGGTCAAATCATAAGTGGTGCGGCCATGATCATGGCCATCCAGGTGCTTTTAGATCATGGTATTGATTTGGAAAAGATTAGCGTGGTGGTTTATTTGGCCACTGAAGTTGGTATCCGACGTATATTAAATGCATTTGATAACAAAGTCAACATTTTTGCTGGTATGATCATCTCCAGAGAAAAGTTACAAAATCATCAATACAAATGGGCATTGACCAGATTTTTTGATTCAAAGTATTTTGGTTGTGATTGA","protein_sequence":"MSHRIAPSKERSSSFISILDDETRDTLKANAVMDGEVDVKKTKGKSSRYIPPWTTPYIIGIGGASGSGKTSVAAKIVSSINVPWTVLISLDNFYNPLGPEDRARAFKNEYDFDEPNAINLDLAYKCILNLKEGKRTNIPVYSFVHHNRVPDKNIVIYGASVVVIEGIYALYDRRLLDLMDLKIYVDADLDVCLARRLSRDIVSRGRDLDGCIQQWEKFVKPNAVKFVKPTMKNADAIIPSMSDNATAVNLIINHIKSKLELKSNEHLRELIKLGSSPSQDVLNRNIIHELPPTNQVLSLHTMLLNKNLNCADFVFYFDRLATILLSWALDDIPVAHTNIITPGEHTMENVIACQFDQVTAVNIIRSGDCFMKSLRKTIPNITIGKLLIQSDSQTGEPQLHCEFLPPNIEKFGKVFLMEGQIISGAAMIMAIQVLLDHGIDLEKISVVVYLATEVGIRRILNAFDNKVNIFAGMIISREKLQNHQYKWALTRFFDSKYFGCD"},{"created_at":"2011-05-26T16:56:27.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase small chain 1","uniprot_id":"P09938","uniprot_name":"RIR2_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR2","num_residues":399,"molecular_weight":"46147.0","theoretical_pi":"4.9","general_function":"Involved in oxidoreductase activity","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SMQ","cellular_location":"Nucleus.","genbank_gene_id":"M17221","genbank_protein_id":"172448","gene_card_id":"RNR2","chromosome_location":"chromosome 10","locus":"YJL026W","synonyms":["Ribonucleotide reductase R2 subunit 1","Ribonucleotide reductase small subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" nucleoside diphosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" deoxyribonucleoside diphosphate metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Ribonuc_red_sm","identifier":"PF00268"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGCCTAAAGAGACCCCTTCCAAAGCTGCTGCCGATGCATTGTCCGACTTGGAAATCAAAGATTCCAAGTCCAACCTTAACAAGGAATTGGAGACATTGAGAGAGGAAAACAGAGTAAAGTCAGACATGCTTAAGGAGAAATTGAGCAAGGACGCTGAAAATCACAAGGCTTACTTGAAATCTCATCAAGTTCACCGTCACAAACTTAAGGAAATGGAAAAGGAGGAACCTTTGTTGAATGAAGACAAGGAGAGAACTGTTCTTTTCCCTATCAAGTACCATGAAATCTGGCAAGCCTACGAAGCTTCTTTCTGGACCGCTGAAACCGCTGAAGAAATTGATTTGTCTAAGGATATCCATGACTGGAACAACAGAATGAACGAAAACGAGAGATTTTTCATTTCCAGAGTTCTTGCCTTTTTCGCCGCTTCTGACGGTATTGTTAATGAAAACTTGGTTGAAAACTTCTCCACCGAAGTCCAAATTCCAGAGGCAAAGAGTTTCTACGGTTTCCAAATCATGATTGAAAATATTCACTCTGAAACTTACTCCTTGTTGATCGATACTTACATCAAGGACCCTAAAGAAAGTGAATTCTTGTTCAATGCCATTCACACCATCCCAGAAATCGGTGAGAAGGCCGAATGGGCTTTAAGATGGATTCAAGACGCTGACGCCTTGTTTGGTGAAAGACTAGTTGCCTTTGCCTCCATTGAAGGTGTCTTTTTCTCCGGTTCCTTTGCCTCCATTTTCTGGTTGAAAAAGAGAGGTATGATGCCCGGTTTAACCTTTTCCAACGAATTGATCTGTAGAGACGAAGGTTTGCACACCGACTTTGCATGCTTGTTGTTCGCCCATTTGAAGAACAAACCAGACCCAGCCATTGTTGAAAAAATTGTCACCGAGGCTGTGGAAATTGAACAAAGATACTTCTTGGACGCCTTACCAGTTGCTTTGCTAGGTATGAACGCTGACTTAATGAACCAATACGTTGAGTTCGTCGCCGACAGACTGTTGGTTGCTTTCGGTAACAAGAAATACTACAAGGTCGAAAACCCCTTCGATTTCATGGAAAACATCTCCTTGGCCGGTAAGACCAACTTCTTCGAAAAGAGAGTTTCTGACTACCAAAAGGCTGGTGTTATGTCCAAGTCGACTAAGCAAGAAGCCGGTGCTTTCACCTTCAACGAAGACTTTTAA","protein_sequence":"MPKETPSKAAADALSDLEIKDSKSNLNKELETLREENRVKSDMLKEKLSKDAENHKAYLKSHQVHRHKLKEMEKEEPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNADLMNQYVEFVADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQEAGAFTFNEDF"},{"created_at":"2011-05-26T16:57:01.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Nucleoside diphosphate kinase","uniprot_id":"P36010","uniprot_name":"NDK_YEAST","enzyme":true,"transporter":false,"gene_name":"YNK1","num_residues":153,"molecular_weight":"17166.59961","theoretical_pi":"9.05","general_function":"Involved in nucleoside diphosphate kinase activity","specific_function":"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage","reactions":[{"id":1786,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1787,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1788,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1789,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1790,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1791,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1792,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1793,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1794,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2454,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion intermembrane space.","altext":"ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion intermembrane space.","genbank_gene_id":"AY558263","genbank_protein_id":"45270416","gene_card_id":"YNK1","chromosome_location":"chromosome 11","locus":"YKL067W","synonyms":["NDK","NDP kinase"],"enzyme_classes":["2.7.4.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" nucleoside diphosphate kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" CTP biosynthetic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" pyrimidine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" UTP biosynthetic process"},{"category":"Process","description":" GTP biosynthetic process"}],"pfams":[{"name":"NDK","identifier":"PF00334"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTCTAGTCAAACAGAAAGAACTTTTATTGCGGTAAAACCAGATGGTGTCCAGAGGGGCTTAGTATCTCAAATTCTATCTCGTTTTGAAAAAAAAGGTTACAAACTAGTTGCTATTAAATTAGTTAAAGCGGATGATAAATTACTAGAGCAACATTACGCAGAGCATGTTGGTAAACCATTTTTCCCAAAGATGGTATCCTTTATGAAGTCTGGTCCCATTTTGGCCACGGTCTGGGAGGGAAAAGATGTGGTTAGACAAGGAAGAACTATTCTTGGTGCTACTAATCCTTTGGGCAGTGCACCAGGTACCATTAGAGGTGATTTCGGTATTGACCTAGGCAGAAACGTCTGTCACGGCAGTGATTCTGTTGATAGCGCTGAACGTGAAATCAATTTGTGGTTTAAGAAGGAAGAGTTAGTTGATTGGGAATCTAATCAAGCTAAGTGGATTTATGAATGA","protein_sequence":"MSSQTERTFIAVKPDGVQRGLVSQILSRFEKKGYKLVAIKLVKADDKLLEQHYAEHVGKPFFPKMVSFMKSGPILATVWEGKDVVRQGRTILGATNPLGSAPGTIRGDFGIDLGRNVCHGSDSVDSAEREINLWFKKEELVDWESNQAKWIYE"},{"created_at":"2011-05-26T16:58:03.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase large chain 1","uniprot_id":"P21524","uniprot_name":"RIR1_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR1","num_residues":888,"molecular_weight":"99560.20313","theoretical_pi":"6.1","general_function":"Involved in oxidation-reduction process","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":14262,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006740","source":"Smpdb"},{"id":14274,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006749","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18813","genbank_protein_id":"603306","gene_card_id":"RNR1","chromosome_location":"chromosome 5","locus":"YER070W","synonyms":["Ribonucleotide reductase R1 subunit 1","Ribonucleotide reductase large subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" ribonucleoside-diphosphate reductase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" protein 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(R)-5-phosphomevalonate.","export":false,"pw_reaction_id":null,"source":null},{"id":14369,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006887","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X06114","genbank_protein_id":"4287","gene_card_id":"ERG12","chromosome_location":"chromosome 13","locus":"YMR208W","synonyms":["MK","MvK","Ergosterol biosynthesis protein 12","Regulation of autonomous replication protein 1"],"enzyme_classes":["2.7.1.36"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" mevalonate kinase 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CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCATTACCGTTCTTAACTTCTGCACCGGGAAAGGTTATTATTTTTGGTGAACACTCTGCTGTGTACAACAAGCCTGCCGTCGCTGCTAGTGTGTCTGCGTTGAGAACCTACCTGCTAATAAGCGAGTCATCTGCACCAGATACTATTGAATTGGACTTCCCGGACATTAGCTTTAATCATAAGTGGTCCATCAATGATTTCAATGCCATCACCGAGGATCAAGTAAACTCCCAAAAATTGGCCAAGGCTCAACAAGCCACCGATGGCTTGTCTCAGGAACTCGTTAGTCTTTTGGATCCGTTGTTAGCTCAACTATCCGAATCCTTCCACTACCATGCAGCGTTTTGTTTCCTGTATATGTTTGTTTGCCTATGCCCCCATGCCAAGAATATTAAGTTTTCTTTAAAGTCTACTTTACCCATCGGTGCTGGGTTGGGCTCAAGCGCCTCTATTTCTGTATCACTGGCCTTAGCTATGGCCTACTTGGGGGGGTTAATAGGATCTAATGACTTGGAAAAGCTGTCAGAAAACGATAAGCATATAGTGAATCAATGGGCCTTCATAGGTGAAAAGTGTATTCACGGTACCCCTTCAGGAATAGATAACGCTGTGGCCACTTATGGTAATGCCCTGCTATTTGAAAAAGACTCACATAATGGAACAATAAACACAAACAATTTTAAGTTCTTAGATGATTTCCCAGCCATTCCAATGATCCTAACCTATACTAGAATTCCAAGGTCTACAAAAGATCTTGTTGCTCGCGTTCGTGTGTTGGTCACCGAGAAATTTCCTGAAGTTATGAAGCCAATTCTAGATGCCATGGGTGAATGTGCCCTACAAGGCTTAGAGATCATGACTAAGTTAAGTAAATGTAAAGGCACCGATGACGAGGCTGTAGAAACTAATAATGAACTGTATGAACAACTATTGGAATTGATAAGAATAAATCATGGACTGCTTGTCTCAATCGGTGTTTCTCATCCTGGATTAGAACTTATTAAAAATCTGAGCGATGATTTGAGAATTGGCTCCACAAAACTTACCGGTGCTGGTGGCGGCGGTTGCTCTTTGACTTTGTTACGAAGAGACATTACTCAAGAGCAAATTGACAGCTTCAAAAAGAAATTGCAAGATGATTTTAGTTACGAGACATTTGAAACAGACTTGGGTGGGACTGGCTGCTGTTTGTTAAGCGCAAAAAATTTGAATAAAGATCTTAAAATCAAATCCCTAGTATTCCAATTATTTGAAAATAAAACTACCACAAAGCAACAAATTGACGATCTATTATTGCCAGGAAACACGAATTTACCATGGACTTCATAA","protein_sequence":"MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS"},{"created_at":"2011-05-26T16:59:39.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoribosylaminoimidazole 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CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14240,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006683","source":"Smpdb"},{"id":14241,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006686","source":"Smpdb"},{"id":14242,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006799","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M59824","genbank_protein_id":"171003","gene_card_id":"ADE2","chromosome_location":"chromosome 15","locus":"YOR128C","synonyms":["AIR carboxylase","AIRC"],"enzyme_classes":["4.1.1.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside 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in ATP binding","specific_function":"Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 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14","locus":"YNR057C","synonyms":["DTB synthetase","Dethiobiotin synthase","DTBS"],"enzyme_classes":["6.3.3.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" dethiobiotin synthase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" magnesium ion 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(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OBG","cellular_location":null,"genbank_gene_id":"L22015","genbank_protein_id":"349755","gene_card_id":"ADE1","chromosome_location":"chromosome 1","locus":"YAR015W","synonyms":["SAICAR synthetase"],"enzyme_classes":["6.3.2.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside 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process"}],"pfams":[{"name":"SAICAR_synt","identifier":"PF01259"}],"pathways":[{"name":"Purine 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6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic 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Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null},{"id":4146,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006447","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49702","genbank_protein_id":"817872","gene_card_id":"FOL3","chromosome_location":"chromosome 13","locus":"YMR113W","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"}],"pfams":[{"name":"Mur_ligase_M","identifier":"PF08245"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGCCATTGAATTGGGACTTTCCCGTATTACAAAACTACTAGAGCATTTAGGCAATCCGCAAAACTCACTTAGAGTGCTGCACATTGCAGGGACAAATGGTAAAGGTTCAGTATGTACTTACCTATCTTCTGTGTTGCAACAAAAGTCCTACCAAATTGGAAAATTTACCACTCCACACTTGGTGCATGTTACTGATTCCATTACAATCAACAATAAGCCGATTCCGTTAGAGAGATACCAGAATATTAGATTACAACTAGAAGCTTTAAACAAGTCACACTCTTTAAAATGTACGGAATTCGAGCTATTAACATGTACCGCATTCAAATATTTTTATGATGTGCAGTGCCAATGGTGTGTCATAGAAGTAGGCCTTGGCGGAAGACTTGATGCGACCAATGTTATTCCAGGCGCAAATAAGGCATGTTGTGGTATTACTAAAATCAGTTTGGATCATGAAAGCTTTTTAGGTAACACCTTGTCTGAAATCTCTAAAGAGAAAGCAGGTATAATAACAGAAGGGGTACCCTTCACAGTGATTGATGGAACCAATGAGGCAAGTGTTATAAATGTTGTGAAAGAAAGATGCAAGGCTTTAGGGTCTGAACTATCCGTTACAGATTCTCAACTTAACGGAAATATGATTGACACCAACTCCTGGGGTTGTTTTGACTTGGCAAAATTGCCACTGAATGGAGAATATCAGATATTTAATCTCAGGGTGGCCATGGGTATGTTAGACTACTTACAAATGAACGAACTTATTGATATTACCAAGAATGAAGTAAGTACGAGATTGGCGAAGGTTGATTGGCCAGGAAGGTTATATCGTATGGATTATCGCTTTGACAAAGTAAGTAATAGGACAGTGCCTATATTAATGGACGGTGCCCACAATGGCTCAGCTGCAGTAGAGTTAGTTAAGTACCTAAGAAAGGAGTACGGAAACCAGCCTTTGACCTTTGTGATGGCAGTAACGCATGGGAAAAACTTGGAGCCGCTGCTCCAGCCATTATTGAGGCCTATAGATCAAGTAATTCTTACTCGGTTTAATAATGTGGAAGGTATGCCCTGGATTCATGCCACTGATCCTGAAGAAATAAAAGATTTTATTTTGACTCAAGGATACACAAAGGAGATAGTGATTGAAAATGATTTACATCAGGTATTGCCTTCTCTGGCGCATGTATCAGACGAGCAAAGACGGCCAATTGTTGTATGCGGTTCACTGTATTTATGTGGTGAATTATTACGGATTCACAATAGTCACTTGAGAAACTAA","protein_sequence":"MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEPLLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN"},{"created_at":"2011-05-26T17:51:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, mitochondrial","uniprot_id":"P09440","uniprot_name":"C1TM_YEAST","enzyme":true,"transporter":false,"gene_name":"MIS1","num_residues":975,"molecular_weight":"106216.0","theoretical_pi":"9.02","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":3849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006370","source":"Smpdb"},{"id":3850,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006371","source":"Smpdb"},{"id":3851,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006372","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"J03724","genbank_protein_id":"171953","gene_card_id":"MIS1","chromosome_location":"chromosome 2","locus":"YBR084W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate 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derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTGTCGAGACTATCTTTATTGAGTAACTCGAGGGCGTTCCAACAGGCCAGATGGCGCATTTACCGCTTAAAAGTTTCGCCAACTGTGCATGCTTCTCAATACCATATTCTTTCTGGTAGGAAACTTGCTCAATCTATTCGAGAAAAAGCCAATGATGAGATACAAGCCATTAAGCTTAAGCATCCTAATTTCAAGCCTACCTTGAAAATCATTCAAGTCGGGGCCAGACCAGACTCATCTACGTACGTGAGGATGAAATTGAAAGCTTCAAAGGACAGCAATGTAGACTGTATCATAGAGAAGTTACCAGCAGAAATCACTGAAGTTGAGCTTTTGAAGAAAATTAGTGACATCAATGATGATGACTCTATCCATGGGTTGCTAATTCAACTACCTCTACCGCGTCACTTGGATGAAACCACGATTACAAACGCTGTGGACTTTAAAAAGGACGTTGATGGGTTCCACAGATATAATGCTGGTGAATTGGCTAAAAAAGGAGGGAAACCATACTTCATACCATGTACTCCTTATGGTTGCATGAAATTACTTGAAGAAGCTCATGTTAAGTTAGATGGTAAGAACGCCGTCGTGTTAGGCAGATCAAGTATCGTCGGAAATCCAATTGCTTCGTTGTTGAAAAATGCGAATGCCACTGTTACTGTCTGTCATAGTCATACAAGGAACATTGCAGAAGTGGTCTCCCAAGCTGATATAGTTATCGCAGCTTGCGGTATTCCTCAATACGTTAAATCAGACTGGATTAAAGAAGGCGCCGTGGTTATTGATGTAGGTATCAACTACGTACCTGATATCAGTAAGAAAAGTGGGCAAAAATTAGTTGGTGATGTTGATTTTGATTCTGTAAAGGAAAAGACATCTTATATTACCCCTGTTCCTGGTGGAGTGGGTCCAATGACTGTCGCTATGCTTGTTTCCAATGTACTATTAGCTGCTAAAAGGCAATTCGTGGAATCTGAAAAGCTTCCAGTTATCAAACCTCTTCCATTACACTTAGAAAGTCCAGTGCCTTCAGATATTGATATATCAAGAGCTCAGAGTCCTAAGCATATCAAGCAAGTTGCCGAGGAGTTGGGAATCCACTCTCACGAATTAGAATTATACGGCCACTATAAGGCAAAAATTTCTCCAAATATTTTTAAAAGATTAGAATCTAGAGAAAACGGTAAGTACGTCCTTGTTGCAGGTATTACTCCGACTCCATTGGGTGAAGGTAAATCCACTACGACTATGGGGTTGGTGCAGGCTTTATCCGCTCATTTAGGGAAACCATCCATCGCGAACGTTAGACAACCATCTCTTGGCCCAACCCTGGGTGTCAAAGGTGGTGCTGCTGGTGGTGGTTATGCCCAAGTTATTCCTATGGACGAGTTCAATTTACATTTGACCGGGGATATTCATGCTATCAGCGCTGCGAACAATCTTCTTGCAGCAGCTATCGACACTAGAATGTTCCATGAAGCCACTCAGAAGAATGATAGTACATTTTACAAGAGACTAGTTCCAAGAAAAAAAGGCATCAGAAAGTTTACCCCATCCATGCAGAGAAGGCTTAAAAGATTGGATATTGAAAAAGAAGACCCTGATGCTTTAACACCTGAAGAAGTCAAAAGATTTGCTAGATTGAACATAAATCCCGATACTATCACTATCAGAAGAGTTGTCGACATCAATGACAGGATGTTAAGACAAATTACCATTGGCGAAGCCGCTACGGAGAAGGGTTTTACAAGGACCACTGGATTCGATATCACTGTTGCCTCTGAATTAATGGCCATTTTAGCTCTATCTAAAAGCTTACACGAGATGAAGGAACGTATTGGACGCATGGTTATTGGTGCTGATTATGATAACAAACCAGTAACAGTAGAAGATATTGGCTGTACCGGTGCTCTGACTGCATTATTACGTGACGCTATAAAGCCTAACTTAATGCAAACTTTGGAAGGGACCCCCGTAATGGTTCACGCTGGTCCTTTCGCCAACATCTCCATCGGCGCATCATCAGTAATTGCAGACTTAATGGCATTGAAGCTTGTTGGTTCAGAAAAGAACCCGTTAAATGACAAGAACATCCATGAACCTGGTTATGTAGTTACTGAAGCAGGATTCGATTTTGCCATGGGTGGTGAAAGATTCTTTGATATCAAATGTCGTTCCTCTGGATTGGTGCCAGATGCAGTTGTCTTAGTCGCAACCGTAAGAGCTTTGAAATCTCATGGAGGTGCTCCAAATGTTAAGCCCGGACAATCATTACCAAAAGAATACACAGAGGAAAACATCGATTTTGTTGCCAAGGGTGTTAGTAATTTGGTTAAGCAGATTGAAAACATCAAAACGTTTGGAATACCAGTCGTTGTAGCAATCAACAGATTTGAAACAGACTCACAGGCAGAGATTGAGGTAATCAAGAAAGCAGCCTTGAATGCTGGCGCATCTCATGCCGTTACTTCTAATCACTGGATGGAAGGTGGTAAAGGTGCAGTAGAATTAGCACATGCTGTGGTAGATGCAACGAAAGAACCAAAGAACTTTAACTTTTTGTACGACGTCAATAGCTCCATCGAGGACAAGCTTACCAGCATCGTCCAAAAAATGTATGGTGGGGCAAAAATCGAAGTATCACCAGAAGCCCAAAAAAAGATAGACACCTACAAAAAACAAGGCTTCGGTAATCTTCCCATCTGTATTGCTAAGACACAATATTCATTATCCCATGATCCATCATTAAAGGGTGTTCCTAGAGGTTTTACGTTCCCCATCAGGGATGTGAGAGCTTCAATAGGTGCAGGTTATTTATACGCTTTGGCTGCAGAAATTCAAACCATACCGGGTCTATCGACATATGCTGGTTACATGGCAGTAGAAGTCGACGACGACGGTGAAATTGAAGGTCTATTTTAA","protein_sequence":"MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELAHAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGYMAVEVDDDGEIEGLF"},{"created_at":"2011-05-26T17:53:55.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate 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Nucleus","genbank_gene_id":"AY692966","genbank_protein_id":"51013383","gene_card_id":"ADE3","chromosome_location":"chromosome 7","locus":"YGR204W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCTGGTCAAGTGTTGGACGGCAAAGCATGCGCTCAGCAGTTTAGAAGCAATATTGCTAATGAAATCAAAAGCATTCAAGGTCACGTGCCTGGGTTTGCACCTAACCTTGCCATCATTCAAGTAGGCAACAGACCAGACTCAGCCACATATGTACGCATGAAGCGTAAGGCAGCTGAAGAGGCCGGCATTGTTGCTAATTTCATTCATTTAGATGAATCCGCTACTGAATTTGAAGTTCTGCGTTACGTGGACCAGCTGAATGAGGACCCACATACACACGGTATTATCGTGCAACTACCATTACCCGCTCATTTGGACGAGGATAGAATCACCTCGAGAGTGTTGGCAGAAAAGGACGTGGACGGGTTCGGGCCCACCAACATTGGCGAATTGAATAAGAAGAACGGACACCCATTCTTTTTGCCCTGCACGCCCAAGGGGATCATTGAGCTGCTTCACAAGGCCAACGTCACGATTGAAGGTTCCCGGTCCGTTGTGATCGGAAGATCTGACATTGTTGGCTCTCCTGTTGCAGAATTGTTAAAATCTCTAAACTCCACCGTCACCATCACTCATTCTAAAACCCGTGATATCGCATCATACTTACACGACGCGGACATCGTAGTCGTTGCCATCGGCCAACCAGAATTTGTGAAGGGTGAATGGTTCAAACCAAGAGACGGCACTTCCAGTGATAAGAAAACCGTGGTAATTGATGTTGGCACCAACTACGTTGCTGATCCTTCCAAAAAGTCCGGTTTCAAATGTGTTGGTGACGTTGAGTTCAATGAAGCAATCAAATACGTCCATCTAATCACTCCAGTGCCCGGTGGTGTGGGCCCCATGACGGTGGCTATGTTAATGCAAAATACCTTGATTGCTGCCAAACGCCAAATGGAAGAATCCTCGAAGCCTTTGCAGATTCCTCCCTTGCCATTGAAGTTGCTAACACCTGTTCCTTCCGATATAGACATCTCCAGAGCACAACAGCCAAAGCTTATCAACCAGCTTGCTCAAGAATTGGGTATTTACTCTCATGAGTTGGAGCTGTACGGACATTACAAGGCCAAAATTTCTCCTAAAGTCATCGAAAGGCTGCAGACGCGCCAAAATGGTAAGTACATCTTGGTGTCTGGTATCACACCAACACCACTGGGAGAGGGTAAATCCACTACAACAATGGGTCTTGTCCAGGCACTAACGGCTCACTTGGGCAAGCCAGCCATTGCGAACGTCAGACAACCCTCCCTAGGACCCACTTTAGGTGTCAAAGGTGGTGCTGCGGGTGGTGGTTATTCCCAAGTCATCCCAATGGACGAATTCAACTTACATTTGACTGGTGACATTCACGCCATTGGTGCGGCTAACAACCTACTTGCTGCCGCTATTGACACTAGAATGTTCCATGAGACCACTCAAAAGAACGACGCTACCTTCTACAACAGACTAGTGCCTAGAAAGAACGGAAAGAGAAAGTTTACTCCCTCCATGCAAAGAAGATTGAACAGACTGGGTATTCAAAAGACCAACCCCGATGATCTAACACCCGAAGAGATCAACAAATTCGCCAGATTGAACATTGACCCGGACACTATTACTATCAAGAGGGTGGTCGATATCAACGACAGAATGTTAAGACAAATCACCATTGGTCAAGCCCCTACCGAGAAGAACCACACAAGAGTTACTGGATTCGATATCACCGTTGCTTCTGAATTGATGGCTATTCTTGCTCTTTCAAAGGACTTGAGGGACATGAAGGAACGTATTGGAAGAGTCGTTGTTGCTGCTGACGTAAACAGGTCTCCAGTCACTGTTGAAGATGTGGGTTGTACCGGTGCCTTAACCGCTTTATTAAGAGACGCTATCAAGCCCAACTTGATGCAAACTTTAGAAGGTACTCCTGTCTTGGTCCATGCCGGCCCATTTGCCAACATCTCTATCGGTGCCTCTTCTGTTATTGCTGATCGCGTGGCTTTGAAATTGGTTGGTACCGAGCCAGAGGCAAAAACAGAAGCTGGTTATGTGGTTACTGAAGCAGGGTTCGATTTCACTATGGGTGGTGAAAGATTCTTCAACATCAAGTGCCGTTCCTCTGGATTGACACCTAATGCTGTGGTCTTGGTTGCTACTGTTAGGGCATTGAAGTCACACGGTGGTGCTCCAGATGTCAAACCTGGCCAACCTTTACCTTCCGCATACACTGAAGAGAATATCGAGTTTGTCGAAAAAGGTGCCGCTAACATGTGTAAACAAATTGCCAACATTAAGCAATTTGGCGTCCCCGTCGTTGTCGCAATTAACAAGTTTGAAACTGACACTGAAGGTGAAATAGCCGCCATTAGAAAAGCCGCTTTGGAAGCTGGTGCATTTGAAGCCGTAACCTCTAACCATTGGGCCGAAGGTGGTAAAGGTGCTATCGACTTGGCCAAGGCCGTCATCGAAGCTTCCAACCAACCAGTGGACTTCCATTTCCTATATGACGTTAACTCCTCCGTTGAAGACAAATTAACTACTATCGTTCAAAAGATGTACGGTGGTGCCGCAATCGATATCTTGCCTGAAGCACAACGCAAGATTGACATGTACAAGGAACAAGGTTTCGGTAACTTGCCAATTTGTATCGCCAAGACACAATACTCTTTATCCCACGATGCAACTTTGAAAGGTGTTCCAACCGGGTTCACTTTCCCCATCAGAGACGTCAGATTGTCTAATGGTGCTGGATACTTATACGCTCTTGCCGCCGAAATACAAACCATTCCTGGTTTGGCTACCTATGCTGGTTACATGGCCGTGGAAGTCGATGATGACGGTGAGATCGATGGCCTGTTCTAA","protein_sequence":"MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF"},{"created_at":"2011-05-26T17:58:25.000Z","updated_at":"2011-05-29T05:06:21.000Z","name":"Riboflavin kinase","uniprot_id":"Q03778","uniprot_name":"RIFK_YEAST","enzyme":true,"transporter":false,"gene_name":"FMN1","num_residues":218,"molecular_weight":"24536.90039","theoretical_pi":"4.84","general_function":"Involved in riboflavin kinase activity","specific_function":"Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme","reactions":[{"id":1941,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2500,"direction":"\u003e","locations":"Microsome. Mitochondrion inner membrane. Endoplasmic reticulum (Potential).","altext":"ATP + riboflavin = ADP + FMN.","export":false,"pw_reaction_id":null,"source":null},{"id":14114,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006545","source":"Smpdb"}],"signal_regions":"1-19","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Microsome. Mitochondrion inner membrane. Endoplasmic reticulum (Potential).","genbank_gene_id":"AY557733","genbank_protein_id":"45269357","gene_card_id":"FMN1","chromosome_location":"chromosome 4","locus":"YDR236C","synonyms":["Flavin mononucleotide kinase 1"],"enzyme_classes":["2.7.1.26"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" riboflavin kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" riboflavin metabolic process"},{"category":"Process","description":" riboflavin biosynthetic process"}],"pfams":[{"name":"Flavokinase","identifier":"PF01687"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"}],"gene_sequence":"ATGTTTACGTGGACTATTTATGTTTCGTTATTGCTAGTGTTAGCAGGTACTTTCTTAATGAACCGAAATACGAATACAGATATAATTGATACTTTTAAACGAGAAGTCGATTTGCCAATACCTGCGCAACCAGGTCCACCATTCCCGCTTGTTACTGACTATTGTGACATTGTATGTGGATTTGGCCGCGGATCCGCCGAATTGGGTATTCCCACTGCCAATGTACCTATAAATCAGTTACCTAAAGGTATCAACGATTTGGATTTAGGGGTTTACTTTGGGTTTGCTCACATTAAAACTGTTGATGGTCAAGAACTATCGGTGGAAACAAGGCGGGATGGAAGAACTGTGGTTTATAATTACGGTCAATATTTAAGTGAAGCGAACGATGATTTGTCCGTACTTCCTATGGTACTTTCAGTTGGGAAAAATCCATTCTACGGAAATGATTTCAAAACCATGGAATTACATATTATACATGATTTTAAAAATGATTTTTATGGGGCCAGGGTCAAGTTCAATATTTTAGGTCATATCAGACCCGAATTGAACTACACTACTAAGGAAGCTCTGATCGAAGACATCAATATCGATATTAGGACTGCGCAGACTGTCCTTGCCACTCCACCGTATCAAGTATTCAAACAACAATTATAG","protein_sequence":"MFTWTIYVSLLLVLAGTFLMNRNTNTDIIDTFKREVDLPIPAQPGPPFPLVTDYCDIVCGFGRGSAELGIPTANVPINQLPKGINDLDLGVYFGFAHIKTVDGQELSVETRRDGRTVVYNYGQYLSEANDDLSVLPMVLSVGKNPFYGNDFKTMELHIIHDFKNDFYGARVKFNILGHIRPELNYTTKEALIEDINIDIRTAQTVLATPPYQVFKQQL"},{"created_at":"2011-05-26T18:38:53.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Bis(5'-adenosyl)-triphosphatase","uniprot_id":"P49775","uniprot_name":"HNT2_YEAST","enzyme":true,"transporter":false,"gene_name":"HNT2","num_residues":206,"molecular_weight":"23541.59961","theoretical_pi":"7.9","general_function":"Involved in catalytic activity","specific_function":"Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock","reactions":[{"id":1324,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2544,"direction":"\u003e","locations":"Cytoplasm. Nucleus. Mitochondrion","altext":"P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus. Mitochondrion","genbank_gene_id":"U28374","genbank_protein_id":"849222","gene_card_id":"HNT2","chromosome_location":"chromosome 4","locus":"YDR305C","synonyms":["AP3A hydrolase","AP3Aase","Diadenosine 5',5'''-P1,P3-triphosphate hydrolase","Dinucleosidetriphosphatase","Hit family protein 2"],"enzyme_classes":["3.6.1.29"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"HIT","identifier":"PF01230"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGATCTTAAGCAAAACAAAGAAACCTAAAAGCATGAATAAGCCAATATATTTCAGCAAGTTTCTTGTAACTGAACAAGTTTTCTATAAGTCAAAATATACGTATGCATTGGTAAACTTGAAACCAATTGTACCCGGACATGTACTGATCGTTCCACTGAGAACTACGGTTTTAAACTTATCAGATCTGACCATGCCTGAATCTCAAGATTATTTCAAGACTTTACAGTTAATACATAGATTTATTAAGTGGCAATATAAGGCTGACTCTATCAACGTTGCCATCCAAGATGGACCTGAGGCCGGACAGTCGGTACCCCACTTGCATACACACATTATTCCACGTTATAAAATAAACAATGTAGGGGATTTAATATACGATAAATTAGATCATTGGGATGGTAATGGGACTTTGACTGATTGGCAAGGAAGAAGAGACGAATATTTGGGTGTTGGTGGTAGGCAAGCAAGAAAAAATAACTCTACATCGGCCACTGTAGACGGGGATGAACTCTCACAAGGTCCTAATGTCTTGAAGCCAGACAGTCAAAGGAAGGTTCGAGCTTTAACCGAAATGAAAAAAGAAGCTGAGGATCTTCAAGCCAGACTAGAAGAATTTGTATCTTCTGATCCTGGTTTAACACAATGGTTATAG","protein_sequence":"MNKPIYFSKFLVTEQVFYKSKYTYALVNLKPIVPGHVLIVPLRTTVLNLSDLTMPESQDYFKTLQLIHRFIKWQYKADSINVAIQDGPEAGQSVPHLHTHIIPRYKINNVGDLIYDKLDHWDGNGTLTDWQGRRDEYLGVGGRQARKNNSTSATVDGDELSQGPNVLKPDSQRKVRALTEMKKEAEDLQARLEEFVSSDPGLTQWL"},{"created_at":"2011-05-26T18:41:58.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Thiamine pyrophosphokinase","uniprot_id":"P35202","uniprot_name":"THI80_YEAST","enzyme":true,"transporter":false,"gene_name":"THI80","num_residues":319,"molecular_weight":"36615.69922","theoretical_pi":"6.26","general_function":"Involved in thiamine diphosphokinase activity","specific_function":"Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP)","reactions":[{"id":2001,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2002,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2546,"direction":"\u003e","locations":null,"altext":"ATP + thiamine = AMP + thiamine diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14443,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006957","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG0","cellular_location":null,"genbank_gene_id":"D14417","genbank_protein_id":"416427","gene_card_id":"THI80","chromosome_location":"chromosome 15","locus":"YOR143C","synonyms":["TPK","Thiamine kinase"],"enzyme_classes":["2.7.6.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" diphosphotransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" thiamin diphosphokinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" thiamin diphosphate biosynthetic process"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"}],"pfams":[{"name":"TPK_catalytic","identifier":"PF04263"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGAGCGAGGAGTGTATTGAAAATCCTGAACGTATTAAAATTGGTACTGATTTAATCAACATCCGAAATAAAATGAACTTAAAAGAACTAATCCATCCAAACGAGGATGAAAACTCTACCCTACTCATACTTAATCAAAAAATTGACATTCCTAGACCGTTGTTTTACAAAATTTGGAAGCTGCATGACTTGAAGGTCTGTGCAGATGGTGCAGCCAATAGATTATATGACTACCTAGATGATGACGAAACCCTAAGGATAAAATATCTTCCCAATTATATTATTGGCGATCTGGATTCACTATCAGAAAAGGTTTACAAGTATTATAGGAAAAACAAAGTAACTATAATAAAACAAACTACACAATATTCGACTGATTTCACGAAGTGCGTTAATTTGATCTCTCTACACTTCAATTCACCAGAATTTCGTTCTTTAATATCGAATAAAGACAATCTTCAGTCAAATCATGGAATTGAACTGGAAAAGGGTATTCACACATTATACAATACTATGACCGAGTCCTTGGTTTTCTCGAAAGTGACTCCAATTAGTCTATTAGCACTAGGAGGAATTGGTGGTAGATTTGATCAGACGGTTCACTCAATAACGCAATTGTATACCTTATCCGAGAATGCAAGCTATTTCAAGCTTTGTTACATGACTCCAACAGACTTAATATTCTTAATCAAAAAAAATGGAACTTTGATTGAGTATGATCCCCAATTTAGGAACACTTGTATAGGAAATTGTGGGTTGTTGCCTATTGGAGAGGCTACTTTGGTTAAGGAAACCCGTGGTTTAAAGTGGGATGTTAAAAACTGGCCAACTAGCGTGGTCACCGGAAGAGTCAGCAGTAGTAACAGATTTGTTGGGGATAATTGTTGTTTCATTGATACCAAAGATGACATCATTTTGAATGTAGAAATATTCGTTGATAAATTAATAGATTTTTTGTAA","protein_sequence":"MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL"},{"created_at":"2011-05-26T18:45:56.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Adenylate kinase 2","uniprot_id":"P26364","uniprot_name":"KAD2_YEAST","enzyme":true,"transporter":false,"gene_name":"ADK2","num_residues":225,"molecular_weight":"25193.69922","theoretical_pi":"9.42","general_function":"Involved in ATP binding","specific_function":"This small ubiquitous enzyme is essential for maintenance and cell growth","reactions":[{"id":1276,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1277,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1278,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2551,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm, cytosol. Mitochondrion intermembrane space;Mitochondrion","altext":"ATP + AMP = 2 ADP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558457","genbank_protein_id":"45270804","gene_card_id":"ADK2","chromosome_location":"chromosome 5","locus":"YER170W","synonyms":["AK 2","ATP-AMP transphosphorylase 2"],"enzyme_classes":["2.7.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenylate kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"},{"name":"ADK_lid","identifier":"PF05191"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAAAGCAGACGCGAAACAAATAACACATCTACTCAAACCTCTTCGACTTTTATTATTGGGGGCTCCAGGGTCAGGTAAAGGGACACAGACTTCGAGATTACTAAAGCAAATTCCACAATTATCTTCAATTTCGTCAGGCGACATTTTACGTCAGGAAATAAAATCTGAATCTACCCTAGGCCGAGAGGCTACTACCTACATTGCTCAAGGCAAGTTATTACCGGATGATCTCATAACGCGTCTGATAACTTTTCGTCTTTCGGCATTGGGTTGGTTAAAACCATCTGCCATGTGGTTGCTCGATGGATTTCCTCGAACTACTGCGCAAGCTTCTGCCTTAGACGAGCTGCTGAAACAGCATGACGCCAGCTTGAATCTAGTGGTAGAGCTAGATGTACCCGAATCCACCATATTAGAAAGGATCGAGAACAGATATGTTCACGTTCCTAGTGGGAGAGTGTATAACTTACAATATAATCCTCCCAAAGTGCCAGGATTAGACGATATCACCGGAGAACCATTGACCAAGAGGCTTGATGACACAGCGGAAGTGTTTAAAAAAAGGCTAGAAGAGTACAAGAAAACAAATGAGCCTTTAAAAGATTATTACAAAAAAAGTGGGATTTTTGGTACCGTCTCTGGGGAAACATCAGATATTATCTTCCGAAATTATTGA","protein_sequence":"MKADAKQITHLLKPLRLLLLGAPGSGKGTQTSRLLKQIPQLSSISSGDILRQEIKSESTLGREATTYIAQGKLLPDDLITRLITFRLSALGWLKPSAMWLLDGFPRTTAQASALDELLKQHDASLNLVVELDVPESTILERIENRYVHVPSGRVYNLQYNPPKVPGLDDITGEPLTKRLDDTAEVFKKRLEEYKKTNEPLKDYYKKSGIFGTVSGETSDIIFRNY"},{"created_at":"2011-05-26T18:54:17.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Putative adenylate kinase FAP7","uniprot_id":"Q12055","uniprot_name":"KAD6_YEAST","enzyme":true,"transporter":false,"gene_name":"FAP7","num_residues":197,"molecular_weight":"22723.0","theoretical_pi":"4.27","general_function":"Nucleotide transport and metabolism","specific_function":"Required for the activation of POS9 and for stabilizing its interaction with the transcriptosome in response to oxidative stress. Required for 20S rRNA processing at site D","reactions":[{"id":2551,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm, cytosol. Mitochondrion intermembrane space;Mitochondrion","altext":"ATP + AMP = 2 ADP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z67750","genbank_protein_id":"1061273","gene_card_id":"FAP7","chromosome_location":"chromosome 4","locus":"YDL166C","synonyms":["ATP-AMP transphosphorylase FAP7","POS9-activating factor 7"],"enzyme_classes":["2.7.4.3"],"go_classes":[],"pfams":[],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGAAGCAAGACGGTATGGACCGAATATCATTGTTACAGGAACACCAGGATGTGGCAAGTCGTCTACGTGTGAGTTTTTAAAAAATAAACTGAAGGATTACAAATACTATAACATTTCGGATTTCGCCAAAGATAACGACTGTTTCGAAGGATATGATGAGGGCCGTAAATCGCACATTGTCGATGAAGACAAACTGCTGGACATGCTAGAGCCTCTTTTGAGACAGGGAAATAGTATTGTCGATTGGCATGTCAATGATGTGTTCCCAGAGAGGCTGATTGACTTGGTGGTGGTGTTGAGATGCGATAACTCTAACTTGTATTCAAGATTGCATGCAAGAGGCTATCATGACTCTAAGATCGAGGAAAACCTCGATGCCGAGATTATGGGTGTCGTCAAACAGGATGCCGTGGAATCATACGAACCGCACATTGTGGTAGAGCTACAAAGCGATACGAAAGAAGATATGGTATCTAACGTATCCCGTATTGTTGCTTGGGAAAAGATGTGGTTAGAACAACATCCAGATGGAGTCACAAATGAATATCAAGGGCCTCGTAGCGATGACGAAGACGATGAAGACAGTGAGTAG","protein_sequence":"MEARRYGPNIIVTGTPGCGKSSTCEFLKNKLKDYKYYNISDFAKDNDCFEGYDEGRKSHIVDEDKLLDMLEPLLRQGNSIVDWHVNDVFPERLIDLVVVLRCDNSNLYSRLHARGYHDSKIEENLDAEIMGVVKQDAVESYEPHIVVELQSDTKEDMVSNVSRIVAWEKMWLEQHPDGVTNEYQGPRSDDEDDEDSE"},{"created_at":"2011-05-26T18:59:10.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenylate kinase 1","uniprot_id":"P07170","uniprot_name":"KAD1_YEAST","enzyme":true,"transporter":false,"gene_name":"ADK1","num_residues":222,"molecular_weight":"24254.5","theoretical_pi":"6.37","general_function":"Involved in ATP binding","specific_function":"Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in the cytoplasm and mitochondrion intermembrane space","reactions":[{"id":1276,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1277,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1278,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2551,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm, cytosol. Mitochondrion intermembrane space;Mitochondrion","altext":"ATP + AMP = 2 ADP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1AKY","cellular_location":"Cytoplasm, cytosol. Mitochondrion intermembrane space","genbank_gene_id":"AY558578","genbank_protein_id":"45271046","gene_card_id":"ADK1","chromosome_location":"chromosome 4","locus":"YDR226W","synonyms":["AK 1","ATP-AMP transphosphorylase 1","Adenylate kinase cytosolic and mitochondrial"],"enzyme_classes":["2.7.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenylate kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"},{"name":"ADK_lid","identifier":"PF05191"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCTAGCTCAGAATCCATTAGAATGGTCCTAATTGGCCCACCTGGTGCCGGTAAAGGTACTCAAGCTCCAAATTTGCAAGAGCGTTTCCATGCCGCTCACTTGGCCACTGGTGACATGTTGAGATCTCAAATCGCAAAGGGCACTCAATTAGGTTTGGAAGCAAAGAAAATTATGGACCAAGGTGGTTTAGTCTCTGATGACATTATGGTTAACATGATCAAGGATGAATTGACCAACAATCCAGCTTGTAAGAATGGGTTCATCTTGGACGGTTTCCCAAAAACCATTCCTCAGGCTGAAAAATTGGACCAAATGTTGAAAGAACAAGGAACTCCTTTGGAAAAAGCCATCGAATTGAAGGTTGATGATGAATTGTTGGTTGCCAGAATTACCGGTAGATTAATTCACCCAGCCTCTGGCAGATCCTACCACAAGATCTTTAACCCACCAAAGGAAGACATGAAGGATGACGTCACCGGTGAAGCTTTAGTTCAAAGATCTGATGACAATGCAGACGCCTTGAAGAAGAGATTAGCTGCTTACCATGCTCAAACCGAACCAATTGTTGACTTTTACAAAAAGACCGGTATCTGGGCTGGTGTTGATGCTTCCCAACCTCCTGCTACTGTTTGGGCTGACATCTTGAACAAGCTAGGTAAGGATTAA","protein_sequence":"MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKD"},{"created_at":"2011-05-26T19:06:52.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Peroxisomal adenine nucleotide transporter 1","uniprot_id":"Q06497","uniprot_name":"ANT1_YEAST","enzyme":false,"transporter":true,"gene_name":"ANT1","num_residues":328,"molecular_weight":"36367.0","theoretical_pi":"10.33","general_function":"Involved in adenine nucleotide transmembrane transporte","specific_function":"Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxydation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation","reactions":[],"signal_regions":"None","transmembrane_regions":"1-21;78-98;128-148;185-202;226-246;277-297","pdb_id":null,"cellular_location":"Peroxisome membrane; Multi-pass membrane protein","genbank_gene_id":"U40829","genbank_protein_id":"1066487","gene_card_id":"ANT1","chromosome_location":"chromosome 16","locus":"YPR128C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTTAACTCTAGAGTCTGCATTAACTGGCGCTGTGGCTTCGGCAATGGCCAATATTGCAGTTTATCCGCTGGATTTATCGAAGACGATCATTCAGTCACAAGTATCTCCTTCTTCAAGTGAGGATAGTAACGAAGGTAAAGTTTTGCCCAATAGGAGATATAAGAATGTTGTAGATTGCATGATAAACATATTCAAAGAAAAGGGTATTTTGGGTCTGTATCAAGGTATGACAGTCACTACGGTGGCCACATTTGTCCAGAATTTTGTTTATTTCTTTTGGTACACATTTATCAGAAAGTCCTACATGAAACATAAGCTGTTAGGACTGCAATCACTGAAAAACCGCGATGGTCCTATCACACCTTCTACGATTGAAGAATTGGTACTTGGGGTAGCAGCTGCCAGTATATCGCAACTTTTTACTAGTCCCATGGCTGTGGTAGCTACAAGACAACAAACAGTCCATTCTGCAGAGTCTGCCAAATTTACCAACGTTATTAAGGACATTTACCGTGAAAATAATGGGGACATAACTGCTTTTTGGAAAGGTTTAAGAACAGGTTTAGCATTGACGATAAATCCTTCCATCACATATGCCTCTTTTCAAAGACTTAAAGAAGTTTTTTTCCATGACCATTCCAACGATGCTGGCAGTTTGTCAGCAGTGCAAAATTTCATTTTGGGTGTCCTTTCCAAGATGATTTCGACTCTAGTTACGCAACCCTTGATTGTCGCTAAAGCAATGCTTCAAAGCGCTGGCTCTAAATTCACTACTTTCCAAGAAGCGCTACTATACTTGTACAAAAATGAAGGGTTAAAATCTCTTTGGAAGGGAGTTCTTCCTCAATTGACAAAGGGTGTCATTGTGCAAGGTCTGTTGTTTGCTTTCAGAGGAGAATTGACAAAATCTTTAAAGAGGCTAATATTCTTGTACTCTTCTTTTTTCCTAAAGCACAACGGACAACGCAAGCTGGCTTCCACTTGA","protein_sequence":"MLTLESALTGAVASAMANIAVYPLDLSKTIIQSQVSPSSSEDSNEGKVLPNRRYKNVVDCMINIFKEKGILGLYQGMTVTTVATFVQNFVYFFWYTFIRKSYMKHKLLGLQSLKNRDGPITPSTIEELVLGVAAASISQLFTSPMAVVATRQQTVHSAESAKFTNVIKDIYRENNGDITAFWKGLRTGLALTINPSITYASFQRLKEVFFHDHSNDAGSLSAVQNFILGVLSKMISTLVTQPLIVAKAMLQSAGSKFTTFQEALLYLYKNEGLKSLWKGVLPQLTKGVIVQGLLFAFRGELTKSLKRLIFLYSSFFLKHNGQRKLAST"},{"created_at":"2011-05-26T19:26:59.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Nicotinamide riboside kinase","uniprot_id":"P53915","uniprot_name":"NRK1_YEAST","enzyme":true,"transporter":false,"gene_name":"NRK1","num_residues":240,"molecular_weight":"27689.30078","theoretical_pi":"6.68","general_function":"Involved in ATP binding","specific_function":"Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)","reactions":[{"id":1954,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2567,"direction":"\u003e","locations":null,"altext":"ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":2568,"direction":"\u003e","locations":null,"altext":"ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":4191,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006490","source":"Smpdb"},{"id":4192,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006496","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558011","genbank_protein_id":"45269912","gene_card_id":"NRK1","chromosome_location":"chromosome 14","locus":"YNL129W","synonyms":["NRK","NmR-K","Nicotinic acid riboside kinase","Ribosylnicotinamide kinase","RNK","Ribosylnicotinic acid kinase"],"enzyme_classes":["2.7.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTCGAAAAAAGTGATATTAGTTGCATTGAGTGGATGCTCCTCCAGTGGTAAGACGACAATTGCGAAACTTACAGCAAGTTTATTCACGAAGGCTACATTAATTCATGAAGATGACTTTTACAAACATGATAATGAAGTGCCAGTAGATGCTAAATATAACATTCAAAATTGGGATTCGCCAGAAGCTCTTGATTTTAAACTTTTCGGTAAAGAATTAGATGTGATCAAACAAACTGGTAAAATAGCCACCAAACTTATACACAATAACAACGTAGATGATCCCTTTACAAAGTTCCACATTGATAGACAAGTTTGGGACGAGTTAAAGGCTAAGTATGACTCTATTAATGACGACAAATATGAAGTTGTAATTGTAGATGGGTTTATGATTTTCAATAATACTGGAATATCAAAAAAATTTGATTTGAAGATATTAGTGCGTGCTCCCTATGAAGTACTAAAAAAAAGGAGGGCTTCCAGAAAAGGATACCAGACTTTGGATTCTTTCTGGGTGGATCCGCCGTATTATTTCGACGAATTTGTGTATGAATCTTATCGTGCAAATCATGCGCAGTTATTTGTTAATGGAGACGTAGAAGGTTTACTAGACCCAAGGAAGTCAAAGAATATAAAAGAGTTCATAAATGATGATGACACTCCAATTGCGAAACCTTTAAGCTGGGTGTGCCAAGAGATTCTAAAGCTTTGTAAGGATTAG","protein_sequence":"MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD"},{"created_at":"2011-05-26T19:28:04.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Homoserine kinase","uniprot_id":"P17423","uniprot_name":"KHSE_YEAST","enzyme":true,"transporter":false,"gene_name":"THR1","num_residues":357,"molecular_weight":"38712.0","theoretical_pi":"5.05","general_function":"Involved in ATP binding","specific_function":"Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate","reactions":[{"id":1641,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2569,"direction":"\u003e","locations":null,"altext":"ATP + L-homoserine = ADP + O-phospho-L-homoserine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M37692","genbank_protein_id":"172978","gene_card_id":"THR1","chromosome_location":"chromosome 8","locus":"YHR025W","synonyms":["HK","HSK"],"enzyme_classes":["2.7.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" homoserine kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" phosphorus metabolic process"},{"category":"Process","description":" phosphate metabolic process"}],"pfams":[{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"}],"gene_sequence":"ATGGTTCGTGCCTTCAAAATTAAAGTTCCAGCTTCTTCCGCCAATATCGGCCCTGGTTATGATGTTCTTGGTGTCGGTCTTTCTCTATTCTTGGAGTTAGATGTCACCATCGACTCCAGCCAAGCTCAGGAAACAAACGACGATCCCAACAACTGCAAGCTGTCTTACACTAAAGAAAGTGAAGGCTATTCTACGGTCCCATTGCGTTCTGATGCTAACCTGATTACCAGGACTGCGTTATATGTGTTGCGTTGCAACAATATTAGAAACTTCCCCTCCGGAACCAAAGTTCACGTCTCCAACCCAATCCCACTTGGCCGTGGATTGGGTTCCTCTGGTGCAGCAGTTGTGGCAGGTGTTATTTTAGGTAACGAAGTGGCCCAATTGGGTTTCTCTAAGCAACGTATGTTGGACTACTGTTTGATGATTGAACGTCATCCAGACAACATAACCGCTGCTATGATGGGAGGCTTTTGCGGTTCATTCCTAAGGGACTTGACCCCACAAGAGGTGGAAAGACGTGAGATTCCATTGGCTGAGGTGCTTCCAGAACCTTCTGGTGGTGAAGATACCGGTCTGGTTCCCCCATTACCTCCCACCGATATCGGTAGACATGTCAAATACCAATGGAACCCCGCCATTAAATGTATTGCGATCATCCCACAGTTCGAGTTGTCCACCGCCGACTCCAGAGGCGTTCTTCCAAAAGCCTACCCAACCCAGGACTTGGTTTTCAATCTACAAAGATTGGCCGTCTTGACCACAGCTTTGACCATGGACCCACCTAATGCCGACTTAATCTACCCTGCTATGCAAGATCGTGTCCACCAACCTTATAGAAAGACATTGATCCCAGGTCTCACGGAAATCTTATCATGTGTCACCCCATCCACATACCCTGGCCTATTGGGTATCTGCTTGTCAGGTGCAGGCCCAACTATCTTGGCTTTGGCCACTGAGAATTTCGAAGAAATCTCTCAAGAAATTATCAACAGGTTCGCCAAAAACGGCATCAAGTGCTCCTGGAAACTACTGGAGCCTGCCTACGATGGTGCTAGCGTCGAACAGCAATGA","protein_sequence":"MVRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSQAQETNDDPNNCKLSYTKESEGYSTVPLRSDANLITRTALYVLRCNNIRNFPSGTKVHVSNPIPLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGFCGSFLRDLTPQEVERREIPLAEVLPEPSGGEDTGLVPPLPPTDIGRHVKYQWNPAIKCIAIIPQFELSTADSRGVLPKAYPTQDLVFNLQRLAVLTTALTMDPPNADLIYPAMQDRVHQPYRKTLIPGLTEILSCVTPSTYPGLLGICLSGAGPTILALATENFEEISQEIINRFAKNGIKCSWKLLEPAYDGASVEQQ"},{"created_at":"2011-05-26T19:29:06.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Inositol-pentakisphosphate 2-kinase","uniprot_id":"Q06667","uniprot_name":"IPK1_YEAST","enzyme":true,"transporter":false,"gene_name":"IPK1","num_residues":281,"molecular_weight":"32917.69922","theoretical_pi":"7.95","general_function":"Involved in ATP binding","specific_function":"Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate","reactions":[{"id":1660,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2570,"direction":"\u003e","locations":"Nucleus","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14853,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007030","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"AY557740","genbank_protein_id":"45269371","gene_card_id":"IPK1","chromosome_location":"chromosome 4","locus":"YDR315C","synonyms":["Inositol-1,3,4,5,6-pentakisphosphate 2-kinase","Ins(1,3,4,5,6)P5 2-kinase","InsP5 2-kinase"],"enzyme_classes":["2.7.1.158"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol pentakisphosphate 2-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ins_P5_2-kin","identifier":"PF06090"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGCAAGTCATCGGACGTGGTGGGGCAAATATACTGATTGATTATGGGGATCCTACGTGGTTGTGGCGATGCTGCATCCGTTGGCCCGATCTGTTATCATCAAATAATTCTTATACAATCAAAAACATCAGTTATATTAAAGATTATGTAGAACCTCTTCTACATGGCTTGCTTTGCCCGATGTATCTGATTGACGTCGATATAGAAGCTATAAGGCCAATTCTCAGTGACTTTATTCTAAATTTAGACGATAAGGTAGTCAAAGTTATCAAAATTAAAAATCTCACCAATAATACCTCAAATCTGATATTAAATAACCACTTTTTAAAATCTTATTGTTCACAAAATCTGCAAACAGTTATTTTAGAATTGAAGCCTAAATGGTTATACTATGATACAGATTACTGTAGGAACTGTACTCATAATGCATTTAAGGGTAGAGGCACTAAGTACTGTTACAATCAATTACTAATGAATCCAGCACACTTGGAATTAATATTTGGAGAATGTAATATATTTCCGGTTAAGTTTAAAGATGCCATGCATGAGTACTTGCGCAATGACAATAACATTTTCAAGATCCTTTATGATTTACAGAAAAAACTTACAAAGAACACAACTCCAATAAGTGACATAAAATCAATCAACGATGTAAACGATGAGCATCTGCTACTCATGACACTCAGAGACGTGACATGTTTCATTGAATGGAACAGTGCTGAAAATGCGTTGCACGTGAATATAATAGATGTAGATCTAAAGCCGAAAGAAAAATGGACCCATTGGACAAAAACTTACAGCCAGTTGACATCAAGCCAAAAAATTTATCATACTTCAAATAAATAA","protein_sequence":"MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK"},{"created_at":"2011-05-26T19:31:39.000Z","updated_at":"2011-05-26T19:31:39.000Z","name":"Uncharacterized protein YKL215C","uniprot_id":"P28273","uniprot_name":"YKV5_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":1286,"molecular_weight":"140426.0","theoretical_pi":"6.75","general_function":"Involved in hydrolase activity","specific_function":null,"reactions":[{"id":2576,"direction":"\u003e","locations":"Cytoplasmic","altext":"ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"X75951","genbank_protein_id":"473135","gene_card_id":null,"chromosome_location":null,"locus":"YKL215C","synonyms":[],"enzyme_classes":["3.5.2.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Hydant_A_N","identifier":"PF05378"},{"name":"Hydantoinase_A","identifier":"PF01968"},{"name":"Hydantoinase_B","identifier":"PF02538"}],"pathways":[],"gene_sequence":"ATGCAGAAAGGAAACATAAGAATTGCCATCGATAAGGGTGGAACTTTCACTGATTGTGTGGGGAATATTGGTACAGGTAAACAAGAACATGATACTGTCATCAAGCTCTTGTCGGTGGATCCCAAAAACTATCCAGATGCTCCCCTTGAAGGCATAAGACGTCTCTTGGAGGTGCTTGAACACAAGACAATTCCTCGCGGTATTCCTCTAGACATCTCTAATGTGAGAAGTTTAAGAATGGGGACAACCCTAGCTACAAACTGCGCTCTAGAAAGAAATGGTGAACGTTGTGCCTTCATTACTACGAAAGGCTTTAAGGATTCATTGCTGATTGGAGACCAAACCAGGCCAGATATCTTCAACTTAAATATAAAAAAGGTAGTGCCATTATATGACACTGTAGTTGAAATAGATGAGAGAGTTACTTTAGAAGATTTCTCGGAAGACCCTTATTTTACCAAATCGTCTCCTAATGAACAAGAAGGTATCCTGGAAGGTAATAGTGGCGAAATGGTAAGGGTCATAAAGAAGCCAGATGAATCAAGCGTAAGATCTATTCTGAAAGTGCTTTATGCTAGCGGAATCAAGTCTATTGCGATAGCATTTTTACACTCATACACTTTTCCAGACCATGAGCGAATTGTTGGTAATATTGCCAGGGAGATTGGGTTTTCTCATGTTTCATTATCATCTGAAGTCTCTCCAATGATAAAATTTTTACCGAGGGCTCACAGTTCTGTCGCAGATGCCTACCTTACTCCGGTAATTAAAAAGTACTTGAATAGCATTTCTGCAGGTTTGAGCCACGCAGAAGATACCCACATTCAATTCATGCAGTCTGATGGTGGTTTAGTGGATGGGGGAAAATTTTCCGGTTTGAAATCTATTTTATCTGGTCCTGCAGGTGGCGTAATAGGTTATTCTAGTACATGCTATGATAAAAATAATAACATACCCTTAATAGGCTTTGACATGGGAGGAACATCTACTGATGTCAGTAGGTACGGCGATGGGAGGTTAGAACATGTTTTTGAAACTGTTACCGCAGGGATCATCATACAATCTCCTCAACTTGACATCCATACTGTTGCTGCTGGAGGAAGTTCTATTTTGTCATGGAAAAACGGGTTATTCAGAGTAGGCCCTGATTCAGCAGCTGCTGATCCAGGCCCTGCAGCCTACAGAAAGGGCGGGCCTTTGACCATTACAGACGCCAACCTCTTTTTAGGACGTTTGGTTCCTGAGTTCTTCCCCAAAATTTTTGGGCCCAATGAGGATGAATCACTTGACTTAGAAACCACTACTTTGAAATTCAGAGAATTAACAGATGTCATCAATAAGGATCTGAATTCAAATCTAACCATGGAAGAGGTTGCCTATGGATTTATCAAAGTAGCTAACGAATGCATGGCAAGACCTGTGAGGGCCATTACAGAAGCAAAAGGACATGTAGTATCTCAGCATCGGTTAGTTTCCTTTGGCGGGGCTGGCGGGCAACACGCCATAGCGGTTGCAGATTCATTGGGCATTGACACTGTTTTAATTCATAGATATTCTTCTATCTTGTCCGCTTATGGCATTTTCTTAGCAGATGTTATTGAAGAAAACCAAGAGCCTTGCTCTTTTATCTTGGGTGAGCCAGAGACCATCTTGAAAGTGAAAAAAAGATTCTTAGAACTTTCTAAAAATTCAATCAAAAACCTTTTATCTCAGTCGTTTTCTCGGGAGGACATAGTCTTGGAAAGATATTTAAATCTCAGATATGAAGGTACTGAAACCAGTTTGATGATATTACAAAAATATGATGACCAATGGAATTTTAGGGAATGGTTCTCTGAAGCTCATAAAAAAGAGTTCGGATTCTCATTCGATGACAAACGAATTATAATTGATGATATAAGGATAAGAGCAATTGGGAAATCAGGCGTTAGAAAAGAAAAAACGGTTGATGAGCAATTGATTGAAATTTCCCATTTCAAGAAAGCCGACGTGTCAAAGGATGCTAGTTTTACCCAGAAAGCATATTTTGACAACAAATGGGTCGACACTGCGGTCTTCAAAATTGATGATCTTCCTGCCGGAACAATTATCGAGGGCCCAGCCATATTGGCTGACGGTACCCAAACAAATATTATTTTACCAAACAGCCAAGCAACAATTTTAAACTCTCATATATTTATCAAGATCAACCAAAAGGCTGCGAAGACATTATCTAAAAGCGGATATGAACTTGATATAGATCCAATCTTATTGTCTATTTTCAGTCATAGGTTTATGGATATCGCCCTCCAGATGGGTACTCAATTGAGGAAAACTTCTGTTTCAACTAACGTCAAAGAGAGATTAGATTTTTCATGTGCACTATTCGACTCTAAAGGAAACTTAGTCGCTAACGCTCCTCATGTACCTGTTCACTTAGGATCAATGTCAACCTGCATATCAGCACAGGCGAAGTTATGGGAAGGCAAATTAAAGCCTGGTGATGTTTTAATCACAAACCATCCGGATATTGGTGGTACTCATTTACCAGACATAACAGTAATAACTCCTTCTTTCTCTTCAACTGGCGAATTGATATTTTATGTGGCTTCAAGAGCCCATCATGCAGATATTGGAGGTATTCTACCCGGTTCAGTGCCTCCAAATTCCAAAGAATTGTACGAAGAAGGAACCGCAATTTATTCCGAATTGGTTGTCAAAGAGGGAATTTTCCAGGAAGAATTAATTTACAAGCTTTTCGTAGAAGATCCAGGCAAATACCCAGGCTGCTCAGGTTCAAGAAGATTTAGTGATAACATAAGCGATTTAAAAGCGCAAGTCGCAGCTAACACAAAAGGGATACAGTTAATTGGGTCATTAACTAAGGAATATGATCTGGCTACAATATTGAAATACATGGCTGCAATTCAGACAAATGCATCTGAATCCATAAAAAAAATGCTTGCAAAAATGGTTGAACATTTTGGCACAACGAAGTTTTCTGGCGAAGATCGCTTAGATGATGGAAGCTTAATTAAACTACAAGTTATCATAAGACCTGAAAAAGAGGAGTATATTTTTAATTTCGATGGCACTTCTCCCCAAGTTTATGGTAATTTAAATGCACCAGAGGCTATTACTAATTCTGCGATTCTTTATTGTCTACGGTGTCTAGTAGGCGAAGATATTCCTTTAAATCAAGGTTGTTTAAAACCCTTAACAATAAAAATTCCTGCTGGTTCCCTCTTGAGCCCCCGATCCGGTGCTGCTGTTGTCGGAGGCAATGTATTAACTTCCCAAAGAGTGACAGATGTAATCTTAAAAACATTTAACGTCATGGCAGATTCTCAAGGTGACTGTAACAACTTTACATTTGGAACTGGAGGAAATTCTGGTAACAAAACCGATAAGCAGATCAAAGGCTTTGGATATTATGAAACCATATGTGGCGGCTCGGGGGCTGGTGCAGATTCATGGAGAGGAAGTGGTTGGAATGGCTCAGACGCTGTACACACGAATATGACCAATACAAGAATGACAGATACTGAGGTATTTGAAAGGAGATACCCCGTTCTGTTGAAAGAGTTCTCGATCAGAAGAGGTTCAGGAGGCAAAGGTAAATATACTGGCGGAAATGGCGTAGTAAGGGATGTTCAATTTCGGAAGGCTGTAACAGCATCTATATTATCAGAACGTCGTGTCATTGGCCCTCATGGTATAAAGGGAGGACAAGACGGTAGTAGAGGTGAGAATTTATGGGTAAGACATAGCACAGGCGCATTAATCAATGTCGGCGGTAAAAATACGATTTACGCTCAACCCGGTGATCGATTCATCATTAAAACCCCTGGTGGTGGGGGATTTGGACAATACAAGGATTAA","protein_sequence":"MQKGNIRIAIDKGGTFTDCVGNIGTGKQEHDTVIKLLSVDPKNYPDAPLEGIRRLLEVLEHKTIPRGIPLDISNVRSLRMGTTLATNCALERNGERCAFITTKGFKDSLLIGDQTRPDIFNLNIKKVVPLYDTVVEIDERVTLEDFSEDPYFTKSSPNEQEGILEGNSGEMVRVIKKPDESSVRSILKVLYASGIKSIAIAFLHSYTFPDHERIVGNIAREIGFSHVSLSSEVSPMIKFLPRAHSSVADAYLTPVIKKYLNSISAGLSHAEDTHIQFMQSDGGLVDGGKFSGLKSILSGPAGGVIGYSSTCYDKNNNIPLIGFDMGGTSTDVSRYGDGRLEHVFETVTAGIIIQSPQLDIHTVAAGGSSILSWKNGLFRVGPDSAAADPGPAAYRKGGPLTITDANLFLGRLVPEFFPKIFGPNEDESLDLETTTLKFRELTDVINKDLNSNLTMEEVAYGFIKVANECMARPVRAITEAKGHVVSQHRLVSFGGAGGQHAIAVADSLGIDTVLIHRYSSILSAYGIFLADVIEENQEPCSFILGEPETILKVKKRFLELSKNSIKNLLSQSFSREDIVLERYLNLRYEGTETSLMILQKYDDQWNFREWFSEAHKKEFGFSFDDKRIIIDDIRIRAIGKSGVRKEKTVDEQLIEISHFKKADVSKDASFTQKAYFDNKWVDTAVFKIDDLPAGTIIEGPAILADGTQTNIILPNSQATILNSHIFIKINQKAAKTLSKSGYELDIDPILLSIFSHRFMDIALQMGTQLRKTSVSTNVKERLDFSCALFDSKGNLVANAPHVPVHLGSMSTCISAQAKLWEGKLKPGDVLITNHPDIGGTHLPDITVITPSFSSTGELIFYVASRAHHADIGGILPGSVPPNSKELYEEGTAIYSELVVKEGIFQEELIYKLFVEDPGKYPGCSGSRRFSDNISDLKAQVAANTKGIQLIGSLTKEYDLATILKYMAAIQTNASESIKKMLAKMVEHFGTTKFSGEDRLDDGSLIKLQVIIRPEKEEYIFNFDGTSPQVYGNLNAPEAITNSAILYCLRCLVGEDIPLNQGCLKPLTIKIPAGSLLSPRSGAAVVGGNVLTSQRVTDVILKTFNVMADSQGDCNNFTFGTGGNSGNKTDKQIKGFGYYETICGGSGAGADSWRGSGWNGSDAVHTNMTNTRMTDTEVFERRYPVLLKEFSIRRGSGGKGKYTGGNGVVRDVQFRKAVTASILSERRVIGPHGIKGGQDGSRGENLWVRHSTGALINVGGKNTIYAQPGDRFIIKTPGGGGFGQYKD"},{"created_at":"2011-05-26T19:33:27.000Z","updated_at":"2011-06-04T23:16:29.000Z","name":"Alpha-factor-transporting ATPase","uniprot_id":"P12866","uniprot_name":"STE6_YEAST","enzyme":false,"transporter":true,"gene_name":"STE6","num_residues":1290,"molecular_weight":"144764.0","theoretical_pi":"8.06","general_function":"Involved in ATP binding","specific_function":"STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone","reactions":[{"id":2578,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein","altext":"ATP + H(2)O + alpha-factor(In) = ADP + phosphate + alpha-factor(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"26-46;76-96;151-171;174-194;263-283;297-317;716-736;764-784;839-859;866-886;946-966;982-1002","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"M26376","genbank_protein_id":"172758","gene_card_id":"STE6","chromosome_location":"chromosome 11","locus":"YKL209C","synonyms":["Mating factor A secretion protein STE6","Multiple drug resistance protein homolog","P-glycoprotein"],"enzyme_classes":["3.6.3.48"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" primary active transmembrane transporter activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" P-P-bond-hydrolysis-driven transmembrane transporter activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of substances"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"ABC_membrane","identifier":"PF00664"},{"name":"ABC_tran","identifier":"PF00005"}],"pathways":[],"gene_sequence":"ATGAACTTTTTAAGTTTTAAGACTACAAAACACTATCACATTTTCAGGTACGTGAACATACGGAATGACTACAGGCTGTTAATGATAATGATAATAGGTACCGTGGCAACAGGCCTAGTGCCGGCAATTACTTCTATCCTGACGGGCAGAGTGTTCGATCTACTATCAGTTTTCGTGGCTAATGGGTCACATCAAGGTTTGTATTCCCAACTAGTACAGAGGTCAATGGCAGTAATGGCACTTGGTGCGGCTTCTGTGCCAGTAATGTGGCTTTCTCTAACAAGTTGGATGCACATCGGCGAGAGACAAGGCTTTAGAATACGGTCACAGATATTGGAGGCATATTTGGAGGAAAAGCCAATGGAATGGTACGACAATAATGAAAAATTGTTAGGAGATTTTACTCAAATCAACAGATGTGTGGAAGAGCTAAGATCAAGCTCCGCAGAGGCATCAGCCATAACTTTCCAGAATTTAGTTGCAATATGTGCGCTTCTGGGGACGTCATTCTACTATTCTTGGTCATTAACTTTAATTATTCTTTGCAGCTCTCCAATAATCACATTTTTTGCAGTGGTGTTTTCCAGAATGATTCATGTATATTCAGAGAAGGAGAATTCTGAAACGAGTAAAGCAGCCCAATTACTTACATGGTCGATGAATGCCGCTCAATTAGTGAGATTATATTGTACACAACGTCTAGAAAGGAAAAAATTCAAGGAAATCATACTAAATTGTAACACTTTCTTCATCAAGAGTTGCTTTTTTGTTGCTGCAAACGCTGGGATCTTGAGATTTTTGACGTTGACTATGTTTGTACAGGGATTCTGGTTTGGTTCCGCAATGATCAAAAAGGGCAAGCTGAACATTAACGATGTAATCACTTGCTTCCATTCATGCATTATGCTGGGCTCGACTTTAAATAATACATTACACCAAATAGTTGTTCTTCAAAAAGGCGGAGTGGCTATGGAAAAAATCATGACTCTATTAAAAGATGGATCCAAGCGAAATCCTTTAAATAAAACTGTAGCCCACCAATTTCCACTAGATTATGCCACCAGTGATCTAACATTTGCTAATGTTTCGTTTTCTTATCCAAGCAGACCTTCGGAAGCAGTTTTAAAGAACGTTAGTTTAAATTTCTCTGCAGGACAATTTACTTTCATAGTAGGAAAATCAGGCTCAGGTAAATCTACATTATCCAACTTATTATTAAGGTTCTACGATGGCTATAATGGATCGATATCTATCAATGGCCACAATATCCAAACAATCGACCAAAAATTGCTAATTGAAAATATCACCGTCGTAGAACAGCGTTGTACCCTATTTAATGATACTCTTAGAAAAAATATTCTTTTAGGTTCAACAGATTCGGTAAGAAATGCCGATTGCAGCACCAATGAAAATAGACATTTAATCAAAGATGCCTGTCAAATGGCTCTTCTGGATAGATTTATTCTAGACCTTCCCGATGGACTGGAAACATTAATTGGGACTGGGGGTGTCACACTAAGTGGCGGGCAACAACAAAGAGTTGCTATAGCACGTGCATTCATCAGAGATACTCCAATATTATTCTTAGACGAAGCTGTATCGGCTCTAGATATTGTTCATCGCAACCTGTTGATGAAGGCAATTAGGCATTGGAGGAAAGGAAAGACTACAATCATATTGACGCATGAGTTGAGCCAAATTGAATCTGATGACTATTTATATTTAATGAAGGAAGGTGAAGTTGTTGAAAGCGGCACCCAGTCTGAACTTCTAGCCGATCCGACCACTACATTTAGCACATGGTATCACCTACAGAATGACTACTCTGATGCGAAAACTATTGTAGATACAGAGACTGAAGAAAAATCTATACACACTGTGGAAAGTTTTAACTCTCAATTGGAAACACCAAAACTTGGATCATGCTTAAGTAATCTGGGATATGATGAGACAGATCAGTTGTCCTTTTACGAAGCAATCTATCAAAAAAGATCGAACGTTAGAACAAGAAGGGTTAAAGTTGAAGAGGAAAATATTGGGTATGCACTAAAACAACAAAAGAACACCGAAAGTTCAACAGGGCCACAACTTCTGAGCATTATTCAGATTATCAAAAGAATGATTAAAAGCATAAGATACAAAAAAATTCTAATCTTGGGACTGCTATGTTCTCTTATCGCAGGCGCCACAAATCCCGTCTTTTCATACACATTCAGTTTCTTACTAGAAGGAATTGTCCCATCCACGGATGGAAAAACTGGCTCTTCACATTATTTGGCGAAATGGTCGCTTCTTGTTCTTGGTGTGGCTGCGGCAGATGGTATTTTCAATTTTGCTAAAGGATTCCTATTAGATTGCTGCAGTGAATACTGGGTTATGGATCTTAGAAATGAAGTTATGGAAAAACTGACGAGAAAGAATATGGACTGGTTTTCTGGTGAAAACAACAAGGCTTCTGAAATTTCTGCTCTAGTCTTGAATGATTTGCGAGATTTGAGGTCTTTGGTCTCTGAATTTTTGAGTGCAATGACTAGTTTCGTTACCGTATCAACGATTGGACTAATTTGGGCGTTAGTATCGGGCTGGAAGTTAAGTTTGGTTTGTATTTCGATGTTTCCACTCATAATTATATTTTCAGCAATATATGGAGGCATTTTACAAAAATGCGAAACAGATTATAAGACATCTGTTGCTCAGTTAGAAAACTGCCTGTACCAGATTGTCACTAACATTAAAACCATTAAGTGCTTACAAGCTGAATTTCATTTTCAATTGACCTACCATGACTTGAAGATAAAAATGCAACAAATTGCCTCCAAACGCGCCATTGCCACAGGATTTGGTATATCTATGACAAACATGATTGTCATGTGTATCCAAGCTATTATTTACTACTATGGCCTAAAGCTGGTTATGATTCACGAGTACACCTCAAAGGAAATGTTTACGACTTTCACTTTGTTATTATTCACTATTATGTCATGCACTAGCCTAGTAAGTCAGATACCCGATATAAGTAGAGGCCAACGTGCTGCCAGTTGGATCTATAGGATTCTTGATGAAAAGCATAATACCCTAGAGGTTGAAAACAATAATGCTAGAACAGTGGGAATAGCTGGTCACACCTACCATGGCAAAGAAAAAAAACCAATCGTTTCAATTCAAAATTTGACATTTGCCTATCCATCTGCACCTACCGCCTTTGTTTACAAAAACATGAATTTTGACATGTTTTGCGGACAGACGTTAGGTATCATTGGTGAATCAGGCACAGGAAAGTCTACACTTGTGCTTTTATTAACAAAACTTTATAATTGTGAAGTAGGCAAAATTAAAATAGACGGTACGGACGTAAATGACTGGAATTTGACAAGTTTAAGAAAAGAAATTTCAGTGGTTGAGCAAAAACCTTTATTATTCAATGGAACCATCAGAGATAACCTAACTTATGGTTTACAAGATGAAATACTTGAAATTGAAATGTATGATGCATTAAAATACGTAGGAATCCATGACTTTGTAATTTCATCACCTCAGGGCTTGGATACACGTATTGATACAACTTTACTGTCTGGTGGACAAGCGCAAAGGCTTTGCATAGCCAGAGCACTTCTGAGAAAATCAAAAATTCTGATTTTAGATGAGTGTACTTCAGCCTTGGATTCTGTCAGCTCCTCTATCATCAATGAGATCGTCAAAAAAGGTCCACCTGCTCTACTAACAATGGTTATAACGCATAGTGAACAAATGATGAGGTCTTGTAACTCGATTGCAGTTCTTAAAGATGGTAAAGTGGTTGAGCGAGGTAACTTCGACACTTTATATAATAATCGCGGGGAATTATTCCAAATTGTTTCCAACCAAAGCAGTTAA","protein_sequence":"MNFLSFKTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGRVFDLLSVFVANGSHQGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTTLLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNRGELFQIVSNQSS"},{"created_at":"2011-05-26T19:34:05.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Probable ribokinase","uniprot_id":"P25332","uniprot_name":"RBSK_YEAST","enzyme":true,"transporter":false,"gene_name":"RBK1","num_residues":333,"molecular_weight":"36923.80078","theoretical_pi":"4.93","general_function":"Involved in phosphotransferase activity, alcohol group as acceptor","specific_function":"ATP + D-ribose = ADP + D-ribose 5-phosphate","reactions":[{"id":1445,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1944,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2579,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + D-ribose = ADP + D-ribose 5-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X56909","genbank_protein_id":"4492","gene_card_id":"RBK1","chromosome_location":"chromosome 3","locus":"YCR036W","synonyms":[],"enzyme_classes":["2.7.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" ribokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" pentose metabolic process"},{"category":"Process","description":" D-ribose metabolic process"}],"pfams":[{"name":"PfkB","identifier":"PF00294"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"}],"gene_sequence":"ATGGGTATTACAGTAATAGGTTCTCTAAACTATGATTTGGACACATTTACGGATAGATTACCTAACGCTGGAGAAACTTTCAGGGCTAACCACTTCGAAACACATGCTGGTGGTAAGGGATTGAACCAAGCTGCGGCCATTGGTAAATTAAAAAACCCCAGCAGCAGATATAGTGTTCGAATGATTGGTAATGTTGGAAATGATACATTTGGTAAACAATTGAAGGACACTTTATCCGATTGCGGAGTCGATATCACTCACGTCGGTACTTACGAAGGCATTAATACGGGTACCGCTACCATATTAATTGAAGAGAAAGCTGGTGGCCAAAATAGGATATTGATTGTAGAAGGTGCTAACAGCAAGACTATTTATGACCCGAAACAGTTGTGTGAAATTTTTCCAGAGGGCAAGGAGGAAGAAGAGTATGTTGTTTTTCAACACGAAATTCCTGATCCTCTTTCCATTATTAAATGGATACATGCGAACAGGCCGAATTTTCAGATCGTATATAACCCCTCACCTTTCAAGACCATGCCTAAGAAAGATTGGGAGTTGGTAGACCTTTTGGTCGTTAATGAAATTGAGGGTCTTCAAATCGTGGAAAGTGTATTTGATAATGAACTTGTTGAAGAAATAAGGGAGAAGATAAAGGACGACTTTTTAGGAGAATATCGTAAAATTTGTGAGCTTTTGTATGAAAAACTCATGAATCGAAAGAAAAGAGGAATTGTGGTTATGACTTTGGGTTCGAGAGGGGTGCTTTTCTGTTCGCACGAAAGCCCTGAAGTACAATTCCTTCCGGCTATTCAAAATGTTTCGGTTGTTGATACTACAGGAGCTGGAGATACTTTCCTGGGCGGTTTGGTTACTCAATTGTATCAAGGAGAGACCTTGTCTATGGCTATAAAGTTCTCTACATTAGCTAGTTCATTGACCATTCAAAGAAAAGGTGCTGCTGAAAGCATGCCACTGTATAAAGATGTTCAGAAAGATGCATAA","protein_sequence":"MGITVIGSLNYDLDTFTDRLPNAGETFRANHFETHAGGKGLNQAAAIGKLKNPSSRYSVRMIGNVGNDTFGKQLKDTLSDCGVDITHVGTYEGINTGTATILIEEKAGGQNRILIVEGANSKTIYDPKQLCEIFPEGKEEEEYVVFQHEIPDPLSIIKWIHANRPNFQIVYNPSPFKAMPKKDWELVDLLVVNEIEGLQIVESVFDNELVEEIREKIKDDFLGEYRKICELLYEKLMNRKKRGIVVMTLGSRGVLFCSHESPEVQFLPAIQNVSVVDTTGAGDTFLGGLVTQLYQGETLSTAIKFSTLASSLTIQRKGAAESMPLYKDVQKDA"},{"created_at":"2011-05-26T19:38:14.000Z","updated_at":"2011-06-04T23:18:38.000Z","name":"Copper-transporting ATPase","uniprot_id":"P38995","uniprot_name":"ATU2_YEAST","enzyme":false,"transporter":true,"gene_name":"CCC2","num_residues":1004,"molecular_weight":"109828.0","theoretical_pi":"4.79","general_function":"Involved in nucleotide binding","specific_function":"Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles","reactions":[{"id":2583,"direction":"\u003e","locations":"Membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein","altext":"ATP + H(2)O + Cu(2+)(In) = ADP + phosphate + Cu(2+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"263-283;304-324;336-356;371-391;529-549;578-598;902-924;928-950","pdb_id":"1FVS","cellular_location":"Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein","genbank_gene_id":"L36317","genbank_protein_id":"538515","gene_card_id":"CCC2","chromosome_location":"chromosome 4","locus":"YDR270W","synonyms":["Cu(2+)-ATPase"],"enzyme_classes":["3.6.3.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" metal ion transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" di-, tri-valent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" copper ion transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" copper-transporting ATPase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" copper-exporting ATPase activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" metal ion transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"},{"name":"HMA","identifier":"PF00403"}],"pathways":[],"gene_sequence":"ATGAGAGAAGTGATACTTGCTGTACATGGAATGACATGCAGCGCCTGTACTAATACAATCAATACGCAGTTACGAGCTTTAAAGGGTGTAACAAAATGTGATATTAGTTTAGTGACTAATGAGTGCCAGGTGACATACGATAACGAGGTTACCGCCGATTCTATTAAGGAAATTATAGAGGATTGTGGATTTGACTGTGAGATACTAAGAGATTCTGAAATTACAGCCATAAGTACGAAGGAAGGACTACTGAGTGTACAAGGTATGACCTGTGGGTCTTGTGTTTCTACAGTCACCAAACAAGTGGAAGGCATTGAGGGTGTTGAATCGGTAGTCGTTTCCTTGGTAACGGAAGAGTGCCATGTTATTTATGAACCGTCCAAGACAACGCTAGAAACCGCCAGAGAAATGATTGAAGACTGTGGATTTGACTCAAATATTATTATGGATGGCAACGGGAATGCAGACATGACCGAAAAAACGGTGATCTTGAAAGTAACTAAGGCTTTCGAGGACGAATCCCCACTCATACTTTCTTCAGTAAGCGAAAGGTTTCAATTTTTGTTAGACCTAGGTGTAAAATCGATAGAAATTTCTGATGATATGCACACACTCACCATAAAATACTGTTGTAACGAACTCGGCATTAGAGATTTATTGAGGCACCTTGAGAGGACCGGATATAAATTCACTGTATTTTCCAATTTAGATAATACTACCCAGTTAAGGCTTCTCTCTAAAGAGGACGAGATAAGATTCTGGAAAAAAAACAGCATAAAATCCACCCTTTTGGCTATAATATGTATGCTATTGTATATGATTGTCCCTATGATGTGGCCAACAATTGTTCAGGACCGCATATTCCCTTACAAAGAAACCTCCTTTGTTAGAGGTCTGTTCTACAGAGATATTTTGGGTGTAATATTGGCAAGCTATATTCAGTTCAGCGTTGGTTTTTACTTTTACAAGGCAGCATGGGCATCTTTAAAGCACGGTTCAGGAACCATGGATACACTAGTTTGTGTTTCCACTACTTGTGCATACACATTTTCTGTGTTTTCTTTAGTTCACAATATGTTCCATCCCTCAAGTACTGGCAAACTCCCAAGGATCGTTTTCGACACATCAATCATGATCATTTCATATATTTCCATCGGGAAATATTTGGAAACTTTAGCTAAATCACAAACATCAACCGCACTTTCTAAATTAATTCAGCTCACTCCATCGGTGTGTTCAATTATATCTGACGTGGAGCGGAATGAAACCAAGGAAATTCCCATAGAATTATTGCAAGTGAACGATATAGTGGAGATTAAACCAGGGATGAAAATTCCTGCTGATGGCATCATAACAAGAGGTGAATCTGAAATTGACGAGTCGTTAATGACAGGCGAATCCATTTTGGTGCCCAAGAAAACTGGTTTTCCGGTTATTGCTGGTTCTGTTAATGGACCTGGACATTTCTACTTCAGAACTACTACCGTTGGGGAGGAAACTAAATTAGCAAATATTATCAAGGTAATGAAAGAAGCACAATTGAGTAAAGCTCCCATTCAGGGGTATGCAGATTATTTAGCCTCTATTTTTGTTCCGGGGATCCTAATTTTGGCAGTATTGACTTTCTTTATTTGGTGTTTTATTTTAAACATCTCGGCTAATCCTCCCGTCGCTTTCACCGCAAATACTAAGGCTGATAATTTTTTTATTTGCTTACAAACTGCTACTTCTGTTGTCATCGTCGCATGCCCATGTGCATTGGGACTTGCCACGCCGACTGCTATAATGGTGGGTACAGGGGTTGGAGCTCAGAATGGTGTCTTAATAAAGGGCGGAGAAGTATTGGAAAAATTCAATAGTATTACTACTTTTGTTTTTGATAAAACAGGTACCTTAACTACAGGTTTTATGGTTGTGAAAAAGTTCCTTAAAGATTCAAATTGGGTTGGAAACGTGGATGAAGACGAAGTTCTCGCCTGTATAAAAGCAACGGAATCCATTAGTGACCATCCAGTTTCGAAAGCAATTATACGTTATTGTGATGGTTTGAACTGTAATAAGGCTTTAAATGCCGTTGTTTTAGAAAGCGAATACGTGCTTGGAAAGGGAATAGTCTCAAAGTGTCAAGTTAATGGAAATACTTATGATATTTGTATTGGGAACGAGGCGCTGATTTTGGAGGATGCATTAAAAAAATCCGGATTTATTAACAGTAATGTCGACCAAGGAAACACTGTATCATACGTATCAGTAAACGGGCATGTGTTTGGCTTGTTCGAGATTAATGATGAAGTTAAACATGATTCTTACGCAACAGTTCAGTATCTACAAAGAAATGGATATGAAACGTATATGATTACTGGCGATAATAACTCAGCAGCAAAAAGAGTCGCTAGAGAAGTAGGTATAAGCTTCGAAAATGTTTACAGCGATGTGTCACCCACAGGCAAATGTGATCTCGTGAAAAAAATTCAAGATAAAGAAGGTAATAACAAGGTTGCTGTTGTTGGCGATGGCATTAACGACGCTCCCGCTTTAGCACTGAGTGATCTAGGTATTGCCATTTCAACAGGTACGGAGATTGCTATTGAAGCAGCTGATATTGTTATACTGTGCGGTAATGATCTGAATACTAATAGTTTGAGAGGACTGGCCAACGCCATCGATATTTCACTAAAAACGTTCAAAAGAATAAAGCTGAATTTGTTCTGGGCACTTTGCTATAATATATTCATGATTCCGATTGCTATGGGTGTGCTCATTCCTTGGGGCATAACTCTTCCTCCAATGCTCGCCGGTTTAGCGATGGCATTCAGCTCGGTCAGTGTCGTTCTAAGTTCATTGATGTTGAAGAAGTGGACTCCACCGGATATTGAATCACATGGGATTTCAGATTTCAAGTCCAAATTTTCGATTGGGAATTTTTGGTCAAGGCTTTTTTCTACGCGGGCTATTGCAGGTGAGCAAGACATAGAATCACAGGCCGGACTAATGTCAAACGAAGAAGTCTTGTAA","protein_sequence":"MREVILAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNEVTADSIKEIIEDCGFDCEILRDSEITAISTKEGLLSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQLRLLSKEDEIRFWKKNSIKSTLLAIICMLLYMIVPMMWPTIVQDRIFPYKETSFVRGLFYRDILGVILASYIQFSVGFYFYKAAWASLKHGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIVFDTSIMIISYISIGKYLETLAKSQTSTALSKLIQLTPSVCSIISDVERNETKEIPIELLQVNDIVEIKPGMKIPADGIITRGESEIDESLMTGESILVPKKTGFPVIAGSVNGPGHFYFRTTTVGEETKLANIIKVMKEAQLSKAPIQGYADYLASIFVPGILILAVLTFFIWCFILNISANPPVAFTANTKADNFFICLQTATSVVIVACPCALGLATPTAIMVGTGVGAQNGVLIKGGEVLEKFNSITTFVFDKTGTLTTGFMVVKKFLKDSNWVGNVDEDEVLACIKATESISDHPVSKAIIRYCDGLNCNKALNAVVLESEYVLGKGIVSKCQVNGNTYDICIGNEALILEDALKKSGFINSNVDQGNTVSYVSVNGHVFGLFEINDEVKHDSYATVQYLQRNGYETYMITGDNNSAAKRVAREVGISFENVYSDVSPTGKCDLVKKIQDKEGNNKVAVVGDGINDAPALALSDLGIAISTGTEIAIEAADIVILCGNDLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNIFMIPIAMGVLIPWGITLPPMLAGLAMAFSSVSVVLSSLMLKKWTPPDIESHGISDFKSKFSIGNFWSRLFSTRAIAGEQDIESQAGLMSNEEVL"},{"created_at":"2011-05-26T19:42:27.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 4","uniprot_id":"Q12246","uniprot_name":"LCB4_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB4","num_residues":624,"molecular_weight":"69638.60156","theoretical_pi":"6.39","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"Z75078","genbank_protein_id":"1420417","gene_card_id":"LCB4","chromosome_location":"chromosome 15","locus":"YOR171C","synonyms":["LCB kinase 4","Sphinganine kinase 4"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGGTGGTGCAGAAAAAACTTAGGGCTATCTTGACCGATGAAGGTGTATTGATCAAATCGCAATCACACCATATGTTCAATAAGCATGGTCAACTCAGAAGCGGAGATTCTTTATCCTTGTTGAGCTGCTTGTCCTGTCTGGATGATGGAACTTTGAGCTCTGATGGAGGTTCTTTTGATGAGGATGATTCCCTGGAACTGTTGCCTCTTAATACTACCATTCCGTTCAACAGAATTTTGAACGCAAAATATGTGAATGTCGGTCAGAAAGGCTTCAATAATGGCAAAATTTCTTCGAATCCTTTTCAAACGGAAAATCTGAGTTCTTCGTCTGAAAATGACGACGTTGAGAATCATAGTTTGAGCAATGATAAGGCTCCTGTAAGCGAATCACAGTCATTTCCCAAAAAAGACAAGTGGGATACAAAAACGAACACTGTGAAGGTGTCTCCCGATGATTCACAGGATAACTCACCATCTTTAGGGATAAAAGATAATCAACAGTTAATTGAGTTAACTTTTGCTGTACCCAAGGGCCATGATGTTATACCACAAAAATTAACCTTGTTAATAGATCACGTTTCTAGGAAATCGAGAGCAAATACCGGAGAGGAGAACATTTCTTCTGGTACTGTGGAAGAAATCCTGGAAAAAAGTTATGAAAATTCCAAGAGAAACAGATCGATATTAGTCATTATTAATCCCCACGGTGGTAAAGGTACTGCTAAAAATTTATTCCTGACAAAAGCAAGGCCAATACTAGTGGAAAGTGGCTGCAAAATAGAAATTGCATACACAAAATATGCCCGTCACGCCATCGATATTGCCAAAGATTTAGATATCAGCAAATACGATACCATTGCATGTGCCTCGGGTGATGGTATTCCATACGAAGTAATTAATGGGCTTTATAGAAGACCCGACAGAGTGGATGCGTTCAATAAACTAGCCGTAACTCAGCTACCTTGCGGTTCAGGAAATGCTATGAGCATTTCATGTCATTGGACAAATAACCCATCGTACGCCGCTCTGTGCCTTGTCAAATCCATTGAAACAAGAATAGACTTAATGTGTTGTTCCCAACCTTCTTATATGAACGAATGGCCAAGATTATCCTTTTTGAGTCAGACGTACGGCGTTATTGCAGAATCTGATATTAACACTGAATTCATCAGATGGATGGGTCCCGTTAGGTTTAATTTGGGTGTAGCATTCAACATTATCCAAGGTAAGAAATATCCCTGCGAAGTTTTCGTCAAATATGCTGCCAAATCTAAAAAGGAATTAAAAGTTCATTTCTTAGAAAATAAAGATAAAAACAAAGGATGTTTAACCTTCGAACCAAATCCTAGCCCAAACTCTTCGCCGGATTTACTATCTAAAAACAATATCAACAACAGTACAAAAGATGAACTTTCACCGAATTTTCTCAACGAGGACAACTTTAAATTAAAGTATCCGATGACGGAACCAGTACCTAGAGACTGGGAGAAAATGGATTCAGAGCTAACTGATAACTTAACAATCTTTTACACAGGGAAAATGCCGTATATTGCTAAGGACACCAAATTTTTTCCCGCTGCTTTACCAGCGGATGGTACCATTGATTTAGTCATAACGGATGCAAGAATCCCAGTGACAAGAATGACACCAATTTTATTATCCTTGGATAAAGGTTCTCATGTATTAGAGCCAGAAGTTATTCACTCAAAAATATTGGCTTATAAGATTATACCAAAAGTGGAGTCAGGTTTATTTTCAGTGGATGGTGAAAAGTTTCCTTTGGAACCCTTGCAAGTGGAAATAATGCCCATGTTATGCAAGACGTTGCTAAGGAATGGTAGATATATCGATACAGAGTTTGAATCCATGTAG","protein_sequence":"MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM"},{"created_at":"2011-05-26T19:49:11.000Z","updated_at":"2011-07-22T17:53:54.000Z","name":"Acetyl-CoA carboxylase, mitochondrial","uniprot_id":"P32874","uniprot_name":"HFA1_YEAST","enzyme":true,"transporter":false,"gene_name":"HFA1","num_residues":2273,"molecular_weight":"259161.0","theoretical_pi":"8.95","general_function":"Involved in acetyl-CoA carboxylase activity","specific_function":"Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase","reactions":[{"id":1239,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2586,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2587,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"D78165","genbank_protein_id":"2804173","gene_card_id":"HFA1","chromosome_location":"chromosome 13","locus":"YMR207C","synonyms":["ACC","Biotin carboxylase"],"enzyme_classes":["6.4.1.2","6.3.4.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" CoA carboxylase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" acetyl-CoA carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"ACC_central","identifier":"PF08326"},{"name":"Carboxyl_trans","identifier":"PF01039"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"}],"gene_sequence":"AAAGGGAAGACAATTACACACGGCCAAAGCTGGGGGGCTCGCCGGATACATTCTCACTTTTACATTACCATATTCACAATTACTTGCATTCGAATAGGACAGTACAAGCTCGCGTTATATTTGGATCCTTATCGATTCTATAATATAACGGGCAGCCAGATAGTACGGTTGAAAGGACAGCGCCCTGAATACAGAAAACGCATTTTTGCCCATTCGTATAGGCATTCATCTCGAATAGGTTTGAATTTTCCATCTAGAAGAAGGTATTCCAATTATGTGGATCGAGGCAATATTCATAAACATACTCGATTACCGCCCCAGTTCATAGGGCTAAATACTGTGGAAAGTGCCCAACCTTCAATATTAAGAGATTTTGTTGATTTACGTGGTGGACATACTGTTATTTCAAAGATCTTAATAGCAAACAATGGTATTGCTGCGGTGAAAGAAATGAGATCTATAAGAAAATGGGCGTACGAGACGTTCAATGATGAAAAAATCATTCAATTCGTGGTAATGGCGACACCTGATGATTTACACGCAAATTCGGAGTATATTAGAATGGCAGACCAATATGTGCAGGTACCAGGGGGTACCAACAACAACAATTACGCCAACATAGACTTAATACTGGACGTGGCAGAGCAAACGGATGTGGATGCGGTCTGGGCTGGATGGGGCCATGCTTCTGAAAATCCGTGTCTTCCTGAGCTGTTAGCTAGTTCACAAAGGAAAATACTATTCATTGGTCCTCCTGGGCGCGCTATGAGATCATTGGGTGACAAGATTTCTTCCACTATTGTAGCACAAAGCGCTAAAATCCCGTGTATCCCTTGGTCTGGTTCACATATAGACACTATCCATATCGATAACAAGACGAACTTTGTATCTGTGCCGGATGATGTATATGTAAGGGGATGTTGTTCCTCACCTGAAGATGCTTTAGAAAAGGCTAAATTAATAGGATTTCCTGTAATGATTAAGGCATCCGAAGGTGGTGGAGGTAAGGGCATTAGGCGAGTAGATAATGAGGATGATTTTATTGCATTATATCGCCAAGCAGTGAATGAGACACCTGGGTCGCCTATGTTTGTTATGAAAGTTGTCACTGATGCTCGTCACTTAGAGGTACAGTTATTAGCTGACCAATATGGCACTAACATTACATTGTTTGGGAGAGACTGTTCCATACAAAGGCGGCACCAAAAGATTATAGAAGAGGCACCAGTGACAATAACCAAGCCTGAAACGTTTCAAAGGATGGAACGCGCAGCAATTCGTCTAGGTGAATTGGTAGGTTATGTTTCTGCGGGCACTGTCGAATACTTATATTCACCAAAAGATGATAAATTTTACTTTTTAGAACTGAATCCGAGACTACAAGTAGAGCATCCAACGACAGAAATGATATCTGGCGTAAACCTTCCTGCCACTCAACTGCAAATCGCCATGGGCATTCCTATGCACATGATAAGTGATATCAGAAAACTTTATGGTTTAGATCCAACGGGAACTTCGTATATTGATTTTAAAAATTTAAAGAGACCCTCGCCAAAAGGCCATTGTATTTCATGCAGGATCACTTCAGAAGATCCTAATGAAGGTTTCAAGCCCTCCACTGGGAAAATACATGAGCTCAATTTTCGTTCTTCTTCCAATGTTTGGGGTTACTTCTCAGTAGGAAATAATGGTGCTATTCACTCATTTTCAGATTCCCAATTTGGGCACATTTTTGCTGTAGGAAACGATAGGCAAGATGCAAAGCAAAACATGGTTTTAGCTCTAAAAGATTTTTCCATCCGAGGAGAATTCAAAACCCCCATAGAGTACCTGATAGAGCTATTAGAAACTCGGGACTTTGAGAGTAATAACATATCGACTGGTTGGTTAGATGATTTGATTTTGAAAAATTTATCTTCCGATAGCAAACTAGATCCAACGCTCGCTATTATCTGTGGTGCCGCAATGAAAGCATACGTTTTCACAGAAAAGGTGAGGAATAAGTATTTGGAATTATTGCGGAGGGGCCAAGTTCCACCTAAAGATTTTCTTAAAACGAAGTTTCCTGTTGACTTCATTTTCGATAATAATAGATACTTGTTCAATGTTGCTCAATCATCTGAAGAACAATTTATTCTTTCTATCAATAAGTCTCAATGTGAAGTTAATGTTCAAAAATTGTCCAGTGACTGCTTGTTGATCTCCGTTGACGGTAAATGCCATACAGTTTATTGGAAGGACGATATCAGAGGTACAAGACTTTCGATAGACTCCAATACCATATTTTTAGAAGCTGAACTCAATCCCACTCAAGTGATCTCTCCAACTCCGGGGAAATTGGTGAAATATTTGGTCCGAAGTGGTGATCACGTTTTTGCTGGACAGCAATATGCAGAAATAGAAATAATGAAAATGCAGATGCCACTAGTAGCGAAAAGTGATGGTGTAATTGAGTTACTAAGACAGCCCGGTTCCATAATTGAGGCTGGTGATGTCATCGCAAAATTGACTTTGGATTCGCCGTCCAAAGCTAACGAATCGTCTTTATACCGCGGAGAATTACCTGTTTTAGGTCCACCGCTAATAGAGGGTAGCCGACCAAACCATAAGCTCAGAGTCTTAATAAATAGGTTAGAAAATATTCTCAATGGATATCATGAAAACTCTGGAATAGAAACTACTCTAAAAGAGTTGATAAAAATATTGAGAGATGGTAGGCTTCCTTATTCAGAATGGGATTCCCAAATTTCTACGGTACGCAATAGACTACCAAGGCAATTGAATGAGGGGCTGGGAAATCTAGTCAAGAAATCTGTTTCTTTTCCTGCAAAGGAACTGCACAAATTAATGAAGCGCTACTTGGAAGAAAATACAAATGATCATGTAGTTTATGTTGCCTTACAGCCACTTCTTAAAATTAGTGAAAGGTATAGCGAAGGTTTAGCTAATCACGAATGTGAAATTTTTTTAAAGTTGATTAAAAAGTACTATGCTGTTGAGAAAATTTTTGAAAATCATGATATACATGAAGAAAGAAACTTACTAAATCTGCGGAGGAAAGACCTTACAAACTTAAAAGAAATTTTGTGCATAAGTTTATCGCATGCTAACGTAGTCGCAAAGAACAAGTTAGTAACTGCAATATTGCATGAATACGAGCCATTGTGCCAGGATTCCTCTAAGATGTCTTTAAAATTCAGGGCTGTTATACATGATTTGGCAAGTTTGGAATCTAAGTGGGCTAAAGAGGTTGCTGTAAAGGCAAGATCAGTGCTACTCAGAGGGATTTTCCCTCCCATAAAGAAAAGAAAAGAGCATATTAAAACTCTCCTGCAATTGCACATAAAGGATACTGGTGCCGAAAACATTCACAGCAGGAACATATATTCCTGTATGAGGGATTTTGGTAATTTAATACATTCAAATCTGATACAACTTCAGGATTTGTTCTTTTTTTTTGGCCATCAAGATACGGCTCTTTCCAGTATAGCATCTGAAATTTATGCAAGGTATGCCTACGGCAATTATCAATTAAAAAGTATTAAGATTCATAAAGGAGCGCCTGATTTACTAATGTCATGGCAATTCAGCTCATTAAGAAATTATTTAGTCAATTCTGATGGTGAGAGTGATGAGTTTACAAAACTTTCTAAACCTCCCTCAACATCAGGTAAGAGCTCAGCAAATAGTTTTGGTCTTCTTGTCAACATGCGTGCGCTTGAATCTCTGGAAAAGACATTAGACGAGGTATACGAACAAATTCATATTCCTGAGGAAAGACTTTCCAGCGGAGAGAACTCTCTTATTGTTAATATTTTATCTCCTATTCGTTACAGAAGTGAAAATGATCTAATTAAAACTTTAAAAATTAAACTTCATGAAAATGAGAGAGGTCTATCCAAGCTCAAGGTTAATCGTATTACATTTGCATTTATCGCCGCGAATGCGCCCGCTGTTAAATTTTACTCCTTTGATGGAACTACGTACGATGAAATCTCTCAAATAAGAAATATGGATCCATCCTATGAAGCACCGTTAGAGTTAGGAAAAATGTCGAACTATAAAATCAGATCACTACCTACATACGATAGTAGTATACGCATTTTTGAAGGTATTAGCAAATTTACGCCGCTAGATAAAAGGTTCTTTGTCAGGAAAATCATAAATTCCTTCATGTATAATGATCAAAAAACAACCGAAGAAAACTTGAAAGCGGAAATCAATGCTCAAGTGGTTTATATGTTAGAACATCTAGGAGCAGTTGACATCTCAAATTCAGACTTGAATCATATTTTTTTAAGTTTCAATACAGTTCTTAACATACCAGTACATCGTCTCGAGGAAATTGTGAGTACAATTCTAAAGACTCACGAAACCAGATTGTTTCAAGAAAGAATCACAGATGTAGAAATTTGCATCTCTGTTGAGTGCCTAGAAACAAAGAAGCCAGCCCCGCTTAGATTACTTATTTCTAATAAATCTGGGTATGTGGTAAAAATTGAGACATATTACGAAAAGATAGGGAAAAATGGGAATCTGATTTTGGAACCGTGTAGTGAGCAGAGCCATTATAGCCAGAAATCTCTCTCTCTTCCTTACTCGGTCAAGGATTGGCTACAACCTAAAAGGTACAAAGCTCAATTCATGGGTACAACATATGTGTACGATTTCCCAGGTCTGTTTCATCAAGCTGCAATCCAACAGTGGAAAAGGTATTTTCCAAAACATAAGCTGAATGACAGTTTTTTTAGTTGGGTTGAATTGATAGAACAAAACGGTAATTTAATAAAAGTAAACAGGGAGCCAGGCCTTAATAATATAGGGATGGTTGCTTTTGAGATTATGGTTCAGACACCTGAATATCCTGAAGGGCGTAACATGATCGTGATTTCTAATGATATTACCTACAATATTGGATCTTTTGGACCGAGAGAAGATTTGTTTTTTGATAGGGTCACAAATTATGCAAGAGAGAGAGGGATCCCGAGGATATACTTGGCGGCGAATTCAGGAGCTAAATTGGGTATAGCCGAAGAGCTGATCCCTCTATTTCGTGTAGCATGGAATGACCCCTCTGATCCAACAAAGGGTTTCCAGTACTTATACTTAGCTCCAAAAGACATGCAGCTACTGAAAGATTCTGGGAAAGGAAATTCGGTTGTTGTTGAACACAAGATGGTATACGGTGAAGAGAGATATATTATTAAAGCAATAGTCGGATTCGAAGAGGGTTTAGGTGTTGAATGTTTACAGGGCTCGGGTTTAATTGCTGGTGCCACTTCGAAAGCGTATAGAGACATTTTCACTATTACTGCTGTTACTTGTCGGTCCGTTGGTATAGGTTCCTATCTGGTCAGACTAGGACAACGTACTATTCAGGTGGAGGATAAGCCTATCATACTGACGGGTGCATCGGCGATTAATAAAGTTTTGGGTACCGATATCTATACATCTAACCTACAAATTGGCGGAACCCAAATCATGTATAAAAACGGAATAGCGCATTTAACAGCCAGTAATGATATGAAAGCCATCGAAAAAATAATGACATGGTTATCATATGTCCCGGCGAAAAGAGATATGAGTCCTCCACTTCTTGAAACTATGGATAGATGGGATAGGGATGTAGACTTCAAACCTGCCAAGCAAGTGCCATATGAGGCAAGGTGGTTGATAGAGGGTAAATGGGACTCAAATAACAACTTCCAGTCAGGCCTATTTGATAAGGATTCGTTTTTTGAGACATTATCTGGATGGGCCAAAGGTGTAATAGTTGGAAGAGCACGTCTTGGAGGTATTCCCGTGGGTGTTATTGCGGTAGAAACTAAGACTATCGAAGAAATAATCCCCGCTGACCCAGCTAATCTGGATTCTTCAGAGTTTTCCGTTAAAGAAGCAGGACAGGTGTGGTATCCAAATTCCGCGTTCAAAACAGCTCAAACTATAAATGATTTTAACTATGGTGAGCAATTACCATTGATTATCTTAGCCAATTGGAGGGGATTTTCTGGCGGTCAAAGGGATATGTACAATGAAGTACTAAAGTACGGGTCTTTTATTGTTGACGCTCTGGTTGACTACAAACAACCCATACTGATATACATTCCGCCCTTTGGTGAATTAAGGGGCGGATCATGGGTTGTTATAGATCCAACTATTAATCCTGAACAAATGGAAATGTATGCCGATGTTGAATCTAGGGGAGGTGTGTTAGAACCTGACGGAGTAGTTAGCATAAAATACCGTAAGGAGAAAATGATAGAGACGATGATTCGATTAGACTCCACATATGGACATTTGAGAAGAACGTTGACAGAAAAAAAGTTATCTTTGGAAAAACAAAATGATCTTACGAAGAGATTGAAAATAAGAGAGAGACAGTTGATACCAATTTACAATCAAATCAGCATACAGTTTGCAGATTTACATGATAGATCGACTAGGATGCTAGTTAAAGGAGTAATCCGAAATGAGTTGGAATGGAAAAAGTCACGCAGATTTTTATATTGGAGACTGAGAAGGAGGTTGAACGAGGGACAAGTGATCAAAAGACTGCAAAAAAAAACATGTGATAACAAAACGAAAATGAAGTACGACGACCTGTTGAAAATAGTTCAGTCATGGTATAACGATCTGGATGTTAATGATGACAGAGCAGTAGTGGAGTTCATAGAAAGAAATTCGAAAAAAATTGACAAGAACATTGAAGAGTTTGAGATCTCGCTGTTGATCGATGAGCTTAAGAAAAAATTTGAAGACAGAAGGGGAAACATTGTCCTTGAAGAGCTAACTAGGTTGGTGGACAGTAAGCGAAAGAGATAG","protein_sequence":"KGKTITHGQSWGARRIHSHFYITIFTITCIRIGQYKLALYLDPYRFYNITGSQIVRLKGQRPEYRKRIFAHSYRHSSRIGLNFPSRRRYSNYVDRGNIHKHTRLPPQFIGLNTVESAQPSILRDFVDLRGGHTVISKILIANNGIAAVKEMRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQVPGGTNNNNYANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNEDDFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGKIHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEFKTPIEYLIELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKAYVFTEKVRNKYLELLRRGQVPPKDFLKTKFPVDFIFDNNRYLFNVAQSSEEQFILSINKSQCEVNVQKLSSDCLLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVISPTPGKLVKYLVRSGDHVFAGQQYAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDVIAKLTLDSPSKANESSLYRGELPVLGPPLIEGSRPNHKLRVLINRLENILNGYHENSGIETTLKELIKILRDGRLPYSEWDSQISTVRNRLPRQLNEGLGNLVKKSVSFPAKELHKLMKRYLEENTNDHVVYVALQPLLKISERYSEGLANHECEIFLKLIKKYYAVEKIFENHDIHEERNLLNLRRKDLTNLKKILCISLSHANVVAKNKLVTAILHEYEPLCQDSSKMSLKFRAVIHDLASLESKWAKEVAVKARSVLLRGIFPPIKKRKEHIKTLLQLHIKDTGAENIHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSIASEIYARYAYGNYQLKSIKIHKGAPDLLMSWQFSSLRNYLVNSDGESDEFTKLSKPPSTSGKSSANSFGLLVNMRALESLEKTLDEVYEQIHIPEERLSSGENSLIVNILSPIRYRSENDLIKTLKIKLHENERGLSKLKVNRITFAFIAANAPAVKFYSFDGTTYDEISQIRNMDPSYEAPLELGKMSNYKIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVVYMLEHLGAVDISNSDLNHIFLSFNTVLNIPVHRLEEIVSTILKTHETRLFQERITDVEICISVECLETKKPAPLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKSLSLPYSVKDWLQPKRYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLNDSFFSWVELIEQNGNLIKVNREPGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERGIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLYLAPKDMQLLKDSGKGNSVVVEHKMVYGEERYIIKAIVGFEEGLGVECLQGSGLIAGATSKAYRDIFTITAVTCRSVGIGSYLVRLGQRTIQVEDKPIILTGASAINKVLGTDIYTSNLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDMSPPLLETMDRWDRDVDFKPAKQVPYEARWLIEGKWDSNNNFQSGLFDKDSFFETLSGWAKGVIVGRARLGGIPVGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGEQLPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVIDPTINPEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKKLSLEKQNDLTKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRRFLYWRLRRRLNEGQVIKRLQKKTCDNKTKMKYDDLLKIVQSWYNDLDVNDDRAVVEFIERNSKKIDKNIEEFEISLLIDELKKKFEDRRGNIVLEELTRLVDSKRKR"},{"created_at":"2011-05-26T19:54:39.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 5","uniprot_id":"Q06147","uniprot_name":"LCB5_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB5","num_residues":687,"molecular_weight":"77564.60156","theoretical_pi":"6.86","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"U17244","genbank_protein_id":"577178","gene_card_id":"LCB5","chromosome_location":"chromosome 12","locus":"YLR260W","synonyms":["LCB kinase 5","Sphinganine kinase 5"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACTTTGAAACCTTCAAAGAGACGTAAGGGCAGGTCTCGCCATTCCAGGAAGAAGCAAATAACGTCAGCGATACTGACTGAGGAAGGAATAATGATCAAGGCAAAACCATCAAGTCCTTACACATACGCAAATAGAATGGCAGATAAACGAAGTCGCAGCAGCATTGACAACATCAGTAGAACTAGCTTTCAAAGCAACATCAGTAGAACTAGCTTTCAAAGCAACAGTGATAACAACAGTATATTTGAAACGGCTTCACTAATTAGCTGTGTTACCTGTTTAAGCGATACTGATACAATAGACAGATCGGAAACATCGACAACGGATACAAGTAAAGATGATCTTTCTGCTAATCCAAAACTTCATTATCCTTCGGTGAATGGTCAATTGCCAGCAAACACCGTTATCCCCTATGGACGAATTCTGGATGCCAGATACATTGAAAAGGAACCTCTGCATTATTATGATGCCAATTCATCACCCAGTTCACCTTTAAGCAGCTCAATGAGTAACATTAGTGAAAAGTGTGATCTTGATGAATTAGAGTCTTCCCAAAAAAAAGAAAGGAAGGGCAACTCGCTATCGCGAGGAAGTAACAGTAGTAGTAGCCTCCTGACTTCCAGATCTCCTTTTACGAAACTAGTAGAGGTTATATTTGCTAGGCCAAGACGGCATGACGTTGTACCCAAAAGGGTTTCATTGTATATTGACTATAAACCCCATTCATCTTCTCACTTAAAAGAAGAAGATGACTTGGTTGAGGAGATTTTAAAGAGAAGCTACAAAAACACTAGAAGGAACAAATCCATATTTGTGATCATTAATCCGTTTGGTGGTAAAGGTAAGGCGAAAAAACTGTTTATGACAAAGGCAAAGCCGTTACTATTAGCAAGTCGGTGTTCCATAGAAGTGGTTTATACAAAATACCCTGGTCATGCTATAGAGATCGCGCGGGAAATGGATATTGACAAATATGACACTATTGCTTGCGCTTCGGGAGATGGCATTCCTCATGAGGTGATCAATGGGTTATACCAAAGGCCTGATCATGTCAAAGCATTCAACAATATCGCCATTACAGAAATTCCATGCGGATCAGGTAACGCAATGAGCGTATCCTGCCACTGGACAAACAATCCTTCGTACTCAACTTTATGCTTAATTAAATCGATAGAGACTAGAATTGATTTGATGTGTTGTTCGCAGCCTTCTTATGCAAGAGAGCACCCAAAGTTATCATTTTTAAGTCAAACATATGGTCTCATTGCAGAAACTGACATAAACACTGAATTTATTAGATGGATGGGACCTGCAAGGTTTGAATTGGGTGTAGCCTTCAATATCATACAAAAAAAAAAATATCCTTGTGAGATATATGTAAAGTATGCTGCCAAATCAAAAAACGAGTTAAAAAATCATTACCTGGAACACAAAAATAAAGGGTCGTTAGAATTCCAGCATATTACTATGAACAAAGATAACGAGGATTGTGATAATTACAATTACGAAAATGAATACGAAACCGAAAACGAAGATGAAGATGAAGATGCGGATGCGGATGACGAAGACTCCCACTTGATATCTCGTGATCTGGCAGATTCTAGTGCTGATCAAATTAAAGAGGAAGATTTCAAAATAAAATATCCATTAGATGAAGGTATCCCTAGTGACTGGGAAAGATTGGATCCTAATATTTCGAACAACCTAGGTATCTTCTATACGGGTAAAATGCCATATGTGGCTGCTGACACTAAATTCTTTCCGGCAGCGCTTCCTTCAGATGGTACAATGGATATGGTTATCACCGATGCAAGAACCTCGTTGACGAGGATGGCACCAATCCTGCTGGGACTAGATAAGGGTTCCCATGTTTTACAACCGGAAGTCTTACACTCTAAAATTTTGGCATACAAGATAATACCAAAGCTAGGGAACGGCTTGTTCTCTGTCGATGGCGAGAAATTTCCTCTAGAGCCCCTTCAAGTCGAAATTATGCCACGCTTATGCAAGACGTTACTGAGAAATGGCCGTTATGTGGACACAGATTTCGATTCTATGTGA","protein_sequence":"MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM"},{"created_at":"2011-05-26T19:59:05.000Z","updated_at":"2011-06-04T23:25:51.000Z","name":"Calcium-transporting ATPase 1","uniprot_id":"P13586","uniprot_name":"ATC1_YEAST","enzyme":false,"transporter":true,"gene_name":"PMR1","num_residues":950,"molecular_weight":"104570.0","theoretical_pi":"5.36","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway","reactions":[{"id":2588,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"93-111;117-133;289-309;324-344;815-835;845-862;885-905;910-930","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"M25488","genbank_protein_id":"172199","gene_card_id":"PMR1","chromosome_location":"chromosome 7","locus":"YGL167C","synonyms":["Bypass SOD defects protein 1","Golgi Ca(2+)-ATPase"],"enzyme_classes":["3.6.3.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" di-, tri-valent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" calcium ion transmembrane transporter activity"},{"category":"Function","description":" calcium-transporting ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" di-, tri-valent inorganic cation transport"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" divalent metal ion transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" calcium ion transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic 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cation-transporting ATPase 1","uniprot_id":"P39986","uniprot_name":"ATC6_YEAST","enzyme":false,"transporter":true,"gene_name":"SPF1","num_residues":1215,"molecular_weight":"135267.0","theoretical_pi":"6.56","general_function":"Involved in nucleotide binding","specific_function":"ATP + H(2)O = ADP + phosphate","reactions":[{"id":2589,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein","altext":"ATP + H(2)O = ADP + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"22-43;50-72;192-214;218-236;400-419;433-454;994-1013;1021-1037;1056-1079;1100-1122;1134-1153;1171-1193","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U18530","genbank_protein_id":"602398","gene_card_id":"SPF1","chromosome_location":"chromosome 5","locus":"YEL031W","synonyms":[],"enzyme_classes":["3.6.3.-"],"go_classes":[{"category":"Component","description":" cell 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substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGACAAAGAAATCATTTGTGAGCAGTCCTATTGTTAGGGACTCGACATTGCTGGTACCAAAGTCATTAATAGCAAAGCCGTACGTATTACCGTTTTTCCCGTTATACGCTACCTTTGCCCAACTATATTTCCAGCAATATGATCGTTACATCAAAGGACCTGAGTGGACTTTTGTCTACTTGGGGACATTGGTATCCTTGAACATCCTAGTCATGTTAATGCCTGCTTGGAATGTCAAGATCAAGGCGAAATTCAACTACAGTACTACTAAAAATGTCAATGAAGCTACTCACATTCTCATCTACACCACTCCAAATAATGGTTCTGATGGTATCGTTGAAATTCAGAGAGTAACTGAAGCGGGCTCTTTGCAGACTTTTTTCCAATTTCAAAAGAAAAGATTCTTGTGGCATGAAAATGAGCAGGTATTTTCTTCACCAAAGTTCCTTGTTGATGAATCCCCAAAGATCGGTGATTTCCAAAAATGTAAGGGCCATTCCGGTGACCTAACTCATTTGAAGAGACTATATGGTGAGAATAGTTTTGATATTCCTATTCCAACATTTATGGAATTATTCAAAGAGCACGCTGTTGCGCCATTGTTTGTTTTCCAAGTTTTCTGTGTTGCCTTATGGCTATTGGATGAGTTCTGGTATTATTCTTTGTTTAACTTATTCATGATTATCTCCATGGAGGCAGCTGCAGTATTTCAAAGATTAACTGCCTTGAAGGAATTTAGAACTATGGGTATCAAACCTTATACCATTAACGTGTTTAGAAACAAAAAATGGGTAGCATTGCAAACCAATGAATTGTTACCTATGGATTTAGTGTCTATAACAAGAACCGCCGAGGAGAGCGCAATTCCTTGCGATTTGATCTTGCTCGATGGCTCCGCTATTGTTAATGAAGCAATGCTTTCAGGTGAATCTACTCCCTTGTTAAAGGAATCCATTAAATTACGTCCTAGTGAAGATAATTTACAACTGGACGGTGTTGACAAGATTGCTGTGTTACATGGTGGTACAAAGGCATTACAAGTAACACCTCCTGAACATAAATCGGATATCCCTCCTCCACCTGATGGAGGTGCCTTAGCCATCGTCACCAAAACTGGCTTTGAAACATCTCAGGGTTCTTTAGTTCGAGTTATGATTTACTCCGCTGAACGTGTTTCCGTCGATAATAAGGAAGCGTTGATGTTCATTCTTTTCTTGTTGATTTTCGCTGTTATTGCATCCTGGTACGTTTGGGTTGAGGGTACAAAAATGGGTAGAATTCAATCCAAATTGATCTTGGACTGTATATTAATTATTACATCTGTTGTTCCTCCTGAGTTACCAATGGAATTGACCATGGCTGTCAACAGTTCTCTGGCCGCCCTTGCCAAGTTCTATGTCTATTGTACTGAACCATTTAGAATTCCATTTGCTGGTAGAATTGATGTTTGTTGTTTCGATAAAACTGGTACTTTGACCGGCGAAGATCTTGTGTTTGAAGGTCTAGCTGGTATCTCTGCGGACTCCGAAAACATTCGTCACTTGTACAGCGCTGCCGAAGCACCAGAAAGTACAATTCTTGTCATTGGTGCTGCTCACGCTTTAGTTAAATTGGAAGATGGTGATATTGTTGGTGACCCAATGGAAAAGGCGACCTTAAAGGCTGTTGGTTGGGCTGTCGAAAGAAAAAACAGTAACTATAGAGAGGGCACCGGAAAATTGGATATTATCCGTAGATTTCAATTTTCTTCTGCTTTAAAAAGGTCTGCTTCTATTGCTTCTCACAACGATGCCTTGTTTGCTGCTGTCAAAGGTGCACCTGAAACGATTCGTGAAAGGCTTTCTGACATTCCCAAGAATTATGACGAAATCTATAAATCCTTTACACGCTCTGGTTCAAGAGTTTTGGCTTTGGCTTCTAAGTCGTTGCCAAAAATGTCTCAGTCTAAAATTGATGATCTAAACCGTGATGATGTTGAATCTGAATTAACCTTTAATGGGTTTTTGATTTTCCATTGTCCTCTGAAGGATGACGCTATTGAAACCATTAAAATGTTAAATGAATCCTCCCATCGTTCTATTATGATTACTGGTGATAATCCATTAACTGCTGTTCATGTGGCTAAAGAAGTTGGCATAGTTTTTGGCGAAACTTTAATCTTAGACAGAGCAGGTAAATCTGACGACAATCAGTTGCTGTTCCGTGATGTTGAAGAGACAGTTTCCATCCCATTTGATCCATCAAAAGACACTTTTGATCATTCTAAATTATTTGATAGATATGATATTGCTGTTACTGGATATGCTTTGAATGCCTTGGAAGGGCATTCTCAATTAAGGGATCTATTACGTCACACCTGGGTTTACGCACGTGTTTCACCATCCCAAAAGGAGTTCTTGCTGAATACACTAAAGGATATGGGATATCAAACTTTAATGTGCGGTGATGGTACTAATGATGTTGGTGCTTTGAAACAAGCTCATGTTGGTATTGCATTGTTGAATGGTACCGAAGAAGGTTTGAAAAAATTGGGTGAACAACGCAGATTGGAAGGTATGAAAATGATGTATATAAAGCAAACTGAATTTATGGCTAGATGGAATCAACCACAGCCACCTGTTCCTGAACCGATTGCACACTTATTCCCACCTGGTCCAAAAAATCCTCATTATCTGAAAGCTTTAGAAAGCAAAGGTACCGTCATTACGCCAGAAATCAGAAAAGCAGTTGAAGAAGCAAATTCCAAACCTGTTGAAGTCATCAAACCAAATGGACTATCGGAAAAAAAACCTGCTGACTTAGCTTCTTTGTTGTTGAACTCTGCTGGTGATGCCCAAGGTGATGAAGCACCAGCTCTAAAGTTAGGAGATGCATCTTGCGCTGCCCCTTTTACCTCGAAACTGGCCAATGTTTCTGCTGTTACTAACATTATACGTCAAGGCCGTTGTGCTTTAGTTAACACAATTCAAATGTACAAAATCTTGGCCTTGAATTGTTTAATCAGTGCCTACTCTTTGTCCATCATTTACATGGCTGGTGTCAAATTTGGTGATGGTCAAGCCACTGTCTCCGGTTTGTTACTATCGGTTTGTTTCTTGAGTATTTCCCGTGGTAAACCTTTAGAAAAACTATCCAAGCAAAGGCCACAGTCCGGAATTTTCAATGTTTACATTATGGGATCTATTTTGTCTCAATTTGCCGTTCATATTGCCACTTTAGTTTACATCACTACAGAGATTTATAAATTGGAACCCAGAGAGCCACAAGTTGATCTTGAAAAGGAATTTGCTCCATCATTATTGAATACGGGTATTTTCATCATTCAGTTGGTACAACAAGTCTCTACATTTGCTGTCAATTATCAAGGTGAGCCATTCAGAGAAAACATTAGGAGTAACAAAGGTATGTATTATGGTTTATTGGGTGTGACAGGTTTGGCACTTGCAAGTGCTACTGAATTTTTACCTGAGCTAAACGAAGCCATGAAGTTTGTGCCAATGACTGATGACTTTAAGATTAAGTTGACCCTAACATTATTGCTCGATTTCTTTGGTAGTTGGGGTGTCGAGCATTTTTTCAAGTTTTTCTTCATGGACGACAAACCATCAGACATTTCTGTGCAACAGGTCAAGATTGCCTCTAAATGA","protein_sequence":"MTKKSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFQQYDRYIKGPEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKMSQSKIDDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGMKMMYIKQTEFMARWNQPQPPVPEPIAHLFPPGPKNPHYLKALESKGTVITPEIRKAVEEANSKPVEVIKPNGLSEKKPADLASLLLNSAGDAQGDEAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVKIASK"},{"created_at":"2011-05-26T20:14:27.000Z","updated_at":"2011-05-27T15:01:08.000Z","name":"Phosphatidylinositol 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Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.","genbank_gene_id":"X85021","genbank_protein_id":"728710","gene_card_id":"LSB6","chromosome_location":"chromosome 10","locus":"YJL100W","synonyms":["PI4-kinase","PtdIns-4-kinase","LAS seventeen-binding protein 6","LAS17-binding protein 6"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"}],"pathways":[{"name":"Inositol phosphate 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adenosine-5'-phosphosulfate 3'-phosphotransferase","Adenosine-5'-phosphosulfate kinase","APS kinase"],"enzyme_classes":["2.7.1.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic 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kinase BUD16","uniprot_id":"P39988","uniprot_name":"BUD16_YEAST","enzyme":true,"transporter":false,"gene_name":"BUD16","num_residues":312,"molecular_weight":"35558.89844","theoretical_pi":"6.51","general_function":"Involved in pyridoxal kinase activity","specific_function":"Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Important for bud site selection","reactions":[{"id":2592,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18530","genbank_protein_id":"602396","gene_card_id":"BUD16","chromosome_location":"chromosome 5","locus":"YEL029C","synonyms":["Bud site selection protein 16"],"enzyme_classes":["2.7.1.35"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" pyridoxal kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" vitamin B6 metabolic 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kinase","uniprot_id":"P21373","uniprot_name":"UTR1_YEAST","enzyme":true,"transporter":false,"gene_name":"UTR1","num_residues":530,"molecular_weight":"59468.69922","theoretical_pi":"7.18","general_function":"Involved in NAD+ kinase activity","specific_function":"Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors","reactions":[{"id":1760,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1765,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2593,"direction":"\u003e","locations":null,"altext":"ATP + NAD(+) = ADP + NADP(+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB044344","genbank_protein_id":"18181874","gene_card_id":"UTR1","chromosome_location":"chromosome 10","locus":"YJR049C","synonyms":["Unknown transcript 1 protein"],"enzyme_classes":["2.7.1.23"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" NAD+ kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"NAD_kinase","identifier":"PF01513"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGAAGGAGAATGACATGAATAATGGCGTAGATAAATGGGTAAATGAGGAAGATGGTCGAAATGATCATCATAACAACAATAATAACTTGATGAAGAAGGCCATGATGAACAATGAGCAAATTGATAGAACTCAGGATATCGACAACGCCAAAGAAATGTTGAGGAAAATATCAAGTGAAAGCAGCTCGCGCAGAAGCTCCCTGTTGAATAAAGATTCATCTCTCGTGAACGGCAATGCAAACAGTGGCGGTGGTACGAGCATTAACGGAACAAGAGGAAGTTCTAAGAGTAGTAATACACACTTTCAGTATGCCTCCACGGCGTATGGTGTAAGAATGTTGAGTAAAGATATATCTAATACCAAAGTGGAACTGGATGTGGAAAATTTGATGATTGTTACGAAACTCAACGATGTCTCACTGTATTTCTTAACAAGAGAGTTGGTAGAATGGGTTTTGGTACATTTTCCACGTGTGACTGTTTATGTGGATTCCGAATTGAAAAACAGCAAAAAATTTGCCGCTGGCGAGTTATGTGAAGATAGTAAATGTAGAGAATCAAGGATCAAGTATTGGACAAAGGATTTCATCAGGGAACATGATGTTTTCTTCGATTTGGTAGTGACTTTGGGTGGCGACGGTACTGTTCTTTTTGTAAGTTCCATTTTTCAGAGACATGTACCACCCGTTATGTCGTTTTCATTAGGGTCTCTAGGATTTTTAACAAATTTTAAGTTTGAACATTTCAGGGAGGATTTACCTCGGATTATGAATCATAAAATCAAGACAAATTTACGGTTGAGGTTGGAGTGCACAATTTATCGTAGACACCGCCCTGAAGTAGACCCAAACACGGGGAAGAAAATATGTGTGGTGGAAAAACTAAGCACACACCACATTTTGAACGAAGTGACCATCGATCGTGGTCCAAGTCCTTTTCTATCCATGTTAGAATTGTATGGTGACGGCTCATTAATGACCGTTGCGCAGGCGGACGGACTGATTGCTGCTACTCCGACTGGGTCCACGGCCTATTCTTTGAGTGCAGGTGGGTCATTGGTATGCCCAACCGTCAATGCAATCGCTTTAACACCCATTTGTCCACATGCATTGAGTTTCAGACCCATCATCTTACCAGAAAGTATAAATTTAAAAGTGAAAGTCTCGATGAAGTCAAGGGCTCCAGCATGGGCGGCTTTTGATGGGAAAGATAGAATTGAATTGCAAAAAGGTGATTTTATAACCATATGCGCCAGCCCATATGCTTTTCCAACCGTGGAAGCCTCGCCCGATGAGTTTATTAACAGTATCAGTCGACAACTAAACTGGAATGTGAGGGAACAACAAAAGTCCTTTACGCATATTTTGTCCCAAAAGAACCAAGAAAAATATGCACATGAGGCGAACAAAGTCAGAAATCAAGCAGAACCTTTAGAGGTAATAAGAGATAAATACTCTCTGGAAGCAGACGCTACTAAGGAAAACAACAACGGAAGCGATGATGAGAGCGACGATGAGAGTGTAAACTGCGAAGCTTGCAAATTAAAGCCTTCGAGCGTCCCAAAACCTTCTCAAGCAAGGTTTTCAGTATAA","protein_sequence":"MKENDMNNGVDKWVNEEDGRNDHHNNNNNLMKKAMMNNEQIDRTQDIDNAKEMLRKISSESSSRRSSLLNKDSSLVNGNANSGGGTSINGTRGSSKSSNTHFQYASTAYGVRMLSKDISNTKVELDVENLMIVTKLNDVSLYFLTRELVEWVLVHFPRVTVYVDSELKNSKKFAAGELCEDSKCRESRIKYWTKDFIREHDVFFDLVVTLGGDGTVLFVSSIFQRHVPPVMSFSLGSLGFLTNFKFEHFREDLPRIMNHKIKTNLRLRLECTIYRRHRPEVDPNTGKKICVVEKLSTHHILNEVTIDRGPSPFLSMLELYGDGSLMTVAQADGLIAATPTGSTAYSLSAGGSLVCPTVNAIALTPICPHALSFRPIILPESINLKVKVSMKSRAPAWAAFDGKDRIELQKGDFITICASPYAFPTVEASPDEFINSISRQLNWNVREQQKSFTHILSQKNQEKYAHEANKVRNQAEPLEVIRDKYSLEADATKENNNGSDDESDDESVNCEACKLKPSSVPKPSQARFSV"},{"created_at":"2011-05-26T20:23:56.000Z","updated_at":"2011-05-27T15:01:08.000Z","name":"Pyruvate carboxylase 1","uniprot_id":"P11154","uniprot_name":"PYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PYC1","num_residues":1178,"molecular_weight":"130098.0","theoretical_pi":"6.15","general_function":"Involved in catalytic activity","specific_function":"Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second","reactions":[{"id":1932,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2594,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.","export":false,"pw_reaction_id":null,"source":null},{"id":14121,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006553","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"J03889","genbank_protein_id":"172102","gene_card_id":"PYC1","chromosome_location":"chromosome 7","locus":"YGL062W","synonyms":["Pyruvic carboxylase 1","PCB 1"],"enzyme_classes":["6.4.1.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" pyruvate carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" gluconeogenesis"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"HMGL-like","identifier":"PF00682"},{"name":"PYC_OADA","identifier":"PF02436"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTCGCAAAGAAAATTCGCCGGCTTGAGAGATAACTTCAATCTCTTGGGTGAAAAGAACAAAATATTGGTGGCTAATAGAGGAGAAATTCCAATCAGAATTTTTCGTACCGCTCATGAACTGTCTATGCAGACGGTAGCTATATATTCTCATGAAGATCGTCTTTCAACGCACAAACAAAAGGCTGACGAAGCATACGTCATAGGTGAAGTAGGCCAATATACCCCCGTCGGCGCTTATTTGGCCATTGACGAAATCATTTCCATTGCCCAAAAACACCAGGTAGATTTCATCCATCCAGGTTATGGGTTCTTGTCTGAAAATTCGGAATTTGCCGACAAAGTAGTGAAGGCCGGTATCACTTGGATTGGCCCTCCAGCTGAAGTTATTGACTCCGTGGGTGATAAGGTCTCAGCTAGAAACCTGGCAGCAAAAGCTAATGTGCCCACCGTTCCTGGTACACCAGGTCCTATAGAAACTGTAGAGGAAGCACTTGACTTCGTCAATGAATACGGCTACCCGGTGATCATTAAGGCCGCCTTTGGTGGTGGTGGTAGAGGTATGAGAGTCGTTAGAGAAGGTGACGACGTGGCAGATGCCTTTCAACGTGCTACCTCCGAAGCCCGTACTGCCTTCGGTAATGGTACCTGCTTTGTGGAAAGATTCTTGGACAAGCCAAAGCATATTGAAGTTCAATTGTTGGCCGATAACCACGGAAACGTGGTTCATCTTTTCGAAAGAGACTGTTCCGTGCAGAGAAGACACCAAAAGGTTGTCGAAGTGGCCCCAGCAAAGACTTTACCCCGTGAAGTCCGTGACGCCATTTTGACAGATGCAGTTAAATTGGCCAAAGAGTGTGGCTACAGAAATGCGGGTACTGCTGAATTCTTGGTTGATAACCAAAATAGACACTATTTCATTGAAATTAATCCAAGAATCCAAGTGGAACATACCATCACAGAAGAAATTACCGGTATAGATATTGTGGCGGCTCAGATCCAAATTGCGGCAGGTGCCTCTCTACCCCAGCTGGGCCTATTCCAGGACAAAATTACGACTCGTGGCTTTGCCATTCAGTGCCGTATTACCACGGAAGACCCTGCTAAGAACTTCCAACCAGATACCGGTAGAATAGAAGTGTACCGTTCTGCAGGTGGTAATGGTGTTAGACTGGATGGTGGTAACGCCTATGCAGGAACAATAATCTCACCTCATTACGACTCAATGCTGGTCAAATGCTCATGCTCCGGTTCCACCTACGAAATCGTTCGTAGAAAAATGATTCGTGCATTAATCGAGTTCAGAATTAGAGGTGTCAAGACCAACATTCCCTTCCTATTGACTCTTTTGACCAATCCAGTATTTATTGAGGGTACATACTGGGGGACTTTTATTGACGACACCCCACAACTGTTCCAAATGGTTTCATCACAAAACAGGGCCCAAAAACTTTTACATTACCTCGCCGACGTGGCAGACAATGGTTCATCTATCAAGGGTCAAATTGGCTTGCCAAAATTAAAATCAAATCCAAGTGTCCCCCATTTGCACGATGCTCAGGGCAATGTCATCAACGTTACAAAGTCTGCACCACCATCCGGATGGAGGCAAGTGCTACTAGAAAAGGGGCCAGCTGAATTTGCCAGACAAGTTAGACAGTTCAATGGTACTTTATTGATGGACACCACCTGGAGAGACGCTCATCAATCTCTACTTGCAACAAGAGTCAGAACCCACGATTTGGCTACAATCGCTCCAACAACCGCACATGCCCTTGCAGGTGCTTTCGCCTTAGAATGTTGGGGTGGTGCCACATTCGATGTTGCAATGAGATTTTTGCATGAGGATCCATGGCAACGTTTGAGAAAATTAAGATCTCTGGTGCCTAATATTCCATTCCAAATGTTATTGCGTGGTGCCAATGGTGTGGCTTATTCTTCATTGCCTGACAATGCTATTGACCATTTCGTCAAGCAAGCCAAGGATAATAGTGTTGATATATTTAGAGTCTTTGATGCCTTAAATGACTTGGAACAATTGAAGGTCGGTGTAGATGCTGTGAAGAAGGCAGGTGGTGTTGTAGAAGCCACTGTTTGTTTCTCTGGGGATATGCTTCAGCCAGGCAAGAAATACAATTTGGATTACTACTTGGAAATTGCTGAAAAAATTGTCCAAATGGGCACTCATATCCTGGGTATCAAAGATATGGCAGGTACCATGAAGCCAGCAGCTGCCAAACTACTGATTGGATCTTTGAGGGCTAAGTACCCTGATCTCCCAATACATGTTCACACTCACGATTCTGCAGGTACTCGTGTTGCATCAATGACTGCGTGTGCTCTGGCGGGCGCCGATGTCGTTGATGTTGCCATCAACTCAATGTCTGGTTTAACTTCACAACCATCAATCAATGCTCTGTTGGCTTCATTAGAAGGTAATATTGACACTGGTATTAACGTTGAGCATGTCCGTGAACTAGATGCATATTGGGCAGAGATGAGATTGTTATACTCTTGTTTCGAGGCTGACTTGAAGGGCCCAGATCCAGAAGTTTATCAACATGAAATCCCAGGTGGTCAATTGACAAACTTGTTGTTTCAAGCCCAACAATTGGGTCTTGGAGAACAATGGGCCCAAACAAAAAGAGCTTACAGAGAAGCCAATTATTTATTGGGTGATATTGTCAAAGTTACCCCAACTTCGAAGGTCGTTGGTGATCTGGCAAAATTTATGGTCTCCAATAAATTAACTTCCGATGATGTGAGACGCCTGGCTAATTCTTTGGATTTCCCTGACTCTGTTATGGATTTCTTCGAAGGCTTAATCGGCCAACCATATGGTGGGTTCCCAGAACCATTTAGATCAGACGTTTTAAGGAACAAGAGAAGAAAGTTGACTTGTCGTCCAGGCCTGGAACTAGAGCCATTTGATCTCGAAAAAATTAGAGAAGACTTGCAGAATAGATTTGGTGATGTTGATGAGTGCGACGTTGCTTCTTATAACATGTACCCAAGAGTTTATGAAGACTTCCAAAAGATGAGAGAAACGTATGGTGATTTATCTGTATTGCCAACAAGAAGCTTTTTGTCTCCACTAGAGACTGACGAAGAAATTGAAGTTGTAATCGAACAAGGTAAAACGCTAATTATCAAGCTACAGGCTGTGGGTGATTTGAACAAAAAGACCGGTGAAAGAGAAGTTTACTTTGATTTGAATGGTGAAATGAGAAAAATTCGTGTTGCTGACAGATCACAAAAAGTGGAAACTGTTACTAAATCCAAAGCAGACATGCATGATCCATTACACATTGGTGCACCAATGGCAGGTGTCATTGTTGAAGTTAAAGTTCATAAAGGATCACTAATAAAGAAGGGCCAACCTGTAGCCGTATTAAGCGCCATGAAAATGGAAATGATTATATCTTCTCCATCCGATGGACAAGTTAAAGAAGTGTTTGTCTCTGATGGTGAAAATGTGGACTCTTCTGATTTATTAGTTCTATTAGAAGACCAAGTTCCTGTTGAAACTAAGGCATGA","protein_sequence":"MSQRKFAGLRDNFNLLGEKNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLEDQVPVETKA"},{"created_at":"2011-05-26T20:25:28.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Phosphomevalonate 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13","locus":"YMR220W","synonyms":[],"enzyme_classes":["2.7.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" phosphorus metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" phosphorylation"}],"pfams":[{"name":"GHMP_kinases_C","identifier":"PF08544"},{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCAGAGTTGAGAGCCTTCAGTGCCCCAGGGAAAGCGTTACTAGCTGGTGGATATTTAGTTTTAGATACAAAATATGAAGCATTTGTAGTCGGATTATCGGCAAGAATGCATGCTGTAGCCCATCCTTACGGTTCATTGCAAGGGTCTGATAAGTTTGAAGTGCGTGTGAAAAGTAAACAATTTAAAGATGGGGAGTGGCTGTACCATATAAGTCCTAAAAGTGGCTTCATTCCTGTTTCGATAGGCGGATCTAAGAACCCTTTCATTGAAAAAGTTATCGCTAACGTATTTAGCTACTTTAAACCTAACATGGACGACTACTGCAATAGAAACTTGTTCGTTATTGATATTTTCTCTGATGATGCCTACCATTCTCAGGAGGATAGCGTTACCGAACATCGTGGCAACAGAAGATTGAGTTTTCATTCGCACAGAATTGAAGAAGTTCCCAAAACAGGGCTGGGCTCCTCGGCAGGTTTAGTCACAGTTTTAACTACAGCTTTGGCCTCCTTTTTTGTATCGGACCTGGAAAATAATGTAGACAAATATAGAGAAGTTATTCATAATTTAGCACAAGTTGCTCATTGTCAAGCTCAGGGTAAAATTGGAAGCGGGTTTGATGTAGCGGCGGCAGCATATGGATCTATCAGATATAGAAGATTCCCACCCGCATTAATCTCTAATTTGCCAGATATTGGAAGTGCTACTTACGGCAGTAAACTGGCGCATTTGGTTGATGAAGAAGACTGGAATATTACGATTAAAAGTAACCATTTACCTTCGGGATTAACTTTATGGATGGGCGATATTAAGAATGGTTCAGAAACAGTAAAACTGGTCCAGAAGGTAAAAAATTGGTATGATTCGCATATGCCAGAAAGCTTGAAAATATATACAGAACTCGATCATGCAAATTCTAGATTTATGGATGGACTATCTAAACTAGATCGCTTACACGAGACTCATGACGATTACAGCGATCAGATATTTGAGTCTCTTGAGAGGAATGACTGTACCTGTCAAAAGTATCCTGAAATCACAGAAGTTAGAGATGCAGTTGCCACAATTAGACGTTCCTTTAGAAAAATAACTAAAGAATCTGGTGCCGATATCGAACCTCCCGTACAAACTAGCTTATTGGATGATTGCCAGACCTTAAAAGGAGTTCTTACTTGCTTAATACCTGGTGCTGGTGGTTATGACGCCATTGCAGTGATTACTAAGCAAGATGTTGATCTTAGGGCTCAAACCGCTAATGACAAAAGATTTTCTAAGGTTCAATGGCTGGATGTAACTCAGGCTGACTGGGGTGTTAGGAAAGAAAAAGATCCGGAAACTTATCTTGATAAATAA","protein_sequence":"MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLDK"},{"created_at":"2011-05-26T20:26:05.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Putative pyridoxal kinase BUD17","uniprot_id":"P53727","uniprot_name":"BUD17_YEAST","enzyme":true,"transporter":false,"gene_name":"BUD17","num_residues":317,"molecular_weight":"35366.5","theoretical_pi":"6.78","general_function":"Involved in pyridoxal kinase activity","specific_function":"Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Important for bud site selection","reactions":[{"id":2592,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692946","genbank_protein_id":"51013343","gene_card_id":"BUD17","chromosome_location":"chromosome 14","locus":"YNR027W","synonyms":["Bud site selection protein 17"],"enzyme_classes":["2.7.1.35"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" pyridoxal kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" vitamin B6 metabolic process"},{"category":"Process","description":" pyridoxine metabolic process"},{"category":"Process","description":" pyridoxine biosynthetic process"}],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"}],"pathways":[{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"}],"gene_sequence":"ATGACCAGTACATTACATACGACAAAAAAAGTGCTCTCCATTCAATCACACGTCATACATGGCTACGTGGGAAACAAGGCCGCTACGTTCCCACTTCAATACAGAGGTTGGGATGTGGACGTATTGAACACAGTTCAGTTTTCTAACCACTCGGGGTACGCCCACTTCACAGGCTTCAAATGCAGCACTGAGGAGTTGGTAGACATTGTAGAGAAGGGCTTGATTGGGTCTCTTAGAATCAAGTATGATGCCGTACTTAGTGGCTATTTACCCAATGGTCAAGCCCTGCAAAAGGTAGCAGGAATAGTGGGTCAATTATGTGAGGGGAGTGAAAACGTCAAGTGGATATTAGATCCTGTACTGGGCGATAATGGAAGGCTGTACGTGGATCGAGAATGTGTTGCGGTATACCAAGACATTTTACAAAACTTCAAAATTTTTTTGGCCACACCAAATCAGTTTGAAATGGAACTGTTGGTGGGGATGTCAATTCGTACCTTAGACGACGCTAAGCAGGCATTTAAACTATTTCATAAAAAGTACCCTCGAGTAAGCCGAATAGTTGTCACTAGTCTGGAATTATCTGAATTCCTGAGCAACGACACTTACGTAGTAGCAGGGTTTGATTGCTCGGCCAGTGAAGAGATATTCTTCTATGAAATCCCCAAGATCAACGCAAAATTTAGTGGAAGTGGTGATTTAATCAGCGCCATGCTCACTGACTCGTTACTAGGCGACCGCCGCTGCACACAGCTGTCATTAAGCGCATCCTTGGGCCAAGTGCTGTGGCTCGTCACCAGTATCCTACAAAAAACGTATGATTTAAACATAGCTGAGCGGGGCCCACAAGATTCCACGATAGATATCAAGGATTTAAAGCTGATTCAGTGTAGAGACATCCTAAAGCAAGATCTCATACCCTCCATTGGCAAGCCAAAAACCATTAAAATATGA","protein_sequence":"MTSTLHTTKKVLSIQSHVIHGYVGNKAATFPLQYRGWDVDVLNTVQFSNHSGYAHFTGFKCSTEELVDIVEKGLIGSLRIKYDAVLSGYLPNVQALQKVAGIVGQLCEGSENVKWILDPVLGDNGRLYVDRECVAVYQDILQNFKIFLATPNQFEMELLVGMSIRTLDDAKQAFKLFHKKYPRVSRIVVTSLELSEFLSNDTYVVAGFDCSASEEIFFYEIPKINAKFSGSGDLISAMLTDSLLGDRRCTQLSLSASLGQVLWLVTSILQKTYDLNIAERGPQDSTIDIKDLKLIQCRDILKQDLIPSIGKPKTIKI"},{"created_at":"2011-05-26T20:26:33.000Z","updated_at":"2011-05-26T20:26:33.000Z","name":"Probable gluconokinase","uniprot_id":"Q03786","uniprot_name":"GNTK_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":193,"molecular_weight":"22174.5","theoretical_pi":"7.2","general_function":"Involved in ATP binding","specific_function":"ATP + D-gluconate = ADP + 6-phospho-D- gluconate","reactions":[{"id":2596,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-gluconate = ADP + 6-phospho-D-gluconate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49701","genbank_protein_id":"817834","gene_card_id":null,"chromosome_location":null,"locus":"YDR248C","synonyms":["Gluconate kinase"],"enzyme_classes":["2.7.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" sulfur metabolic process"},{"category":"Process","description":" sulfate assimilation"}],"pfams":[{"name":"APS_kinase","identifier":"PF01583"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"}],"gene_sequence":"ATGACAGAGAAACACAAAACTATGGGGAAATTTAAGGTTATTGTATTGGCAGGTACTGCAGGTACAGGAAAATCAACCATTGCAGGTGAACTAATCCATGAATTTAAAGATATATACCCGGATTTGAAATTCATCGAAGGTGATGATTTACACCCGCCTGCCAACGTAGAAAAGATGACAAGAGGGATTCCATTAAATGACGACGACCGTTGGGACTGGTTGAAAAAAGTTGCCGTAGAATCTACAAAAGCTGCAGCAAGCACTAAGGAGCATTTGTCAATTGTTGCTTGCTCGAGCTTGAAGAAGAAATACAGAGATTTGATTAGGCACACATGCCCTGAATCGGAGTTCCATTTTATCTTTTTGTATGCAAGTAAAATAGAAGTTCTGAAAAGGCTCAAAACAAGGAAGGGTCATTTCATGAAAGCTGATATGATGGAGTCTCAATTCAGGGATCTGGAGTTACCAGACATCAACGACGAAACTGACTGTGACATTGTTCCCTTAGATTTCAAAACGTTTTATCAAATTGAAAAAGATGTTATACAGGTGGTAAAAAGTAAAGTTTTGAATATTGAGTAA","protein_sequence":"MTEKHKTMGKFKVIVLAGTAGTGKSTIAGELIHEFKDIYPDLKFIEGDDLHPPANVEKMTRGIPLNDDDRWDWLKKVAVESTKAAASTKEHLSIVACSSLKKKYRDLIRHTCPESEFHFIFLYASKIEVLKRLKTRKGHFMKADMMESQFRDLELPDINDETDCDIVPLDFKTFYQIEKDVIQVVKSKVLNIE"},{"created_at":"2011-05-26T20:31:54.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Glutamate 5-kinase","uniprot_id":"P32264","uniprot_name":"PROB_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO1","num_residues":428,"molecular_weight":"47161.69922","theoretical_pi":"6.75","general_function":"Involved in cellular amino acid biosynthetic process","specific_function":"Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline","reactions":[{"id":1570,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2597,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + L-glutamate = ADP + L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3716,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006232","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M85293","genbank_protein_id":"172241","gene_card_id":"PRO1","chromosome_location":"chromosome 4","locus":"YDR300C","synonyms":["GK","Gamma-glutamyl kinase"],"enzyme_classes":["2.7.2.11"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glutamate 5-kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" proline metabolic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"PUA","identifier":"PF01472"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGGATGCTAATGAGAGTAAATCGTATACTATAGTGATCAAATTAGGCTCTTCATCGCTAGTAGATGAAAAAACCAAAGAACCTAAGTTAGCTATCATGTCGCTTATTGTCGAAACTGTAGTCAAATTGAGAAGAATGGGACACAAAGTTATCATCGTGTCCAGTGGTGGTATTGCTGTTGGTTTGAGGACTATGCGTATGAATAAAAGACCAAAACATTTAGCAGAAGTTCAGGCCATCGCAGCTATTGGGCAGGGTAGATTGATCGGGAGATGGGATCTTCTGTTTTCGCAATTTGATCAACGTATCGCTCAAATTCTATTGACCAGAAATGATATTCTGGACTGGACCCAATATAAGAACGCTCAAAACACAATTAATGAATTGTTGAACATGGGCGTTATTCCCATTGTGAATGAAAACGACACACTATCTGTTAGAGAAATCAAATTTGGTGACAATGACACTTTATCAGCAATTACTTCTGCTTTAATCCATGCAGATTATCTTTTCTTACTGACAGATGTTGACTGTTTGTATACTGATAATCCAAGGACAAACCCAGATGCCATGCCGATCTTAGTTGTCCCAGATCTCTCAAAGGGTTTGCCCGGTGTGAATACTGCTGGTGGTTCAGGTTCTGACGTTGGGACCGGTGGTATGGAAACTAAATTGGTTGCTGCAGATTTGGCAACGAATGCCGGTGTTCATACGTTGATCATGAAAAGCGATACACCTGCGAATATAGGTAGAATTGTCGAGTATATGCAAACTCTAGAACTTGACGATGAAAATAAAGTTAAACAAGCATATAATGGCGATTTAACGGATTTGCAAAAAAGAGAATTTGAGAAATTAAAGGCTCTTAACGTTCCACTACATACGAAGTTCATTGCTAATGATAATAAACACCATCTAAAGAATAGAGAGTTTTGGATTTTACACGGTCTTGTCTCTAAAGGCGCTGTTGTTATAGACCAAGGTGCGTACCGAGCCTTAACAAGGAAAAATAAGGCGGGATTATTGCCAGCAGGTGTTATTGATGTTCAGGGCACTTTCCATGAGTTAGAATGTGTTGACATAAAAGTTGGTAAAAAGTTACCAGATGGCACGTTAGATCCAGATTTTCCCTTGCAAACAGTAGGCAAGGCAAGATGCAATTACACGAGTTCTGAATTAACTAAAATTAAAGGTTTGCACAGTGACCAAATCGAAGAGGAATTGGGCTATAATGACAGCGAATATGTCGCTCATAGAGAAAATTTGGCATTCCCACCTCGTTGA","protein_sequence":"MKDANESKSYTIVIKLGSSSLVDEKTKEPKLAIMSLIVETVVKLRRMGHKVIIVSSGGIAVGLRTMRMNKRPKHLAEVQAIAAIGQGRLIGRWDLLFSQFDQRIAQILLTRNDILDWTQYKNAQNTINELLNMGVIPIVNENDTLSVREIKFGDNDTLSAITSALIHADYLFLLTDVDCLYTDNPRTNPDAMPILVVPDLSKGLPGVNTAGGSGSDVGTGGMETKLVAADLATNAGVHTLIMKSDTPANIGRIVEYMQTLELDDENKVKQAYNGDLTDLQKREFEKLKALNVPLHTKFIANDNKHHLKNREFWILHGLVSKGAVVIDQGAYAALTRKNKAGLLPAGVIDVQGTFHELECVDIKVGKKLPDGTLDPDFPLQTVGKARCNYTSSELTKIKGLHSDQIEEELGYNDSEYVAHRENLAFPPR"},{"created_at":"2011-05-26T20:34:43.000Z","updated_at":"2011-05-26T20:34:43.000Z","name":"V-type proton ATPase catalytic subunit A","uniprot_id":"P17255","uniprot_name":"VATA_YEAST","enzyme":true,"transporter":false,"gene_name":"TFP1","num_residues":1071,"molecular_weight":"118636.0","theoretical_pi":"6.05","general_function":"Involved in ATP binding","specific_function":"PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates \"homing\", a genetic event that converts a VMA1 allele lacking VDE into one that contains it","reactions":[{"id":2599,"direction":"\u003e","locations":"Mitochondrion. Mitochondrion inner membrane.; Multi-pass membrane protein;Cell membrane;Endomembrane system. Vacuole membrane (Probable).","altext":"ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1JVA","cellular_location":"Endomembrane system. Vacuole membrane (Probable).","genbank_gene_id":"J05409","genbank_protein_id":"171650","gene_card_id":"TFP1","chromosome_location":null,"locus":null,"synonyms":["V-ATPase subunit A","Vacuolar proton pump subunit A","Endonuclease PI-SceI","Sce VMA intein","VMA1-derived endonuclease","VDE"],"enzyme_classes":["3.6.3.14","3.1.-.-"],"go_classes":[{"category":"Component","description":" proton-transporting two-sector ATPase complex, catalytic domain"},{"category":"Component","description":" proton-transporting two-sector ATPase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" DNA binding"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" endonuclease activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" proton-transporting ATPase activity, rotational mechanism"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" monovalent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" hydrogen ion transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" hydrogen ion transporting ATP synthase activity, rotational mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nuclease activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" ATP metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" hydrogen transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" proton transport"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" intein-mediated protein splicing"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" protein metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" protein maturation"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" protein processing"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" protein splicing"},{"category":"Process","description":" ATP synthesis coupled proton transport"},{"category":"Process","description":" purine nucleoside triphosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" purine ribonucleoside triphosphate metabolic process"}],"pfams":[{"name":"ATP-synt_ab","identifier":"PF00006"},{"name":"ATP-synt_ab_C","identifier":"PF00306"},{"name":"ATP-synt_ab_N","identifier":"PF02874"},{"name":"Hom_end","identifier":"PF05204"},{"name":"Hom_end_hint","identifier":"PF05203"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGGCTGGTGCAATTGAAAACGCTCGTAAGGAAATAAAAAGAATCTCATTAGAAGACCATGCTGAATCTGAATATGGTGCCATCTATTCTGTCTCTGGTCCGGTCGTCATTGCTGAAAATATGATTGGTTGTGCCATGTACGAATTGGTCAAGGTCGGTCACGATAACCTGGTGGGTGAAGTCATTAGAATTGACGGTGACAAGGCCACCATCCAAGTTTACGAAGAAACTGCAGGCCTTACGGTCGGTGACCCTGTTTTGAGAACAGGTAAGCCTCTGTCGGTAGAATTGGGTCCTGGTCTGATGGAAACCATTTACGATGGTATTCAAAGACCTTTGAAAGCCATTAAGGAAGAATCGCAATCGATTTATATCCCAAGAGGTATTGACACTCCAGCTTTGGATAGGACTATCAAGTGGCAATTTACTCCGGGAAAGTTTCAAGTCGGCGATCATATTTCCGGTGGTGATATTTACGGTTCCGTTTTTGAGAATTCGCTAATTTCAAGCCATAAGATTCTTTTGCCACCAAGATCAAGAGGTACAATCACTTGGATTGCTCCAGCTGGTGAGTACACTTTGGATGAGAAGATTTTGGAAGTTGAATTTGATGGCAAGAAGTCTGATTTCACTCTTTACCATACTTGGCCTGTTCGTGTTCCAAGACCAGTTACTGAAAAGTTATCTGCTGACTATCCTTTGTTAACAGGTCAAAGAGTTTTGGATGCTTTGTTTCCTTGTGTTCAAGGTGGTACGACATGTATTCCAGGTGCTTTTGGTTGTGGTAAGACCGTTATCTCTCAATCTTTGTCCAAGTACTCCAATTCTGACGCCATTATCTATGTCGGGTGCTTTGCCAAGGGTACCAATGTTTTAATGGCGGATGGGTCTATTGAATGTATTGAAAACATTGAGGTTGGTAATAAGGTCATGGGTAAAGATGGCAGACCTCGTGAGGTAATTAAATTGCCCAGAGGAAGAGAAACTATGTACAGCGTCGTGCAGAAAAGTCAGCACAGAGCCCACAAAAGTGACTCAAGTCGTGAAGTGCCAGAATTACTCAAGTTTACGTGTAATGCGACCCATGAGTTGGTTGTTAGAACACCTCGTAGTGTCCGCCGTTTGTCTCGTACCATTAAGGGTGTCGAATATTTTGAAGTTATTACTTTTGAGATGGGCCAAAAGAAAGCCCCCGACGGTAGAATTGTTGAGCTTGTCAAGGAAGTTTCAAAGAGCTACCCAATATCTGAGGGGCCTGAGAGAGCCAACGAATTAGTAGAATCCTATAGAAAGGCTTCAAATAAAGCTTATTTTGAGTGGACTATTGAGGCCAGAGATCTTTCTCTGTTGGGTTCCCATGTTCGTAAAGCTACCTACCAGACTTACGCTCCAATTCTTTATGAGAATGACCACTTTTTCGACTACATGCAAAAAAGTAAGTTTCATCTCACCATTGAAGGTCCAAAAGTACTTGCTTATTTACTTGGTTTATGGATTGGTGATGGATTGTCTGACAGGGCAACTTTTTCGGTTGATTCCAGAGATACTTCTTTGATGGAACGTGTTACTGAATATGCTGAAAAGTTGAATTTGTGCGCCGAGTATAAGGACAGAAAAGAACCACAAGTTGCCAAAACTGTTAATTTGTACTCTAAAGTTGTCAGAGGTAATGGTATTCGCAATAATCTTAATACTGAGAATCCATTATGGGACGCTATTGTTGGCTTAGGATTCTTGAAGGACGGTGTCAAAAATATTCCTTCTTTCTTGTCTACGGACAATATCGGTACTCGTGAAACATTTCTTGCTGGTCTAATTGATTCTGATGGCTATGTTACTGATGAGCATGGTATTAAAGCAACAATAAAGACAATTCATACTTCTGTCAGAGATGGTTTGGTTTCCCTTGCTCGTTCTTTAGGCTTAGTAGTCTCGGTTAACGCAGAACCTGCTAAGGTTGACATGAATGGCACCAAACATAAAATTAGTTATGCTATTTATATGTCTGGTGGAGATGTTTTGCTTAACGTTCTTTCGAAGTGTGCCGGCTCTAAAAAATTCAGGCCTGCTCCCGCCGCTGCTTTTGCACGTGAGTGCCGCGGATTTTATTTCGAGTTACAAGAATTGAAGGAAGACGATTATTATGGGATTACTTTATCTGATGATTCTGATCATCAGTTTTTGCTTGCCAACCAGGTTGTCGTCCATAATTGCGGAGAAAGAGGTAATGAAATGGCAGAAGTCTTGATGGAATTCCCAGAGTTATATACTGAAATGAGCGGTACTAAAGAACCAATTATGAAGCGTACTACTTTGGTCGCTAATACATCTAACATGCCGGTTGCAGCCAGAGAAGCTTCTATTTACACTGGTATCACTCTTGCAGAATACTTCAGAGATCAAGGTAAAAATGTTTCTATGATTGCAGACTCTTCTTCAAGATGGGCTGAAGCTTTGAGAGAAATTTCTGGTCGTTTGGGTGAGATGCCTGCTGATCAAGGTTTCCCAGCTTATTTGGGTGCTAAGTTGGCCTCCTTTTACGAAAGAGCCGGTAAAGCTGTTGCTTTAGGTTCCCCAGATCGTACTGGTTCCGTTTCCATCGTTGCTGCCGTTTCGCCAGCCGGTGGTGATTTCTCAGATCCTGTTACTACTGCTACATTGGGTATCACTCAAGTCTTTTGGGGTTTAGACAAGAAATTGGCTCAAAGAAAGCATTTCCCATCTATCAACACATCTGTTTCTTACTCCAAATACACTAATGTCTTGAACAAGTTTTATGATTCCAATTACCCTGAATTTCCTGTTTTAAGAGATCGTATGAAGGAAATTCTATCAAACGCTGAAGAATTAGAACAAGTTGTTCAATTAGTTGGTAAATCGGCCTTGTCTGATAGTGATAAGATTACTTTGGATGTTGCCACTTTAATCAAGGAAGATTTCTTGCAACAAAATGGTTACTCCACTTATGATGCTTTCTGTCCAATTTGGAAGACATTTGATATGATGAGAGCCTTCATCTCGTATCATGACGAAGCTCAAAAAGCTGTTGCTAATGGTGCCAACTGGTCAAAACTAGCTGACTCTACTGGTGACGTTAAGCATGCCGTTTCTTCATCTAAATTTTTTGAACCAAGCAGGGGTGAAAAGGAAGTCCATGGCGAATTCGAAAAATTGTTGAGCACTATGCAAGAAAGATTTGCTGAATCTACCGATTAA","protein_sequence":"MAGAIENARKEIKRISLEDHAESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSRGTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGKTVISQSLSKYSNSDAIIYVGCFAKGTNVLMADGSIECIENIEVGNKVMGKDGRPREVIKLPRGRETMYSVVQKSQHRAHKSDSSREVPELLKFTCNATHELVVRTPRSVRRLSRTIKGVEYFEVITFEMGQKKAPDGRIVELVKEVSKSYPISEGPERANELVESYRKASNKAYFEWTIEARDLSLLGSHVRKATYQTYAPILYENDHFFDYMQKSKFHLTIEGPKVLAYLLGLWIGDGLSDRATFSVDSRDTSLMERVTEYAEKLNLCAEYKDRKEPQVAKTVNLYSKVVRGNGIRNNLNTENPLWDAIVGLGFLKDGVKNIPSFLSTDNIGTRETFLAGLIDSDGYVTDEHGIKATIKTIHTSVRDGLVSLARSLGLVVSVNAEPAKVDMNGTKHKISYAIYMSGGDVLLNVLSKCAGSKKFRPAPAAAFARECRGFYFELQELKEDDYYGITLSDDSDHQFLLANQVVVHNCGERGNEMAEVLMEFPELYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKHAVSSSKFFEPSRGEKEVHGEFEKLLSTMQERFAESTD"},{"created_at":"2011-05-26T20:35:53.000Z","updated_at":"2011-06-05T01:33:28.000Z","name":"Calcium-transporting ATPase 2","uniprot_id":"P38929","uniprot_name":"ATC2_YEAST","enzyme":false,"transporter":true,"gene_name":"PMC1","num_residues":1173,"molecular_weight":"130860.0","theoretical_pi":"7.42","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium","reactions":[{"id":2588,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"115-139;153-173;350-368;389-409;900-922;930-950;977-998;1011-1029;1066-1086;1100-1120","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"U03060","genbank_protein_id":"454003","gene_card_id":"PMC1","chromosome_location":"chromosome 7","locus":"YGL006W","synonyms":["Vacuolar Ca(2+)-ATPase"],"enzyme_classes":["3.6.3.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" di-, tri-valent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" calcium ion transmembrane transporter activity"},{"category":"Function","description":" calcium-transporting ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" di-, tri-valent inorganic cation transport"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" divalent metal ion transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" calcium ion transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cation_ATPase_C","identifier":"PF00689"},{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGTCTAGACAAGACGAAAATTCTGCTTTACTAGCGAATAATGAAAATAACAAACCATCGTATACGGGAAATGAGAACGGAGTCTACGATAATTTCAAATTATCAAAAAGTCAACTTTCGGATCTTCATAACCCTAAATCAATAAGATCATTTGTCAGATTATTTGGATATGAGTCTAACAGCCTCTTCAAATACTTGAAAACAGATAAAAATGCAGGCATTTCTCTTCCAGAAATATCAAATTATCGAAAGACAAACCGGTATAAAAATTATGGCGATAATTCACTTCCTGAAAGAATACCAAAGTCTTTTTTACAATTAGTATGGGCTGCTTTTAATGACAAAACAATGCAATTACTGACAGTCGCCGCTGTTGTTTCCTTTGTTTTAGGTCTATACGAACTATGGATGCAACCTCCACAGTATGATCCTGAAGGAAATAAAATTAAGCAAGTTGACTGGATTGAAGGGGTTGCTATCATGATTGCGGTCTTTGTGGTAGTTCTAGTGAGTGCCGCTAACGATTACCAGAAGGAGTTGCAATTTGCAAAGCTAAATAAAAAGAAGGAAAACCGTAAAATTATAGTCATAAGAAATGATCAGGAAATATTAATTTCCATTCACCACGTTTTAGTCGGTGATGTCATTTCATTACAAACCGGTGATGTTGTCCCCGCTGATTGTGTTATGATATCAGGGAAGTGTGAGGCAGATGAATCATCCATCACTGGTGAATCTAACACAATACAGAAATTTCCGGTGGATAACTCATTAAGAGATTTCAAAAAATTTAATTCTATCGATAGTCATAACCATAGCAAACCATTAGATATAGGTGACGTTAACGAAGACGGTAACAAGATTGCTGATTGTATGTTGATTTCAGGTTCCAGAATTCTCTCTGGCTTGGGCAGGGGTGTCATCACGTCCGTGGGTATAAACTCAGTTTACGGTCAAACCATGACTTCATTAAATGCCGAACCTGAAAGTACTCCATTACAGTTACATTTGAGCCAATTGGCTGATAATATATCCGTTTACGGTTGCGTGTCTGCTATAATTCTTTTCTTGGTCCTTTTCACTAGGTACTTATTTTACATAATACCTGAGGATGGCAGGTTCCATGATCTAGATCCCGCTCAAAAGGGTTCTAAATTTATGAACATTTTTATCACATCTATCACGGTTATTGTGGTGGCTGTTCCGGAAGGTTTACCATTAGCTGTAACTTTGGCCTTAGCGTTTGCAACAACAAGAATGACAAAAGACGGTAATTTAGTACGGGTTTTAAGAAGCTGTGAAACGATGGGATCTGCTACTGCAGTGTGCTCTGATAAGACTGGCACTTTGACAGAAAATGTCATGACTGTCGTTCGTGGCTTCCCGGGCAATTCTAAATTTGATGATAGTAAATCGTTGCCCGTTAGCGAACAAAGGAAGCTGAATTCTAAGAAAGTTTTTGAAGAAAATTGTTCGTCATCCTTGAGAAATGATTTATTAGCCAATATTGTCCTGAATTCTACCGCCTTCGAAAACAGAGATTATAAGAAAAACGATAAAAATACAAATGGTAGTAAAAATATGTCAAAAAATTTGAGTTTTTTAGATAAGTGTAAATCTAGATTATCGTTTTTTAAAAAAGGCAACAGGGAAGATGACGAGGATCAATTATTCAAAAATGTCAACAAGGGTAGGCAAGAACCCTTTATTGGCTCTAAAACGGAAACAGCCTTACTCAGTTTGGCAAGATTATCATTAGGATTACAACCGGGAGAATTGCAATATTTGAGAGATCAACCGATGGAAAAGTTTAATATCGAAAAAGTTGTTCAAACAATTCCGTTTGAAAGTTCTCGTAAATGGGCCGGCTTAGTGGTAAAGTACAAAGAAGGCAAAAATAAAAAACCATTTTACAGGTTTTTCATTAAAGGTGCAGCAGAAATTGTTTCCAAGAATTGTTCGTACAAGAGGAATTCAGATGATACTTTGGAAGAAATCAATGAGGACAATAAAAAAGAAACTGATGATGAAATCAAAAATCTTGCGTCCGATGCTCTCAGAGCCATAAGTGTTGCCCACAAAGATTTCTGCGAATGTGATAGCTGGCCCCCTGAACAGCTGCGTGATAAAGACTCACCAAATATAGCTGCTCTTGACTTGCTATTTAACAGTCAAAAGGGCTTAATTCTAGATGGTTTACTTGGGATTCAAGACCCTTTACGTGCAGGCGTTAGGGAGTCAGTACAACAGTGCCAACGTGCTGGTGTAACTGTGCGTATGGTTACTGGTGACAATATATTAACAGCAAAAGCAATCGCGAGGAATTGTGCGATTCTTTCTACTGATATTAGTTCAGAGGCTTATTCTGCAATGGAAGGCACTGAATTCAGAAAGTTAACGAAAAACGAACGTATAAGAATCCTGCCAAATTTAAGGGTCTTAGCAAGGTCTTCGCCTGAGGATAAAAGGTTATTAGTAGAAACATTGAAGGGGATGGGAGATGTTGTTGCGGTCACTGGCGATGGTACGAACGATGCTCCAGCTTTAAAGCTAGCTGATGTTGGTTTCTCAATGGGTATTTCCGGTACGGAGGTTGCCAGAGAGGCTTCTGACATTATTTTGATGACTGATGATTTCTCAGCTATTGTCAACGCTATTAAGTGGGGAAGATGTGTTTCAGTCTCCATAAAAAAGTTCATACAGTTTCAATTAATTGTTAATATCACCGCAGTGATTTTAACGTTCGTTTCATCCGTTGCATCTAGTGATGAAACATCAGTACTGACGGCGGTCCAACTGTTATGGATCAATCTAATCATGGATACTCTAGCAGCTTTAGCTTTAGCCACTGATAAACCCGATCCAAATATCATGGACAGAAAACCTAGGGGCCGCTCAACTTCTTTGATTTCTGTGTCAACTTGGAAAATGATTCTATCACAAGCTACATTGCAGTTGATAGTTACTTTCATTTTGCATTTTTACGGGCCAGAGTTATTCTTCAAGAAACATGAAGATGAAATAACAAGTCACCAACAGCAGCAACTGAATGCCATGACATTCAACACTTTTGTTTGGTTGCAATTTTTTACCATGTTAGTATCGAGAAAATTAGATGAAGGTGATGGTATATCAAACTGGAGAGGCAGGATTTCTGCCGCCAATTTGAATTTCTTCCAAGACTTGGGTAGAAACTATTATTTTCTCACGATCATGGCGATCATTGGCAGCTGTCAAGTTTTAATCATGTTTTTTGGTGGCGCACCATTTTCTATTGCCAGACAAACCAAATCAATGTGGATAACCGCGGTACTGTGTGGTATGTTGTCTCTAATCATGGGGGTGCTAGTGAGAATCTGCCCCGATGAAGTAGCAGTGAAGGTATTTCCGGCTGCTTTCGTTCAAAGATTCAAGTACGTATTTGGACTCGAGTTCCTCAGAAAAAACCATACTGGAAAACACGACGATGAAGAAGCGCTGTTGGAGGAATCTGATAGTCCAGAGTCCACCGCCTTTTATTAA","protein_sequence":"MSRQDENSALLANNENNKPSYTGNENGVYDNFKLSKSQLSDLHNPKSIRSFVRLFGYESNSLFKYLKTDKNAGISLPEISNYRKTNRYKNYGDNSLPERIPKSFLQLVWAAFNDKTMQLLTVAAVVSFVLGLYELWMQPPQYDPEGNKIKQVDWIEGVAIMIAVFVVVLVSAANDYQKELQFAKLNKKKENRKIIVIRNDQEILISIHHVLVGDVISLQTGDVVPADCVMISGKCEADESSITGESNTIQKFPVDNSLRDFKKFNSIDSHNHSKPLDIGDVNEDGNKIADCMLISGSRILSGLGRGVITSVGINSVYGQTMTSLNAEPESTPLQLHLSQLADNISVYGCVSAIILFLVLFTRYLFYIIPEDGRFHDLDPAQKGSKFMNIFITSITVIVVAVPEGLPLAVTLALAFATTRMTKDGNLVRVLRSCETMGSATAVCSDKTGTLTENVMTVVRGFPGNSKFDDSKSLPVSEQRKLNSKKVFEENCSSSLRNDLLANIVLNSTAFENRDYKKNDKNTNGSKNMSKNLSFLDKCKSRLSFFKKGNREDDEDQLFKNVNKGRQEPFIGSKTETALLSLARLSLGLQPGELQYLRDQPMEKFNIEKVVQTIPFESSRKWAGLVVKYKEGKNKKPFYRFFIKGAAEIVSKNCSYKRNSDDTLEEINEDNKKETDDEIKNLASDALRAISVAHKDFCECDSWPPEQLRDKDSPNIAALDLLFNSQKGLILDGLLGIQDPLRAGVRESVQQCQRAGVTVRMVTGDNILTAKAIARNCAILSTDISSEAYSAMEGTEFRKLTKNERIRILPNLRVLARSSPEDKRLLVETLKGMGDVVAVTGDGTNDAPALKLADVGFSMGISGTEVAREASDIILMTDDFSAIVNAIKWGRCVSVSIKKFIQFQLIVNITAVILTFVSSVASSDETSVLTAVQLLWINLIMDTLAALALATDKPDPNIMDRKPRGRSTSLISVSTWKMILSQATLQLIVTFILHFYGPELFFKKHEDEITSHQQQQLNAMTFNTFVWLQFFTMLVSRKLDEGDGISNWRGRISAANLNFFQDLGRNYYFLTIMAIIGSCQVLIMFFGGAPFSIARQTKSMWITAVLCGMLSLIMGVLVRICPDEVAVKVFPAAFVQRFKYVFGLEFLRKNHTGKHDDEEALLEESDSPESTAFY"},{"created_at":"2011-05-26T20:46:41.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Diphosphomevalonate decarboxylase","uniprot_id":"P32377","uniprot_name":"MVD1_YEAST","enzyme":true,"transporter":false,"gene_name":"MVD1","num_residues":396,"molecular_weight":"44115.5","theoretical_pi":"5.49","general_function":"Involved in ATP binding","specific_function":"ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)","reactions":[{"id":1740,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2600,"direction":"\u003e","locations":null,"altext":"ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14371,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006889","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1FI4","cellular_location":null,"genbank_gene_id":"AY693152","genbank_protein_id":"51013755","gene_card_id":"MVD1","chromosome_location":"chromosome 14","locus":"YNR043W","synonyms":["Ergosterol biosynthesis protein 19","Mevalonate pyrophosphate decarboxylase","Mevalonate-5-diphosphate decarboxylase","MDD","MDDase"],"enzyme_classes":["4.1.1.33"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" diphosphomevalonate decarboxylase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" phosphorus metabolic process"}],"pfams":[{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGACCGTTTACACAGCATCCGTTACCGCACCCGTCAACATCGCAACCCTTAAGTATTGGGGGAAAAGGGACACGAAGTTGAATCTGCCCACCAATTCGTCCATATCAGTGACTTTATCGCAAGATGACCTCAGAACGTTGACCTCTGCGGCTACTGCACCTGAGTTTGAACGCGACACTTTGTGGTTAAATGGAGAACCACACAGCATCGACAATGAAAGAACTCAAAATTGTCTGCGCGACCTACGCCAATTAAGAAAGGAAATGGAATCGAAGGACGCCTCATTGCCCACATTATCTCAATGGAAACTCCACATTGTCTCCGAAAATAACTTTCCTACAGCAGCTGGTTTAGCTTCCTCCGCTGCTGGCTTTGCTGCATTGGTCTCTGCAATTGCTAAGTTATACCAATTACCACAGTCAACTTCAGAAATATCTAGAATAGCAAGAAAGGGGTCTGGTTCAGCTTGTAGATCGTCGTTTGGCGGATACGTGGCCTGGGAAATGGGAAAAGCTGAAGATGGTCATGATTCCATGGCAGTACAAATCGCAGACAGCTCTGACTGGCCTCAGATGAAAGCTTGTGTCCTAGTTGTCAGCGATATTAAAAAGGATGTGAGTTCCACTCAGGGTATGCAATTGACCGTGGCAACCTCCGAACTATTTAAAGAAAGAATTGAACATGTCGTACCAAAGAGATTTGAAGTCATGCGTAAAGCCATTGTTGAAAAAGATTTCGCCACCTTTGCAAAGGAAACAATGATGGATTCCAACTCTTTCCATGCCACATGTTTGGACTCTTTCCCTCCAATATTCTACATGAATGACACTTCCAAGCGTATCATCAGTTGGTGCCACACCATTAATCAGTTTTACGGAGAAACAATCGTTGCATACACGTTTGATGCAGGTCCAAATGCTGTGTTGTACTACTTAGCTGAAAATGAGTCGAAACTCTTTGCATTTATCTATAAATTGTTTGGCTCTGTTCCTGGATGGGACAAGAAATTTACTACTGAGCAGCTTGAGGCTTTCAACCATCAATTTGAATCATCTAACTTTACTGCACGTGAATTGGATCTTGAGTTGCAAAAGGATGTTGCCAGAGTGATTTTAACTCAAGTCGGTTCAGGCCCACAAGAAACAAACGAATCTTTGATTGACGCAAAGACTGGTCTACCAAAGGAATAA","protein_sequence":"MTVYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLWLNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLPTLSQWKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVLVVSDIKKDVSSTQGMQLTVATSELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSFHATCLDSFPPIFYMNDTSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKLFAFIYKLFGSVPGWDKKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGSGPQETNESLIDAKTGLPKE"},{"created_at":"2011-05-26T20:54:30.000Z","updated_at":"2011-05-27T15:01:10.000Z","name":"Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21","uniprot_id":"Q08975","uniprot_name":"THI21_YEAST","enzyme":true,"transporter":false,"gene_name":"THI21","num_residues":551,"molecular_weight":"61333.69922","theoretical_pi":"5.77","general_function":"Involved in phosphomethylpyrimidine kinase activity","specific_function":"Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probaby that of HMP to HMP- P","reactions":[{"id":1650,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1877,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2601,"direction":"\u003e","locations":"","altext":"ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":2602,"direction":"\u003e","locations":"","altext":"ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":14435,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006949","source":"Smpdb"},{"id":14436,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006950","source":"Smpdb"},{"id":14437,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006951","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z73614","genbank_protein_id":"1370532","gene_card_id":"THI21","chromosome_location":"chromosome 16","locus":"YPL258C","synonyms":["Hydroxymethylpyrimidine kinase","HMP kinase","Hydroxymethylpyrimidine phosphate kinase","HMP-P kinase","HMP-phosphate kinase","HMPP kinase"],"enzyme_classes":["2.7.1.49","2.7.4.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphomethylpyrimidine kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" thiamin biosynthetic process"}],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"},{"name":"TENA_THI-4","identifier":"PF03070"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine 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4-amino-2-methyl-5-diphosphomethylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":2603,"direction":"\u003e","locations":null,"altext":"thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.","export":false,"pw_reaction_id":null,"source":null},{"id":14435,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006949","source":"Smpdb"},{"id":14436,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006950","source":"Smpdb"},{"id":14437,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006951","source":"Smpdb"},{"id":14438,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006952","source":"Smpdb"},{"id":14439,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006955","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692780","genbank_protein_id":"51013011","gene_card_id":"THI20","chromosome_location":"chromosome 15","locus":"YOL055C","synonyms":["Hydroxymethylpyrimidine kinase","HMP 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kinase","uniprot_id":"Q04430","uniprot_name":"PANK_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":367,"molecular_weight":"40902.89844","theoretical_pi":"6.35","general_function":"Involved in pantothenate kinase activity","specific_function":"Plays a role in the physiological regulation of the intracellular CoA concentration","reactions":[{"id":1830,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2605,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.","export":false,"pw_reaction_id":null,"source":null},{"id":3766,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006289","source":"Smpdb"},{"id":3767,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006657","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U33057","genbank_protein_id":"927798","gene_card_id":null,"chromosome_location":null,"locus":"YDR531W","synonyms":["Pantothenic acid kinase"],"enzyme_classes":["2.7.1.33"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" pantothenate kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" coenzyme A biosynthetic process"}],"pfams":[{"name":"Fumble","identifier":"PF03630"}],"pathways":[{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGCCGCGAATTACTCAAGAGATATCTTACAATTGCGATTATGGCGACAATACTTTCAACCTTGCTATTGATATAGGAGGCACTCTGGCTAAAGTAGTCTTCTCGCCTATACACAGTAACAGGCTGATGTTCTACACCATTGAAACAGAGAAAATTGACAAGTTCATGGAACTTCTGCATTCTATTATCAAAGAACATAACAATGGATGCTATAGAATGACTCATATAATTGCCACTGGTGGTGGCGCCTTCAAGTTTTATGATTTGTTGTATGAAAATTTTCCTCAAATAAAAGGTATATCGAGGTTCGAAGAAATGGAAGGCTTAATTCACGGTTTAGACTTTTTCATTCATGAGATTCCCGATGAAGTTTTCACTTACAACGATCAAGATGGCGAAAGGATAATACCCACCAGTTCCGGCACCATGGACTCAAAGGCTATCTACCCATACCTTCTAGTCAATATAGGGTCGGGTGTCTCAATATTAAAAGTCACCGAACCAAACAATTTTAGTAGAGTAGGCGGTTCTTCACTGGGAGGAGGAACTCTTTGGGGCCTATTATCACTAATTACTGGCGCTCAAACTTATGATCAGATGCTCGATTGGGCACAAGAGGGTGACAATTCTAGCGTTGATATGCTAGTTGGAGATATTTATGGAACAGACTATAATAAAATTGGTCTAAAGTCGTCAGCTATTGCAAGTTCATTTGGTAAAGTTTTCCAAAATAGAATGACATCTAACAAATCTTTGGAAAACAACGAAAATAAATTATATTCCTCACATGAGTCTATTGAGAAAAACAATGGACAAATGTTTAAGAATCCTGATATTTGTAAAAGTCTTCTATTCGCCATCTCCAACAATATTGGGCAAATAGCTTATTTGCAAGCTAAAATCAATAATATACAGAATATATACTTTGGCGGATCTTATACCAGAGGACATTTGACTACCATGAACACTTTGAGCTACGCTATTAATTTTTGGTCACAAGGATCAAAGCAAGCGTTTTTTCTCAAACATGAAGGCTATTTGGGTGCAATGGGTGCTTTCCTAAGCGCGTCTCGTCATTCATCTACTAAGAAAACAAGTACGTAG","protein_sequence":"MPRITQEISYNCDYGDNTFNLAIDIGGTLAKVVFSPIHSNRLMFYTIETEKIDKFMELLHSIIKEHNNGCYRMTHIIATGGGAFKFYDLLYENFPQIKGISRFEEMEGLIHGLDFFIHEIPDEVFTYNDQDGERIIPTSSGTMDSKAIYPYLLVNIGSGVSILKVTEPNNFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQEGDNSSVDMLVGDIYGTDYNKIGLKSSAIASSFGKVFQNRMTSNKSLENNENKLYSSHESIEKNNGQMFKNPDICKSLLFAISNNIGQIAYLQAKINNIQNIYFGGSYTRGHLTTMNTLSYAINFWSQGSKQAFFLKHEGYLGAMGAFLSASRHSSTKKTST"},{"created_at":"2011-05-26T21:12:09.000Z","updated_at":"2011-07-22T17:54:13.000Z","name":"Aspartokinase","uniprot_id":"P10869","uniprot_name":"AK_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM3","num_residues":527,"molecular_weight":"58109.19922","theoretical_pi":"6.64","general_function":"Involved in amino acid binding","specific_function":"ATP + L-aspartate = ADP + 4-phospho-L- aspartate","reactions":[{"id":1333,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2606,"direction":"\u003e","locations":null,"altext":"ATP + L-aspartate = ADP + 4-phospho-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3783,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006304","source":"Smpdb"},{"id":3854,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006375","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03526","genbank_protein_id":"171693","gene_card_id":"HOM3","chromosome_location":"chromosome 5","locus":"YER052C","synonyms":["Aspartate kinase"],"enzyme_classes":["2.7.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Function","description":" aspartate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"ACT","identifier":"PF01842"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCAATGGATTTCCAACCTACATCAAGTCATTCGAACTGGGTCGTGCAAAAGTTCGGTGGTACATCTGTCGGTAAATTTCCCGTCCAAATAGTGGATGACATTGTGAAGCACTATTCTAAACCTGACGGCCCAAACAATAATGTCGCTGTCGTTTGTTCCGCCCGTTCTTCATACACCAAGGCTGAAGGTACCACTTCTCGTCTTTTGAAATGTTGTGATTTGGCTTCGCAAGAATCTGAATTTCAAGACATTATCGAAGTTATCAGACAAGACCATATCGATAATGCCGACCGCTTCATTCTCAATCCTGCCTTGCAAGCCAAGTTAGTGGATGATACCAATAAAGAACTTGAACTGGTCAAGAAATATTTAAATGCTTCAAAAGTTTTGGGTGAAGTGAGTTCACGTACAGTAGATCTGGTGATGTCATGTGGTGAGAAGTTGAGTTGTTTGTTCATGACTGCTTTATGTAATGACCGTGGCTGTAAGGCCAAATATGTGGATTTGAGCCACATTGTTCCCTCTGATTTCAGTGCCAGCGCTTTGGATAACAGTTTCTACACTTTCCTGGTTCAAGCATTGAAAGAAAAATTGGCCCCCTTTGTAAGTGCTAAAGAGCGTATCGTTCCAGTCTTTACAGGGTTTTTTGGTTTAGTTCCAACTGGTCTTCTGAATGGTGTTGGTCGTGGCTATACCGATTTATGTGCCGCTTTGATAGCAGTTGCTGTAAATGCTGATGAACTACAAGTTTGGAAGGAAGTTGATGGTATATTTACTGCTGATCCTCGTAAGGTTCCTGAAGCACGTTTGCTAGACAGTGTTACTCCAGAAGAAGCTTCTGAATTAACATATTATGGTTCCGAAGTTATACATCCTTTTACGATGGAACAAGTTATTAGGGCTAAGATTCCTATTAGAATCAAGAATGTTCAAAATCCATTAGGTAACGGTACCATTATCTACCCAGATAATGTAGCAAAGAAGGGTGAATCTACTCCACCACATCCTCCTGAGAACTTATCCTCATCTTTCTATGAAAAGAGAAAGAGAGGTGCCACTGCTATCACCACCAAAAATGACATTTTCGTCATCAACATTCATTCCAATAAGAAAACCCTATCCCATGGTTTCCTAGCTCAAATATTTACCATCCTGGATAAGTACAAGTTAGTCGTAGATTTAATATCTACTTCTGAAGTTCATGTTTCGATGGCTTTGCCCATTCCAGATGCAGACTCATTAAAATCTCTGAGACAAGCTGAGGAAAAATTGAGAATTTTAGGTTCTGTTGATATCACAAAGAAGTTGTCTATTGTTTCATTAGTTGGTAAACATATGAAACAATACATCGGCATTGCTGGTACCATGTTTACTACTCTTGCTGAAGAAGGCATCAACATTGAAATGATTTCTCAAGGGGCAAATGAAATAAACATATCCTGCGTTATCAATGAATCTGACTCCATAAAAGCGCTACAATGTATTCATGCCAAGTTACTAAGTGAGCGGACAAATACTTCAAACCAATTTGAACATGCCATTGATGAACGTTTAGAACAATTGAAAAGACTTGGAATTTAA","protein_sequence":"MPMDFQPTSSHSNWVVQKFGGTSVGKFPVQIVDDIVKHYSKPDGPNNNVAVVCSARSSYTKAEGTTSRLLKCCDLASQESEFQDIIEVIRQDHIDNADRFILNPALQAKLVDDTNKELELVKKYLNASKVLGEVSSRTVDLVMSCGEKLSCLFMTALCNDRGCKAKYVDLSHIVPSDFSASALDNSFYTFLVQALKEKLAPFVSAKERIVPVFTGFFGLVPTGLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRKVPEARLLDSVTPEEASELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDNVAKKGESTPPHPPENLSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTILDKYKLVVDLISTSEVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITKKLSIVSLVGKHMKQYIGIAGTMFTTLAEEGINIEMISQGANEINISCVINESDSIKALQCIHAKLLSERTNTSNQFEHAIDERLEQLKRLGI"},{"created_at":"2011-05-26T21:15:10.000Z","updated_at":"2011-07-22T17:53:54.000Z","name":"Acetyl-CoA carboxylase","uniprot_id":"Q00955","uniprot_name":"ACAC_YEAST","enzyme":true,"transporter":false,"gene_name":"FAS3","num_residues":2233,"molecular_weight":"250351.0","theoretical_pi":"6.21","general_function":"Involved in acetyl-CoA carboxylase activity","specific_function":"Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase","reactions":[{"id":1239,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2586,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2587,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":3705,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003286","source":"Smpdb"},{"id":3706,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006568","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OD4","cellular_location":"Cytoplasm","genbank_gene_id":"Z71631","genbank_protein_id":"1302498","gene_card_id":"FAS3","chromosome_location":null,"locus":"YNR016C","synonyms":["ACC","Biotin carboxylase"],"enzyme_classes":["6.4.1.2","6.3.4.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" CoA carboxylase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" acetyl-CoA carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"ACC_central","identifier":"PF08326"},{"name":"Carboxyl_trans","identifier":"PF01039"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGAGCGAAGAAAGCTTATTCGAGTCTTCTCCACAGAAGATGGAGTACGAAATTACAAACTACTCAGAAAGACATACAGAACTTCCAGGTCATTTCATTGGCCTCAATACAGTAGATAAACTAGAGGAGTCCCCGTTAAGGGACTTTGTTAAGAGTCACGGTGGTCACACGGTCATATCCAAGATCCTGATAGCAAATAATGGTATTGCCGCCGTGAAAGAAATTAGATCCGTCAGAAAATGGGCATACGAGACGTTCGGCGATGACAGAACCGTCCAATTCGTCGCCATGGCCACCCCAGAAGATCTGGAGGCCAACGCAGAATATATCCGTATGGCCGATCAATACATTGAAGTGCCAGGTGGTACTAATAATAACAACTACGCTAACGTAGACTTGATCGTAGACATCGCCGAAAGAGCAGACGTAGACGCCGTATGGGCTGGCTGGGGTCACGCCTCCGAGAATCCACTATTGCCTGAAAAATTGTCCCAGTCTAAGAGGAAAGTCATCTTTATTGGGCCTCCAGGTAACGCCATGAGGTCTTTAGGTGATAAAATCTCCTCTACCATTGTCGCTCAAAGTGCTAAAGTCCCATGTATTCCATGGTCTGGTACCGGTGTTGACACCGTTCACGTGGACGAGAAAACCGGTCTGGTCTCTGTCGACGATGACATCTATCAAAAGGGTTGTTGTACCTCTCCTGAAGATGGTTTACAAAAGGCCAAGCGTATTGGTTTTCCTGTCATGATTAAGGCATCCGAAGGTGGTGGTGGTAAAGGTATCAGACAAGTTGAACGTGAAGAAGATTTCATCGCTTTATACCACCAGGCAGCCAACGAAATTCCAGGCTCCCCCATTTTCATCATGAAGTTGGCCGGTAGAGCGCGTCACTTGGAAGTTCAACTGCTAGCAGATCAGTACGGTACAAATATTTCCTTGTTCGGTAGAGACTGTTCCGTTCAGAGACGTCATCAAAAAATTATCGAAGAAGCACCAGTTACAATTGCCAAGGCTGAAACATTTCACGAGATGGAAAAGGCTGCCGTCAGACTGGGGAAACTAGTCGGTTATGTCTCTGCCGGTACCGTGGAGTATCTATATTCTCATGATGATGGAAAATTCTACTTTTTAGAATTGAACCCAAGATTACAAGTCGAGCATCCAACAACGGAAATGGTCTCCGGTGTTAACTTACCTGCAGCTCAATTACAAATCGCTATGGGTATCCCTATGCATAGAATAAGTGACATTAGAACTTTATATGGTATGAATCCTCATTCTGCCTCAGAAATCGATTTCGAATTCAAAACTCAAGATGCCACCAAGAAACAAAGAAGACCTATTCCAAAGGGTCATTGTACCGCTTGTCGTATCACATCAGAAGATCCAAACGATGGATTCAAGCCATCGGGTGGTACTTTGCATGAACTAAACTTCCGTTCTTCCTCTAATGTTTGGGGTTACTTCTCCGTGGGTAACAATGGTAATATTCACTCCTTTTCGGACTCTCAGTTCGGCCATATTTTTGCTTTTGGTGAAAATAGACAAGCTTCCAGGAAACACATGGTTGTTGCCCTGAAGGAATTGTCCATTAGGGGTGATTTCAGAACTACTGTGGAATACTTGATCAAACTTTTGGAAACTGAAGATTTCGAGGATAACACTATTACCACCGGTTGGTTGGACGATTTGATTACTCATAAAATGACCGCTGAAAAGCCTGATCCAACTCTTGCCGTCATTTGCGGTGCCGCTACAAAGGCTTTCTTAGCATCTGAAGAAGCCCGCCACAAGTATATCGAATCCTTACAAAAGGGACAAGTTCTATCTAAAGACCTACTGCAAACTATGTTCCCTGTAGATTTTATCCATGAGGGTAAAAGATACAAGTTCACCGTAGCTAAATCCGGTAATGACCGTTACACATTATTTATCAATGGTTCTAAATGTGATATCATACTGCGTCAACTATCTGATGGTGGTCTTTTGATTGCCATAGGCGGTAAATCGCATACCATCTATTGGAAAGAAGAAGTTGCTGCTACAAGATTATCCGTTGACTCTATGACTACTTTGTTGGAAGTTGAAAACGATCCAACCCAGTTGCGTACTCCATCCCCTGGTAAATTGGTTAAATTCTTGGTGGAAAATGGTGAACACATTATCAAGGGCCAACCATATGCAGAAATTGAAGTTATGAAAATGCAAATGCCTTTGGTTTCTCAAGAAAATGGTATCGTCCAGTTATTAAAGCAACCTGGTTCTACCATTGTTGCAGGTGATATCATGGCTATTATGACTCTTGACGATCCATCCAAGGTCAAGCACGCTCTACCATTTGAAGGTATGCTGCCAGATTTTGGTTCTCCAGTTATCGAAGGAACCAAACCTGCCTATAAATTCAAGTCATTAGTGTCTACTTTGGAAAACATTTTGAAGGGTTATGACAACCAAGTTATTATGAACGCTTCCTTGCAACAATTGATAGAGGTTTTGAGAAATCCAAAACTGCCTTACTCAGAATGGAAACTACACATCTCTGCTTTACATTCAAGATTGCCTGCTAAGCTAGATGAACAAATGGAAGAGTTAGTTGCACGTTCTTTGAGACGTGGTGCTGTTTTCCCAGCTAGACAATTAAGTAAATTGATTGATATGGCCGTGAAGAATCCTGAATACAACCCCGACAAATTGCTGGGCGCCGTCGTGGAACCATTGGCGGATATTGCTCATAAGTACTCTAACGGGTTAGAAGCCCATGAACATTCTATATTTGTCCATTTCTTGGAAGAATATTACGAAGTTGAAAAGTTATTCAATGGTCCAAATGTTCGTGAGGAAAATATCATTCTGAAATTGCGTGATGAAAACCCTAAAGATCTAGATAAAGTTGCGCTAACTGTTTTGTCTCATTCGAAAGTTTCAGCGAAGAATAACCTGATCCTAGCTATCTTGAAACATTATCAACCATTGTGCAAGTTATCTTCTAAAGTTTCTGCCATTTTCTCTACTCCTCTACAACATATTGTTGAACTAGAATCTAAGGCTACCGCTAAGGTCGCTCTACAAGCAAGAGAAATTTTGATTCAAGGCGCTTTACCTTCGGTCAAGGAAAGAACTGAACAAATTGAACATATCTTAAAATCCTCTGTTGTGAAGGTTGCCTATGGCTCATCCAATCCAAAGCGCTCTGAACCAGATTTGAATATCTTGAAGGACTTGATCGATTCTAATTACGTTGTGTTCGATGTTTTACTTCAATTCCTAACCCATCAAGACCCAGTTGTGACTGCTGCAGCTGCTCAAGTCTATATTCGTCGTGCTTATCGTGCTTACACCATAGGAGATATTAGAGTTCACGAAGGTGTCACAGTTCCAATTGTTGAATGGAAATTCCAACTACCTTCAGCTGCGTTCTCCACCTTTCCAACTGTTAAATCTAAAATGGGTATGAACAGGGCTGTTTCTGTTTCAGATTTGTCATATGTTGCAAACAGTCAGTCATCTCCGTTAAGAGAAGGTATTTTGATGGCTGTGGATCATTTAGATGATGTTGATGAAATTTTGTCACAAAGTTTGGAAGTTATTCCTCGTCACCAATCTTCTTCTAACGGACCTGCTCCTGATCGTTCTGGTAGCTCCGCATCGTTGAGTAATGTTGCTAATGTTTGTGTTGCTTCTACAGAAGGTTTCGAATCTGAAGAGGAAATTTTGGTAAGGTTGAGAGAAATTTTGGATTTGAATAAGCAGGAATTAATCAATGCTTCTATCCGTCGTATCACATTTATGTTCGGTTTTAAAGATGGGTCTTATCCAAAGTATTATACTTTTAACGGTCCAAATTATAACGAAAATGAAACAATTCGTCACATTGAGCCGGCTTTGGCCTTCCAACTGGAATTAGGAAGATTGTCCAACTTCAACATTAAACCAATTTTCACTGATAATAGAAACATCCATGTCTACGAAGCTGTTAGTAAGACTTCTCCATTGGATAAGAGATTCTTTACAAGAGGTATTATTAGAACGGGTCATATCCGTGATGACATTTCTATTCAAGAATATCTGACTTCTGAAGCTAACAGATTGATGAGTGATATATTGGATAATTTAGAAGTCACCGACACTTCAAATTCTGATTTGAATCATATCTTCATCAACTTCATTGCGGTGTTTGATATCTCTCCAGAAGATGTCGAAGCCGCCTTCGGTGGTTTCTTAGAAAGATTTGGTAAGAGATTGTTGAGATTGCGTGTTTCTTCTGCCGAAATTAGAATCATCATCAAAGATCCTCAAACAGGTGCCCCAGTACCATTGCGTGCCTTGATCAATAACGTTTCTGGTTATGTTATCAAAACAGAAATGTACACCGAAGTCAAGAACGCAAAAGGTGAATGGGTATTTAAGTCTTTGGGTAAACCTGGATCCATGCATTTAAGACCTATTGCTACTCCTTACCCTGTTAAGGAATGGTTGCAACCAAAACGTTATAAGGCACACTTGATGGGTACCACATATGTCTATGACTTCCCAGAATTATTCCGCCAAGCATCGTCATCCCAATGGAAAAATTTCTCTGCAGATGTTAAGTTAACAGATGATTTCTTTATTTCCAACGAGTTGATTGAAGATGAAAACGGCGAATTAACTGAGGTGGAAAGAGAACCTGGTGCCAACGCTATTGGTATGGTTGCCTTTAAGATTACTGTAAAGACTCCTGAATATCCAAGAGGCCGTCAATTTGTTGTTGTTGCTAACGATATCACATTCAAGATCGGTTCCTTTGGTCCACAAGAAGACGAATTCTTCAATAAGGTTACTGAATATGCTAGAAAGCGTGGTATCCCAAGAATTTACTTGGCTGCAAACTCAGGTGCCAGAATTGGTATGGCTGAAGAGATTGTTCCACTATTTCAAGTTGCATGGAATGATGCTGCCAATCCGGACAAGGGCTTCCAATACTTATACTTAACAAGTGAAGGTATGGAAACTTTAAAGAAATTTGACAAAGAAAATTCTGTTCTCACTGAACGTACTGTTATAAACGGTGAAGAAAGATTTGTCATCAAGACAATTATTGGTTCTGAAGATGGGTTAGGTGTCGAATGTCTACGTGGATCTGGTTTAATTGCTGGTGCAACGTCAAGGGCTTACCACGATATCTTCACTATCACCTTAGTCACTTGTAGATCCGTCGGTATCGGTGCTTATTTGGTTCGTTTGGGTCAAAGAGCTATTCAGGTCGAAGGCCAGCCAATTATTTTAACTGGTGCTCCTGCAATCAACAAAATGCTGGGTAGAGAAGTTTATACTTCTAACTTACAATTGGGTGGTACTCAAATCATGTATAACAACGGTGTTTCACATTTGACTGCTGTTGACGATTTAGCTGGTGTAGAGAAGATTGTTGAATGGATGTCTTATGTTCCAGCCAAGCGTAATATGCCAGTTCCTATCTTGGAAACTAAAGACACATGGGATAGACCAGTTGATTTCACTCCAACTAATGATGAAACTTACGATGTAAGATGGATGATTGAAGGTCGTGAGACTGAAAGTGGATTTGAATATGGTTTGTTTGATAAAGGGTCTTTCTTTGAAACTTTGTCAGGATGGGCCAAAGGTGTTGTCGTTGGTAGAGCCCGTCTTGGTGGTATTCCACTGGGTGTTATTGGTGTTGAAACAAGAACTGTCGAGAACTTGATTCCTGCTGATCCAGCTAATCCAAATAGTGCTGAAACATTAATTCAAGAACCTGGTCAAGTTTGGCATCCAAACTCCGCCTTCAAGACTGCTCAAGCTATCAATGACTTTAACAACGGTGAACAATTGCCAATGATGATTTTGGCCAACTGGAGAGGTTTCTCTGGTGGTCAACGTGATATGTTCAACGAAGTCTTGAAGTATGGTTCGTTTATTGTTGACGCATTGGTGGATTACAAACAACCAATTATTATCTATATCCCACCTACCGGTGAACTAAGAGGTGGTTCATGGGTTGTTGTCGATCCAACTATCAACGCTGACCAAATGGAAATGTATGCCGACGTCAACGCTAGAGCTGGTGTTTTGGAACCACAAGGTATGGTTGGTATCAAGTTCCGTAGAGAAAAATTGCTGGACACCATGAACAGATTGGATGACAAGTACAGAGAATTGAGATCTCAATTATCCAACAAGAGTTTGGCTCCAGAAGTACATCAGCAAATATCCAAGCAATTAGCTGATCGTGAGAGAGAACTATTGCCAATTTACGGACAAATCAGTCTTCAATTTGCTGATTTGCACGATAGGTCTTCACGTATGGTGGCCAAGGGTGTTATTTCTAAGGAACTGGAATGGACCGAGGCACGTCGTTTCTTCTTCTGGAGATTGAGAAGAAGATTGAACGAAGAATATTTGATTAAAAGGTTGAGCCATCAGGTAGGCGAAGCATCAAGATTAGAAAAGATCGCAAGAATTAGATCGTGGTACCCTGCTTCAGTGGACCATGAAGATGATAGGCAAGTCGCAACATGGATTGAAGAAAACTACAAAACTTTGGACGATAAACTAAAGGGTTTGAAATTAGAGTCATTCGCTCAAGACTTAGCTAAAAAGATCAGAAGCGACCATGACAATGCTATTGATGGATTATCTGAAGTTATCAAGATGTTATCTACCGATGATAAAGAAAAATTGTTGAAGACTTTGAAATAA","protein_sequence":"MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEESPLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKPAYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILIQGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTVKSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRITFMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK"},{"created_at":"2011-05-26T21:15:58.000Z","updated_at":"2011-07-22T17:54:40.000Z","name":"Thymidylate kinase","uniprot_id":"P00572","uniprot_name":"KTHY_YEAST","enzyme":true,"transporter":false,"gene_name":"CDC8","num_residues":216,"molecular_weight":"24687.19922","theoretical_pi":"5.41","general_function":"Involved in thymidylate kinase activity","specific_function":"Catalyzes the conversion of dTMP to dTDP","reactions":[{"id":1474,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2607,"direction":"\u003e","locations":null,"altext":"ATP + dTMP = ADP + dTDP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"3TMK","cellular_location":null,"genbank_gene_id":"K01783","genbank_protein_id":"171204","gene_card_id":"CDC8","chromosome_location":"chromosome 10","locus":"YJR057W","synonyms":["dTMP kinase"],"enzyme_classes":["2.7.4.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" thymidylate kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" pyrimidine nucleoside diphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" pyrimidine deoxyribonucleoside diphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" dTDP biosynthetic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"}],"pfams":[{"name":"Thymidylate_kin","identifier":"PF02223"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGATGGGTCGTGGCAAATTAATACTGATAGAAGGATTGGATAGGACTGGTAAAACCACGCAATGTAATATTCTTTACAAAAAATTGCAACCAAACTGTAAACTATTGAAGTTCCCCGAAAGGTCTACCCGAATCGGAGGACTCATAAACGAATATTTGACGGATGATACTTTCCAATTATCAGATCAGGCAATTCACCTCTTGTTTTCGGCAAATAGATGGGAAATAGTTGACAAGATAAAGAAAGATTTACTAGAAGGCAAGAACATTGTCATGGACAGATATGTTTATTCTGGAGTGGCATATTCTGCCGCTAAGGGGACAAATGGAATGGATTTGGATTGGTGCTTGCAACCCGATGTAGGGTTGCTGAAACCGGATTTGACATTATTTTTAAGCACTCAAGATGTCGACAATAACGCCGAAAAATCTGGATTTGGTGACGAAAGATACGAAACTGTTAAGTTTCAAGAAAAAGTGAAGCAAACTTTTATGAAGCTATTGGATAAAGAGATAAGGAAAGGCGATGAGTCAATCACGATTGTAGACGTTACTAATAAGGGCATTCAGGAAGTTGAAGCGCTTATTTGGCAAATCGTTGAGCCTGTTTTGAGTACGCATATTGATCATGATAAATTTTCGTTCTTCTAG","protein_sequence":"MMGRGKLILIEGLDRTGKTTQCNILYKKLQPNCKLLKFPERSTRIGGLINEYLTDDSFQLSDQAIHLLFSANRWEIVDKIKKDLLEGKNIVMDRYVYSGVAYSAAKGTNGMDLDWCLQPDVGLLKPDLTLFLSTQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLDKEIRKGDESITIVDVTNKGIQEVEALIWQIVEPVLSTHIDHDKFSFF"},{"created_at":"2011-05-26T21:20:36.000Z","updated_at":"2011-05-27T15:01:10.000Z","name":"Phosphatidylinositol 4-kinase STT4","uniprot_id":"P37297","uniprot_name":"STT4_YEAST","enzyme":true,"transporter":false,"gene_name":"STT4","num_residues":1900,"molecular_weight":"214605.0","theoretical_pi":"7.51","general_function":"Involved in binding","specific_function":"Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway","reactions":[{"id":2054,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":34400,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R026916","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D13717","genbank_protein_id":"454207","gene_card_id":"STT4","chromosome_location":"chromosome 12","locus":"YLR305C","synonyms":["PI4-kinase","PtdIns-4-kinase"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" phosphoinositide-mediated signaling"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Stress-activated signalling pathways: cell wall stress test 1","kegg_map_id":null}],"gene_sequence":"ATGAGATTTACCAGAGGATTGAAAGCCTCTTCATCTTTAAGAGCGAAAGCTATTGGAAGACTAACTAAACTTTCGACGGGTGCACCAAATGATCAAAACAGTAATGGTACAACATTAGATTTGATAACTCATACATTGCCTATTTTTTATTCCACAAATACGTCAAAGATATATACTATACCACTTACATTGAGTGAATGGGAAGTACTAACTTCGCTTTGTGTTGCAATCCCTACCACGCTCGATCTGGTAGAGACAATGCTTAAAGAAATAATTGCGCCTTATTTTCTGGAAACTCCAAGACAAAGAATTTCAGATGTTCTGTCCTCGAAATTCAAGTTGGAACAGATGAGAAATCCGATTGAATTGCTAACTTTCCAGCTGACTAAGTTTATGATTCAAGCTTGTGAACAGTATCCCGTTCTTTATGAAAATATAGGCGGCATCATTTCAACTTATTTTGAGCGTGTATTAAAGATTTTTACTATTAAACAATCTGGTCTACTATCATTAGTGGGCTTTATTAATGCATTTATCCAGTTTCCCAACTCTACAGAGCTTACTAAATTCACCTGGAAAAAGTTAGCGAAACTTGTGCTTCGTGGATCATTTCTAAACGAAGTTGATAAGATTTTGAATTCCTCAGCAACGTTTACCAATGATTCAATCGTCCAGTATTACGATGCTGGAAATGAGCTATCCAGTGCCTACTTATTGGAATTAATATCTCGCTTGCAAGTTTCGCTAATATCTCATCTGTTAAACACTTCACATGTCGGCGCCAACTTGAGTGAGTTCTTACTAAATCAACAATACCAATTTTACAAATTTGATCAAGAAGTAGCCGATGAAAACGATGATACGAAGTGTATTGATGACTTTTTTTTCAACGTAAGAAGCAATAAACAGTTTTTTACAGACATGTGTAAAATTTCCCTGCAATTTTGTTCTGAGTCACATATTCTCGACCTATCTACAGACAACCGTGCAAGATTTTCTTTTGATACTCGAGCCCACTACCTACAAACGCTATGTTTAATTCCGTTTATAGAAGATACAGAAAGCGAGCTTTTTGAAAGTTTTACAAACGTTGTTTCTGAATCTATTGATAAATTTTTCTTATCTGATGTCGTTACACCATCTTTGATAAAAGCAATTGTAGCTTCTGCCTCATTACTGAATTTTTTCACGGAAAAATTGTCATTAACTCTGATTCGTATGTTTCCTTTATTGGTAGCGTCTCCACATATCACGACTGAAACAGTTAATGATGTTGCAAAAATATTCACCACAGGGTTATACCCTCTAAATGAAGATGCAATTGTGAGTACAATTTATTCCATGAACAACTTATTAGCTGTTTCCGAGGACGGATCGCCCGTCCCGGTGCTCCGTGAGCGCCAATTAACAATAACATCTGGAAAAAATATTGAGAAAGACTACTTTCCCTTGCGAAATTCATCTGCCAGTTTGGATGGCACTGGTGCTCTGCTCGGAAATACAACTGTGGGCCAACTTTCCTCCCATGATGTCAATAGTGGAGCTACTATGACATACCATGCCTCTTTGATATCTAATTGTGTGGCTGCAACGACTACAATCGCCTCATACTATAACACCCAAAGCATAACAGCTTTGACTATCTCTATTCTTACGCAAAAAGTTAATTCTATGTCAAAGGAATTAGACGGTGTTATTTTGAATTCTTTGGCAAGACTGGCTCCGAATACTTCACTGACAGAATTTTCGCTTTTACTAAAGTTCTTCAAATCGAGAACTGTTATTGCAACAAAAATTGATGATAGCGCACTATTGAAAAATATTATTAAAGCGAAATGTGTGATATCAAAAGAATTGTTGGCCAGGCATTTTTCAAGTGACTTATATTTCATGTATCTTCATGATCTATTGGACTCAATTATTGCCAGTGGGGAAGTAGAACGATTGGAACATCACAGACCTCAAACGGAGATTTCCCGTGTTGCTGATCAAATCGCTACCTACTTAGAGCCCCTCGCCGCTCTACTACCTGTTCCAGGCGATACGCCATTGGACATCAATAAGGATGAAGTCACTACAAACAAGTTTAGGAACGCCTGGTTTAATTTTGTCATCCATGGGTACCACTTGGGCGGGCCTATTGTCAAACGAAATTTTTCTTTCTTATTAACTATTGCCTATAATTCACCACCGCTGGCTTCTGAATTTCCTGCTAATAACAAGGAGCTTTCATTGGAAATGAATACAATTTTGCGCCGCGGTTCATCTAACGAAAATATCAAACAACAAAAACAGCAGATAACCGAATATTTCAATACCAATATTGTTCAGTACAGAACAACTTCATCGTCTAAAATCATGTTTTTAGCGGCTGCCGTTCTTCTAGAAACGATAAGATGCGAGGCAGGTGATTGTTCGAAGACTCTACTGTACTTCTCAGACCCCTCCATTCTTTCCGGTTCAATTGAGAAGTGTATTGCAGTTTTGTCGGTTTCCATGATTAGAAAATATGCTAGGTTGATTCAAAAGGGTAACGATGCCATATTCAACTCCAAAATGATTGCTCAACAACTTAATAACTTGCTACTTTGCCTTTCTCATAGGGAACCAACTTTGCAGGATGCCGCTTTTCATGCCTGTGAAATATTTATCAGATCTATTCCATCATCGTTATGTCATCATTTGTCTCTCTACACCTTATTAGATATGTTAACAGCCCTATTTGATAGTATCTTGGACTCAGAGGCGCATAAATTTGAACCACGGTATGAATTTAAATTAAAACATTCTAAGACAACAATATTGGTTCCAAGCTCATCGTCCTGGCGCGCTACGACACTATCAAGATTGCACAAGTCAGCTAAAGAATGGGTAAGAATTCTATTGAATAGAAGCAACCAGGATACTAAGATTTTGTTGCAATCATACATATCAGATCTCGGTGAGTACAGCAGGCTAAATTCTGTTGAATTTGGTGTCTCATTTGCCATGGATATGGCTGGTTTGATTTTACCTGCAGATAAGGAATTATCAAGGCTTACTTATTATGGTCCAGAGAAACCTAACACGATTTCTGGATTTATATCTTTACATTCTTGGAGGTCAAAATATCTTTTCGATACCGCTATTACATCATCACCAGAGGATATCAAAAGGCAAATAGGTATTTCCACTCAAAACATAAGAAAAAATTTGACCTTAGGAAATAAGATTATAACTAAAGACGTAACTGATTTTCTTGATATGGCTACCGCGTTGTTAATTCTTGGCAATGGTGCACCAGCGTCATTGATATATGATATTGTGCACATCCCGTTCGAAGTCTTCACCTCTGCATCTTTAAAGATTGCTACAAACGTATGGTTAACAATCATAACTGAGAAGCCCGAAGTTGCACATTTGCTTTTAGTTGAAGTATGCTATTGCTGGATGCGCTCCATTGATGACAATATTGGTCTCTATTCTCGCGATCATGACTTAAAGGGCGAAGAATACCAAAAAATGGAATATTCCCCTTACGACAAAGCAGGTATCAACAGAGATGCAAAAAATGCATCCCAAGCTATGCAACCACATCTTCATGTTATTAAATTTTTTGCTTCCCATTTCGAGGGCACACTATTTCAAAGTGACTTTTTATTGAAAATTTTCACGAAATGTGCGCTTTATGGTATCAAGAATCTGTATAAGGCTTCACTACACCCGTTCGCTAGAATGATTCGCCACGAATTATTGTTATTCGCGACTCTCGTACTAAACGCAAGTTATAAGCAGGGATCCAAGTATATGGGCCGTTTGTCGCAAGAAATCACAAACGGTGCCCTAAGTTGGTTTAAAAGACCAGTAGCGTGGCCATTCGGCTCAAATGAGCTGAAAATCAAAGCAGATTTATCTGTTACTAGGGACCTTTTCCTTCAGCTCAACAAATTAAGCTCGCTAATGTCACGTCATTGCGGGAAAGATTACAAGATCCTGAACTATTTCTTGGCAAGCGAAATCCAGCAGATTCAAACCTGGCTTACTCCGACTGAGAAGATTGAAGGAGCCGACAGCAACGAGCTTACAAGCGATATCGTTGAAGCTACCTTTGCTAAAGATCCAACATTAGCAATAAATCTCTTACAACGATGTTATAGCAAGAAAGCTGAGGATGTTTTAGTGGGCTTAGTTGCAAAACATGCTTTAATGTGTGTGGGGTCCCCAAGTGCTCTTGACCTGTTCATAAAAGGAAGCCACCTGAGCAGTAAGAAAGACCTACACGCAACCTTATACTGGGCGCCAGTGAGCCCGTTAAAATCTATCAACCTTTTCCTTCCCGAATGGCAAGGTAATTCTTTTATCTTACAATTCAGCATATATTCGTTGGAATCACAAGATGTGAACTTGGCATTCTTCTATGTTCCTCAAATCGTACAATGTTTGAGATACGATAAAACCGGATATGTCGAAAGATTGATTTTGGATACTGCGAAAATTAGTGTGTTATTTTCTCATCAAATAATCTGGAATATGCTTGCAAACTGCTACAAGGATGATGAAGGTATACAAGAAGATGAAATCAAACCAACTCTAGATCGTATTAGGGAGCGTATGGTTTCAAGTTTCAGCCAATCTCATCGCGATTTTTACGAACGTGAATTTGAATTCTTCGACGAAGTAACTGGCATATCTGGTAAGTTGAAACCATACATAAAAAAAAGTAAGGCTGAAAAGAAACATAAGATCGATGAAGAAATGAGCAAAATTGAGGTGAAACCTGATGTTTATTTACCTTCTAATCCTGACGGTGTAGTTATTGATATTGATCGGAAGAGTGGTAAGCCACTTCAATCTCACGCAAAGGCGCCTTTTATGGCGACCTTTAAAATAAAGAAAGACGTAAAAGATCCTTTGACAGGTAAAAACAAGGAAGTTGAAAAATGGCAAGCTGCTATCTTCAAAGTCGGTGATGACTGTAGGCAAGATGTTCTAGCGTTACAATTGATCTCGCTATTTAGAACCATTTGGTCTAGTATTGGCTTGGATGTCTACGTTTTTCCCTACAGAGTTACTGCGACGGCACCGGGTTGTGGTGTCATCGATGTGCTACCCAATTCGGTATCCCGTGATATGTTAGGACGTGAAGCTGTTAATGGATTATATGAATATTTCACTAGTAAATTTGGTAATGAATCTACTATCGAATTTCAAAACGCACGAAACAACTTTGTTAAATCCTTAGCGGGATATAGCGTAATTTCGTATTTGTTGCAATTCAAGGATAGACATAATGGTAACATTATGTACGATGATCAAGGACATTGTCTACATATCGATTTTGGGTTTATTTTTGATATTGTCCCAGGTGGTATCAAGTTTGAAGCAGTACCATTCAAGCTGACGAAAGAAATGGTTAAAGTGATGGGAGGTTCGCCCCAGACCCCAGCGTATCTGGACTTTGAAGAACTTTGTATCAAGGCATATCTAGCCGCCCGTCCGCACGTGGAGGCCATAATTGAGTGTGTAAATCCTATGTTAGGAAGCGGTCTCCCCTGCTTTAAGGGTCACAAGACAATTAGGAATCTAAGAGCAAGATTTCAACCTCAAAAAACCGATCACGAAGCTGCACTATATATGAAGGCGCTAATCCGTAAAAGTTATGAAAGTATATTCACTAAAGGTTATGATGAATTCCAAAGGCTCACAAATGGCATTCCGTACTGA","protein_sequence":"MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLELISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRSNKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVCYCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY"},{"created_at":"2011-05-26T21:23:19.000Z","updated_at":"2011-05-27T15:01:11.000Z","name":"Plasma membrane ATPase 1","uniprot_id":"P05030","uniprot_name":"PMA1_YEAST","enzyme":true,"transporter":false,"gene_name":"PMA1","num_residues":918,"molecular_weight":"99618.39844","theoretical_pi":"4.72","general_function":"Involved in nucleotide binding","specific_function":"The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses","reactions":[{"id":2599,"direction":"\u003e","locations":"Mitochondrion. Mitochondrion inner membrane.; Multi-pass membrane protein;Cell membrane;Endomembrane system. Vacuole membrane (Probable).","altext":"ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"116-136;141-160;292-313;326-347;720-738;755-774;825-845;858-874","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"X03534","genbank_protein_id":"4187","gene_card_id":"PMA1","chromosome_location":"chromosome 7","locus":"YGL008C","synonyms":["Proton pump 1"],"enzyme_classes":["3.6.3.6"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGACTGATACATCATCCTCTTCATCATCCTCTTCAGCATCTTCTGTTTCAGCTCATCAGCCAACTCAAGAAAAGCCTGCTAAGACTTACGATGACGCTGCATCTGAATCTTCTGACGATGACGATATCGATGCTTTAATCGAAGAACTACAATCTAATCACGGTGTCGACGACGAAGACAGTGATAACGATGGTCCAGTTGCCGCCGGTGAAGCTAGACCAGTTCCAGAAGAATATTTACAAACTGACCCATCTTACGGTTTAACTTCCGATGAAGTTTTGAAAAGAAGAAAGAAGTACGGTTTGAATCAAATGGCTGACGAAAAAGAATCTTTAGTCGTTAAGTTCGTTATGTTTTTCGTCGGTCCAATTCAATTCGTTATGGAAGCCGCTGCTATTTTGGCTGCCGGTTTGTCCGATTGGGTCGATTTCGGTGTTATCTGTGGTTTGTTAATGTTAAACGCTGGTGTTGGTTTCGTTCAAGAATTCCAAGCTGGTTCTATTGTCGATGAATTGAAAAAGACTTTGGCTAACACTGCTGTTGTTATCAGAGACGGTCAATTGGTTGAAATTCCAGCCAACGAAGTCGTCCCAGGTGATATTTTGCAATTGGAAGATGGTACTGTTATCCCAACTGATGGTCGTATTGTCACTGAAGACTGTTTCTTGCAAATCGATCAATCTGCTATTACTGGTGAATCTTTGGCTGTCGACAAACATTACGGTGACCAAACTTTCTCTTCTTCCACTGTTAAGAGAGGTGAAGGTTTCATGGTTGTTACCGCTACCGGTGACAACACTTTCGTTGGTAGAGCTGCTGCTTTGGTTAACAAAGCCGCTGGTGGTCAAGGTCATTTCACTGAAGTTTTGAACGGTATTGGTATTATCTTATTGGTTTTGGTCATTGCCACTTTGTTGTTGGTCTGGACTGCTTGTTTCTACAGAACCAACGGTATTGTTAGAATCTTGAGATACACTCTAGGTATTACTATTATTGGTGTCCCAGTCGGTTTGCCAGCTGTCGTTACCACCACTATGGCCGTCGGTGCTGCTTACTTGGCTAAGAAACAAGCCATTGTTCAAAAGTTGTCTGCTATTGAATCCTTGGCTGGTGTCGAAATCTTGTGTTCCGACAAAACCGGTACTTTGACCAAGAACAAGTTGTCCTTGCACGAACCATACACTGTTGAAGGTGTTTCTCCAGACGACTTGATGTTGACTGCTTGTTTGGCTGCTTCCAGAAAGAAGAAGGGTTTGGATGCTATTGATAAGGCTTTCTTGAAGTCTTTGAAGCAATATCCAAAGGCTAAGGACGCTTTGACCAAGTACAAGGTTTTGGAATTCCATCCATTTGACCCTGTCTCCAAGAAGGTTACTGCCGTTGTCGAATCTCCAGAAGGTGAAAGAATTGTTTGTGTTAAGGGTGCTCCATTATTCGTCTTGAAGACTGTCGAAGAAGATCACCCAATCCCAGAAGATGTCCATGAAAACTACGAAAACAAGGTTGCTGAATTGGCTTCTAGAGGGTTCCGTGCTTTAGGTGTTGCTAGAAAGAGAGGTGAAGGTCACTGGGAAATCTTGGGTGTTATGCCATGTATGGATCCACCAAGAGACGATACTGCTCAAACTGTTAGCGAAGCTAGACACTTGGGTCTAAGAGTTAAGATGTTAACTGGTGATGCTGTTGGTATTGCTAAGGAAACTTGTAGACAATTGGGTTTGGGTACCAACATTTACAACGCTGAAAGATTAGGTCTAGGTGGCGGTGGTGACATGCCAGGTTCTGAATTAGCTGATTTTGTTGAAAATGCCGATGGTTTCGCTGAAGTTTTCCCACAACATAAATACAGAGTTGTTGAAATCTTGCAAAACAGAGGTTACTTGGTTGCTATGACTGGTGATGGTGTTAACGATGCTCCATCTTTGAAGAAGGCTGATACTGGTATTGCTGTCGAAGGTGCTACTGATGCTGCCAGATCTGCTGCTGATATTGTTTTCTTGGCTCCTGGTCTATCTGCTATTATTGATGCTTTGAAGACCTCCAGACAAATTTTTCACAGAATGTACTCTTACGTTGTTTACCGTATTGCTTTGTCTCTACATTTGGAAATCTTCTTGGGTCTATGGATTGCTATTTTGGATAACTCTTTGGACATTGATTTGATTGTTTTCATCGCTATTTTCGCTGATGTTGCTACTTTGGCTATTGCTTACGATAATGCTCCTTACTCTCCAAAGCCCGTTAAATGGAACCTACCAAGATTATGGGGTATGTCTATTATTTTGGGCATAGTTTTAGCTATAGGTTCTTGGATTACCTTGACTACTATGTTCTTACCAAAGGGTGGTATTATCCAAAACTTCGGTGCTATGAACGGTATTATGTTCTTGCAAATTTCCTTGACTGAAAACTGGTTGATTTTCATTACCAGAGCTGCTGGTCCATTCTGGTCTTCTATCCCATCCTGGCAATTGGCTGGTGCCGTCTTCGCTGTCGACATCATCGCTACCATGTTTACCTTATTCGGTTGGTGGTCTGAAAACTGGACTGATATTGTTACTGTCGTCCGTGTCTGGATCTGGTCTATCGGTATCTTCTGTGTTTTGGGTGGTTTCTACTACGAAATGTCCACTTCTGAAGCCTTTGACAGATTGATGAACGGTAAGCCAATGAAGGAAAAGAAGTCTACCAGAAGTGTCGAAGACTTCATGGCTGCTATGCAAAGAGTCTCTACTCAACACGAAAAGGAAACCTAA","protein_sequence":"MTDTSSSSSSSSASSVSAHQPTQEKPAKTYDDAASESSDDDDIDALIEELQSNHGVDDEDSDNDGPVAAGEARPVPEEYLQTDPSYGLTSDEVLKRRKKYGLNQMADEKESLVVKFVMFFVGPIQFVMEAAAILAAGLSDWVDFGVICGLLMLNAGVGFVQEFQAGSIVDELKKTLANTAVVIRDGQLVEIPANEVVPGDILQLEDGTVIPTDGRIVTEDCFLQIDQSAITGESLAVDKHYGDQTFSSSTVKRGEGFMVVTATGDNTFVGRAAALVNKAAGGQGHFTEVLNGIGIILLVLVIATLLLVWTACFYRTNGIVRILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLKQYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPRDDTAQTVSEARHLGLRVKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILDNSLDIDLIVFIAIFADVATLAIAYDNAPYSPKPVKWNLPRLWGMSIILGIVLAIGSWITLTTMFLPKGGIIQNFGAMNGIMFLQISLTENWLIFITRAAGPFWSSIPSWQLAGAVFAVDIIATMFTLFGWWSENWTDIVTVVRVWIWSIGIFCVLGGFYYEMSTSEAFDRLMNGKPMKEKKSTRSVEDFMAAMQRVSTQHEKET"},{"created_at":"2011-05-26T21:24:30.000Z","updated_at":"2011-05-27T15:01:11.000Z","name":"Sulfiredoxin","uniprot_id":"P36077","uniprot_name":"SRX1_YEAST","enzyme":true,"transporter":false,"gene_name":"SRX1","num_residues":127,"molecular_weight":"13853.90039","theoretical_pi":"9.25","general_function":"Involved in DNA binding","specific_function":"Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase","reactions":[{"id":2608,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY558350","genbank_protein_id":"45270590","gene_card_id":"SRX1","chromosome_location":"chromosome 11","locus":"YKL086W","synonyms":["Sulphiredoxin"],"enzyme_classes":["1.8.98.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" DNA binding"},{"category":"Function","description":" sulfiredoxin activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ParBc","identifier":"PF02195"}],"pathways":[],"gene_sequence":"ATGTCACTACAAAGCAACAGTGTAAAACCAACAGAAATTCCTCTCTCAGAGATCAGACGCCCCCTAGCGCCTGTGTTGGATCCTCAAAAGATCGACGCAATGGTGGCCACAATGAAGGGCATTCCCACCGCTAGCAAGACATGCTCTCTAGAACAGGCTGAGGCGGCTGCCTCAGCCGGGGAACTGCCGCCCGTGGACGTGCTGGGCGTGCGAGTCAAGGGACAGACGCTATATTATGCCTTCGGCGGCTGCCACCGTCTACAGGCATACGACCGCCGGGCTCGCGAAACGCAGAACGCCGCCTTCCCCGTGCGCTGCAGGGTGCTACCGGCCACTCCCCGCCAAATCCGCATGTACCTGGGCAGCAGTCTCGACATCGAATAA","protein_sequence":"MSLQSNSVKPTEIPLSEIRRPLAPVLDPQKIDAMVATMKGIPTASKTCSLEQAEAAASAGELPPVDVLGVRVKGQTLYYAFGGCHRLQAYDRRARETQNAAFPVRCRVLPATPRQIRMYLGSSLDIE"},{"created_at":"2011-05-26T21:25:22.000Z","updated_at":"2011-05-26T21:25:22.000Z","name":"Pyruvate kinase 1","uniprot_id":"P00549","uniprot_name":"KPYK1_YEAST","enzyme":true,"transporter":false,"gene_name":"PYK1","num_residues":500,"molecular_weight":"54544.10156","theoretical_pi":"7.78","general_function":"Involved in magnesium ion binding","specific_function":"ATP + pyruvate = ADP + phosphoenolpyruvate","reactions":[{"id":1936,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2609,"direction":"\u003e","locations":"","altext":"ATP + pyruvate = ADP + phosphoenolpyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":3818,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006332","source":"Smpdb"},{"id":14120,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006551","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1A3X","cellular_location":null,"genbank_gene_id":"AY693107","genbank_protein_id":"51013665","gene_card_id":"PYK1","chromosome_location":null,"locus":"YAL038W","synonyms":["PK 1"],"enzyme_classes":["2.7.1.40"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" alkali metal ion 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fermentation","kegg_map_id":null}],"gene_sequence":"ATGCCAGAGTCCAGATTGCAGAGACTAGCTAATTTGAAAATAGGAACTCCGCAGCAGCTCAGACGCACCTCCATAATAGGTACCATTGGGCCCAAGACAAATAGCTGCGAGGCCATTACTGCTCTGAGAAAAGCTGGTTTGAACATCATTCGATTGAACTTTTCCCATGGCTCCTACGAATTCCATCAATCAGTAATCGAAAATGCTGTGAAATCGGAACAGCAATTCCCTGGCAGGCCGCTCGCCATTGCCCTGGATACCAAGGGTCCCGAGATCAGAACAGGTCGCACGTTAAATGACCAAGATCTTTATATCCCCGTAGACCACCAAATGATCTTTACCACTGACGCAAGTTTTGCAAACACCTCCAATGATAAAATCATGTATATAGACTATGCTAACCTGACAAAAGTTATCGTTCCGGGGAGATTTATATACGTGGACGACGGGATTCTCTCTTTTAAAGTGCTCCAAATCATTGACGAATCTAATTTAAGGGTGCAAGCGGTAAACTCGGGTTATATCGCATCTCATAAAGGTGTTAATCTGCCTAATACCGACGTTGATTTGCCCCCCTTGTCCGCCAAAGACATGAAGGACTTGCAATTCGGAGTCCGCAATGGCATTCACATCGTATTTGCCTCTTTCATAAGAACTTCAGAAGATGTGTTGTCTATCAGAAAAGCGTTGGGTTCTGAAGGGCAAGATATCAAGATTATATCCAAGATAGAAAACCAGCAAGGGTTGGATAATTTTGACGAAATCCTGGAAGTCACGGATGGTGTTATGATAGCGAGAGGCGATTTAGGAATTGAAATCCTGGCACCTGAAGTATTAGCCATTCAAAAAAAGCTGATTGCAAAATGTAATTTGGCGGGCAAACCTGTCATTTGCGCGACTCAGATGCTGGATTCAATGACACACAATCCGAGACCGACAAGGGCTGAAGTATCGGATGTGGGTAACGCTGTGTTGGATGGTGCTGATTGTGTTATGCTTTCTGGAGAAACGGCGAAGGGTGATTATCCGGTGAATGCAGTTAATATTATGGCGGCGACCGCTCTGATTGCTGAAAGTACTATCGCTCATTTGGCTCTTTATGACGATCTCAGAGACGCCACTCCCAAACCTACTTCCACTACGGAAACTGTAGCAGCTGCAGCTACCGCAGCAATCTTGGAGCAAGATGGTAAGGCCATCGTTGTATTATCTACTACAGGGAACACGGCAAGGCTACTGTCGAAGTATAGACCAAGCTGCCCTATCATATTAGTAACAAGACACGCAAGAACGGCAAGAATTGCGCATTTGTATAGAGGTGTTTTCCCATTTCTGTATGAACCGAAACGCCTAGACGACTGGGGTGAGGATGTTCATAGGCGCCTAAAGTTTGGTGTTGAAATGGCGAGGTCTTTCGGAATGGTGGACAACGGTGATACTGTTGTTTCCATTCAAGGATTCAAAGGAGGAGTCGGCCATTCCAATACCTTACGCATTTCTACTGTTGGTCAAGAATTCTAG","protein_sequence":"MPESRLQRLANLKIGTPQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPLAIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRISTVGQEF"},{"created_at":"2011-05-26T21:32:44.000Z","updated_at":"2011-05-27T15:01:11.000Z","name":"Putative glucokinase-2","uniprot_id":"Q04409","uniprot_name":"EMI2_YEAST","enzyme":true,"transporter":false,"gene_name":"EMI2","num_residues":500,"molecular_weight":"55920.30078","theoretical_pi":"6.21","general_function":"Involved in ATP binding","specific_function":"Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake. Involved in sporulation. Required for the full activation of the early meiotic inducer IME1","reactions":[{"id":2610,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-glucose = ADP + D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3796,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006315","source":"Smpdb"},{"id":3797,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006316","source":"Smpdb"},{"id":3798,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006318","source":"Smpdb"},{"id":3799,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006340","source":"Smpdb"},{"id":3800,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006859","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"},{"id":14346,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006861","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U33057","genbank_protein_id":"927785","gene_card_id":"EMI2","chromosome_location":"chromosome 4","locus":"YDR516C","synonyms":["Early meiotic induction protein 2","Glucose kinase 2","GLK-2"],"enzyme_classes":["2.7.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic 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Metabolism","kegg_map_id":null},{"name":"Glycolysis I","kegg_map_id":null}],"gene_sequence":"ATGTCATTTGAAAATTTACATAAAGTCAATGCTGAGGCATTGGAAGATGCAGTGGTTGAGATCTGCTCCTCATTGCAGGTTGATGCAGCAAAGTTGGACGAACTAACAGCGTACTTCATTGAATGTATGGAAAAGGGGTTGAATAACACCTCTGTAGGCGAAGAAAAGACGGTGGACAAGGGTCTACCCATGATCCCTACATATGTAACCAGTTTGCCCAATGGGACGGAACGTGGTGTTTTGCTGGCTGCAGATTTAGGTGGGACTCACTTCAGAGTGTGTTCTGTGACTTTGAATGGTGACGGAACCTTTGATATGCAGCAATTGAAGTCTAAGATTCCGGAAGAATATCTAAATGACAAGGATGTCACCAGCGAGGAGCTGTTTAGCTACCTGGGTCGCCGTACAAGGGCCTTCGTTAGGAAGCATCATCCTGAGTTGTTGAAGTCCACGGGGGAGAACATAAAACCTTTGAAAATGGGATTTACCTTCTCATATCCCGTTGACCAAACCTCTTTGAGTTCCGGTACTTTAATCAGATGGACCAAAAGCTTCAAGATTGAAGACACGGTCGGCAAGGATGTCGTGAGGTTATACCAGGAGCAATTAGACATTCAGGGGCTCTCTATGATTAATGTGGTAGCTTTGACCAACGACACGGTTGGCACTTTCCTATCCCACTGCTACACTTCAGGCTCTCGTCCATCGAGTGCTGGTGAGATTAGCGAGCCTGTCATTGGTTGTATCTTTGGTACTGGTACTAACGGTTGCTATATGGAGGATATTGAAAACATCAAGAAGCTACCAGATGAGCTCAGAACAAGACTGCTGCATGAAGGAAAAACCCAAATGTGCATCAACATCGAATGGGGTTCTTTCGACAATGAATTGAAACATTTGTCTGCTACAAAGTATGACATCGATATTGACCAAAAATTTTCTCCAAATCCAGGTTACCATCTATTTGAAAAAAGAATTTCCGGCATGTACTTGGGTGAGCTGTTAAGGAACATCCTGGTGGACTTGCATGCAAGGGGCTTAATCTTGGGACAGTATCGTAATTACGATCAATTACCTCACCGTTTAAAGACTCCTTTCCAATTGTGCAGTGAAGTTCTTTCCAGGATTGAAATCGATGATTCGACAAACTTGCGTGAAACTGAATTGTCGTTTTTGCAGAGTTTGAGGCTACCGACCACTTTTGAAGAACGTAAAGCAATTCAAAATCTGGTCCGTTCCATTACGAGAAGGTCTGCATATCTAGCAGCCGTTCCGATTGCCGCCATCCTAATCAAGACAAACGCTTTGAACAAAAGATATCACGGTGAGGTAGAAATTGGTTTTGACGGTTATGTCATCGAATACTATCCTGGATTCAGATCCATGCTGAGACATGCTTTGGCATTAAGTCCAATTGGCACTGAGGGTGAACGTAAGATACATTTGCGTCTAGCCAAAGATGGGTCCGGTGTTGGCGCAGCTTTGTGTGCTCTGGTGGCATAA","protein_sequence":"MSFENLHKVNAEALEDAVVEICSSLQVDAAKLDELTAYFIECMEKGLNNTSVGEEKTVDKGLPMIPTYVTSLPNGTERGVLLAADLGGTHFRVCSVTLNGDGTFDMQQLKSKIPEEYLNDKDVTSEELFSYLGRRTRAFVRKHHPELLKSTGENIKPLKMGFTFSYPVDQTSLSSGTLIRWTKSFKIEDTVGKDVVRLYQEQLDIQGLSMINVVALTNDTVGTFLSHCYTSGSRPSSAGEISEPVIGCIFGTGTNGCYMEDIENIKKLPDELRTRLLHEGKTQMCINIEWGSFDNELKHLSATKYDIDIDQKFSPNPGYHLFEKRISGMYLGELLRNILVDLHARGLILGQYRNYDQLPHRLKTPFQLCSEVLSRIEIDDSTNLRETELSFLQSLRLPTTFEERKAIQNLVRSITRRSAYLAAVPIAAILIKTNALNKRYHGEVEIGFDGYVIEYYPGFRSMLRHALALSPIGTEGERKIHLRLAKDGSGVGAALCALVA"},{"created_at":"2011-05-26T21:33:53.000Z","updated_at":"2011-06-05T00:19:27.000Z","name":"Probable phospholipid-transporting ATPase DNF3","uniprot_id":"Q12674","uniprot_name":"ATC8_YEAST","enzyme":false,"transporter":true,"gene_name":"DNF3","num_residues":1656,"molecular_weight":"188318.0","theoretical_pi":"6.74","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)","reactions":[{"id":2611,"direction":"\u003e","locations":"Membrane;Endosome membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein;Cell membrane","altext":"ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"165-185;452-472;496-516;1158-1178;1319-1339;1366-1386;1396-1416;1433-1453;1474-1494","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49705","genbank_protein_id":"825567","gene_card_id":"DNF3","chromosome_location":"chromosome 13","locus":"YMR162C","synonyms":[],"enzyme_classes":["3.6.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" lipid transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" phospholipid transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" phospholipid-translocating ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic 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process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGGGCATAGCTGATGGGCAAAGAAGAAGATCTTCATCACTACGAACGCAGATGTTCAACAAGCATTTGTATGATAAATATCGCGGAAGAACTGATGATGAGATAGAGTTAGAAGATATAAATGAGAGTAAGACGTTCTCCGGTAGCGATAATAACGATAAAGATGACAGAGATGAAACAAGCGGCAATTATGCTGCTGAAGAGGATTATGAAATGGAAGAGTATGGTAGTCCTGATGTGTCATATAGCATTATCACTAAAATACTTGATACTATCCTAGATCGAAGGAGGACGTTCCATTCGAAAGACGGTAGACATATTCCGATTATATTAGATCATAATGCAATTGAATACAAACAAGCTGCTACTAAAAGGGATGGTCATTTGATAGACGAAAGGTTCAACAAGCCTTACTGCGACAACCGAATAACTTCATCAAGATATACATTCTATTCCTTTTTGCCTAGACAGTTGTATGCACAATTTTCAAAGTTAGCCAATACTTATTTTTTCATTGTCGCAGTATTACAAATGATACCTGGATGGTCTACAACTGGTACTTATACAACTATTATCCCCTTATGTGTATTTATGGGTATATCCATGACAAGAGAGGCTTGGGACGATTTCAGGAGACATCGTTTAGATAAGGAAGAGAACAATAAACCAGTGGGAGTGTTGGTTAAAGATGGAAATAATGACGCACAAGAAGTTTATACACTACCAAGTAGTGTTGTCTCATCCACTGCATATCTAACTAAATCGGCCGCTGCTGAAAATAATCCACCTTTAAACGATGATCGGAACTCCTCTCAAGGACACTTCTTAGACACGCACTTCAATAACTTTGAACTACTCAAGAATAAATACAATGTTCATATTCATCAAAAGAAGTGGGAAAAACTTCGTGTTGGAGACTTCGTACTTCTCACACAAGATGATTGGGTACCTGCAGATCTGCTTTTATTGACATGTGACGGCGAAAATAGCGAATGTTTCGTTGAAACGATGGCTTTAGATGGCGAAACAAATTTGAAAAGTAAACAACCCCATCCAGAATTAAATAAGTTAACCAAAGCCGCATCAGGTCTTGCAAATATTAATGCTCAAGTTACCGTGGAAGATCCCAATATTGATTTATATAATTTTGAAGGTAATCTTGAATTGAAAAACCATCGCAATGATACCATAATGAAATACCCTCTAGGTCCTGATAATGTCATTTATCGTGGTAGTATTTTGAGGAATACTCAAAATGTTGTTGGTATGGTCATTTTCAGTGGTGAGGAAACAAAAATCAGAATGAATGCTTTAAAAAACCCAAGAACGAAAGCCCCTAAGCTACAAAGGAAGATAAATATGATTATCGTGTTTATGGTGTTTGTCGTTGCCACAATATCTTTATTTTCTTATCTTGGCCATGTTTTGCATAAGAAAAAATATATCGACCAGAACAAAGCATGGTATCTATTTCAGGCAGATGCTGGCGTAGCACCCACAATAATGTCTTTTATCATCATGTATAACACTGTGATTCCTTTGTCCCTATATGTAACAATGGAAATTATCAAGGTAGTCCAAAGTAAAATGATGGAATGGGACATAGACATGTACCATGCAGAAACGAACACGCCATGCGAATCGAGAACTGCCACCATTCTGGAGGAATTGGGGCAAGTATCTTATATTTTTAGTGATAAAACCGGAACGCTGACGGATAATAAGATGATATTTCGGAAATTTTCTTTATGTGGATCATCTTGGCTGCATAATGTAGATCTCGGTAATTCTGAGGATAACTTTGAAGACAACAGAGACAATACGAACTCCTTGAGACTACCACCAAAAGCTCACAACGGCTCTAGTATAGACGTTGTTTCCATTGGAGATCAAAATGTTCTTGATCGGTTAGGATTTTCGGACGCACCAATTGAAAAAGGGCATCGTCCATCTTTGGACAACTTTCCTAAATCTAGGAATTCTATTGAATATAAGGGAAATTCATCAGCAATTTATACAGGCCGTCCCAGTATGAGATCACTTTTTGGGAAAGATAATTCACATCTAAGTAAACAAGCTTCGGTTATTTCACCCTCCGAGACATTTTCGGAGAACATTAAAAGTTCGTTTGATTTAATTCAGTTTATTCAAAGATATCCGACCGCCCTGTTTTCTCAAAAGGCTAAATTTTTCTTCTTATCATTAGCTCTTTGTCATAGCTGTCTTCCCAAAAAAACTCATAACGAATCAATAGGAGAAGACTCCATAGAGTATCAGTCTTCATCTCCAGATGAATTAGCACTAGTAACCGCTGCTAGAGACCTTGGTTATATTGTATTGAATAGAAATGCACAGATTTTGACCATTAAAACTTTTCCAGACGGTTTTGACGGTGAAGCAAAATTGGAAAATTATGAAATTTTGAACTATATTGACTTCAATTCTCAAAGAAAGAGAATGTCTGTTCTTGTACGTATGCCAAATCAACCAAATCAAGTTCTTTTAATTTGCAAAGGTGCTGATAACGTTATTATGGAGCGTTTACATGATCGCGAATTGGCTGCCAAAAAAATGGCAGACATATGCACCAGTACCAAAGAACGTAAAGACGCAGAAGCAGAGCTGGTTCTCCAGCAAAGAAAGTCTCTGGAAAGAATGGTAGATGAAGAGGCTATGGCCAGGACCTCATTGAGAAATTCTTTGTCTAGCGTACCGAGAGCAAGTTTATCATTGCAGGCAGTGAGAAAAAGTCTTTCAATGAAGAACAGCAGGACCCGTGATCCAGAGAAACAAATTGACTCCATTGATCAATTTCTAGAAACGGTCAAGAAATCTGATCAGGAGATTGGCAGCGTTGTAAATAAAAGCAGGAAGTCACTCCATAAGCAACAAATAGAAAAATATGGGCCGCGAATTTCGATAGATGGAACACATTTTCCGAACAACAATGTCCCAATAGACACAAGAAAAGAAGGACTACAGCATGATTACGATACAGAAATTTTGGAGCACATTGGAAGCGATGAGTTAATTTTGAATGAAGAGTATGTTATTGAAAGAACTTTGCAAGCCATCGATGAGTTTTCGACTGAAGGCTTAAGAACTCTGGTCTATGCTTACAAATGGATCGATATTGGGCAGTATGAAAATTGGAATAAACGCTATCACCAAGCCAAAACCTCCCTTACTGATAGAAAAATCAAAGTCGATGAGGCAGGTGCAGAAATCGAGGATGGTTTAAATCTGTTAGGGGTAACTGCAATCGAAGACAAGTTACAAGACGGCGTTTCAGAAGCTATAGAAAAGATCAGAAGAGCCGGTATAAAAATGTGGATGCTAACAGGGGATAAAAGGGAAACGGCTATAAATATAGGGTATTCGTGTATGTTAATCAAAGATTATTCTACGGTAGTCATTTTAACTACTACTGATGAAAATATTATATCAAAGATGAATGCGGTTTCTCAAGAAGTTGATTCCGGAAACATAGCACACTGCGTTGTTGTAATTGACGGTGCCACGATGGCCATGTTTGAAGGAAATCCTACATACATGTCTGTATTTGTTGAGCTTTGCACTAAAACAGACTCGGTAATATGTTGCCGTGCTTCACCTTCTCAAAAAGCCCTTATGGTTTCCAACATAAGAAATACCGATCCAAACTTAGTCACGTTGGCAATAGGTGATGGTGCGAATGATATTGCCATGATACAATCTGCCGATATAGGTGTTGGAATAGCCGGTAAGGAGGGATTGCAAGCATCTAGAGTATCTGATTATTCTATTGGCCAATTTCGGTTTCTCTTGAAATTGTTATTTGTTCATGGGCGTTATAACTATATTCGCACCTCCAAGTTTATGCTTTGCACGTTTTACAAAGAAATTACGTTTTACTTTACGCAGTTGATATATCAAAGATATACAATGTTTTCAGGCTCCTCTCTATATGAGCCATGGTCATTGTCCATGTTCAATACTCTATTCACATCACTACCGGTTCTATGTATTGGTATGTTTGAGAAAGACTTGAAACCAATGACTCTACTAACAGTCCCTGAATTATATTCGTACGGGCGCCTTTCACAAGGTTTTAATTGGTTAATATTCATGGAGTGGGTTATCTTGGCAACTACGAATTCTCTTATCATTACATTTTTAAATGTTGTAATGTGGGGTATGAGTTCTCTTTCAGATAACACTATGTATCCTCTAGGTCTCATCAATTTCACAGCCATTGTTGCCTTAATTAACGTTAAATCCCAATTTGTTGAAATGCACAATAGGAATTGGCTGGCTTTTACTTCTGTAGTTCTATCCTGTGGAGGTTGGTTAGTGTGGTGTTGTGCCCTTCCTATTTTGAATAATACTGACCAAATATATGATGTAGCATATGGCTTTTACAATCATTTTGGTAAAGACATTACATTCTGGTGTACTAGCTTGGTGTTGGCACTGTTACCTATCACTTTAGATATAGTTTACAAAACATTCAAAGTTATGATATGGCCATCAGATTCTGATATTTTTGCTGAGCTGGAACAAAAAAGTGATATCAGAAAGAAGCTGGAACTAGGAGCCTATAGCGAAATGAGGCAAGGATGGACGTGGGATAAAGATCCCAGTACTTTCACAAGGTACACAGACAAAGTTCTTTCAAGGCCAAGAACTAATTCACGTGCAAGTGCAAAAACTCATAACAGCAGCATATATTCAATGTCAAATGGGAATGTAGACCATTCCTCAAAAAAAAATTTCTTTGGAAACTCTTCTAAAAAGAGCTCTGAACGATACGAGGTATTACCTAGTGGCAAGTTAATCAAGCGACCATCCTTGAAAACACAAAGCAGTAAAGACAGTATTGGCGGCAATATAACTACTAAACTGACGAAGAAACTGAAGCTTCCATCGAGGAATGTGGAAGATGAAGATGTGAACCAGATTATTCAGGCAAGGCTAAAGGATCTGGAGTAA","protein_sequence":"MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE"},{"created_at":"2011-05-26T21:37:51.000Z","updated_at":"2011-06-05T00:20:59.000Z","name":"Probable phospholipid-transporting ATPase DNF2","uniprot_id":"Q12675","uniprot_name":"ATC4_YEAST","enzyme":false,"transporter":true,"gene_name":"DNF2","num_residues":1612,"molecular_weight":"182617.0","theoretical_pi":"6.04","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles","reactions":[{"id":2611,"direction":"\u003e","locations":"Membrane;Endosome membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein;Cell membrane","altext":"ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).","export":false,"pw_reaction_id":null,"source":null},{"id":34386,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000206","source":"Smpdb"},{"id":34387,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000207","source":"Smpdb"},{"id":34388,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000208","source":"Smpdb"},{"id":34390,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000210","source":"Smpdb"},{"id":34392,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000212","source":"Smpdb"},{"id":34394,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000214","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"253-273;278-298;599-619;640-660;1232-1252;1263-1283;1314-1334;1351-1371;1378-1398;1419-1439","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z47746","genbank_protein_id":"633628","gene_card_id":"DNF2","chromosome_location":"chromosome 4","locus":"YDR093W","synonyms":[],"enzyme_classes":["3.6.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" lipid transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" phospholipid transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" phospholipid-translocating ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" lipid transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" phospholipid transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGTCAAGTCCCTCCAAACCCACTTCTCCCTTCGTGGATGATATTGAGCATGAATCGGGATCAGCATCTAATGGTCTGTCGTCCATGTCACCATTTGACGATAGTTTTCAATTTGAAAAACCCAGTAGTGCGCATGGAAATATTGAAGTAGCGAAAACCGGCGGTTCTGTTTTGAAGCGACAATCTAAGCCAATGAAAGATATTAGCACACCCGATCTCTCAAAAGTTACTTTTGATGGAATCGATGATTATAGTAACGATAATGATATTAATGATGATGATGAACTCAATGGTAAAAAAACCGAGATACATGAACACGAAAATGAGGTGGATGATGACCTCCATTCGTTCCAGGCAACACCTATGCCTAATACTGGAGGCTTTGAGGATGTTGAGTTGGATAACAATGAAGGTAGCAACAATGATTCCCAGGCAGATCATAAGTTGAAAAGAGTACGTTTTGGTACAAGAAGAAATAAGTCAGGTAGGATAGATATAAATAGGTCAAAAACATTGAAATGGGCCAAGAAGAACTTCCACAATGCTATTGATGAATTCAGTACAAAAGAAGACAGTCTCGAAAATTCAGCCTTGCAAAATAGGTCTGATGAGTTGAGAACAGTTTACTATAATTTACCCTTGCCGGAGGACATGCTTGACGAGGACGGCTTACCGTTGGCAGTTTACCCGCGTAATAAAATCAGGACTACGAAGTATACTCCATTAACATTTTTTCCCAAGAACATTCTTTTCCAATTTCATAATTTTGCCAATATTTACTTTTTAATACTGTTGATTCTAGGTGCTTTTCAAATATTTGGTGTGACAAATCCAGGTTTTGCATCCGTTCCCCTAATTGTCATCGTAATTATCACTGCTATTAAGGATGGTATCGAAGATTCCAGAAGGACTGTATTGGATTTAGAAGTTAATAATACAAGAACACATATCTTAAGCGGGGTGAAGAATGAAAATGTTGCTGTTGATAACGTTTCCTTATGGAGGCGTTTCAAGAAAGCGAATACAAGGGCATTGATTAAAATTTTTGAGTATTTTTCAGAAAACCTCACTGCTGCTGGTAGAGAAAAGAAGTTACAGAAAAAAAGGGAAGAATTACGAAGGAAGAGGAACTCGAGAAGCTTTGGGCCACGTGGGTCTCTGGATTCAATTGGTAGTTACAGAATGTCTGCCGACTTTGGTCGTCCCTCTTTGGATTATGAGAACCTGAATCAAACAATGTCACAGGCTAACAGGTATAACGATGGTGAAAATTTAGTTGATCGAACGCTACAGCCAAACCCTGAATGTAGGTTTGCCAAGGATTACTGGAAAAATGTTAAAGTTGGTGATATTGTTCGTGTTCACAATAACGATGAAATTCCTGCTGATATGATCTTATTATCGACATCAGATGTTGATGGCGCTTGTTATGTGGAAACCAAAAATTTGGATGGTGAAACAAATCTAAAGGTCCGTCAATCATTAAAATGTAGCAAGATTATTAAGAGTTCAAGGGATATTACCAGGACGAAGTTTTGGGTTGAAAGTGAAGGCCCACATGCCAACTTGTATTCTTATCAAGGTAATTTCAAATGGCAAGATACACAAAATGGAAACATCAGAAATGAGCCTGTAAATATCAATAACTTATTATTGAGAGGTTGTACCTTGAGAAACACTAAGTGGGCCATGGGTATGGTTATTTTTACTGGTGACGATACCAAGATTATGATAAACGCTGGTGTCACTCCAACCAAAAAATCCAGAATTTCAAGAGAGTTGAATTTTTCTGTGATTTTGAATTTTGTACTATTGTTTATCCTATGTTTCACTGCTGGTATTGTTAACGGTGTTTATTATAAACAGAAACCTCGATCGAGAGATTATTTTGAATTTGGTACCATTGGAGGTTCTGCCTCAACTAACGGTTTTGTTTCTTTTTGGGTGGCGGTTATTCTTTATCAGTCATTGGTTCCGATCTCTTTATATATTTCTGTGGAAATTATTAAGACAGCACAGGCTATTTTCATTTACACTGATGTTTTGTTGTATAATGCCAAGCTAGACTATCCATGTACACCAAAGTCGTGGAACATCTCCGATGATTTGGGTCAAATTGAGTATATTTTTTCAGATAAAACAGGCACCTTGACACAAAATGTGATGGAATTCAAAAAATGTACTATTAACGGTGTGTCTTATGGACGTGCCTATACGGAGGCACTAGCAGGCCTGAGGAAGAGACAAGGTGTTGATGTCGAATCGGAAGGTCGTCGCGAAAAGGAAGAGATAGCAAAAGATAGGGAAACAATGATCGACGAATTAAGATCAATGAGTGATAATACACAGTTTTGTCCGGAGGATTTAACTTTTGTATCTAAGGAAATTGTGGAAGACTTGAAAGGATCCAGTGGCGACCATCAACAAAAGTGCTGTGAACACTTTTTGCTGGCGCTCGCATTATGTCATTCTGTCCTTGTGGAGCCAAATAAAGATGATCCTAAAAAACTGGACATCAAGGCTCAATCACCTGATGAGTCTGCCTTAGTTTCCACCGCCAGACAATTAGGGTACAGTTTCGTTGGTAGTTCAAAAAGTGGATTGATAGTAGAGATCCAGGGTGTTCAAAAGGAGTTCCAAGTTCTGAACGTACTTGAATTCAATTCGTCGAGAAAAAGGATGAGTTGCATTATCAAGATCCCTGGCTCTACACCAAAGGATGAACCTAAAGCACTGTTAATATGTAAAGGTGCGGATTCCGTTATCTATTCAAGATTAGATCGCACTCAAAACGACGCTACTTTGTTGGAAAAGACGGCCCTCCATTTGGAAGAATATGCCACAGAAGGTTTAAGAACATTATGTTTGGCTCAAAGAGAGCTCACGTGGTCCGAGTATGAACGTTGGGTTAAGACTTATGATGTGGCCGCTGCATCCGTTACTAATAGGGAGGAAGAGTTGGACAAAGTTACTGACGTTATTGAACGTGAGCTTATTTTGCTTGGTGGTACGGCCATTGAGGATCGTTTACAAGATGGTGTTCCTGATTCGATTGCCCTCTTGGCCGAGGCCGGTATTAAGTTATGGGTCCTAACGGGTGATAAAGTGGAAACTGCCATTAACATTGGTTTTTCCTGCAATGTTTTGAACAATGATATGGAATTATTGGTTGTGAAGGCTTCCGGCGAAGATGTAGAAGAATTTGGTAGTGACCCTATTCAAGTGGTTAACAATTTGGTGACAAAATACTTAAGGGAAAAATTTGGCATGAGTGGATCCGAGGAGGAGTTAAAAGAAGCTAAAAGAGAGCATGGTTTGCCACAGGGAAATTTTGCTGTCATTATCGATGGCGATGCGCTAAAAGTTGCTTTGAATGGTGAAGAAATGAGACGCAAGTTCTTGCTACTGTGTAAGAATTGTAAAGCTGTTTTGTGTTGCAGAGTTTCTCCAGCACAAAAGGCTGCAGTGGTCAAGTTGGTAAAAAAGACCTTAGACGTTATGACCTTGGCCATTGGTGATGGTTCGAATGATGTAGCCATGATTCAATCGGCGGACGTTGGTGTTGGTATCGCGGGTGAAGAAGGCAGACAAGCTGTCATGTGTTCTGATTATGCCATCGGGCAGTTCAGATATGTGACAAGACTGGTATTGGTGCATGGTAAATGGTGTTATAAGAGACTGGCAGAGATGATCCCACAGTTTTTCTACAAGAACGTTATTTTTACGCTATCCCTGTTCTGGTATGGTATTTACAATAATTTCGATGGGTCGTATTTGTTTGAGTATACGTACTTGACATTCTACAATCTTGCATTCACATCCGTACCTGTTATTTTACTAGCAGTACTCGACCAAGATGTTTCCGACACCGTTTCGATGCTGGTGCCACAGTTGTACCGTGTGGGTATCCTAAGAAAAGAATGGAACCAAACCAAATTTCTTTGGTACATGTTGGATGGTGTATACCAATCTGTGATATGCTTCTTTTTCCCCTATTTGGCGTACCATAAAAACATGGTTGTAACTGAAAATGGCCTTGGACTAGACCACCGTTACTTTGTCGGTGTCTTCGTTACAGCAATTGCAGTCACTTCATGTAACTTTTACGTCTTCATGGAACAGTATAGATGGGACTGGTTCTGTGGCCTATTCATATGTCTATCACTGGCCGTGTTTTACGGCTGGACGGGTATATGGACAAGCTCGTCGTCAAGTAACGAATTTTACAAGGGTGCGGCGCGTGTATTCGCACAACCTGCCTATTGGGCAGTACTTTTCGTTGGCGTGCTGTTCTGCCTACTGCCAAGATTCACCATTGACTGTATCAGAAAGATATTCTATCCGAAAGATATAGAGATCGTTAGAGAAATGTGGTTACGCGGTGATTTTGACCTCTACCCACAAGGCTACGACCCTACGGACCCTAGCAGGCCCAGAATAAACGAAATACGTCCCCTTACAGATTTCAAAGAGCCCATTTCACTGGACACTCATTTTGATGGTGTCAGCCACTCACAAGAGACCATAGTCACAGAGGAAATACCAATGAGTATACTCAATGGTGAGCAAGGCTCGCGCAAGGGGTACCGTGTCTCTACCACTCTGGAACGCCGTGACCAGCTCAGCCCCGTTACAACAACGAACAACTTGCCTAGAAGATCAATGGCCAGTGCCCGCGGAAATAAGCTCAGAACTTCGCTGGATCGCACAAGAGAAGAGATGCTTGCCAACCACCAACTGGACACAAGATACTCCGTGGAAAGAGCACGTGCCTCGCTGGATCTGCCGGGTATCAATCATGCAGAGACGCTGCTCAGCCAGCGCAGCAGGGACCGTTAA","protein_sequence":"MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR"},{"created_at":"2011-05-26T21:49:04.000Z","updated_at":"2011-06-05T00:23:53.000Z","name":"Probable phospholipid-transporting ATPase DRS2","uniprot_id":"P39524","uniprot_name":"ATC3_YEAST","enzyme":false,"transporter":true,"gene_name":"DRS2","num_residues":1355,"molecular_weight":"153843.0","theoretical_pi":"5.25","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly","reactions":[{"id":2611,"direction":"\u003e","locations":"Membrane;Endosome membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein;Cell membrane","altext":"ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"222-242;247-267;450-470;491-511;1013-1033;1044-1064;1095-1115;1132-1152;1162-1182;1203-1223","pdb_id":null,"cellular_location":"Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein","genbank_gene_id":"L01795","genbank_protein_id":"171114","gene_card_id":"DRS2","chromosome_location":"chromosome 1","locus":"YAL026C","synonyms":[],"enzyme_classes":["3.6.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" lipid transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" phospholipid transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" phospholipid-translocating ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" lipid transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" phospholipid transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGAATGACGACAGAGAAACCCCCCCAAAGAGGAAACCTGGGGAGGACGACACGCTTTTCGATATTGACTTCTTAGACGACACGACTTCTCATTCTGGATCCCGTTCAAAGGTCACCAACTCACATGCGAACGGATATTATATACCACCAAGTCATGTACTTCCCGAAGAGACTATCGACTTAGACGCTGATGATGATAACATTGAAAATGATGTCCATGAAAATCTATTTATGAGCAATAACCATGACGACCAAACGTCTTGGAATGCCAATAGATTCGACTCAGATGCATATCAACCACAATCCCTACGAGCAGTCAAGCCTCCCGGTTTATTTGCTAGGTTTGGTAATGGTCTCAAAAATGCCTTTACGTTCAAACGGAAGAAAGGGCCCGAAAGTTTCGAAATGAATCATTACAATGCGGTGACTAATAACGAATTAGACGATAATTATCTAGACTCGAGGAATAAGTTCAACATTAAAATTCTTTTCAACCGGTACATTTTAAGAAAGAACGTTGGCGACGCAGAGGGCAATGGTGAACCAAGAGTCATCCACATCAACGATTCTCTCGCTAATTCCTCCTTCGGTTATAGTGACAACCATATATCTACCACCAAGTATAATTTTGCGACCTTTCTGCCTAAATTTTTGTTCCAAGAATTTTCCAAATACGCTAATCTGTTTTTTTTATGTACATCTGCCATTCAACAGGTGCCTCACGTCTCGCCAACTAATAGATACACCACAATTGGTACTTTATTAGTGGTTTTGATTGTTTCTGCCATGAAGGAATGTATCGAAGATATCAAGAGAGCTAATTCTGATAAAGAATTAAATAATTCGACAGCAGAAATATTTTCAGAAGCACATGATGACTTTGTTGAGAAACGATGGATTGATATTCGTGTAGGTGACATAATTAGAGTAAAATCAGAGGAACCTATTCCTGCTGATACCATAATTTTGTCATCTTCGGAACCGGAGGGTCTTTGCTACATTGAAACTGCCAACTTGGATGGTGAAACAAATTTGAAAATCAAACAGTCGAGAGTAGAAACTGCCAAATTTATAGACGTTAAAACTTTGAAGAACATGAACGGAAAAGTTGTTTCCGAACAGCCGAACTCTAGCTTGTATACTTATGAAGGTACAATGACTTTAAATGATCGTCAAATACCGTTATCTCCTGACCAAATGATTTTAAGAGGTGCAACTTTAAGAAATACTGCATGGATATTTGGTTTAGTTATCTTCACTGGTCATGAAACTAAGTTATTGCGTAATGCTACTGCAACCCCAATTAAAAGAACCGCGGTTGAGAAAATTATCAACAGACAGATTATTCGATTGTTCACAGTTTTAATCGTGCTAATTTTAATTTCTTCAATTGGTAATGTTATTATGTCTACTGCAGATGCCAAACATTTATCGTACCTTTACCTGGAGGGTACCAACAAGGCTGGCTTATTCTTCAAAGACTTTTTAACATTTTGGATTCTATTTTCGAATCTAGTTCCTATTTCTCTATTTGTCACCGTTGAATTAATCAAATATTATCAGGCTTTTATGATAGGTTCAGATCTAGATTTGTACTACGAAAAAACTGATACCCCAACTGTGGTTCGTACATCCTCTTTGGTTGAAGAACTTGGTCAAATAGAATATATATTCAGTGACAAGACAGGAACTTTAACAAGAAATATTATGGAATTTAAATCCTGCTCTATTGCAGGCCATTGCTATATTGATAAAATACCTGAAGATAAAACGGCCACTGTTGAAGATGGGATTGAAGTTGGTTATAGAAAATTTGACGATTTGAAGAAAAAGTTAAATGATCCCTCTGATGAGGATTCACCTATTATCAATGACTTCTTAACATTACTGGCTACCTGTCATACTGTCATTCCAGAATTTCAAAGCGATGGATCTATTAAATATCAAGCAGCCTCTCCAGATGAAGGTGCCCTCGTTCAAGGTGGTGCAGATTTAGGGTATAAGTTTATCATCCGTAAAGGAAACTCTGTAACTGTTTTATTGGAGGAAACTGGCGAGGAAAAAGAGTATCAACTACTTAACATTTGTGAATTTAATTCCACCAGGAAGAGAATGAGCGCTATATTTAGATTTCCGGATGGTTCGATAAAGTTATTCTGTAAAGGTGCTGATACTGTCATTCTGGAAAGATTGGATGATGAAGCTAATCAATATGTAGAAGCTACAATGAGACATTTAGAAGATTATGCATCTGAGGGTTTGCGGACGTTGTGTTTGGCGATGAGAGATATCTCTGAAGGAGAATATGAAGAATGGAATAGCATTTATAATGAGGCTGCCACAACATTAGATAACAGAGCCGAGAAGCTAGACGAAGCCGCAAATCTAATCGAGAAAAATCTAATATTAATTGGTGCAACTGCTATTGAAGATAAGTTACAGGACGGTGTTCCAGAAACTATCCACACATTACAAGAAGCGGGTATTAAAATTTGGGTTTTAACTGGTGACAGACAGGAAACTGCTATTAACATTGGTATGAGTTGCCGTTTATTGAGTGAAGACATGAATTTGTTGATCATCAACGAGGAAACCAGAGATGATACTGAGAGAAATTTGTTAGAGAAGATTAACGCTCTAAACGAGCATCAATTGTCAACACATGATATGAAATCCTTAGCGCTCGTCATTGATGGGAAGTCATTAGGCTTTGCCTTGGAACCAGAATTAGAAGATTATTTGCTAACTGTGGCGAAGCTTTGTAAAGCGGTTATATGTTGCCGTGTATCTCCACTACAGAAAGCCTTGGTTGTTAAAATGGTAAAAAGAAAGTCGTCTTCACTACTGCTAGCCATTGCGAGTGGTGCCAACGATGTTAGTATGATACAGGCAGCTCATGTTGGTGTCGGTATTAGTGGTATGGAAGGTATGCAAGCGGCTCGTTCAGCTGATATAGCTCTTGGCCAATTTAAATTTTTAAAAAAACTATTACTTGTCCATGGCTCCTGGTCTTATCAAAGAATTTCTGTCGCAATTTTGTACTCTTTTTACAAGAATACAGCATTATACATGACGCAGTTTTGGTACGTTTTTGCCAATGCCTTTTCAGGTCAATCCATTATGGAATCATGGACAATGAGTTTCTACAACTTATTCTTCACTGTTTGGCCCCCTTTTGTCATTGGTGTATTTGATCAATTTGTTAGTAGTAGATTACTTGAGCGGTACCCACAATTGTACAAATTAGGACAGAAGGGTCAATTTTTCTCTGTTTACATCTTCTGGGGATGGATTATTAATGGCTTTTTCCATTCTGCAATAGTATTTATTGGCACCATATTGATTTACAGATATGGGTTTGCCTTAAATATGCACGGCGAACTAGCTGATCATTGGTCTTGGGGTGTAACTGTCTACACTACAAGTGTCATTATTGTTTTGGGAAAGGCTGCTTTGGTAACTAATCAATGGACGAAATTCACCTTAATTGCCATTCCTGGTTCCCTCTTATTTTGGTTAATATTCTTCCCAATTTATGCTTCTATATTTCCTCATGCTAACATCTCAAGAGAGTATTATGGTGTGGTTAAACACACGTATGGATCCGGTGTATTTTGGTTAACTTTGATCGTTTTACCAATTTTTGCACTGGTAAGAGATTTTCTATGGAAGTACTATAAAAGAATGTATGAACCAGAAACGTATCATGTTATTCAAGAAATGCAGAAATACAATATCAGCGACTCTAGGCCGCACGTTCAGCAATTTCAAAATGCCATCAGGAAGGTGAGGCAAGTGCAAAGAATGAAAAAACAAAGAGGATTTGCCTTTTCACAGGCTGAAGAGGGTGGGCAAGAAAAAATTGTCAGAATGTATGATACTACTCAAAAGAGAGGTAAGTACGGTGAATTACAAGATGCTTCGGCGAACCCCTTTAATGACAATAATGGACTGGGAAGTAACGACTTTGAAAGTGCAGAACCGTTCATTGAAAATCCATTTGCTGATGGTAATCAAAATTCAAATAGATTCAGTTCTTCGAGAGATGATATTTCATTTGATATATGA","protein_sequence":"MNDDRETPPKRKPGEDDTLFDIDFLDDTTSHSGSRSKVTNSHANGYYIPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTSWNANRFDSDAYQPQSLRAVKPPGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYLDSRNKFNIKILFNRYILRKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETAKFIDVKTLKNMNGKVVSEQPNSSLYTYEGTMTLNDRQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNATATPIKRTAVEKIINRQIIRLFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGTNKAGLFFKDFLTFWILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKSCSIAGHCYIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFLTLLATCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFIIRKGNSVTVLLEETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEANQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILIGATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDTERNLLEKINALNEHQLSTHDMKSLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSPLQKALVVKMVKRKSSSLLLAIASGANDVSMIQAAHVGVGISGMEGMQAARSADIALGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELADHWSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYASIFPHANISREYYGVVKHTYGSGVFWLTLIVLPIFALVRDFLWKYYKRMYEPETYHVIQEMQKYNISDSRPHVQQFQNAIRKVRQVQRMKKQRGFAFSQAEEGGQEKIVRMYDTTQKRGKYGELQDASANPFNDNNGLGSNDFESAEPFIENPFADGNQNSNRFSSSRDDISFDI"},{"created_at":"2011-05-26T21:50:14.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"5',5'''-P-1,P-4-tetraphosphate phosphorylase 2","uniprot_id":"P22108","uniprot_name":"APA2_YEAST","enzyme":true,"transporter":false,"gene_name":"APA2","num_residues":325,"molecular_weight":"36840.5","theoretical_pi":"5.23","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis","reactions":[{"id":1338,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M60265","genbank_protein_id":"171066","gene_card_id":"APA2","chromosome_location":"chromosome 4","locus":"YDR530C","synonyms":["ATP adenylyltransferase","Ap4A phosphorylase II","AP,A phosphorylase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP-4-A phosphorylase"],"enzyme_classes":["2.7.7.53"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGATTGAAGAGAATTTGAAACAGAAAATCCACGATAAGTTCGTTGCAGCCAAAAAGAATGGGCATCTGAAAGTAACGCATGCAGAATCCAAGAAGTTGAAAGATCCTCAAACGACGACACAATATTGGGTGACATTTGCTCCATCTTTGGCACTTAAGCCAGACGCTAACAAGAATAGCGATTCAAAGGCGGAGGACCCGTTCGCCAATCCCGACGAAGAACTAGTGGTGACTGAAGATCTAAATGGTGACGGAGAATATAAGCTGCTACTCAACAAATTTCCTGTGGTCCCTGAACATAGTCTCCTAGTGACAAGCGAGTTTAAAGACCAGAGATCTGCTTTGACGCCAAGTGACTTGATGACTGCTTATAATGTGCTCTGTTCTCTCCAAGGAGACAAGGACGATGATGTCACTTGTGAAAGGTATCTGGTCTTTTATAATTGTGGACCTCATAGCGGTTCCTCACAAGATCACAAACACTTGCAGATCATGCAAATGCCTGAAAAATTTATACCTTTTCAGGACGTATTGTGCAACGGAAAGGATCATTTCTTGCCCACCTTCAACGCAGAGCCATTACAAGATGATAAGGTTTCCTTTGCTCATTTCGTCTTGCCGCTGCCGGAATCGTCTGATCAAGTGGACGAAGATCTTCTTGCTATGTGTTACGTATCTTTGATGCAGAGAGCACTTACATTTTTCCAAGATTGGACCAATGAGTCTCCGGAGTTGACCAAGTCATACAATGTGCTACTGACCAAGAAATGGATCTGTGTAGTTCCAAGATCGCATGCCAAGAGTGGACCGCCATTGATGTTAAACATTAACTCCACGGGGTACTGTGGTATGATCCTCGTTAAAGACAGAGAAAAACTAGAGAACCTCACTGAAGATCCTCATCTTGTGGACAAGTCGTTACTGCAATGCGGTTTCCCCAACACAGCAGGCCAAAAACCAACAGAGTATCACTATTAA","protein_sequence":"MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY"},{"created_at":"2011-05-26T23:59:10.000Z","updated_at":"2011-05-27T15:01:12.000Z","name":"Probable folylpolyglutamate synthase","uniprot_id":"P36001","uniprot_name":"FOLC_YEAST","enzyme":true,"transporter":false,"gene_name":"RMA1","num_residues":430,"molecular_weight":"48142.89844","theoretical_pi":"7.16","general_function":"Involved in tetrahydrofolylpolyglutamate synthase activity","specific_function":"Conversion of folates to polyglutamate derivatives","reactions":[{"id":2486,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion. Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z28131","genbank_protein_id":"486223","gene_card_id":"RMA1","chromosome_location":"chromosome 11","locus":"YKL132C","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"}],"pfams":[],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGGATGATATAAGCGGAAGGCAAACTTTACCTCGAATAAACCGTTTGTTGGAGCACGTGGGAAATCCCCAAGATAGTTTGTCAATCCTACATATAGCGGGAACAAATGGTAAGGAGACAGTATCTAAATTTTTGACATCCATATTGCAGCATCCGGGGCAACAGCGGCAAAGGGTCTTGATTGGTAGGTATACTACATCTTCCTTGCTAAACGCCAAAGAAGAGGATATTAGCATTAATAATGAAGCCATTTCCTTGATAGAGTATTCTAGGATCGAGAAGGAACTTATAGAAGCAGATAGTTCTTTGAAATTACAGTGCAACAACCTCGAACTGCTAACAAGCGTAGCTCTCGTATACTTCGCTAAGAAAAATTGCCAATGGTGCATAATAGAAACTGGTTTAGCTGGAAAACAGGACCCTGGAAGTATAATTGCTGGTCAAAGTAGAGTCTGTTGCGCCATTACTAACGTGGGCATTAGCGATGAAGCTTTTTTATGCAAGTTTTTGTCTCAAATTACTGAAAGTTCCACAAATAAAGCAATTTTTCTATTAGACGGTTCTAATGACGAATTTGTACGAAATACGATAACGAAACGGTGCCATGATGTTGGATGTCCATTAGAAATCACCGACCCTTCTCTTAGGGATTACAATGTACACACAGACACATGGGGCACTCTTGAAGTTCGCCTGCCATACAGTGAAGAAGAATATCAAATATTTAATTTGAGAGTTGCGATAGCGGTTTTAGACTTTTTGAGCAAGGAAAAAAAGGTTTGTATTTCAAAGGATCAACTATCCCAAGGTTTAATATCTGTGGATTGGCCAAGAAGTTTACATCGCTTGGATTACTGTTATGAATCTACTAGTGGAAAGAAAATCGCATTACTATTAGACAACGCAAATAATGCGAAGGCAGCTCGAAATTTAGCCTGCCATTTAAGGACCACGTACGGTGATACGCCATTAACATTTGTCATTGCTATAACAACTGGGAAAAAGGTGTCTCCCTTACTTGATCCGCTAATACGTCCACAAGATTATGTTATTGTGACTAGATTTGGGTCAGTGGTTGGAATGCCGTGGATCCAATCCCTAGAACCGGTGAATCTTCTCGCATTTATCAAAAACCGGTATACGAGAAATGTTAACATGCAGCCGGATCTTCAAAGTGTCTGGACCTTCCTTGAAACAAGTGGGTTAAAGACGATTGTTCCTGTTATCGTATGTGGATCACTGTATATCTGCAAAGAGCTATTGCGCTTACACAACTGTCACTTGCCAGTATAG","protein_sequence":"MDDISGRQTLPRINRLLEHVGNPQDSLSILHIAGTNGKETVSKFLTSILQHPGQQRQRVLIGRYTTSSLLNAKEEDISINNEAISLIEYSRIEKELIEADSSLKLQCNNLELLTSVALVYFAKKNCQWCIIETGLAGKQDPGSIIAGQSRVCCAITNVGISDEAFLCKFLSQITESSTNKAIFLLDGSNDEFVRNTITKRCHDVGCPLEITDPSLRDYNVHTDTWGTLEVRLPYSEEEYQIFNLRVAIAVLDFLSKEKKVCISKDQLSQGLISVDWPRSLHRLDYCYESTSGKKIALLLDNANNAKAARNLACHLRTTYGDTPLTFVIAITTGKKVSPLLDPLIRPQDYVIVTRFGSVVGMPWIQSLEPVNLLAFIKNRYTRNVNMQPDLQSVWTFLETSGLKTIVPVIVCGSLYICKELLRLHNCHLPV"},{"created_at":"2011-05-27T00:02:34.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Guanylate kinase","uniprot_id":"P15454","uniprot_name":"KGUA_YEAST","enzyme":true,"transporter":false,"gene_name":"GUK1","num_residues":187,"molecular_weight":"20637.19922","theoretical_pi":"7.34","general_function":"Involved in protein binding","specific_function":"Essential for recycling GMP and indirectly, cGMP","reactions":[{"id":1443,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1622,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1623,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2618,"direction":"\u003e","locations":null,"altext":"ATP + GMP = ADP + GDP.","export":false,"pw_reaction_id":null,"source":null},{"id":14313,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006812","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1EX7","cellular_location":null,"genbank_gene_id":"L04683","genbank_protein_id":"171625","gene_card_id":"GUK1","chromosome_location":"chromosome 4","locus":"YDR454C","synonyms":["GMP kinase"],"enzyme_classes":["2.7.4.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" guanylate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"}],"pfams":[{"name":"Guanylate_kin","identifier":"PF00625"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCGTCCTATCGTAATTTCTGGCCCAAGTGGTACAGGTAAATCTACACTGTTGAAGAAATTGTTCGCTGAATACCCAGATTCTTTCGGGTTTAGTGTTTCATCCACTACTAGAACCCCAAGAGCTGGCGAAGTAAACGGTAAGGACTATAACTTTGTCTCCGTAGATGAATTCAAATCTATGATTAAGAACAATGAATTCATTGAATGGGCGCAATTCTCCGGTAACTACTATGGTAGTACTGTCGCTTCCGTCAAACAAGTCAGTAAATCTGGTAAGACTTGTATTTTAGATATTGATATGCAGGGTGTCAAATCTGTCAAGGCTATCCCAGAGTTAAATGCCAGGTTTTTGTTTATTGCTCCACCATCGGTCGAGGATTTGAAAAAAAGATTAGAAGGTAGAGGTACGGAGACCGAAGAATCCATCAACAAGAGGTTAAGCGCCGCTCAAGCTGAATTGGCATATGCTGAGACAGGTGCCCATGACAAAGTTATTGTCAATGATGATTTGGACAAGGCCTACAAGGAATTGAAGGATTTTATCTTTGCAGAAAAATGA","protein_sequence":"MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK"},{"created_at":"2011-05-27T00:05:39.000Z","updated_at":"2011-05-27T15:01:12.000Z","name":"Plasma membrane ATPase 2","uniprot_id":"P19657","uniprot_name":"PMA2_YEAST","enzyme":true,"transporter":false,"gene_name":"PMA2","num_residues":947,"molecular_weight":"102171.0","theoretical_pi":"4.66","general_function":"Involved in nucleotide binding","specific_function":"The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses","reactions":[{"id":2599,"direction":"\u003e","locations":"Mitochondrion. Mitochondrion inner membrane.; Multi-pass membrane protein;Cell membrane;Endomembrane system. Vacuole membrane (Probable).","altext":"ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"145-165;170-189;321-342;354-376;749-767;784-803;854-874;887-903","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"J04421","genbank_protein_id":"295644","gene_card_id":"PMA2","chromosome_location":"chromosome 16","locus":"YPL036W","synonyms":["Proton pump 2"],"enzyme_classes":["3.6.3.6"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cation_ATPase_N","identifier":"PF00690"},{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Oxidative 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phospholipid-transporting ATPase DNF1","uniprot_id":"P32660","uniprot_name":"ATC5_YEAST","enzyme":false,"transporter":true,"gene_name":"DNF1","num_residues":1571,"molecular_weight":"177796.0","theoretical_pi":"5.87","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)","reactions":[{"id":2611,"direction":"\u003e","locations":"Membrane;Endosome membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein;Cell membrane","altext":"ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).","export":false,"pw_reaction_id":null,"source":null},{"id":34386,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000206","source":"Smpdb"},{"id":34387,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000207","source":"Smpdb"},{"id":34388,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000208","source":"Smpdb"},{"id":34390,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000210","source":"Smpdb"},{"id":34392,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000212","source":"Smpdb"},{"id":34394,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000214","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"215-235;240-260;554-574;595-615;1189-1209;1220-1240;1271-1291;1308-1328;1335-1355;1376-1396","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U18922","genbank_protein_id":"603407","gene_card_id":"DNF1","chromosome_location":"chromosome 5","locus":"YER166W","synonyms":[],"enzyme_classes":["3.6.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" lipid transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" phospholipid transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" phospholipid-translocating ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" lipid transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" phospholipid transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"}],"pathways":[{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGTCTGGAACTTTTCATGGCGATGGGCATGCTCCCATGTCGCCCTTTGAAGATACATTTCAATTTGAAGATAATAGCAGTAATGAAGATACACATATTGCACCTACCCATTTTGATGATGGTGCAACAAGCAACAAATACAGCCGGCCACAGGTCAGCTTCAATGATGAAACACCCAAAAATAAACGTGAAGATGCAGAAGAATTCACATTTAACGATGACACAGAATATGACAATCATTCCTTTCAGCCAACACCGAAACTTAATAATGGATCTGGGACGTTTGATGATGTGGAATTAGACAATGATAGTGGTGAACCGCACACTAACTACGATGGTATGAAAAGATTCCGGATGGGTACAAAAAGGAATAAAAAAGGAAACCCAATAATGGGAAGATCTAAGACCTTGAAATGGGCTAGGAAGAACATTCCAAACCCATTTGAAGACTTTACGAAGGATGATATTGACCCTGGTGCCATAAATCGTGCGCAAGAACTAAGGACTGTGTATTACAATATGCCCTTACCAAAAGATATGATAGATGAAGAAGGCAACCCCATTATGCAGTATCCTCGTAATAAAATCAGAACTACCAAATATACCCCGTTAACATTCTTACCAAAAAACATTCTATTTCAGTTTCATAATTTCGCCAACGTTTATTTCTTAGTTTTAATAATTTTAGGTGCATTTCAAATTTTTGGTGTCACGAACCCTGGTTTAAGTGCGGTTCCGTTAGTTGTCATTGTTATAATCACTGCGATCAAGGATGCTATTGAAGACTCAAGAAGAACCGTCCTAGATTTAGAGGTGAATAATACCAAGACACATATTTTAGAAGGTGTTGAGAACGAAAATGTCTCAACCGATAATATTTCATTGTGGAGAAGGTTTAAGAAAGCAAACTCTAGACTCCTTTTCAAGTTTATACAATATTGTAAAGAACATTTAACTGAAGAGGGCAAAAAGAAGAGAATGCAGAGAAAGCGTCATGAACTAAGAGTACAAAAAACTGTTGGAACGAGTGGACCCAGATCCTCTCTAGACTCCATTGACAGTTACAGAGTATCTGCAGATTATGGCCGTCCTTCATTGGATTATGATAATTTGGAACAAGGGGCCGGTGAAGCCAATATAGTTGATAGATCCCTACCACCCAGAACTGATTGTAAATTTGCCAAGAATTATTGGAAAGGTGTCAAGGTTGGTGATATTGTTCGTATCCATAACAATGATGAAATCCCTGCTGACATTATCTTACTTTCAACGTCGGATACAGATGGTGCCTGCTACGTAGAAACTAAAAATTTGGATGGTGAAACAAACTTAAAGGTACGCCAATCCTTGAAGTGTACCAATACTATAAGAACGTCAAAAGATATTGCTAGAACAAAATTCTGGATCGAAAGTGAAGGGCCCCACTCAAATTTGTACACTTATCAAGGTAATATGAAATGGAGAAATCTTGCAGATGGCGAGATACGAAATGAGCCAATTACTATTAATAACGTTCTGCTTCGTGGTTGCACTCTTAGAAATACTAAGTGGGCAATGGGTGTTGTAATGTTTACCGGTGGTGACACAAAAATCATGTTAAACTCTGGCATTACACCCACCAAGAAGTCCAGGATTTCAAGAGAACTAAACTTCTCTGTGGTGATAAATTTCGTGCTACTTTTCATCTTATGTTTTGTTTCTGGTATTGCAAATGGTGTATATTACGACAAAAAAGGCAGATCACGGTTTTCCTATGAATTTGGAACAATTGCTGGGTCAGCGGCGACAAACGGTTTCGTCTCATTTTGGGTTGCTGTTATTCTTTACCAATCTTTAGTCCCAATCTCTTTGTACATTTCTGTGGAGATCATCAAAACTGCACAAGCGGCCTTCATTTACGGAGACGTTTTACTCTACAATGCCAAATTGGATTATCCTTGTACACCAAAATCCTGGAATATTTCTGACGATTTAGGTCAAGTGGAATATATATTTTCTGATAAAACAGGTACATTAACTCAAAATGTAATGGAGTTTAAAAAATGTACTATCAATGGTGTTTCATATGGAAGAGCTTACACCGAAGCGTTAGCGGGATTAAGAAAAAGACAAGGTATCGACGTCGAAACCGAAGGTAGGCGTGAGAAGGCCGAAATTGCCAAGGATAGGGATACAATGATCGATGAACTGAGAGCTTTATCAGGAAATTCACAATTTTATCCCGAAGAAGTTACCTTTGTATCAAAGGAGTTCGTTCGCGATTTGAAAGGGGCTAGTGGTGAAGTACAACAAAGATGCTGTGAGCACTTTATGTTAGCATTAGCTTTATGTCACTCCGTCCTTGTAGAAGCAAACCCGGACAATCCAAAAAAACTGGATTTAAAAGCTCAATCTCCAGACGAAGCAGCGTTAGTAGCCACAGCTAGAGATGTAGGATTCAGTTTTGTTGGAAAAACCAAAAAAGGGTTGATAATTGAAATGCAAGGTATTCAAAAAGAATTTGAGATTCTAAATATTTTGGAGTTTAATTCATCGAGAAAAAGAATGTCCTGTATTGTCAAAATTCCGGGTCTGAACCCAGGGGACGAGCCTAGAGCACTTTTAATTTGTAAAGGTGCAGATTCCATTATATACTCAAGATTAAGTCGCCAGAGTGGTAGCAATAGTGAAGCTATTTTGGAAAAAACTGCTTTGCATTTAGAGCAGTACGCTACTGAAGGTTTAAGAACGTTATGCATAGCTCAAAGGGAGTTAAGTTGGTCTGAATACGAAAAATGGAACGAAAAGTACGATATTGCTGCTGCATCATTAGCAAACAGAGAGGATGAATTAGAAGTTGTTGCAGATTCCATTGAACGCGAATTGATATTATTGGGCGGTACAGCTATCGAAGATCGTTTACAAGATGGTGTTCCGGATTGTATAGAGTTGCTTGCAGAGGCAGGAATTAAATTATGGGTTCTTACGGGTGATAAAGTTGAAACAGCTATAAACATTGGATTTTCTTGCAACCTTTTGAATAATGAAATGGAATTGTTAGTTATTAAAACAACTGGTGATGACGTGAAAGAATTCGGATCAGAACCAAGTGAAATTGTGGATGCTTTACTCTCCAAATACTTGAAGGAGTATTTCAACTTAACCGGTTCAGAAGAAGAGATTTTTGAAGCTAAAAAGGATCACGAATTTCCGAAGGGTAATTACGCCATCGTTATCGATGGTGATGCTTTGAAATTGGCGCTATATGGTGAAGATATAAGAAGAAAGTTTCTTTTACTCTGCAAGAATTGTAGAGCTGTCTTATGCTGTAGAGTATCTCCATCTCAAAAAGCAGCCGTTGTTAAGTTAGTCAAGGATTCTCTAGATGTCATGACACTAGCCATCGGCGATGGTTCCAACGACGTCGCCATGATTCAATCTGCGGATGTTGGTATTGGTATTGCCGGTGAAGAAGGTCGACAAGCTGTTATGTGCTCAGACTACGCCATTGGACAATTCAGATATTTGGCTAGATTGGTCCTCGTTCACGGTAGGTGGTCTTATAAGAGACTGGCAGAAATGATTCCTGAGTTTTTTTACAAAAACATGATTTTTGCTTTGGCATTGTTCTGGTATGGTATCTATAATGATTTTGATGGGTCTTACCTGTATGAATACACATACATGATGTTCTATAATTTGGCATTTACATCCCTACCAGTCATCTTCTTAGGTATTCTGGACCAGGACGTGAATGACACAATATCATTAGTGGTCCCTCAGTTATACCGTGTTGGAATTTTAAGGAAAGAATGGAACCAAAGAAAGTTCTTATGGTATATGTTGGACGGATTATATCAGTCTATTATCTGTTTTTTTTTCCCTTACTTGGTTTATCACAAAAATATGATAGTTACGAGCAATGGGTTAGGATTGGATCATCGTTATTTTGTCGGTGTTTATGTGACCACTATTGCTGTAATTTCGTGTAACACATATGTTTTATTACACCAATATAGATGGGATTGGTTTAGTGGATTATTCATTGCACTGTCTTGCCTCGTAGTTTTTGCATGGACGGGAATATGGTCTTCTGCGATAGCTAGTAGAGAATTTTTCAAAGCTGCAGCGCGTATCTATGGAGCACCTTCATTTTGGGCTGTTTTCTTTGTTGCCGTGCTGTTCTGCTTACTGCCCCGTTTCACATATGACAGTTTTCAAAAATTTTTCTACCCAACTGATGTGGAAATAGTAAGAGAGATGTGGCAACATGGCCATTTCGATCATTATCCTCCTGGTTACGATCCAACAGATCCCAACAGACCCAAGGTCACAAAAGCTGGGCAACACGGAGAGAAGATTATAGAAGGCATAGCACTTTCCGACAACTTAGGAGGATCGAACTATTCAAGGGATAGTGTTGTCACAGAGGAGATTCCAATGACTTTCATGCACGGTGAAGATGGAAGTCCTAGCGGATATCAGAAGCAAGAAACCTGGATGACTTCACCCAAGGAAACACAAGATCTTCTTCAATCGCCCCAATTTCAGCAGGCCCAAACGTTCGGAAGAGGCCCATCAACCAACGTCAGGTCATCCTTGGACCGCACAAGAGAACAGATGATCGCCACTAACCAACTAGATAACCGCTACTCTGTGGAAAGAGCGAGAACATCTCTAGATCTACCAGGCGTAACTAACGCAGCCTCCTTAATCGGAACACAACAGAACAATTAA","protein_sequence":"MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN"},{"created_at":"2011-05-27T00:26:08.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 3-kinase VPS34","uniprot_id":"P22543","uniprot_name":"VPS34_YEAST","enzyme":true,"transporter":false,"gene_name":"VPS34","num_residues":875,"molecular_weight":"100920.0","theoretical_pi":"7.9","general_function":"Involved in binding","specific_function":"Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3- kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity","reactions":[{"id":1897,"direction":"\u003e","locations":"vacuole;vacuolar membrane","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2619,"direction":"\u003e","locations":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14857,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007045","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","genbank_gene_id":"U20865","genbank_protein_id":"662340","gene_card_id":"VPS34","chromosome_location":"chromosome 12","locus":"YLR240W","synonyms":["PI3-kinase VPS34","PI3K VPS34","PtdIns-3-kinase VPS34","Carboxypeptidase Y-deficient protein 15","Vacuolar protein sorting-associated protein 34","Vacuolar protein-targeting protein 29"],"enzyme_classes":["2.7.1.137"],"go_classes":[{"category":"Component","description":" phosphoinositide 3-kinase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" phosphoinositide 3-kinase activity"},{"category":"Function","description":" 1-phosphatidylinositol-3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"PI3K_C2","identifier":"PF00792"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCACTGAACAACATAACATTCTGTGTCTCACAGGATCTGGATGTTCCCCTGAAAGTGAAAATCAAGTCATTGGAAGGACATAAGCCACTGTTGAAGCCATCTCAAAAAATCCTGAACCCTGAATTAATGCTGATAGGGTCAAATGTATTCCCTTCTAGTGATCTAATTGTATCCTTACAGGTATTTGATAAAGAGAGAAACAGAAATTTAACTCTTCCGATATACACGCCGTATATTCCTTTCAGAAACTCTAGAACCTGGGATTATTGGTTGACTTTGCCCATACGTATCAAACAGCTTACCTTTAGCAGTCATTTACGCATTATTTTGTGGGAATACAATGGATCCAAGCAAATTCCCTTTTTCAATCTAGAAACGAGCATCTTTAACTTAAAAGACTGTACTTTAAAAAGAGGGTTTGAATCCTTAAAATTTCGTTATGATGTGATTGACCACTGTGAAGTGGTCACTGATAACAAAGATCAAGAAAATTTGAATAAATATTTTCAGGGTGAATTCACGAGACTCCCTTGGCTTGACGAAATCACTATAAGCAAATTAAGGAAACAACGGGAAAATAGGACTTGGCCTCAGGGCACCTTTGTCTTAAACTTAGAATTTCCAATGTTAGAGCTTCCTGTTGTGTTCATCGAAAGGGAAATTATGAATACTCAAATGAATATTCCAACTTTGAAGAACAATCCTGGACTAAGCACAGACTTACGAGAACCGAATAGGAATGATCCTCAAATCAAAATTTCTTTGGGGGACAAATATCACTCCACATTGAAGTTTTACGATCCTGACCAACCAAACAATGATCCAATAGAGGAAAAGTATAGGAGATTGGAAAGAGCATCTAAAAATGCAAACTTGGACAAGCAAGTGAAGCCGGACATTAAAAAGAGGGACTACTTGAATAAAATCATCAACTACCCCCCTGGCACTAAATTAACAGCACATGAAAAGGGTTCAATATGGAAATATAGGTATTATTTGATGAACAATAAAAAAGCTCTTACAAAGTTATTACAGAGTACAAATTTGAGAGAAGAATCGGAAAGAGTAGAGGTTTTAGAACTAATGGACTCATGGGCAGAAATTGATATAGACGACGCATTAGAACTATTAGGCTCAACTTTTAAAAACCTTTCAGTGAGATCGTACGCCGTAAATAGGCTGAAGAAGGCATCAGACAAGGAGCTGGAATTGTACTTATTACAGTTGGTAGAAGCTGTCTGTTTTGAGAACCTGTCCACTTTTTCCGACAAATCTAACAGTGAATTCACTATTGTGGATGCCGTATCTTCGCAAAAGCTTTCGGGTGATTCTATGTTACTATCTACATCGCATGCCAACCAAAAATTATTAAAGTCCATCTCGAGTGAATCGGAAACTTCCGGGACAGAATCGCTACCAATCGTCATTTCTCCCTTGGCTGAGTTTTTGATTAGGAGAGCACTGGTCAACCCAAGGTTAGGAAGTTTTTTCTATTGGTATTTAAAGTCCGAGTCTGAGGACAAGCCATATTTAGACCAGATTTTAAGTTCCTTTTGGAGTAGACTGGATAAAAAATCTCGGAATATACTGAACGATCAAGTCAGGCTAATAAATGTGCTCAGGGAATGTTGTGAAACAATTAAGAGGCTGAAAGATACTACAGCCAAAAAGATGGAATTACTAGTGCATTTATTGGAGACGAAAGTCAGGCCTCTTGTCAAAGTACGACCAATTGCTTTACCACTAGACCCTGATGTGTTGATATGCGACGTTTGTCCTGAAACTTCGAAGGTATTTAAAAGCTCTTTATCGCCACTAAAAATAACATTCAAAACGACCTTAAACCAACCATATCACTTAATGTTTAAGGTTGGCGATGATTTGAGACAAGATCAACTGGTAGTACAGATCATAAGTTTAATGAATGAGTTATTAAAAAATGAAAACGTGGACTTGAAATTGACACCATACAAAATTTTGGCAACAGGACCACAAGAAGGTGCCATTGAATTTATCCCTAATGACACATTAGCTAGCATACTAAGCAAATATCACGGTATTCTTGGCTACCTTAAACTCCACTATCCTGATGAGAACGCGACATTAGGCGTACAAGGCTGGGTTTTAGATAATTTTGTCAAATCTTGTGCTGGCTATTGTGTTATTACATACATCTTAGGTGTCGGCGATAGGCATTTAGACAACTTACTAGTCACGCCAGATGGGCACTTTTTTCACGCAGACTTTGGTTATATCTTGGGTCAGGACCCCAAACCTTTTCCGCCATTAATGAAATTGCCCCCTCAAATTATAGAGGCGTTTGGGGGTGCAGAATCATCAAATTATGATAAATTTCGCAGCTACTGTTTTGTGGCATATTCGATTTTAAGAAGGAATGCAGGCTTAATCTTAAACCTGTTTGAATTAATGAAGACTTCGAACATACCTGATATCAGAATAGATCCCAATGGTGCTATATTACGTGTAAGAGAGAGATTTAATTTGAATATGTCCGAAGAAGATGCCACAGTGCATTTTCAGAATCTAATCAATGATAGTGTAAATGCTTTGCTGCCTATCGTGATTGATCATTTACATAATCTGGCACAATACTGGCGGACCTGA","protein_sequence":"MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT"},{"created_at":"2011-05-27T00:30:41.000Z","updated_at":"2011-05-29T05:06:31.000Z","name":"Phosphoenolpyruvate carboxykinase [ATP]","uniprot_id":"P10963","uniprot_name":"PCKA_YEAST","enzyme":true,"transporter":false,"gene_name":"PCK1","num_residues":549,"molecular_weight":"60982.69922","theoretical_pi":"6.31","general_function":"Involved in phosphoenolpyruvate carboxykinase (ATP) activity","specific_function":"ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)","reactions":[{"id":1859,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2620,"direction":"\u003e","locations":null,"altext":"ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14122,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006554","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U24234","genbank_protein_id":"1000080","gene_card_id":"PCK1","chromosome_location":"chromosome 11","locus":"YKR097W","synonyms":[],"enzyme_classes":["4.1.1.49"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" purine nucleotide binding"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" phosphoenolpyruvate carboxykinase (ATP) activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" phosphoenolpyruvate carboxykinase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" gluconeogenesis"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"}],"pfams":[{"name":"PEPCK_ATP","identifier":"PF01293"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTCCCCTTCTAAAATGAATGCTACAGTAGGATCTACTTCCGAAGTTGAACAAAAAATCAGACAAGAATTGGCTCTTAGTGACGAAGTCACCACCATCAGACGCAATGCTCCAGCTGCCGTTTTGTATGAAGATGGTCTAAAAGAAAATAAAACTGTCATTTCATCAAGCGGTGCATTGATCGCTTATTCCGGTGTTAAAACCGGAAGATCTCCAAAGGACAAACGTATTGTTGAAGAACCTACTTCGAAAGACGAAATTTGGTGGGGTCCGGTCAATAAACCATGTTCTGAAAGAACATGGTCTATCAACCGTGAAAGAGCTGCAGATTACTTGAGAACAAGAGACCACATTTATATTGTCGATGCATTCGCTGGATGGGATCCAAAATACAGAATCAAAGTCCGTGTTGTTTGTGCCAGGGCTTACCACGCTTTATTCATGACAAATATGCTTATTAGACCTACAGAAGAAGAATTAGCCCATTTTGGAGAACCTGATTTTACTGTCTGGAACGCTGGTCAGTTCCCAGCCAATTTACACACCCAGGATATGTCTTCAAAGAGTACTATAGAAATTAACTTCAAAGCAATGGAAATGATCATTTTAGGTACCGAATACGCCGGTGAAATGAAAAAAGGTATTTTCACAGTTATGTTTTACTTGATGCCTGTGCACCATAACGTTTTAACTTTGCACTCTTCCGCCAACCAGGGTATTCAAAACGGTGACGTTACTTTATTCTTTGGCCTAAGTGGTACCGGGAAAACCACTTTATCCGCAGACCCACATAGATTGTTGATCGGCGATGATGAACATTGTTGGTCCGACCATGGTGTCTTCAATATCGAAGGTGGTTGTTACGCCAAGTGTATTAATCTATCTGCTGAAAAGGAGCCTGAAATTTTCGACGCTATCAAGTTTGGTTCTGTATTAGAAAACGTTATCTATGACGAGAAGTCGCACGTAGTCGACTATGACGACTCTTCTATTACTGAAAATACTAGATGTGCCTACCCAATTGACTACATTCCAAGTGCCAAGATTCCATGTTTGGCGGACTCTCATCCAAAGAACATTATCCTGCTAACTTGTGATGCTTCGGGTGTTTTACCACCAGTATCTAAATTGACTCCTGAACAAGTCATGTACCATTTCATCTCTGGTTACACTTCTAAAATGGCTGGTACTGAGCAAGGTGTCACTGAACCTGAACCAACATTTTCATCTTGTTTCGGACAACCCTTCCTAGCCTTACACCCTATTAGATACGCAACCATGTTAGCTACAAACATGTCTCAACATAAAGCTAATGCGTACTTAATCAACACCGGCTGGACTGGTTCTTCCTACGTATCTGGTGGTAAACGTTGCCCATTGAAGTACACAAGGGCCATTCTGGATTCTATTCATGATGGTTCGTTAGCCAATGAAACGTACGAAACTTTACCGATTTTCAATCTTCAAGTACCTACCAAGGTTAACGGTGTTCCAGCTGAGCTCTTGAATCCTGCTAAAAACTGGTCTCAAGGTGAATCCAAATACAGAGGTGCAGTTACCAACTTGGCCAACTTGTTTGTTCAAAATTTCAAGATTTATCAAGACAGAGCCACACCAGATGTATTAGCCGCTGGTCCTCAATTCGAGTAA","protein_sequence":"MSPSKMNATVGSTSEVEQKIRQELALSDEVTTIRRNAPAAVLYEDGLKENKTVISSSGALIAYSGVKTGRSPKDKRIVEEPTSKDEIWWGPVNKPCSERTWSINRERAADYLRTRDHIYIVDAFAGWDPKYRIKVRVVCARAYHALFMTNMLIRPTEEELAHFGEPDFTVWNAGQFPANLHTQDMSSKSTIEINFKAMEMIILGTEYAGEMKKGIFTVMFYLMPVHHNVLTLHSSANQGIQNGDVTLFFGLSGTGKTTLSADPHRLLIGDDEHCWSDHGVFNIEGGCYAKCINLSAEKEPEIFDAIKFGSVLENVIYDEKSHVVDYDDSSITENTRCAYPIDYIPSAKIPCLADSHPKNIILLTCDASGVLPPVSKLTPEQVMYHFISGYTSKMAGTEQGVTEPEPTFSSCFGQPFLALHPIRYATMLATKMSQHKANAYLINTGWTGSSYVSGGKRCPLKYTRAILDSIHDGSLANETYETLPIFNLQVPTKVNGVPAELLNPAKNWSQGESKYRGAVTNLANLFVQNFKIYQDRATPDVLAAGPQFE"},{"created_at":"2011-05-27T00:33:49.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Thiamine biosynthetic bifunctional enzyme","uniprot_id":"P41835","uniprot_name":"THI6_YEAST","enzyme":true,"transporter":false,"gene_name":"THI6","num_residues":540,"molecular_weight":"58058.19922","theoretical_pi":"5.74","general_function":"Involved in catalytic activity","specific_function":"Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole","reactions":[{"id":1646,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2003,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2621,"direction":"\u003e","locations":null,"altext":"2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2622,"direction":"\u003e","locations":null,"altext":"ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.","export":false,"pw_reaction_id":null,"source":null},{"id":14440,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006953","source":"Smpdb"},{"id":14441,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006954","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D31908","genbank_protein_id":"633125","gene_card_id":"THI6","chromosome_location":"chromosome 16","locus":"YPL214C","synonyms":["Thiamine-phosphate pyrophosphorylase","TMP pyrophosphorylase","TMP-PPASE","Hydroxyethylthiazole kinase","4-methyl-5-beta-hydroxyethylthiazole kinase","TH kinase","THZ kinase"],"enzyme_classes":["2.5.1.3","2.7.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" thiamin-phosphate diphosphorylase activity"},{"category":"Function","description":" hydroxyethylthiazole kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" thiamin biosynthetic process"}],"pfams":[{"name":"HK","identifier":"PF02110"},{"name":"TMP-TENI","identifier":"PF02581"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTATTTACTAAGGAAGAAGTTGATTACTCATTATATCTGGTTACAGATTCTACCATGCTTCCACCGGGAACTACTTTATGTTCTCAGGTTGAAGCTGGGTTGAAAAATGGTGTAACGCTAGTTCAAATCCGTGAAAAGGATATTGAAACAAAAAATTTCGTTGCAGAGGCTTTAGAAGTTCAAAAAATATGTAAGAAGTACAATGTTCCACTTATTATCAATGACCGTATAGACGTCGCTATGGCAATTGACGCCGATGGGGTTCATGTGGGCCAGGACGATATGCCAATCCCAATGGTAAGAAAACTTTTGGGCCCTTCTAAAATTCTTGGATGGAGTGTTGGTAAACCTTCGGAGGTAGAGACATTGGCTAAATGGGGGCCAGATATGGTAGATTATATTGGTGTTGGTACTCTTTTCCCTACATCAACAAAGAAAAATCCTAAGAAATCACCCATGGGTCCTCAAGGCGCCATTGCCATTTTGGATGCTTTGGAGGAATTTAAAGCTACATGGTGTAGAACCGTTGGTATTGGTGGTCTTCATCCTGACAATATTCAACGTGTGCTTTGTCAATGTGTTGCTTCAAATGGAAAGAGATCGTTGGATGGTATCTCTCTAGTCAGCGATATTATGGCCGCTCCAGATGCATGTGCAGCAACCAAGAGGTTGAGAGGCTTGTTAGATGCTACCAGATACCAATTTGTTGAGTGCGAGTTAAATAATACATTTCCGACCACAACTTCAATTCAAAACGTTATATCTCAAGTATCAAACAATCGTCCATTAGTGCAACATATCACCAATAAGGTTCATCAAAATTTTGGTGCCAATGTCACTCTAGCTTTAGGCTCATCTCCTATCATGTCTGAAATTGAAAGTGAAGTATCTGAACTAGCAAGAATCCCAAATGCTTCTTTACTGTTAAATACCGGATCAGTGGCACCTATTGAAATGCTAAAAGCCGCAATTAATGCTTATAATGAAGTAAATAGACCCATCACCTTTGACCCGGTCGGGTACAGCGCCACTGAAACAAGGCTCTGTCTAAACAACACTTTGCTCACTTACGGCCAATTTGCTTGTATAAAGGGCAATTGCAGTGAAATACTGTCTCTAGCCAAGTTAAATAACCATAAAATGAAGGGCGTCGACTCTAGCAGCGGCAAAACGAACATCGACACACTTGTGCGCGCTACACAAATTGTGGCATTCCAATACAGGACTGTTGCTGTTTGCACGGGTGAGTTTGATTGCGTTGCTGATGGTACTTTTGGAGGCGAATACAAACTTTCATCAGGAACAGAAGGAATAACCGCTGAAGATCTTCCATGTGTAATAATTGAAGATGGCCCAATTCCTATCATGGGTGACATCACTGCAAGTGGATGTTCACTTGGTTCTACAATTGCTTCCTTTATCGGTGGGTTAGATTCCACTGGAAAACTGTTTGATGCTGTGGTTGGTGCTGTCCTATTATACAAATCAGCTGGTAAGTTGGCTTCCACCCGTTGTCAAGGAAGTGGTTCATTCCATGTCGAATTGATTGACGCATTATATCAATTATTCCATGAAAATAAACCAGAAAAGTGGTCCGCTTCTTTGAAGAAATTCAAATAA","protein_sequence":"MVFTKEEVDYSLYLVTDSTMLPPGTTLCSQVEAGLKNGVTLVQIREKDIETKNFVAEALEVQKICKKYNVPLIINDRIDVAMAIDADGVHVGQDDMPIPMVRKLLGPSKILGWSVGKPSEVETLAKWGPDMVDYIGVGTLFPTSTKKNPKKSPMGPQGAIAILDALEEFKATWCRTVGIGGLHPDNIQRVLCQCVASNGKRSLDGISLVSDIMAAPDACAATKRLRGLLDATRYQFVECELNNTFPTTTSIQNVISQVSNNRPLVQHITNKVHQNFGANVTLALGSSPIMSEIESEVSELARIPNASLLLNTGSVAPIEMLKAAINAYNEVNRPITFDPVGYSATETRLCLNNTLLTYGQFACIKGNCSEILSLAKLNNHKMKGVDSSSGKTNIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFGGEYKLSSGTEGITAEDLPCVIIEDGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDAVVGAVLLYKSAGKLASTRCQGSGSFHVELIDALYQLFHENKPEKWSASLKKFK"},{"created_at":"2011-05-27T00:34:26.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Glucokinase-1","uniprot_id":"P17709","uniprot_name":"HXKG_YEAST","enzyme":true,"transporter":false,"gene_name":"GLK1","num_residues":500,"molecular_weight":"55376.89844","theoretical_pi":"6.13","general_function":"Involved in ATP binding","specific_function":"Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake","reactions":[{"id":1564,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2610,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-glucose = ADP + D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M24077","genbank_protein_id":"577521","gene_card_id":"GLK1","chromosome_location":"chromosome 3","locus":"YCL040W","synonyms":["Glucose kinase 1","GLK-1"],"enzyme_classes":["2.7.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGTCATTCGACGACTTACACAAAGCCACTGAGAGAGCGGTCATCCAGGCCGTGGACCAGATCTGCGACGATTTCGAGGTTACCCCCGAGAAGCTGGACGAATTAACTGCTTACTTCATCGAACAAATGGAAAAAGGTCTAGCTCCACCAAAGGAAGGCCACACATTGGCCTCGGACAAAGGTCTTCCTATGATTCCGGCGTTCGTCACCGGGTCACCCAACGGGACGGAGCGCGGTGTTTTACTAGCCGCCGACCTGGGTGGTACCAATTTCCGTATATGTTCTGTTAACTTGCATGGAGATCATACTTTCTCCATGGAGCAAATGAAGTCCAAGATTCCCGATGATTTGCTAGACGATGAGAACGTCACATCTGACGACCTGTTTGGGTTTCTAGCACGTCGTACACTGGCCTTTATGAAGAAGTATCACCCGGACGAGTTGGCCAAGGGTAAAGACGCCAAGCCCATGAAACTGGGGTTCACTTTCTCATACCCTGTAGACCAGACCTCTCTAAACTCCGGGACATTGATCCGTTGGACCAAGGGTTTCCGCATCGCGGACACCGTCGGAAAGGATGTCGTGCAATTGTACCAGGAGCAATTAAGCGCTCAGGGTATGCCTATGATCAAGGTTGTTGCATTAACCAACGACACCGTCGGAACGTACCTATCGCATTGCTACACGTCCGATAACACGGACTCAATGACGTCCGGAGAAATCTCGGAGCCGGTCATCGGATGTATTTTCGGTACCGGTACCAATGGGTGCTATATGGAGGAGATCAACAAGATCACGAAGTTGCCACAGGAGTTGCGTGACAAGTTGATAAAGGAGGGTAAGACACACATGATCATCAATGTCGAATGGGGGTCCTTCGATAATGAGCTCAAGCACTTGCCTACTACTAAGTATGACGTCGTAATTGACCAGAAACTGTCAACGAACCCGGGATTTCACTTGTTTGAAAAACGTGTCTCAGGGATGTTCTTGGGTGAGGTGTTGCGTAACATTTTAGTGGACTTGCACTCGCAAGGCTTGCTTTTGCAACAGTACAGGTCCAAGGAACAACTTCCTCGCCACTTGACTACACCTTTCCAGTTGTCATCCGAAGTGCTGTCGCATATTGAAATTGACGACTCGACAGGTCTACGTGAAACAGAGTTGTCATTATTACAGAGTCTCAGACTGCCCACCACTCCAACAGAGCGTGTTCAAATTCAAAAATTGGTGCGCGCGATTTCTAGGAGATCTGCGTATTTAGCCGCCGTGCCGCTTGCCGCGATATTGATCAAGACAAATGCTTTGAACAAGAGATATCATGGTGAAGTCGAGATCGGTTGTGATGGTTCCGTTGTGGAATACTACCCCGGTTTCAGATCTATGCTGAGACACGCCTTAGCCTTGTCACCCTTGGGTGCCGAGGGTGAGAGGAAGGTGCACTTGAAGATTGCCAAGGATGGTTCCGGAGTGGGTGCCGCCTTGTGTGCGCTTGTAGCATGA","protein_sequence":"MSFDDLHKATERAVIQAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTERGVLLAADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDELAKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCDGSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA"},{"created_at":"2011-05-27T00:35:21.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphoglycerate kinase","uniprot_id":"P00560","uniprot_name":"PGK_YEAST","enzyme":true,"transporter":false,"gene_name":"PGK1","num_residues":416,"molecular_weight":"44738.0","theoretical_pi":"7.8","general_function":"Involved in phosphoglycerate kinase activity","specific_function":"ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate","reactions":[{"id":1867,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2623,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3814,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006327","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1QPG","cellular_location":"Cytoplasm","genbank_gene_id":"J01342","genbank_protein_id":"1197055","gene_card_id":"PGK1","chromosome_location":"chromosome 3","locus":"YCR012W","synonyms":[],"enzyme_classes":["2.7.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphoglycerate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"}],"pfams":[{"name":"PGK","identifier":"PF00162"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"}],"gene_sequence":"ATGTCTTTATCTTCAAAGTTGTCTGTCCAAGATTTGGACTTGAAGGACAAGCGTGTCTTCATCAGAGTTGACTTCAACGTCCCATTGGACGGTAAGAAGATCACTTCTAACCAAAGAATTGTTGCTGCTTTGCCAACCATCAAGTACGTTTTGGAACACCACCCAAGATACGTTGTCTTGGCTTCTCACTTGGGTAGACCAAACGGTGAAAGAAACGAAAAATACTCTTTGGCTCCAGTTGCTAAGGAATTGCAATCATTGTTGGGTAAGGATGTCACCTTCTTGAACGACTGTGTCGGTCCAGAAGTTGAAGCCGCTGTCAAGGCTTCTGCCCCAGGTTCCGTTATTTTGTTGGAAAACTTGCGTTACCACATCGAAGAAGAAGGTTCCAGAAAGGTCGATGGTCAAAAGGTCAAGGCTTCCAAGGAAGATGTTCAAAAGTTCAGACACGAATTGAGCTCTTTGGCTGATGTTTACATCAACGATGCCTTCGGTACCGCTCACAGAGCTCACTCTTCTATGGTCGGTTTCGACTTGCCACAACGTGCTGCCGGTTTCTTGTTGGAAAAGGAATTGAAGTACTTCGGTAAGGCTTTGGAGAACCCAACCAGACCATTCTTGGCCATCTTAGGTGGTGCCAAGGTTGCTGACAAGATTCAATTGATTGACAACTTGTTGGACAAGGTCGACTCTATCATCATTGGTGGTGGTATGGCTTTCACCTTCAAGAAGGTTTTGGAAAACACTGAAATCGGTGACTCCATCTTCGACAAGGCTGGTGCTGAAATCGTTCCAAAGTTGATGGAAAAGGCCAAGGCCAAGGGTGTCGAAGTCGTCTTGCCAGTCGACTTCATCATTGCTGATGCTTTCTCTGCTGATGCCAACACCAAGACTGTCACTGACAAGGAAGGTATTCCAGCTGGCTGGCAAGGGTTGGACAATGGTCCAGAATCTAGAAAGTTGTTTGCTGCTACTGTTGCAAAGGCTAAGACCATTGTCTGGAACGGTCCACCAGGTGTTTTCGAATTCGAAAAGTTCGCTGCTGGTACTAAGGCTTTGTTAGACGAAGTTGTCAAGAGCTCTGCTGCTGGTAACACCGTCATCATTGGTGGTGGTGACACTGCCACTGTCGCTAAGAAGTACGGTGTCACTGACAAGATCTCCCATGTCTCTACTGGTGGTGGTGCTTCTTTGGAATTATTGGAAGGTAAGGAATTGCCAGGTGTTGCTTTCTTATCCGAAAAGAAATAA","protein_sequence":"MSLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGERNEKYSLAPVAKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASKEDVQKFRHELSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTDKEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELLEGKELPGVAFLSEKK"},{"created_at":"2011-05-27T00:37:20.000Z","updated_at":"2011-05-29T14:01:22.000Z","name":"Probable copper-transporting ATPase","uniprot_id":"P38360","uniprot_name":"ATU1_YEAST","enzyme":false,"transporter":true,"gene_name":"PCA1","num_residues":1216,"molecular_weight":"131838.0","theoretical_pi":"7.54","general_function":"Involved in nucleotide binding","specific_function":"Probably involved in copper transport and in the regulation of cellular copper level","reactions":[{"id":2583,"direction":"\u003e","locations":"Membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein","altext":"ATP + H(2)O + Cu(2+)(In) = ADP + phosphate + Cu(2+)(Out).","export":false,"pw_reaction_id":null,"source":null},{"id":2624,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein","altext":"\nATP + H2O + Cd2+/in = ADP + phosphate + Cd2+/out","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"557-578;593-612;621-641;660-680;809-831;848-865;1162-1181;1191-1209","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z29332","genbank_protein_id":"547580","gene_card_id":"PCA1","chromosome_location":"chromosome 2","locus":"YBR295W","synonyms":["Cu(2+)-ATPase"],"enzyme_classes":["3.6.3.4","3.6.3.3"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" metal ion transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" di-, tri-valent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" copper ion transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" copper-transporting ATPase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" copper-exporting ATPase activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" metal ion transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGAAGCCGGAAAAACTCTTCTCCGGTTTAGGTACCAGCGATGGCGAGTATGGAGTGGTAAATAGCGAGAACATATCAATAGATGCTATGCAAGATAATAGAGGCGAGTGTCATCGTAGATCCATAGAAATGCATGCTAATGACAATCTGGGATTGGTCTCCCAGCGAGACTGTACCAATCGGCCCAAAATTACTCCTCAGGAATGTTTGAGTGAGACTGAGCAGATATGCCATCATGGCGAGAATAGGACTAAGGCTGGGTTAGATGTAGACGATGCTGAAACCGGTGGTGATCACACCAATGAATCCCGTGTAGATGAATGTTGTGCTGAGAAAGTGAACGACACTGAGACTGGCTTGGATGTGGACAGCTGTTGCGGCGATGCTCAAACAGGTGGTGACCACACCAATGAATCCTGTGTTGATGGATGCTGCGTTAGAGATTCTTCAGTGATGGTCGAGGAAGTTACAGGCAGCTGCGAAGCTGTATCTTCTAAAGAACAATTGCTGACCAGCTTTGAAGTTGTTCCAAGCAAATCTGAAGGTCTGCAATCTATTCATGATATTAGAGAGACAACTCGCTGCAATACCAATTCCAACCAACACACAGGGAAGGGTAGGCTTTGCATCGAATCAAGTGACTCTACACTCAAGAAAAGAAGTTGTAAAGTTAGCAGACAGAAAATTGAGGTTTCCAGTAAGCCTGAGTGCTGCAACATTTCATGTGTTGAGCGGATTGCATCTCGTAGCTGTGAAAAGAGGACTTTTAAAGGTAGCACCAATGTTGGAATTTCTGGGAGTAGCTCTACCGACAGTTTAAGCGAGAAGTTCTTCAGCGAACAGTACTCTAGAATGTACAATCGTTACTCCTCAATTTTGAAAAATTTAGGTTGTATCTGTAACTATTTGCGTACTTTGGGAAAAGAATCTTGTTGTCTCCCAAAGGTGCGTTTTTGTAGCGGGGAGGGTGCTTCTAAAAAGACAAAATACTCCTACCGCAACAGTTCTGGATGTTTAACAAAGAAAAAGACCCATGGAGACAAAGAAAGGTTGAGCAATGACAATGGCCATGCTGATTTTGTTTGTTCTAAAAGTTGTTGCACTAAAATGAAGGATTGTGCTGTTACCTCAACTATTTCTGGAACCTCTTCGAGTGAAATTTCAAGAATCGTATCAATGGAACCAATTGAAAATCATCTTAATCTTGAGGCAGGATCTACCGGTACCGAGCACATTGTTCTTAGTGTTTCAGGAATGTCCTGTACTGGTTGTGAATCAAAACTTAAGAAATCATTTGGCGCGCTCAAATGTGTTCACGGTTTGAAGACCAGTTTAATATTATCGCAAGCTGAATTTAATCTGGATCTTGCTCAGGGATCTGTCAAGGATGTTATCAAGCACTTGAGCAAAACTACTGAATTCAAGTACGAACAGATTTCAAATCATGGTTCAACTATAGATGTTGTTGTTCCTTATGCAGCAAAAGATTTTATTAATGAGGAATGGCCACAAGGTGTCACAGAGCTGAAAATTGTTGAGAGAAATATCATTCGTATTTACTTTGACCCAAAGGTTATAGGTGCCAGAGATCTTGTCAATGAAGGATGGAGCGTGCCTGTTAGTATTGCTCCATTCAGTTGTCATCCAACCATTGAAGTGGGAAGGAAGCATTTAGTTCGTGTAGGCTGCACGACCGCTTTATCCATAATATTGACGATCCCGATTCTCGTGATGGCTTGGGCTCCACAGCTTCGTGAAAAAATTTCCACTATCTCCGCGTCAATGGTGCTAGCAACTATTATTCAATTTGTTATTGCAGGACCGTTTTACTTAAATGCCTTGAAGAGTTTGATATTTTCCAGGCTCATTGAAATGGATCTACTAATAGTTTTAAGCACTAGCGCTGCCTACATATTTTCGATTGTATCATTTGGATATTTCGTTGTTGGACGCCCGTTATCTACGGAGCAGTTTTTTGAAACCAGCTCTTTGCTTGTAACTCTCATCATGGTTGGTCGCTTTGTGAGTGAACTAGCTAGACATAGGGCTGTAAAGTCAATATCAGTACGTTCCTTACAGGCCTCTTCTGCTATTCTGGTGGATAAAACTGGTAAAGAGACGGAAATTAATATTAGACTTCTCCAATATGGCGATATTTTTAAGGTTTTACCTGATTCAAGAATCCCAACTGATGGAACAGTCATTTCTGGGTCTTCTGAAGTCGACGAAGCGTTAATCACAGGTGAATCTATGCCAGTCCCGAAAAAGTGTCAATCAATTGTTGTTGCAGGATCGGTGAATGGCACTGGTACTTTGTTTGTGAAGCTGAGCAAGCTTCCAGGGAACAATACTATTAGTACCATAGCCACGATGGTTGATGAAGCAAAATTAACTAAGCCAAAGATCCAAAATATCGCTGATAAAATTGCAAGTTATTTCGTGCCAACTATCATTGGAATCACTGTCGTCACCTTTTGCGTTTGGATAGCGGTTGGAATCCGTGTGGAAAAGCAATCCCGCTCCGATGCCGTAATTCAGGCCATTATATATGCCATTACGGTACTTATCGTTTCGTGTCCCTGCGTGATTGGACTTGCCGTTCCTATCGTATTTGTTATTGCAAGTGGCGTCGCTGCGAAAAGAGGGGTAATCTTCAAATCAGCAGAGAGTATAGAAGTTGCTCACAACACTTCGCATGTTGTCTTCGATAAAACGGGTACCCTAACTGAAGGAAAACTTACTGTAGTACATGAAACTGTTAGGGGTGATCGTCATAATTCTCAATCTTTGTTGCTTGGATTAACTGAAGGAATAAAACACCCAGTTTCCATGGCAATAGCATCCTATCTCAAAGAAAAAGGTGTTTCTGCTCAAAATGTTTCTAATACAAAAGCTGTGACTGGTAAGCGGGTAGAAGGAACATCATACTCTGGTTTGAAGTTACAAGGAGGGAACTGTCGTTGGCTTGGTCATAACAATGATCCTGACGTTCGAAAAGCCCTTGAACAAGGATATTCTGTATTCTGTTTTAGTGTTAATGGTTCAGTCACTGCAGTTTATGCATTAGAGGACTCTTTACGGGCAGATGCTGTCTCCACTATTAACTTGTTACGCCAAAGAGGGATTTCACTACACATTTTATCAGGGGATGACGATGGAGCCGTTCGTTCTATGGCAGCCCGTCTTGGAATTGAAAGCTCCAATATTCGTTCTCACGCAACGCCTGCAGAAAAGAGTGAATATATTAAGGATATTGTCGAAGGAAGAAATTGCGATAGTTCTTCGCAGTCAAAAAGACCGGTTGTTGTTTTTTGCGGTGACGGAACAAACGACGCAATTGGTTTGACTCAAGCAACGATTGGAGTTCATATCAATGAGGGAAGTGAGGTTGCCAAGCTAGCTGCTGATGTAGTTATGTTAAAGCCAAAGCTCAACAATATTTTGACTATGATAACTGTAAGTCAAAAGGCCATGTTTAGGGTCAAATTGAATTTCTTATGGAGTTTTACTTACAACTTATTTGCTATCCTTTTGGCGGCTGGTGCCTTTGTTGACTTTCATATTCCACCAGAGTATGCGGGTTTAGGGGAACTAGTTAGTATCCTCCCTGTAATTTTTGTAGCTATACTTCTGCGTTATGCAAAGATTTAG","protein_sequence":"MKPEKLFSGLGTSDGEYGVVNSENISIDAMQDNRGECHRRSIEMHANDNLGLVSQRDCTNRPKITPQECLSETEQICHHGENRTKAGLDVDDAETGGDHTNESRVDECCAEKVNDTETGLDVDSCCGDAQTGGDHTNESCVDGCCVRDSSVMVEEVTGSCEAVSSKEQLLTSFEVVPSKSEGLQSIHDIRETTRCNTNSNQHTGKGRLCIESSDSTLKKRSCKVSRQKIEVSSKPECCNISCVERIASRSCEKRTFKGSTNVGISGSSSTDSLSEKFFSEQYSRMYNRYSSILKNLGCICNYLRTLGKESCCLPKVRFCSGEGASKKTKYSYRNSSGCLTKKKTHGDKERLSNDNGHADFVCSKSCCTKMKDCAVTSTISGTSSSEISRIVSMEPIENHLNLEAGSTGTEHIVLSVSGMSCTGCESKLKKSFGALKCVHGLKTSLILSQAEFNLDLAQGSVKDVIKHLSKTTEFKYEQISNHGSTIDVVVPYAAKDFINEEWPQGVTELKIVERNIIRIYFDPKVIGARDLVNEGWSVPVSIAPFSCHPTIEVGRKHLVRVGCTTALSIILTIPILVMAWAPQLREKISTISASMVLATIIQFVIAGPFYLNALKSLIFSRLIEMDLLIVLSTSAAYIFSIVSFGYFVVGRPLSTEQFFETSSLLVTLIMVGRFVSELARHRAVKSISVRSLQASSAILVDKTGKETEINIRLLQYGDIFKVLPDSRIPTDGTVISGSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPKIQNIADKIASYFVPTIIGITVVTFCVWIAVGIRVEKQSRSDAVIQAIIYAITVLIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEGKLTVVHETVRGDRHNSQSLLLGLTEGIKHPVSMAIASYLKEKGVSAQNVSNTKAVTGKRVEGTSYSGLKLQGGNCRWLGHNNDPDVRKALEQGYSVFCFSVNGSVTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSEYIKDIVEGRNCDSSSQSKRPVVVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLNNILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFVDFHIPPEYAGLGELVSILPVIFVAILLRYAKI"},{"created_at":"2011-05-27T00:40:12.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"ATP synthase subunit beta, mitochondrial","uniprot_id":"P00830","uniprot_name":"ATPB_YEAST","enzyme":true,"transporter":false,"gene_name":"ATP2","num_residues":511,"molecular_weight":"54793.30078","theoretical_pi":"5.41","general_function":"Involved in ATP binding","specific_function":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits","reactions":[{"id":2599,"direction":"\u003e","locations":"Mitochondrion. Mitochondrion inner membrane.; Multi-pass membrane protein;Cell membrane;Endomembrane system. Vacuole membrane (Probable).","altext":"ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).","export":false,"pw_reaction_id":null,"source":null},{"id":14314,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006818","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Mitochondrion inner membrane.","genbank_gene_id":"M12082","genbank_protein_id":"171110","gene_card_id":"ATP2","chromosome_location":"chromosome 10","locus":"YJR121W","synonyms":[],"enzyme_classes":["3.6.3.14"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" proton-transporting two-sector ATPase complex, catalytic domain"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" proton-transporting two-sector ATPase complex"},{"category":"Component","description":" proton-transporting ATP synthase complex, catalytic core F(1)"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Function","description":" proton-transporting ATPase activity, rotational mechanism"},{"category":"Function","description":" monovalent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrogen ion transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" hydrogen ion transporting ATP synthase activity, rotational mechanism"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrogen-exporting ATPase activity, phosphorylative mechanism"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ATP synthesis coupled proton transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP metabolic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" hydrogen transport"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" proton transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ATP-synt_ab","identifier":"PF00006"},{"name":"ATP-synt_ab_C","identifier":"PF00306"},{"name":"ATP-synt_ab_N","identifier":"PF02874"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGTTTTGCCAAGACTATATACTGCTACATCCCGTGCTGCTTTTAAAGCAGCCAAACAATCCGCTCCGCTTCTATCCACTTCGTGGAAAAGATGTATGGCCTCAGCTGCTCAATCTACTCCAATCACCGGTAAAGTTACCGCTGTCATTGGTGCCATTGTTGACGTTCATTTTGAACAATCAGAGTTGCCCGCTATTTTGAACGCTTTAGAAATTAAAACACCTCAAGGTAAGTTGGTTTTGGAAGTTGCTCAACATTTGGGTGAAAACACTGTCAGAACCATTGCTATGGATGGTACCGAAGGTTTGGTCCGTGGTGAAAAGGTTCTTGACACTGGTGGCCCTATCTCCGTCCCAGTTGGGAGAGAAACTTTAGGGAGAATCATCAACGTTATCGGTGAACCTATTGATGAAAGAGGTCCAATTAAGTCCAAACTAAGAAAGCCAATTCACGCAGACCCTCCTAGTTTTGCAGAACAATCTACTTCGGCTGAAATTTTGGAAACAGGTATCAAAGTCGTCGATCTATTAGCTCCTTATGCCAGAGGTGGTAAGATTGGTCTTTTCGGTGGTGCAGGTGTCGGTAAGACTGTGTTCATTCAAGAATTGATTAACAATATCGCCAAGGCCCATGGTGGTTTTTCCGTTTTCGCCGGTGTTGGTGAAAGGACCAGAGAGGGTAATGACTTGTACCGTGAAATGAAGGAAACTGGAGTCATTAACTTGGAAGGTGAATCCAAGGTCGCCTTAGTTTTCGGTCAAATGAACGAACCTCCAGGAGCCAGAGCCAGAGTCGCTTTAACTGGTTTGACGATCGCTGAATATTTCAGAGATGAAGAAGGTCAAGACGTCTTGTTGTTTATCGACAATATCTTTAGATTTACTCAAGCTGGTTCAGAAGTCTCTGCCCTTTTGGGTCGTATTCCATCTGCCGTCGGTTATCAACCAACTTTGGCCACTGATATGGGTCTCTTACAAGAAAGAATTACCACCACAAAGAAGGGTTCTGTCACTTCTGTGCAAGCCGTTTATGTTCCAGCCGATGATTTAACAGATCCGTCTCCGTCCACATCTTTTGCCCATTTGGACGCATCATCCGTCTTGTCAAGAGGTATTTCAGAATTAGGTATTTACCCTGCAGTGGATCCATTGGATTCTAAATCAAGGTTATTGGATGCCGCCGTTGTCGGTCAAGAACATTATGACGTCGCCTCCAAGGTTCAAGAAACTTTACAGACCTATAAATCTTTACAAGATATCATTGCTATTTTGGGTATGGATGAATTGTCCGAACAAGATAAACTAACTGTCGAAAGGGCAAGAAAGATTCAAAGATTCTTATCTCAACCATTTGCTGTCGCCGAAGTCTTTACTGGTATCCCAGGTAAATTAGTGAGATTAAAGGACACCGTTGCCTCGTTCAAAGCCGTTTTGGAAGGTAAATACGATAATATACCAGAACATGCTTTCTATATGGTTGGTGGTATTGAAGATGTTGTTCGTAAAGCTGAAAAGTTAGCCCGTGAAGCCAACTAG","protein_sequence":"MVLPRLYTATSRAAFKAAKQSAPLLSTSWKRCMASAAQSTPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLGENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDERGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVERARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEHAFYMVGGIEDVVAKAEKLAAEAN"},{"created_at":"2011-05-27T00:42:41.000Z","updated_at":"2011-07-22T17:53:40.000Z","name":"1-phosphatidylinositol-3-phosphate 5-kinase FAB1","uniprot_id":"P34756","uniprot_name":"FAB1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAB1","num_residues":2278,"molecular_weight":"257447.0","theoretical_pi":"8.51","general_function":"Involved in ATP binding","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4","reactions":[{"id":1133,"direction":"\u003c\u003e","locations":"vacuole","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1134,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2625,"direction":"\u003e","locations":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","altext":"ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","genbank_gene_id":"D50617","genbank_protein_id":"836774","gene_card_id":"FAB1","chromosome_location":"chromosome 6","locus":"YFR019W","synonyms":["Phosphatidylinositol-3-phosphate 5-kinase","Type III PIP kinase","PIPkin-III"],"enzyme_classes":["2.7.1.150"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" phosphatidylinositol phosphate kinase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" protein metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphatidylinositol metabolic process"},{"category":"Process","description":" cellular protein metabolic process"}],"pfams":[{"name":"Cpn60_TCP1","identifier":"PF00118"},{"name":"FYVE","identifier":"PF01363"},{"name":"PIP5K","identifier":"PF01504"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCATCGGAAGAACCCCATGCATCTATATCCTTTCCAGATGGCTCACATGTCCGGTCGTCCTCCACTGGTACTTCATCTGTGAACACAATCGATGCTACCTTATCCAGACCGAACTATATTAAGAAACCGTCCCTGCACATTATGTCGACATCTACGACGTCGACTACGACGGATCTAGTGACAAACCCAATTCTGAGCAATATCTCCGTGCCAAAAATAAGCCCCCCCACATCATCCTCGATAGCAACAGCGACATCAACAAGTCACGTGACCGGCACTGCGTCGCATTCGAACATTAAAGCTAATGCTAACACTAGTACCAGCGTGAATAAGAAAAATTTGCCGCCAACAACTAGTGGGAGGATACCCTCTAGCACCATCAAGAGATATCCGAGTCGCTATAAGCCTTCTCACTCGCTGCAGCTGCCCATTAAGAACGACTCCAACTTTAAACGATCTAGCATATATGCCTCCAAATCCACTGTTACTGCTATCCCCATTAGGAACAATCGGCCAATTTCCATGCAGAATTCCTATGCGCGCACTCCTGACAGCGATCATGACGACGTTGGCGATGAAGTGTCTTCGATAAAGAGTGCCTCTTCTTCGTTGACCGCATCCCTGTCCAAGAGTTTCCTGTTCGCATTTTATAACAACCGCAAGAAGGACAAGACCAGTAACAATGGTGTCCTCTCAAAGGAATATTGGATGAAGGACGAGAGTTCTAAAGAATGTTTCAGTTGTGGTAAAACGTTTAACACTTTCAGAAGGAAACACCACTGCAGGATATGCGGCCAAATTTTTTGCAGCAGTTGCACTCTCTTGATAGATGGTGATCGATTCGGCTGTCATGCCAAGATGCGAGTATGTTACAATTGTTATGAGCATGCAGACACATACGAGGACTCCAGTGATGAAGAGAATGATTCTACAATGCAATTGAATGAGCCAAGGTCTCGCTCTCGCTCTCGTTCTTCCAATACCAATCCATATTCTCATTCACATTCGCATTTGCATCTCATTTCACAGGACAACCATAACGGTACCGATCTCCATGATCCAGTAGCAGCAACGGATAACCCTCAACAGCAGAATGAGGTCTACCTATTAAATGACGATGACGTACAAAGTATAATGACCTCAGGTGAAGATTCTAAATTGTTCATTTCTACACCCCCACCACCACCGAAGATGGCCATCCCAGCAACAAAGCAAGGCGGATCGCTGGAAATCTCATTCGATTCGGAAAACGATAGGGCTTTGCATTATCAAGATGACAACCCCGGTCGCCATCATCACCTCGATTCCGTGCCCACAAGGTACACTATCAGAGATATGGACAATATATCACATTACGATACCAACTCTAATTCCACTTTGAGGCCACATTATAACACCAATAACAGCACTATTACCATCAACAACCTCAACAACACTACTTCCAACAACAGCAACTATAACAATACCAATAGCAACAGCAACATCAATAATCCTGCGCATTCCTTAAGAAGGTCTATTTTCCATTATGTAAGCAGCAATAGTGTTAACAAGGACAGTAACAATAGCTCTGCAACACCCGCTTCGTCTGCACAGTCTTCTTCCATACTGGATCCTGCCAATCGTATTATCGGGAATTATGCTCATAGAAATTACAAGTTTAAATTCAACTACAATTCCAAAGGTCCTTCGCAACAAAATGACACGGCAAATGGAAATAATGATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAACAGTGCCAGCGGTATTGCTGACAACAATAACATTCCCTCAAACGACAATGGCACGACGTTCACTCTAGATAAGAAGAAAAGAAACCCACTGACAAAATCTAAATCTACGTCCGCTTACCTAGAATATCCTCTAAACGAGGAAGACTCTTCTGAGGACGAAGGTTCCATGTCCATATATTCTGTATTGAATGATGACCATAAAACTGACAATCCAATTAGATCAATGAGGAACTCCACAAAATCTTTTCAACGAGCGCAAGCTTCACTACAGCGGATGAGGTTTAGAAGGAAAAGTAAAAGCAAGCATTTTCCCAACAATTCGAAAAGTTCCATTTATAGAGACTTAAATTTCTTGACCAATAGTACTCCCAATTTACTTTCTGTAGTAAGCGACGATAATCTATACGACGATTCTTCTCCTTTGCAAGACAAGGCCTCTTCATCCGCTGCAAGCAGACTCACTGACAGAAAATTCAGCAATAGCAGTGGCAGCAATAATAATAGCAATAGTAATAGCAATATCAACACCGATCCTTGGAAGAGAATCGCTAGTATATCGGGATTCAAACTGAAAAAGGAAAAAAAGAGAGAATTAAATGAAGTCTCTCTTTTACATATGCATGCCCTATTAAAACAATTATTGAATGATCAAGAAATTTCCAATCTTCAAGAATGGATAACCCTTCTAGATGGCGCTTTGCGTAAAGTTTTAAGGACCATCCTGAACGCGAGGGATTTGAACACATTAGATTTTAGACAAACTTACGTTAAGATAAAAAGAATTAGTGGTGGATCTCCTCAAAATTCAGAATATATCGACGGGGTTGTCTTTTCGAAAGCATTGCCGTCGAAAACAATGCCACGGCATTTGAAAAACCCAAGGATACTATTAATCATGTTTCCACTGGAGTACCAAAAGAACAATAACCACTTTCTAAGTATAGAGTCCGTCTTTAGGCAAGAGCGCGAATATTTGGATAAACTTGTTTCGAGATTAAAGTCATTACATCCTGATATTATATACGTCGGCGCCAATGTTAGTGGGTACGCGTTAGAACTATTAAATGACTCAGGCATTGTCGTACAGTTTAATATGAAACCACAAGTCATTGAAAGAATTGCCAAGCTAACAGAAGCAGATATTGCCATTTCTGTGGATAAGTTGGCTACGAATATTAAGATGGGTGAATGTGAAACTTTTGAAGTTAAAAGCTACATTTATGGAAACATCAGTAAAACATATACATTTCTTCGGGGCTGTAACCCAGAACTTGGTGGAACAATTTTGTTAAGAGGTGATAGTCTTGAAAACTTGAGAAAAATCAAACAAGTCTCTGAATTTATGGTCTACGCAATTTTTTCATTGAAGTTGGAAAGTTCATTTTTTAACGATAATTTCATACAACTTTCTACAGATGTTTATTTGAAGAGAGCTGAATCCAAAAAACTGCAAGTTTTCGAAGGTTATTTTGCAGATTTCTTGATCAAATTCAATAACAGGATTTTGACTGTATCACCAACGGTAGATTTCCCCATTCCCTTTTTATTGGAAAAAGCCAGAGGCTTGGAAAAGAAGCTCATAGAAAGGATCAATCAATATGAAAGCGAATCTGATTTAGATCGGCAAACGCAACTAAATATGCTTCAAGGCTTAGAATCGACTATCACTAAGAAACACTTAGGAAATTTAATAAAATTCCTGCATGAAATGGAAATTGAAAATTTAGAGCTTGAGTTTCAGAAGAGAAGTCGTCAATGGGAGGTTTCATATTCATCATCACAGAACTTACTTGGTACGGGCTCACACCAGTCTATAACAGTTCTCTACTCAATGGTTTCAACAAAGACTGCCACACCTTGCGTTGGCCCTCAAATTGTTACTATTGACTATTTTTGGGACAGTGATATTTCCATTGGTCAGTTTATCGAGAACGTCGTGGGAACTGCCAGGTATCCCTGCCAACAAGGCTGTAATGGTCTGTATTTGGATCATTATAGAAGCTATGTTCATGGGTCAGGAAAAGTAGACGTTTTAATCGAAAAATTCCAAACTAGATTACCAAAATTAAAAGATATTATCCTCACGTGGAGTTATTGTAAAAAATGTGGGACATCTACTCCGATTTTACAAATTAGCGAAAAAACCTGGAATCATTCTTTCGGTAAATATTTAGAAGTCATGTTTTGGAGTTACAAAGATAGCGTGACAGGAATTGGGAAATGTCCTCATGATTTCACTAAAGATCATGTCAAATACTTTGGTTACAATGATTTAGTGGTTCGACTAGAATATTCTGATTTAGAAGTTCATGAATTGATAACCCCACCACGCAAAATAAAATGGAAACCTCATATCGACATCAAACTGAAGGTGGAACTATACTATAAGATTCTGGAAAAGATCAATAATTTCTATGGGAGTGTCCTAAGTCGGTTGGAACGTATTAAATTGGATAGTATGACTAAAGATAAAGTTCTTAGTGGACAAGCTAAAATTATCGAATTGAAGAGCAATGCTACAGAGGAGCAAAAATTAATGTTGCAAGACCTGGATACTTTTTACGCAGATAGTCCTTGCGATCAACATTTACCATTGAACCTGGTTATCAAATCTCTATACGATAAGGCTGTAAATTGGAACTCTACATTTGCGATATTTGCAAAAAGCTATTTGCCTTCTGAAACTGATATTAGTCGTATCACGGCCAAGCAGCTGAAAAAACTGTTTTACGATTCTTCAAGAAAAGACAGCGAAGACAAAAAATCACTTCATGATGAAAAGGCGAAGACGAGGAAACCAGAAAAGAACGAATTACCGTTAGAGGGATTGAAAGATGTCGAAAAGCCGAAAATTGATAGCAAGAATACGACAGAGAATCGTGACAGAACGAACGAACCACAGAATGCCGTGACGATAACCACTTTTAAAGACGACACTCCAATTATTCCAACAAGTGGTACTAGTCACTTGACAGTTACACCTTCTGCATCGTCGGTTTCTTCTTCTTTGACCCCTCAAACCGAAGAACGTCCGCCAATAAGCAGAAGTGGAACAGGTATATCTATGACTCATGATAAAAGCACTAGACCTAACATAAGAAAAATGAGTAGTGATAGTAGTTTATGTGGACTAGCATCACTTGCTAATGAATATAGTAAAAATAATAAGGTGAGTAAGCTAGCTACATTTTTCGATCAAATGCATTTTGATGCCCTGTCGAAAGAATTTGAACTGGAACGTGAAAGGGAAAGATTACAACTTAATAAGGATAAATACCAAGCCATACGATTACAAACATCCACACCAATTGTGGAAATTTATAAAAATGTCAAAGACGCAGTTGATGAACCGCTTCACTCTAGAAGTTCAGGCAATAATTTGTCATCTGCGAATGTTAAGACTTTGGAGGCACCTGTGGGAGAACATTCCCGGGCCAATAATTGTAATCCTCCTAATTTAGATCAAAACTTGGAAACTGAATTAGAAAATTCCATTAGCCAATGGGGAGAAAACATTTTGAACCCCTCTGGAAAGACCACCGCAAGTACTCATTTAAATTCTAAGCCAGTAGTAAAGGAAACTTCAGAAAATCCAAAGTCAATAGTTAGAGAATCAGATAATTCAAAGTCGGAGCCGCTTCCACCTGTAATAACAACAACAACTGTCAATAAGGTAGAATCCACTCCACAACCTGAAAAATCATTATTGATGAAAACCTTGAGCAACTTTTGGGCAGATCGATCTGCGTATTTGTGGAAACCCCTTGTTTATCCAACCTGTCCTTCGGAACACATTTTTACTGATAGTGACGTTATAATCCGCGAAGATGAACCAAGTTCCTTGATCGCATTTTGCTTAAGTACTTCTGACTATAGAAATAAAATGATGAACTTGAATGTCCAGCAACAACAGCAGCAGCAAACAGCAGAAGCTGCTCCTGCCAAAACAGGAGGAAACAGTGGAGGAACTACGCAAACCGGGGATCCTTCTGTTAACATTTCTCCCTCAGTTTCTACAACTTCTCATAATAAGGGGAGGGACTCAGAAATTTCATCCTTAGTAACCACCAAAGAGGGCTTGTTGAACACCCCTCCCATTGAAGGCGCCCGAGATAGGACCCCACAAGAATCACAAACGCATTCCCAAGCAAATTTAGATACTCTTCAAGAATTAGAGAAAATTATGACAAAAAAAACAGCCACACACTTGAGATATCAATTTGAGGAGGGTTTAACGGTAATGTCATGTAAAATTTTCTTCACAGAACATTTTGACGTGTTTAGAAAGATTTGTGATTGTCAAGAAAACTTCATTCAAAGTTTGTCAAGATGTGTTAAATGGGATTCCAATGGGGGGAAAAGTGGGAGCGGGTTTTTAAAGACTTTGGATGATAGATTTATTATAAAGGAGCTGTCACACGCAGAACTGGAAGCCTTCATAAAATTTGCACCAAGTTATTTTGAATACATGGCACAAGCAATGTTCCATGATTTGCCCACGACTTTGGCTAAAGTATTTGGGTTTTATCAAATTCAAGTAAAAAGCTCTATTTCAAGTTCCAAAAGTTATAAAATGGACGTTATCATTATGGAGAACTTATTTTATGAGAAGAAAACAACAAGAATATTTGATTTGAAGGGTTCCATGAGAAATAGACATGTCGAACAAACAGGTAAAGCTAATGAAGTGTTGTTGGATGAAAATATGGTAGAGTATATTTACGAATCACCTATTCATGTTCGCGAATATGACAAGAAACTTTTAAGAGCTTCTGTTTGGAACGACACATTATTTTTGGCCAAAATGAATGTGATGGATTATTCCTTAGTCATTGGTATTGACAATGAAGGGTATACTTTGACAGTAGGAATCATTGATTTCATTCGAACGTTTACATGGGACAAAAAACTAGAAAGTTGGGTCAAAGAGAAAGGCCTAGTAGGGGGGGCCAGTGTGATCAAGCAGCCTACCGTTGTTACACCAAGACAATATAAAAAACGTTTTAGGGAAGCAATGGAGAGGTATATTTTGATGGTTCCTGATCCGTGGTATTGGGAAGGAAATTAA","protein_sequence":"MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDLVTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTSGRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPPPPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNSTLRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSATPASSAQSSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNNNSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDNPIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVSDDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEKKRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLDFRQTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESVFRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIAISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRKIKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYFADFLIKFNNRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQGLESTITKKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYSMVSTKTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVHGSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWSYKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIKLKVELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLMLQDLDTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQLKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDRTNEPQNAVTITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGISMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERERERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRANNCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKSIVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVYPTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGGTTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDTLQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSNGGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYWEGN"},{"created_at":"2011-05-27T00:43:23.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 4-kinase PIK1","uniprot_id":"P39104","uniprot_name":"PIK1_YEAST","enzyme":true,"transporter":false,"gene_name":"PIK1","num_residues":1066,"molecular_weight":"119922.0","theoretical_pi":"6.46","general_function":"Involved in binding","specific_function":"Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton","reactions":[{"id":1849,"direction":"\u003c\u003e","locations":"vacuole;Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1850,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"},{"id":14859,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007047","source":"Smpdb"},{"id":14860,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007048","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"L20220","genbank_protein_id":"432496","gene_card_id":"PIK1","chromosome_location":"chromosome 14","locus":"YNL267W","synonyms":["PI4-kinase","PtdIns-4-kinase"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" phosphoinositide-mediated signaling"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"Pik1","identifier":"PF11522"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCATAAAGCATCCAGTTCAAAGAAAAGCTTTGATGATACTATTGAACTAAAAAAAAATGAACAATTACTGAAACTGATCAACTCTAGTGAATTCACCCTTCACAATTGTGTGGAGTTACTGTGCAAACACTCCGAAAATATTGGTATACATTACTATTTATGTCAGAAATTGGCCACATTTCCTCACAGCGAACTACAGTTCTATATTCCCCAACTAGTACAGGTCCTCGTCACCATGGAGACAGAATCAATGGCTTTAGAAGATTTACTATTAAGGTTGAGGGCGGAAAACCCTCATTTTGCACTACTGACGTTTTGGCAGTTACAAGCGTTACTAACGGATTTATCTACTGACCCCGCTTCTTATGGCTTCCAAGTGGCTAGAAGAGTCTTAAACAACTTACAAACCAATCTCTTTAACACAAGTTCAGGTAGCGATAAAAATGTTAAAATACATGAAAACGTTGCACCGGCCTTAGTTCTTTCCTCTATGATAATGTCGGCTATAGCATTCCCCCAATTAAGCGAAGTGACCAAACCATTAGTGGAATCTCAAGGTAGAAGACAAAAAGCTTTCGTTTTTAAGTTGGCTAGAAGTGCAATGAAAGATTTTACCAAGAACATGACCTTGAAAAATACCCTACTAAACAAGAAAACTTCCAGATCCAAAAGAGTTAGCTCAAATCGCAGTTCAACTCCGACTTCTCCAATAGATTTAATAGATCCAATAAAAACTAAAGAAGATGCATCCTTCAGGAAATCCAGACATAGTGAGGTAAAATTGGATTTCGACATTGTGGATGATATAGGTAACCAGGTCTTTGAAGAAAGAATCTCATCTTCAATCAAACTCCCAAAACGTAAACCTAAGTATTTGGATAATTCATACGTTCATAGGACATATGATGGCAAAAATATAAACAGGGACGGAAGCATTTCAAATACCGCAAAGGCTCTCGATGGAAATAAAGGTGATTATATTTCTCCAAAGGGACGTAATGATGAAAATAATGAGATTGGTAACAATGAAGATGAAACTGGTGGTGAAACGGAGGAGGACGCGGACGCTTTAAACTCTGATCACTTCACCAGTTCTATGCCAGATCTGCATAATATTCAACCAAGGACTTCTTCTGCTTCATCTGCTTCTTTAGAAGGGACACCTAAGTTAAACAGGACCAATTCCCAACCCCTTTCGCGCCAGGCATTCAAAAACAGTAAAAAAGCGAATTCTTCTTTGAGTCAAGAAATTGACTTGTCGCAATTATCGACCACTTCAAAAATAAAAATGTTAAAAGCAAATTATTTTCGTTGCGAGACACAATTTGCCATTGCGCTAGAAACAATATCTCAAAGGCTAGCTCGAGTACCGACAGAAGCTAGATTGAGTGCCTTACGAGCCGAGTTGTTTCTATTAAACAGGGACCTACCAGCGGAAGTAGATATCCCCACTTTATTGCCTCCAAATAAAAAAGGAAAGTTACATAAATTAGTGACCATTACTGCTAATGAGGCACAAGTTTTGAACTCTGCAGAAAAAGTTCCATATTTACTCCTGATAGAATACTTGAGAGACGAATTTGATTTTGACCCAACAAGTGAAACCAATGAAAGATTATTAAAGAAGATCAGTGGTAATCAGGGAGGCTTGATATTTGATTTAAATTACATGAATAGAAAAGAAAACAACGAAAATAGAAATGAAAGTACTCTTACTAGCAACAACACTCGATCTTCGGTATATGATAGTAACTCGTTCAACAACGGGGCCTCCCGCAATGAAGGTCTATCCAGTACCTCAAGAAGTGATTCAGCGTCCACAGCTCATGTTAGGACTGAAGTCAATAAAGAGGAAGATTTAGGTGATATGTCAATGGTAAAAGTCAGGAACAGAACGGATGACGAAGCGTATAGAAATGCTTTAGTAATACAGAGTGCCGCAAATGTTCCAATTTTACCTGATGATAGTCAAGACAGAAGCCCAGAGTTGAACTTTGGCTCAAACTTGGACGAAGTACTCATCGAGAATGGAATTAATAGCAAAAATATACATAGCCAAACTGACGCTTTAGCAGACCAGATGAGAGTTTCAGCTGTTATGTTAGCACAATTGGATAAGTCGCCACAACAGTTATCAGAAAGTACCAAACAAATCCGCGCTCAAATTATTTCATCAATGAAGGAGGTGCAGGATAAATTTGGTTACCATGATTTGGAAGCCCTTCATGGAATGGCAGGTGAGAGAAAATTGGAAAACGATTTAATGACGGGTGGTATTGACACTTCATATCTAGGTGAAGATTGGGCTACCAAGAAAGAGAGGATACGTAAAACTTCGGAATATGGCCATTTCGAAAACTGGGATTTATGTTCTGTAATCGCCAAGACGGGTGATGATTTGAGACAGGAGGCGTTTGCATACCAGATGATTCAAGCGATGGCCAATATTTGGGTTAAAGAAAAAGTTGACGTTTGGGTTAAAAGAATGAAAATTTTAATTACTAGTGCGAATACGGGACTTGTGGAGACCATCACAAATGCTATGTCTGTGCATAGTATTAAAAAGGCTTTAACCAAAAAAATGATTGAAGATGCAGAACTAGATGACAAGGGTGGTATTGCCTCTTTGAATGATCACTTCCTTAGAGCTTTTGGTAATCCTAATGGATTTAAGTATAGAAGAGCACAAGACAACTTTGCTTCTTCGTTAGCCGCATATTCTGTCATTTGCTATCTCTTGCAGGTTAAAGATAGACACAACGGTAACATTATGATCGATAACGAAGGCCATGTAAGTCACATCGATTTTGGATTTATGCTATCAAATTCACCCGGCTCAGTGGGCTTTGAGGCCGCACCATTCAAATTAACTTACGAATATATTGAACTGCTAGGCGGAGTAGAGGGAGAAGCGTTTAAAAAGTTTGTTGAACTAACTAAAAGTTCGTTCAAGGCTCTGAGAAAGTATGCTGATCAAATCGTATCAATGTGTGAGATTATGCAAAAGGACAATATGCAGCCTTGTTTCGATGCTGGCGAACAAACAAGTGTACAACTACGACAAAGGTTCCAATTGGACTTATCAGAAAAAGAAGTTGATGACTTCGTAGAAAATTTCTTGATAGGTAAATCTTTGGGTAGTATTTACACCAGAATATACGACCAATTTCAACTTATTACACAGGGTATATATAGCTGA","protein_sequence":"MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS"},{"created_at":"2011-05-27T00:58:15.000Z","updated_at":"2011-05-27T15:01:14.000Z","name":"Xylulose kinase","uniprot_id":"P42826","uniprot_name":"XKS1_YEAST","enzyme":true,"transporter":false,"gene_name":"XKS1","num_residues":600,"molecular_weight":"68320.29688","theoretical_pi":"6.82","general_function":"Involved in phosphotransferase activity, alcohol group as acceptor","specific_function":"ATP + D-xylulose = ADP + D-xylulose 5- phosphate","reactions":[{"id":2052,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2626,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-xylulose = ADP + D-xylulose 5-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14079,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006506","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z72979","genbank_protein_id":"1323345","gene_card_id":"XKS1","chromosome_location":"chromosome 7","locus":"YGR194C","synonyms":["Xylulokinase"],"enzyme_classes":["2.7.1.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"FGGY_C","identifier":"PF02782"},{"name":"FGGY_N","identifier":"PF00370"}],"pathways":[{"name":"Pentose and glucuronate interconversions","kegg_map_id":"00040"},{"name":"xylitol degradation","kegg_map_id":null}],"gene_sequence":"ATGTTGTGTTCAGTAATTCAGAGACAGACAAGAGAGGTTTCCAACACAATGTCTTTAGACTCATACTATCTTGGGTTTGATCTTTCGACCCAACAACTGAAATGTCTCGCCATTAACCAGGACCTAAAAATTGTCCATTCAGAAACAGTGGAATTTGAAAAGGATCTTCCGCATTATCACACAAAGAAGGGTGTCTATATACACGGCGACACTATCGAATGTCCCGTAGCCATGTGGTTAGAGGCTCTAGATCTGGTTCTCTCGAAATATCGCGAGGCTAAATTTCCATTGAACAAAGTTATGGCCGTCTCAGGGTCCTGCCAGCAGCACGGGTCTGTCTACTGGTCCTCCCAAGCCGAATCTCTGTTAGAGCAATTGAATAAGAAACCGGAAAAAGATTTATTGCACTACGTGAGCTCTGTAGCATTTGCAAGGCAAACCGCCCCCAATTGGCAAGACCACAGTACTGCAAAGCAATGTCAAGAGTTTGAAGAGTGCATAGGTGGGCCTGAAAAAATGGCTCAATTAACAGGGTCCAGAGCCCATTTTAGATTTACTGGTCCTCAAATTCTGAAAATTGCACAATTAGAACCAGAAGCTTACGAAAAAACAAAGACCATTTCTTTAGTGTCTAATTTTTTGACTTCTATCTTAGTGGGCCATCTTGTTGAATTAGAGGAGGCAGATGCCTGTGGTATGAACCTTTATGATATACGTGAAAGAAAATTCAGTGATGAGCTACTACATCTAATTGATAGTTCTTCTAAGGATAAAACTATCAGACAAAAATTAATGAGAGCACCCATGAAAAATTTGATAGCGGGTACCATCTGTAAATATTTTATTGAGAAGTACGGTTTCAATACAAACTGCAAGGTCTCTCCCATGACTGGGGATAATTTAGCCACTATATGTTCTTTACCCCTGCGGAAGAATGACGTTCTCGTTTCCCTAGGAACAAGTACTACAGTTCTTCTGGTCACCGATAAGTATCACCCCTCTCCGAACTATCATCTTTTCATTCATCCAACTCTGCCAAACCATTATATGGGTATGATTTGTTATTGTAATGGTTCTTTGGCAAGGGAGAGGATAAGAGACGAGTTAAACAAAGAACGGGAAAATAATTATGAGAAGACTAACGATTGGACTCTTTTTAATCAAGCTGTGCTAGATGACTCAGAAAGTAGTGAAAATGAATTAGGTGTATATTTTCCTCTGGGGGAGATCGTTCCTAGCGTAAAAGCCATAAACAAAAGGGTTATCTTCAATCCAAAAACGGGTATGATTGAAAGAGAGGTGGCCAAGTTCAAAGACAAGAGGCACGATGCCAAAAATATTGTAGAATCACAGGCTTTAAGTTGCAGGGTAAGAATATCTCCCCTGCTTTCGGATTCAAACGCAAGCTCACAACAGAGACTGAACGAAGATACAATCGTGAAGTTTGATTACGATGAATCTCCGCTGCGGGACTACCTAAATAAAAGGCCAGAAAGGACTTTTTTTGTAGGTGGGGCTTCTAAAAACGATGCTATTGTGAAGAAGTTTGCTCAAGTCATTGGTGCTACAAAGGGTAATTTTAGGCTAGAAACACCAAACTCATGTGCCCTTGGTGGTTGTTATAAGGCCATGTGGTCATTGTTATATGACTCTAATAAAATTGCAGTTCCTTTTGATAAATTTCTGAATGACAATTTTCCATGGCATGTAATGGAAAGCATATCCGATGTGGATAATGAAAATTGGGATCGCTATAATTCCAAGATTGTCCCCTTAAGCGAACTGGAAAAGACTCTCATCTAA","protein_sequence":"MLCSVIQRQTREVSNTMSLDSYYLGFDLSTQQLKCLAINQDLKIVHSETVEFEKDLPHYHTKKGVYIHGDTIECPVAMWLEALDLVLSKYREAKFPLNKVMAVSGSCQQHGSVYWSSQAESLLEQLNKKPEKDLLHYVSSVAFARQTAPNWQDHSTAKQCQEFEECIGGPEKMAQLTGSRAHFRFTGPQILKIAQLEPEAYEKTKTISLVSNFLTSILVGHLVELEEADACGMNLYDIRERKFSDELLHLIDSSSKDKTIRQKLMRAPMKNLIAGTICKYFIEKYGFNTNCKVSPMTGDNLATICSLPLRKNDVLVSLGTSTTVLLVTDKYHPSPNYHLFIHPTLPNHYMGMICYCNGSLARERIRDELNKERENNYEKTNDWTLFNQAVLDDSESSENELGVYFPLGEIVPSVKAINKRVIFNPKTGMIEREVAKFKDKRHDAKNIVESQALSCRVRISPLLSDSNASSQQRLNEDTIVKFDYDESPLRDYLNKRPERTFFVGGASKNDAIVKKFAQVIGATKGNFRLETPNSCALGGCYKAMWSLLYDSNKIAVPFDKFLNDNFPWHVMESISDVDNENWDRYNSKIVPLSELEKTLI"},{"created_at":"2011-05-27T01:11:54.000Z","updated_at":"2011-05-27T15:01:14.000Z","name":"Pyruvate carboxylase 2","uniprot_id":"P32327","uniprot_name":"PYC2_YEAST","enzyme":true,"transporter":false,"gene_name":"PYC2","num_residues":1180,"molecular_weight":"130166.0","theoretical_pi":"6.47","general_function":"Involved in catalytic activity","specific_function":"Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second","reactions":[{"id":1932,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2594,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.","export":false,"pw_reaction_id":null,"source":null},{"id":14121,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006553","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U35647","genbank_protein_id":"1041735","gene_card_id":"PYC2","chromosome_location":"chromosome 2","locus":"YBR218C","synonyms":["Pyruvic carboxylase 2","PCB 2"],"enzyme_classes":["6.4.1.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" pyruvate carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" gluconeogenesis"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"HMGL-like","identifier":"PF00682"},{"name":"PYC_OADA","identifier":"PF02436"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGAGCAGTAGCAAGAAATTGGCCGGTCTTAGGGACAATTTCAGTTTGCTCGGCGAAAAGAATAAGATCTTGGTCGCCAATAGAGGTGAAATTCCGATTAGAATTTTTAGATCTGCTCATGAGCTGTCTATGAGAACCATCGCCATATACTCCCATGAGGACCGTCTTTCAATGCACAGGTTGAAGGCGGACGAAGCGTATGTTATCGGGGAGGAGGGCCAGTATACACCTGTGGGTGCTTACTTGGCAATGGACGAGATCATCGAAATTGCAAAGAAGCATAAGGTGGATTTCATCCATCCAGGTTATGGGTTCTTGTCTGAAAATTCGGAATTTGCCGACAAAGTAGTGAAGGCCGGTATCACTTGGATCGGCCCTCCAGCTGAAGTTATTGACTCTGTGGGTGACAAAGTCTCTGCCAGACACTTGGCAGCAAGAGCTAACGTTCCTACCGTTCCCGGTACTCCAGGACCTATCGAAACTGTGCAAGAGGCACTTGACTTCGTTAATGAATACGGCTACCCGGTGATCATTAAGGCCGCCTTTGGTGGTGGTGGTAGAGGTATGAGAGTCGTTAGAGAAGGTGACGACGTGGCAGATGCCTTTCAACGTGCTACCTCCGAAGCCCGTACTGCCTTCGGTAATGGTACCTGCTTTGTGGAAAGATTCTTGGACAAGCCAAAGCATATTGAAGTTCAATTGTTGGCTGATAACCACGGAAACGTGGTTCATCTTTTCGAAAGAGACTGTTCTGTGCAAAGAAGACACCAAAAAGTTGTCGAAGTCGCTCCAGCAAAGACTTTGCCCCGTGAAGTTCGTGACGCTATTTTGACAGATGCTGTTAAATTAGCTAAGGTATGTGGTTACAGAAACGCAGGTACCGCCGAATTCTTGGTTGACAACCAAAACAGACACTATTTCATTGAAATTAATCCAAGAATTCAAGTGGAGCATACCATCACTGAAGAAATCACCGGTATTGACATTGTTTCTGCCCAAATCCAGATTGCCGCAGGTGCCACTTTGACTCAACTAGGTCTATTACAGGATAAAATCACCACCCGTGGGTTTTCCATCCAATGTCGTATTACCACTGAAGATCCCTCTAAGAATTTCCAACCGGATACCGGTCGCCTGGAGGTCTATCGTTCTGCCGGTGGTAATGGTGTGAGATTGGACGGTGGTAACGCTTATGCAGGTGCTACTATCTCGCCTCACTACGACTCAATGCTGGTCAAATGTTCATGCTCTGGTTCTACTTATGAAATCGTCCGTAGGAAGATGATTCGTGCCCTGATCGAATTCAGAATCAGAGGTGTTAAGACCAACATTCCCTTCCTATTGACTCTTTTGACCAATCCAGTTTTTATTGAGGGTACATACTGGACGACTTTTATTGACGACACCCCACAACTGTTCCAAATGGTATCGTCACAAAACAGAGCGCAAAAACTGTTACACTATTTGGCAGACTTGGCAGTTAACGGTTCTTCTATTAAGGGTCAAATTGGCTTGCCAAAACTAAAATCAAATCCAAGTGTCCCCCATTTGCACGATGCTCAGGGCAATGTCATCAACGTTACAAAGTCTGCACCACCATCCGGATGGAGACAAGTGCTACTGGAAAAGGGACCATCTGAATTTGCCAAGCAAGTCAGACAGTTCAATGGTACTCTACTGATGGACACCACCTGGAGAGACGCTCATCAATCTCTACTTGCAACAAGAGTCAGAACCCACGATTTGGCTACAATCGCTCCAACAACCGCACATGCCCTTGCAGGTGCTTTCGCTTTAGAATGTTGGGGTGGTGCTACATTCGACGTTGCAATGAGATTCTTGCATGAGGATCCATGGGAACGTCTGAGAAAATTAAGATCTCTGGTGCCTAATATTCCATTCCAAATGTTATTACGTGGTGCCAACGGTGTGGCTTACTCTTCATTACCTGACAATGCTATTGACCATTTTGTCAAGCAAGCCAAGGATAATGGTGTTGATATATTTAGAGTTTTTGATGCCTTGAATGATTTAGAACAATTAAAAGTTGGTGTGAATGCTGTCAAGAAGGCCGGTGGTGTTGTCGAAGCTACTGTTTGTTACTCTGGTGACATGCTTCAGCCAGGTAAGAAATACAACTTAGACTACTACCTAGAAGTTGTTGAAAAAATAGTTCAAATGGGTACACATATCTTGGGTATTAAGGATATGGCAGGTACTATGAAACCGGCCGCTGCCAAATTATTAATTGGCTCCCTAAGAACCAGATATCCGGATTTACCAATTCATGTTCACAGTCATGACTCCGCAGGTACTGCTGTTGCGTCTATGACTGCATGTGCCCTAGCAGGTGCTGATGTTGTCGATGTAGCTATCAATTCAATGTCGGGCTTAACTTCCCAACCATCAATTAATGCACTGTTGGCTTCATTAGAAGGTAACATTGATACTGGGATTAACGTTGAGCATGTTCGTGAATTAGATGCATACTGGGCCGAAATGAGACTGTTGTATTCTTGTTTCGAGGCCGACTTGAAGGGACCAGATCCAGAAGTTTACCAACATGAAATCCCAGGTGGTCAATTGACTAACTTGTTATTCCAAGCTCAACAACTGGGTCTTGGTGAACAATGGGCTGAAACTAAAAGAGCTTACAGAGAAGCCAATTACCTACTGGGAGATATTGTTAAAGTTACCCCAACTTCTAAGGTTGTCGGTGATTTAGCTCAATTCATGGTTTCTAACAAACTGACTTCCGACGATATTAGACGTTTAGCTAATTCTTTGGACTTTCCTGACTCTGTTATGGACTTTTTTGAAGGTTTAATTGGTCAACCATACGGTGGGTTCCCAGAACCATTAAGATCTGATGTATTGAGAAACAAGAGAAGAAAGTTGACGTGCCGTCCAGGTTTAGAATTAGAACCATTTGATCTCGAAAAAATTAGAGAAGACTTGCAGAACAGATTCGGTGATATTGATGAATGCGATGTTGCTTCTTACAATATGTATCCAAGGGTCTATGAAGATTTCCAAAAGATCAGAGAAACATACGGTGATTTATCAGTTCTACCAACCAAAAATTTCCTAGCACCAGCAGAACCTGATGAAGAAATCGAAGTCACCATCGAACAAGGTAAGACTTTGATTATCAAATTGCAAGCTGTTGGTGACTTAAATAAGAAAACTGGGCAAAGAGAAGTGTATTTTGAATTGAACGGTGAATTAAGAAAGATCAGAGTTGCAGACAAGTCACAAAACATACAATCTGTTGCTAAACCAAAGGCTGATGTCCACGATACTCACCAAATCGGTGCACCAATGGCTGGTGTTATCATAGAAGTTAAAGTACATAAAGGGTCTTTGGTGAAAAAGGGCGAATCGATTGCTGTTTTGAGTGCCATGAAAATGGAAATGGTTGTCTCTTCACCAGCAGATGGTCAAGTTAAAGACGTTTTCATTAAGGATGGTGAAAGTGTTGACGCATCAGATTTGTTGGTTGTCCTAGAAGAAGAAACCCTACCCCCATCCCAAAAAAAGTAA","protein_sequence":"MSSSKKLAGLRDNFSLLGEKNKILVANRGEIPIRIFRSAHELSMRTIAIYSHEDRLSMHRLKADEAYVIGEEGQYTPVGAYLAMDEIIEIAKKHKVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARHLAARANVPTVPGTPGPIETVQEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKVCGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVSAQIQIAAGATLTQLGLLQDKITTRGFSIQCRITTEDPSKNFQPDTGRLEVYRSAGGNGVRLDGGNAYAGATISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADLAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPSEFAKQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGAFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVNAVKKAGGVVEATVCYSGDMLQPGKKYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDLPIHVHSHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDIRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPLRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDIDECDVASYNMYPRVYEDFQKIRETYGDLSVLPTKNFLAPAEPDEEIEVTIEQGKTLIIKLQAVGDLNKKTGQREVYFELNGELRKIRVADKSQNIQSVAKPKADVHDTHQIGAPMAGVIIEVKVHKGSLVKKGESIAVLSAMKMEMVVSSPADGQVKDVFIKDGESVDASDLLVVLEEETLPPSQKK"},{"created_at":"2011-05-27T01:18:45.000Z","updated_at":"2011-06-05T00:44:04.000Z","name":"Probable phospholipid-transporting ATPase NEO1","uniprot_id":"P40527","uniprot_name":"ATC7_YEAST","enzyme":false,"transporter":true,"gene_name":"NEO1","num_residues":1151,"molecular_weight":"130217.0","theoretical_pi":"6.43","general_function":"Involved in nucleotide binding","specific_function":"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes","reactions":[{"id":2611,"direction":"\u003e","locations":"Membrane;Endosome membrane;Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein;Cell membrane","altext":"ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"185-205;210-230;368-388;417-437;439-459;948-968;971-991;1021-1041;1053-1073;1079-1099;1110-1130","pdb_id":null,"cellular_location":"Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"Z38060","genbank_protein_id":"557820","gene_card_id":"NEO1","chromosome_location":"chromosome 9","locus":"YIL048W","synonyms":[],"enzyme_classes":["3.6.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" lipid transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" phospholipid transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" phospholipid-translocating ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" lipid transport"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" phospholipid transport"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGCCTAACCCTCCTTCATTTAAGTCACATAAGCAGAATTTATTCAACTCCAACAATAATCAACACGCAAACAGTGTAGATTCTTTTGACTTACATCTCGACGATTCATTTGACGCTGCTTTAGACAGTTTACAAATTAATAATAACCCAGAACCACTTAGTAAGCATAACACTGTTGGAGATAGGGAAAGTTTTGAAATGAGAACAGTAGATGATTTAGACAATTTTTCTAACCATTCTTCGGATTCGCATCGTAAGTCTTCAAACACAGATACCCATCCTTTGATGTATGATAATCGCCTCTCGCAGGATGATAATTTCAAATTTACTAATATTGCTTCGTCACCACCGTCGTCTTCAAACAATATTTTTTCAAAAGCCCTCTCATATTTAAAAGTATCTAACACAAAAAACTGGTCCAAGTTTGGTTCACCCATAGAACTCAGTGATCAACACATCGAAAGAGAAATACATCCAGACACGACTCCTGTGTACGATAGGAATAGATACGTTTCGAATGAACTATCTAATGCCAAATATAATGCCGTTACTTTTGTGCCAACCCTATTATATGAACAGTTCAAATTCTTTTACAATTTATACTTTTTAGTAGTTGCATTATCGCAGGCCGTTCCTGCACTAAGAATAGGGTATTTATCATCGTATATTGTACCTTTAGCATTTGTGCTGACAGTAACCATGGCAAAGGAAGCTATAGATGATATTCAGAGAAGGAGACGTGATAGAGAGTCAAACAATGAACTGTATCATGTAATAACGAGAAATCGTTCCATACCAAGCAAAGACTTAAAAGTTGGAGATCTCATAAAAGTCCATAAAGGTGATCGTATTCCCGCTGATTTGGTTCTTTTACAATCAAGTGAACCATCAGGCGAGTCATTTATCAAAACTGACCAACTAGATGGGGAGACTGACTGGAAACTACGTGTTGCCTGTCCCTTGACCCAAAATCTATCTGAAAATGACTTAATTAACAGAATTAGTATAACAGCCTCTGCTCCTGAGAAATCTATTCATAAATTTTTAGGTAAAGTTACCTATAAGGATTCCACTTCAAACCCTTTGTCTGTAGATAATACTCTATGGGCGAATACTGTTCTAGCTTCCAGTGGATTTTGTATTGCTTGTGTCGTCTACACTGGCAGAGATACTAGGCAAGCTATGAATACAACTACAGCTAAGGTTAAAACTGGCTTATTAGAGCTAGAAATTAACAGTATTTCCAAGATTCTTTGTGCATGTGTTTTTGCCCTGTCAATTCTTTTAGTTGCATTTGCCGGTTTCCACAATGACGACTGGTACATTGACATTTTGAGGTATCTGATATTGTTTTCTACCATCATCCCTGTCTCTTTAAGAGTTAATTTAGATTTAGCCAAAAGTGTTTATGCACATCAGATCGAACACGATAAAACCATTCCTGAAACAATTGTTAGAACGAGTACAATTCCAGAGGATTTAGGCCGTATTGAATACCTTCTAAGCGACAAAACAGGGACGCTTACTCAGAATGATATGCAATTGAAGAAAATACACTTGGGTACTGTATCATACACGTCGGAAACATTAGACATTGTATCCGACTATGTACAATCTCTGGTGAGCTCTAAAAATGACTCTTTGAACAATTCTAAAGTTGCCTTATCAACAACAAGAAAGGATATGTCTTTTCGTGTACGTGATATGATTTTAACTCTAGCAATTTGCCATAACGTTACTCCCACTTTTGAGGATGACGAACTTACATATCAAGCGGCATCACCTGATGAAATTGCTATTGTTAAATTTACCGAGTCGGTTGGCTTATCTCTTTTCAAAAGAGATCGCCATTCAATTTCTTTATTACACGAACATTCTGGTAAGACTTTAAATTACGAAATTTTACAAGTATTCCCATTTAATTCTGATTCTAAGCGTATGGGTATCATTGTTCGTGATGAGCAATTGGATGAATATTGGTTTATGCAAAAAGGGGCCGATACTGTCATGTCAAAAATTGTGGAAAGCAATGATTGGCTAGAGGAAGAAACAGGTAATATGGCTCGTGAAGGTCTACGTACTTTGGTTATCGGTCGTAAAAAATTAAACAAGAAAATTTACGAGCAATTTCAAAAAGAATACAACGATGCCTCTTTGTCAATGCTAAATCGTGATCAACAGATGAGTCAAGTTATCACCAAGTATTTAGAGCATGATCTTGAATTATTGGGTCTAACTGGTGTAGAAGATAAGTTACAGAAGGATGTGAAGTCCTCTATCGAGTTATTAAGAAACGCAGGTATCAAGATTTGGATGCTGACAGGTGATAAAGTTGAAACTGCTCGTTGTGTTTCCATAAGTGCAAAATTAATATCTCGTGGCCAATATGTTCATACGATAACAAAAGTCACAAGACCGGAAGGTGCATTCAATCAGCTGGAGTATCTAAAAATCAATAGAAATGCTTGTCTTTTAATAGATGGTGAATCCCTGGGAATGTTTTTGAAACATTACGAACAGGAATTTTTTGATGTCGTGGTTCATTTACCCACTGTTATTGCTTGCCGTTGTACACCTCAACAGAAGGCAGACGTTGCTTTGGTAATTCGTAAAATGACGGGCAAAAGGGTATGCTGTATTGGTGATGGAGGTAACGATGTTAGTATGATTCAATGTGCAGATGTTGGCGTAGGGATTGTGGGTAAAGAAGGTAAACAAGCTTCTTTAGCTGCTGATTTTTCTATAACGCAATTTTGTCACCTCACCGAATTACTATTATGGCATGGTAGGAACTCTTACAAAAGATCTGCTAAATTGGCTCAATTTGTCATGCATAGAGGTTTAATCATTGCAATTTGCCAAGCGGTATATTCCATCTGTTCGTTGTTCGAACCTATTGCTCTTTATCAAGGTTGGTTAATGGTCGGTTATGCTACCTGCTATACAATGGCTCCAGTCTTTTCATTAACTCTTGATCACGATATCGAAGAGTCATTGACTAAAATATACCCAGAATTGTACAAAGAATTGACTGAAGGTAAGAGCTTATCATATAAGACGTTCTTTGTTTGGGTTCTATTATCGCTATTCCAAGGTTCTGTAATTCAATTATTTTCTCAGGCCTTTACGAGTTTATTAGATACTGATTTCACAAGGATGGTTGCTATCAGCTTCACTGCTTTGGTTGTAAATGAATTAATAATGGTTGCCTTAGAAATCTACACATGGAATAAAACAATGCTCGTCACTGAAATTGCTACTTTACTATTTTACATTGTATCGGTTCCATTTCTTGGCGATTATTTTGATTTAGGTTATATGACTACCGTAAATTACTATGCTGGACTTTTAGTTATATTACTCATCTCGATCTTTCCTGTCTGGACGGCAAAGGCAATTTATAGAAGGCTACATCCTCCAAGTTATGCAAAAGTGCAAGAGTTTGCCACTCCATAA","protein_sequence":"MPNPPSFKSHKQNLFNSNNNQHANSVDSFDLHLDDSFDAALDSLQINNNPEPLSKHNTVGDRESFEMRTVDDLDNFSNHSSDSHRKSSNTDTHPLMYDNRLSQDDNFKFTNIASSPPSSSNNIFSKALSYLKVSNTKNWSKFGSPIELSDQHIEREIHPDTTPVYDRNRYVSNELSNAKYNAVTFVPTLLYEQFKFFYNLYFLVVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNNELYHVITRNRSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIKTDQLDGETDWKLRVACPLTQNLSENDLINRISITASAPEKSIHKFLGKVTYKDSTSNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLELEINSISKILCACVFALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVSLRVNLDLAKSVYAHQIEHDKTIPETIVRTSTIPEDLGRIEYLLSDKTGTLTQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVSSKNDSLNNSKVALSTTRKDMSFRVRDMILTLAICHNVTPTFEDDELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLLHEHSGKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVESNDWLEEETGNMAREGLRTLVIGRKKLNKKIYEQFQKEYNDASLSMLNRDQQMSQVITKYLEHDLELLGLTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRGQYVHTITKVTRPEGAFNQLEYLKINRNACLLIDGESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQKADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAADFSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSLFEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTEGKSLSYKTFFVWVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALVVNELIMVALEIYTWNKTMLVTEIATLLFYIVSVPFLGDYFDLGYMTTVNYYAGLLVILLISIFPVWTAKAIYRRLHPPSYAKVQEFATP"},{"created_at":"2011-05-27T01:21:37.000Z","updated_at":"2011-06-05T00:45:59.000Z","name":"Probable 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part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" ATP biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cation transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"E1-E2_ATPase","identifier":"PF00122"},{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGGATATTCCCTCTTCAAACCAAATTCAACATGGCCAAAGGAGTGAAAGGAACCGAAGAATGCCGAGGGCTTCTTTTTCTTCTACAGCCACTACTTCTACGGCGGCCACATTGACTTCCGCGATGGTACTGGATCAGAACAATTCGGAACCGTACGCAGGTGCAACATTCGAAGCCGTGCCAAGTTCTATTGTATCATTCCATCACCCTCATTCTTTTCAATCAAGCAACCTCCCAAGTCCGCATTCTTCAGGGAACCTAGAGCAGAGAGGCCGCCGATTGACTGAATCAGAGCCTTTAGTATTATCCTCGGCTGAACAGTCTCGAAGCTCTTCTAGAAACCCTTCTCATTTTCGATTTTTCACTCAGGAGCAAATATCCAATGCTGAAGGCGCTTCCACGTTAGAAAATACAGATTATGACATGGCCTGGGATGCCACCCCCGCTTATGAACAAGATAGAATCTATGGTACGGGCCTATCTTCCAGGCGTTCTTCTATTCGAAGTTTTTCCAGAGCATCATCTCTCTCAAATGCAAAGTCTTATGGATCTTTCAGTAAGAGGGGTCGCTCTGGTTCAAGGGCACCACAAAGGCTGGGAGAAAATTCTGACACTGGGTTCGTTTATCATTCCGCTACACATTCATCATCCAGTTTATCGAGATATACGACCAGAGAAAGAATTCCTATTGAACTAGAAAGTCAAACAGATGAAATACTAGAAGACGAGTCTTCTACACATTCTTTAGAATCTTCAGATAGTAGGCGATCTGCAAGCGAAAATAATAGAGGAAGCTTTTCTGGTCATGATGATGTTCATAATCAGCATAGCGAATATCTAAAACCTGACTATCATGAAAAGTTTTATCCACAGTATGCACCAAACTTGCATTACCAAAGGTTTTACATTGCGGAAGAGGATTTAGTTATTGGTATCGCTGCTTACCAGACCTCAAAATTCTGGTATATTATTTACAACCTGTGCTGCTTCTTGACTTTCGGATTAGTTTATCTTTTAACGAGATGGCTTCCCCATCTCAAAGTTAAATTATATGGCGTGAAAGTGCCATTGGCTAAAGCAGAATGGGTCGTGATAGAAAATGAGTTTGGTGAGTTTGTCATACAACCTATCGATCGACAGTGGTATAATAGACCATTAAGTACTGTTTTACCTTTTGAAAATTACCCTAATCCGTCATATGAACCAAATGATATCAATTTGAGCCACCACCATGCCAATGAAATTAATCCAAATGTGCCTATCTTGATCACATTTGAATACAGATATATTAAGTTCATATATTCACCGCTCGATGATCTCTTTAAAACTAACAATAACTGGATAGATCCTGACTGGGTGGATTTAAGTACCGTATCAAATGGTTTAACTAAGGGGGTTCAAGAAGATAGAGAACTTGCGTTTGGTAAAAATCAAATTAATTTGAGAATGAAAACTACTTCAGAAATTTTATTCAATGAAGTGTTGCATCCGTTTTATGTCTTTCAAGTATTTTCGATAATTTTGTGGGGCATTGATGAATACTACTACTACGCCGCATGCATTTTTTTGATTTCTGTACTGTCTATTTTTGATTCATTGAATGAACAGAAGAAAGTATCGAGAAACTTAGCTGAAATGTCGCACTTTCATTGTGACGTTCGTGTTTTGAGGGATAAGTTTTGGACAACGATAAGCTCATCAGAACTAGTTCCGGGCGATATATATGAAGTATCTGACCCAAATATAACAATATTGCCTTGTGACTCTATTCTTCTGTCCAGTGATTGTATAGTCAATGAATCCATGCTAACTGGTGAATCTGTGCCCGTTTCGAAATTTCCAGCTACGGAAGAAACAATGTACCAATTATGTGACGACTTCCAGAGCACCCAAATATCGAGTTTTGTTTCCAAATCCTTCTTGTATAATGGTACAAATATAATTAGAGCAAGAATTGCCCCCGGGCAAACCGCCGCTTTGGCGATGGTTGTAAGGACAGGATTCTCAACAACAAAGGGCTCCTTGGTTCGTTCCATGGTTTTCCCAAAACCAACTGGTTTTAAATTCTATAGAGATTCCTTTAAATATATTGGATTCATGTCATTAATCGCAATTTTCGGTTTTTGCGTCAGTTGCGTTCAGTTCATTAAACTTGGTTTAGACAAAAAGACAATGATATTAAGAGCTTTAGATATCATAACAATTGTAGTGCCACCAGCTCTGCCCGCGACTTTAACCATTGGTACCAATTTTGCTTTGAGTAGGTTAAAGGAGAAGGGAATATTTTGTATCTCTCCAACAAGGCTTAACATTAGTGGTAAAATCGATGTTATGTGTTTTGATAAAACTGGAACACTTACCGAAGATGGCTTAGATGTACTTGGAGTACAAATATCGGAGCCAAATGGGGTTAGAGGCCAGAAGTTTGGAGAACTATTGAGTGATATTCGCCAAGTATTTCCTAAATTTTCTTTGAACGATTGTAGTTCGCCATTAGATTTTAAGTCCAGGAACTTTTTCATGTCATTATTAACATGTCACTCGCTGAGATCAGTTGATGGAAATTTACTCGGTGACCCACTAGACTTTAAAATGTTTCAATTTACCGGTTGGTCATTCGAGGAGGACTTCCAAAAACGAGCATTCCATTCATTATACGAGGGAAGACATGAAGATGATGTTTTCCCAGAAAATTCAGAAATCATTCCTGCGGTAGTTCACCCTGATAGTAATAATAGAGAAAATACGTTTACTGATAATGATCCTCATAATTTTCTAGGGGTGGTGAGAAGCTTTGAATTTTTATCTGAGCTGAGACGTATGAGCGTAATTGTTAAAACGAATAATGACGACGTATATTGGTCGTTTACTAAAGGTGCGCCCGAAGTTATTTCAGAAATATGTAATAAATCAACTTTACCTGCAGATTTTGAAGAAGTACTACGTTGTTACACTCATAACGGATATAGGGTTATTGCATGTGCTGGGAAGACACTTCCAAAAAGAACTTGGTTATATTCCCAAAAAGTATCTAGGGAAGAGGTTGAGTCAAATTTGGAATTTTTAGGTTTCATTATCTTCCAAAATAAACTAAAAAAAGAGACCTCTGAAACTCTGAAAAGTTTACAAGATGCAAACATCAGGACGATAATGTGTACGGGTGATAACATACTTACTGCTATTTCCGTAGGTAGGGAAGCTGGTTTGATACAATGCTCTCGCGTTTATGTTCCATCCATTAATGATACACCCTTGCACGGTGAGCCCGTAATAGTATGGAGGGACGTCAATGAGCCAGATAAAATTTTGGATACCAAGACTTTGAAACCTGTCAAGCTGGGGAATAATAGTGTTGAAAGTCTACGTGAGTGTAACTATACTCTTGCAGTTAGCGGCGATGTATTTAGACTGTTGTTCAGAGATGAAAACGAGATACCAGAGGAATACTTAAACGAGATTTTATTGAATTCATCAATCTACGCAAGAATGTCGCCTGATGAAAAGCATGAATTGATGATACAGCTGCAGAAGCTAGATTATACAGTTGGGTTCTGTGGTGATGGTGCAAATGATTGTGGGGCACTCAAAGCGGCAGACGTAGGTATTTCCCTTTCGGAGGCTGAAGCTTCAGTTGCTGCTCCGTTCACTTCAAAGATATTTAATATTAGCTGCGTACTTGATGTCATTAGGGAAGGGCGTGCTGCGTTAGTTACATCTTTTGCATGTTTCCAGTACATGAGTTTGTACTCTGCCATCCAATTCATCACTATTACTATACTTTACAGCCGTGGTTCTAATTTGGGAGATTTCCAATTCCTGTACATTGATTTATTGCTGATCGTTCCGATCGCAATTTGCATGTCATGGTCCAAATCCTATGAAAAGATAGATAAAAAGAGGCCTTCCGCTAACCTAGTTTCACCTAAGATTTTGGTTCCTCTTTTGATTAGCGTATTCTTGGTGTTTTTATTCCAGTTCATTCCATGGATAATCGTACAAAAGATGAGCTGGTACATCAAGCCAATCGTTGGGGGCGACGACGCCGTGCAATCTTCAGATAATACCGTATTGTTCTTCGTCTCAAATTTTCAATATATTTTGACTGCTATAGTTTTGTCTGTGGGTCCACCATATAGAGAGCCGATGTCAAAAAACTTTGAATTTATCGTTGATATCACTGTCTCTATCGGTGCAAGTCTACTGCTAATGACTTTGGATACAGAATCATACCTTGGTAAGATGTTACAGCTGACCCCTATATCAAACAGTTTTACAATGTTTATCATTGTATGGGTGATATTAAATTACTATGCTCAACTGTATATACCGCCATCGATAAAAGGTTGGTTAAAGAAAAAGAAGAGTAGCAAAAAGTATAAACTACTGATACAAGAAGAAATGAAATTAAAAGAAGTTTAA","protein_sequence":"MDIPSSNQIQHGQRSERNRRMPRASFSSTATTSTAATLTSAMVLDQNNSEPYAGATFEAVPSSIVSFHHPHSFQSSNLPSPHSSGNLEQRGRRLTESEPLVLSSAEQSRSSSRNPSHFRFFTQEQISNAEGASTLENTDYDMAWDATPAYEQDRIYGTGLSSRRSSIRSFSRASSLSNAKSYGSFSKRGRSGSRAPQRLGENSDTGFVYHSATHSSSSLSRYTTRERIPIELESQTDEILEDESSTHSLESSDSRRSASENNRGSFSGHDDVHNQHSEYLKPDYHEKFYPQYAPNLHYQRFYIAEEDLVIGIAAYQTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKVPLAKAEWVVIENEFGEFVIQPIDRQWYNRPLSTVLPFENYPNPSYEPNDINLSHHHANEINPNVPILITFEYRYIKFIYSPLDDLFKTNNNWIDPDWVDLSTVSNGLTKGVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISVLSIFDSLNEQKKVSRNLAEMSHFHCDVRVLRDKFWTTISSSELVPGDIYEVSDPNITILPCDSILLSSDCIVNESMLTGESVPVSKFPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIAPGQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKLGLDKKTMILRALDIITIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKTGTLTEDGLDVLGVQISEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSRNFFMSLLTCHSLRSVDGNLLGDPLDFKMFQFTGWSFEEDFQKRAFHSLYEGRHEDDVFPENSEIIPAVVHPDSNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVISEICNKSTLPADFEEVLRCYTHNGYRVIACAGKTLPKRTWLYSQKVSREEVESNLEFLGFIIFQNKLKKETSETLKSLQDANIRTIMCTGDNILTAISVGREAGLIQCSRVYVPSINDTPLHGEPVIVWRDVNEPDKILDTKTLKPVKLGNNSVESLRECNYTLAVSGDVFRLLFRDENEIPEEYLNEILLNSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGDFQFLYIDLLLIVPIAICMSWSKSYEKIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQKMSWYIKPIVGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKNFEFIVDITVSIGASLLLMTLDTESYLGKMLQLTPISNSFTMFIIVWVILNYYAQLYIPPSIKGWLKKKKSSKKYKLLIQEEMKLKEV"},{"created_at":"2011-05-27T01:31:06.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-formyltetrahydrofolate cyclo-ligase","uniprot_id":"P40099","uniprot_name":"FTHC_YEAST","enzyme":true,"transporter":false,"gene_name":"FAU1","num_residues":211,"molecular_weight":"24058.5","theoretical_pi":"7.14","general_function":"Involved in ATP binding","specific_function":"Utilizes 5-formyltetrahydrofolate (folinic acid) as substrate in an alternative way of folate biosynthesis","reactions":[{"id":1216,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2627,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18922","genbank_protein_id":"603424","gene_card_id":"FAU1","chromosome_location":"chromosome 5","locus":"YER183C","synonyms":["5,10-methenyl-tetrahydrofolate synthetase","MTHFS","Methenyl-THF synthetase"],"enzyme_classes":["6.3.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" cyclo-ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" 5-formyltetrahydrofolate cyclo-ligase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"5-FTHF_cyc-lig","identifier":"PF01812"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCCACTAAGCAATTACTGAGACGTCAAATCAAAAGGGTAATAAATGCTCTTGACTACGATATTATCGCTGCAGAGTCGCATACTATTTCTCAAGCAGTACGCTCATTGATCGCTTCCGCCAATTCTAGGCGTGTAGCGTGTTATATGAGCATGGATAAAGGAGAAGTAACGACTGGAGAAATCATTAAGAATTTATTTCAAGATGGCCAGGAGGTCTTTCTGCCAAGATGTACTCATACTTCTGAATCGAAACACTTCAAATTACGGGAAGATCATCATCCACATTTAATATTCCATCGAATGAGTAGTTTGAAAATGGTTCGTGATTTGAAGCCTCAAGGTCCATATCAACTAAAAGAGCCTGAACCGCATATTGAGGAATCAGATATTCTAGATGTCGTATTGGTGCCTGGAGTGGCGTTTGATATTAAAACTGGTGCAAGGATGGGTCACGGTGCTGGGTATTATGACGATTTTTTCCAACGGTATAAGATACTGCATGAAGGCCAAAAGCCCCTCCTAGTTGGACTATGTCTTATGGAACAGGTGGCCTCTCCAATTCCTTTAGAAAAACATGATTATTCCATGGATTGTATAGTATGCGGAGATGGATCCATACATTGGTTTCAATAA","protein_sequence":"MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ"},{"created_at":"2011-05-27T01:31:38.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"NADH kinase POS5, mitochondrial","uniprot_id":"Q06892","uniprot_name":"POS5_YEAST","enzyme":true,"transporter":false,"gene_name":"POS5","num_residues":414,"molecular_weight":"46246.5","theoretical_pi":"9.4","general_function":"Involved in NAD+ kinase activity","specific_function":"Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH","reactions":[{"id":1760,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2628,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"ATP + NADH = ADP + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"X84260","genbank_protein_id":"668983","gene_card_id":"POS5","chromosome_location":"chromosome 16","locus":"YPL188W","synonyms":[],"enzyme_classes":["2.7.1.86"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" NAD+ kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"NAD_kinase","identifier":"PF01513"}],"pathways":[],"gene_sequence":"ATGTTTGTCAGGGTTAAATTGAATAAACCAGTAAAATGGTATAGGTTCTATAGTACGTTGGATTCACATTCCCTAAAGTTACAGAGCGGCTCGAAGTTTGTAAAAATAGAGGCAGTAAATAACTTGAGGAGTAGTTCATCAGCAGATTTCGTGTCCCCACCAAATTCCAAATTACAATCTTTAATCTGGCAGAACCCTTTACAAAATGTTTATATAACTAAAAAACCATGGACTCCATCCACAAGAGAAGCGATGGTTGAATTCATAACTCATTTACATGAGTCATACCCCGAGGTGAACGTCATTGTTCAACCCGATGTGGCAGAAGAAATTTCCCAGGATTTCAAATCTCCTTTGGAGAATGATCCCAACCGACCTCATATACTTTATACTGGTCCTGAACAAGATATCGTAAACAGAACAGACTTATTGGTGACATTGGGAGGTGATGGGACTATTTTACACGGCGTATCAATGTTCGGAAATACGCAAGTTCCTCCGGTTTTAGCATTTGCTCTGGGCACTCTGGGCTTTCTATTACCGTTTGATTTTAAGGAGCATAAAAAGGTCTTTCAGGAAGTAATCAGCTCTAGAGCCAAATGTTTGCATAGAACACGGCTAGAATGTCATTTGAAAAAAAAGGATAGCAACTCATCTATTGTGACCCATGCTATGAATGACATATTCTTACATAGGGGTAATTCCCCTCATCTCACTAACCTGGACATTTTCATTGATGGGGAATTTTTGACAAGAACGACAGCAGATGGTGTTGCATTGGCCACTCCAACGGGTTCCACAGCATATTCATTATCAGCAGGTGGATCTATTGTTTCCCCATTAGTCCCTGCTATTTTAATGACACCAATTTGTCCTCGCTCTTTGTCATTCCGACCACTGATTTTGCCTCATTCATCCCACATTAGGATAAAGATAGGTTCCAAATTGAACCAAAAACCAGTCAACAGTGTGGTAAAACTTTCTGATGATGGTATTCCTCAACAGGATTTAGATGTTGGTGATGAAAGTTATGTTATAAATGAGGTCGGCACTATATACATAGATGGTACTCAGCTTCCGACGACAAGAAAAACTGAAAATGACTTTAATAATTCAAAAAAGCCTAAAAGGTCAGGGATTTATTGTGTCGCCAAGACCGAGAATGACTGGATTAGAGGAATCAATGAACTTTGTAGGATTCATTCTAGCTTTAGGCTGACCAAGAGACAGACTGATAATGATTAA","protein_sequence":"MFVRVKLNKPVKWYRFYSTLDSHSLKLQSGSKFVKIKPVNNLRSSSSADFVSPPNSKLQSLIWQNPLQNVYITKKPWTPSTREAMVEFITHLHESYPEVNVIVQPDVAEEISQDFKSPLENDPNRPHILYTGPEQDIVNRTDLLVTLGGDGTILHGVSMFGNTQVPPVLAFALGTLGFLSPFDFKEHKKVFQEVISSRAKCLHRTRLECHLKKKDSNSSIVTHAMNDIFLHRGNSPHLTNLDIFIDGEFLTRTTADGVALATPTGSTAYSLSAGGSIVSPLVPAILMTPICPRSLSFRPLILPHSSHIRIKIGSKLNQKPVNSVVKLSVDGIPQQDLDVGDEIYVINEVGTIYIDGTQLPTTRKTENDFNNSKKPKRSGIYCVAKTENDWIRGINELLGFNSSFRLTKRQTDND"},{"created_at":"2011-05-27T01:34:44.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"Probable phosphatidylinositol-4-phosphate 5-kinase MSS4","uniprot_id":"P38994","uniprot_name":"MSS4_YEAST","enzyme":true,"transporter":false,"gene_name":"MSS4","num_residues":779,"molecular_weight":"89319.60156","theoretical_pi":"9.77","general_function":"Involved in phosphatidylinositol phosphate kinase activity","specific_function":"Catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton","reactions":[{"id":1854,"direction":"\u003c\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2055,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2629,"direction":"\u003e","locations":null,"altext":"ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":34399,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R026915","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D13716","genbank_protein_id":"493719","gene_card_id":"MSS4","chromosome_location":"chromosome 4","locus":"YDR208W","synonyms":["1-phosphatidylinositol-4-phosphate kinase","Diphosphoinositide 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process"}],"pfams":[{"name":"PIP5K","identifier":"PF01504"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Stress-activated signalling pathways: cell wall stress test 1","kegg_map_id":null}],"gene_sequence":"ATGTCAGTCTTGCGATCACAACCTCCTTCAGTTGTACCGCTACATCTGACAACATCCACCAGTCGCAAAACAGAACAGGAACCATCGCTATTGCACTCTGCAATAATTGAGCGACATCAAGACCGTTCGGTGCCGAATTCGAATTCGAATCCGGATTCGAACCATCGAATAAAAAAGGATCGCAATAATCACACTAGCTACCATTCTTCATCGAATTCGGAGTCAAACATGGAAAGTCCTCGCTTGTCAGATGGTGAGTCTTCCACTCCGACCTCTATTGAAGAGTTAAACCCAACAATAAATAATTCGAGGCTGGTGAAGAGAAACTACTCAATATCAATTGATCCTTTGCATGACAACAGCAATAATAATACGGATGATGATCATCCAAACACCATAACTTCTCCCCGACCAAATAGCACTAGTAACAAGGAAATGCAGAAATATAGTTTTCCCGAAGGTAAGGAGTCGAAGAAAATAACAACACCCTCGTTAAACTCGAATAATTGTTTGGATTTGGACAATTCCAGTCTTGTTCACACAGATTCGTATATACAAGACTTAAATGACGATCATATTTTACTAAACAAGCGCGTTTCGAGGCGATCTTCCAGAATATCGGCAGTAACAGCAACTTCCACGACAATTAAGCAAAGAAGAAATACTCAGGATTCAAACCTGCCCAATATTCCCTTTCACGCTTCCAAGCATTCTCAAATTCTACCTATGGATGATTCAGATGTAATAAAATTGGCCAATGGAGATACCAGCATGAAACCAAATTCTGCTACTAAAATTAGTCACTCAATGACTTCTTTGCCTCTTCACCCACTTCCACAACCTTCTCAAAAGTCAAAGCAATATCATATGATATCCAAATCAACCACTTCTTTGCCGCCAGAGAATGACCACTACTATCAACACAGTCGTGGCACCAACCATAATCACGCTGCTAATGCTGCTGCTGTTAATAATAATACTACTACTACTACCGCTGCTACGGGTCTGAAAAGATCAGAGTCTGCAACGGCAGAAATTAAGAAGATGAGACAATCTTTGCTGCATAAAAGAGAAATGAAAAGGAAAAGAAAAACATTTTTGGTGGATGACGATCGTGTTTTGATCGGTAATAAAGTCAGTGAAGGCCATGTCAACTTTATTATAGCTTATAACATGCTAACTGGTATTCGTGTCGCAGTGTCACGTTGTTCTGGCATAATGAAACCTTTAACTCCGGCAGACTTTAGATTTACGAAGAAGCTTGCCTTTGATTATCACGGAAATGAATTGACCCCTTCTTCTCAGTATGCATTTAAGTTTAAGGACTACTGTCCCGAAGTCTTTAGGGAACTTCGTGCATTATTCGGCTTAGACCCTGCTGATTATTTGGTTTCGTTAACTTCCAAGTACATTTTGAGTGAGTTGAACTCGCCAGGTAAAAGTGGTTCATTTTTTTATTATTCGAGAGATTACAAATATATTATCAAGACCATACATCATTCTGAGCATATTCATCTGAGAAAGCACATACAAGAATACTATAACCATGTAAGAGACAATCCAAACACTTTGATTTGTCAATTTTATGGTTTGCATAGAGTGAAAATGCCTATATCGTTTCAAAATAAAATTAAGCATCGGAAAATTTACTTCCTAGTCATGAATAACTTATTTCCACCACACTTAGACATTCACATTACTTATGATTTAAAAGGTTCCACATGGGGCCGTTTTACCAATTTGGATAAAGAAAGGTTGGCGAAAGATAGATCATATAGGCCTGTGATGAAAGATTTAAATTGGCTTGAAGAAGGTCAGAAAATTAAATTGGGTCCATTGAAGAAGAAGACTTTTTTGACACAGCTGAAAAAAGATGTGGAATTGCTTGCTAAATTGAATACAATGGACTATTCCTTGTTAATTGGCATTCATGACATCAATAAAGCTAAAGAAGACGACTTACAATTGGCGGATACGGCATCTATTGAGGAGCAACCACAGACTCAAGGACCCATAAGAACCGGTACCGGAACGGTAGTACGACATTTTTTTAGAGAGTTTGAAGGTGGAATTCGAGCATCTGATCAATTCAACAATGATGTGGATTTGATTTATTACGTGGGGATAATCGATTTCTTGACTAATTACTCAGTTATGAAGAAATTAGAAACGTTTTGGAGAAGTCTACGCCATGATACCAAGTTGGTGAGTGCCATACCTCCAAGAGACTACGCCAATAGGTTTTACGAATTCATAGAAGATTCTGTAGATCCTCTGCCCCAGAAAAAAACTCAATCGTCGTATAGAGACGACCCTAACCAGAAAAATTATAAAGACTGA","protein_sequence":"MSVLRSQPPSVVPLHLTTSTSRKTEQEPSLLHSAIIERHQDRSVPNSNSNPDSNHRIKKDRNNHTSYHSSSNSESNMESPRLSDGESSTPTSIEELNPTINNSRLVKRNYSISIDPLHDNSNNNTDDDHPNTITSPRPNSTSNKEMQKYSFPEGKESKKITTPSLNSNNCLDLDNSSLVHTDSYIQDLNDDHILLNKRVSRRSSRISAVTATSTTIKQRRNTQDSNLPNIPFHASKHSQILPMDDSDVIKLANGDTSMKPNSATKISHSMTSLPLHPLPQPSQKSKQYHMISKSTTSLPPENDHYYQHSRGTNHNHAANAAAVNNNTTTTTAATGLKRSESATAEIKKMRQSLLHKREMKRKRKTFLVDDDRVLIGNKVSEGHVNFIIAYNMLTGIRVAVSRCSGIMKPLTPADFRFTKKLAFDYHGNELTPSSQYAFKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGSFFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHVRDNPNTLICQFYGLHRVKMPISFQNKIKHRKIYFLVMNNLFPPHLDIHITYDLKGSTWGRFTNLDKERLAKDRSYRPVMKDLNWLEEGQKIKFGPLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIHDINKAKEDDLQLADTASIEEQPQTQGPIRTGTGTVVRHFFREFEGGIRASDQFNNDVDLIYYVGIIDFLTNYSVMKKLETFWRSLRHDTKLVSAIPPRDYANRFYEFIEDSVDPLPQKKTQSSYRDDPNQKNYKD"},{"created_at":"2011-05-27T02:10:54.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Thiamine 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16","locus":"YPR121W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"},{"name":"TENA_THI-4","identifier":"PF03070"}],"pathways":[],"gene_sequence":"ATGGTTATCATCCTCCTAGGTCTTTGCACATTAGGTTTTCCAAGAACAGCATTCTGTCCCTCCATAATGACAAATTCTACAGTGAGTATTAACACGCCTCCACCATATCTTACTCTAGCTTGTAATGAAAAATTACCAACAGTTATGTCAATTGCTGGATCAGACTCAAGTGGTGGAGCCGGTGTTGAAGCTGATATTAAGACTATCACCGCACACAGATGTTATGCCATGACATGCGTCACTACTTTGACTGCTCAAACTCCAGTGAAGGTGTACGGCGCTCATAATATACCAAAGAAAATGGTATCTCAAATATTAGACGCCAATTTACAGGACATGAAATGTAATGTTATTAAGACTGGCATGCTTACGGTGGATGCAATCGAAGTCTTGCACGAAAAACTTTTGCAACTTGGTGAAAATAGACCCAAGTTAGTAATTGATCCAGTTCTTTGCGCCGCTTCTGACTCTTCTCCAACTGGAAAGGATGTGGTTAGCTTAATCATAGAAAAAATTTCTCCTTTTGCCGACATTTTAACTCCTAACATTTCAGACTGTTTCATGTTACTGGGCGAGAACAGAGAAGTTAGCAAACTACAAGACGTTCTTGAAATCGCGAAAGACCTTTCTAGAATCACCAATTGCTCCAATATTTTAGTGAAGGGAGGCCACATTCCATGTGACGATGGAAAAGAAAAGCATATTACTGACGTTCTTTACTTAGGTGCTGAACAAAAATTCATCACTTTTAAGGGCCAATTCGTTAATACTACACGCACTCATGGCGCTGGATGCACACTGGCTTCTGCTATAGCATCTAACTTGGCTCGCGGTTATTCTCTTTCCCAATCTGTTTATGGTGGTATTGAGTATGTACAGAATGCCATCGCAATTGGCTGTGACGTTACCAAGAAAGCTGTGAAGGTTGGACCAATTAATCACGTTTACGCCGTAGAGATTCCATTAGAAAAAATGCTCACCGACGAATGCTTTACAGCATCTGATGCTGTACCTAAGAAGCCAATCGAAGGTTCTCTTGACAAAATCCCTGGGGGTAGCTTCTTTAATTATCTGATAAATCATCCTAAAGTCAAGCCGCATTGGGATGCCTACGTGAATCACGAATTTGTTAAAAGAGTGGCAGACGGCACATTGGAACGCAAAAAGTTCCAGTTTTTTATTGAACAAGATTATTTATACTTAATTGATTATGTGAGAGTTTGCTGCGTCACAGGTAGTAAATCTCCAACTCTAGAAGATCTAGAAAAGGACCTTGTTATTGCTGATTGCGCCCGTAATGAACTAAATGAACATGAAAGAAGATTAAGAGAAGAATTTGGAGTTAAGGACCCAGATTACTTACAAAAAATTAAGAGAGGTCCCGCATTAAGGGCCTACTGTCGTTACCTAATTGACATTTCCAGAAGAGGAAACTGGCAAGAAATAGTTGTAGCCCTCAACCCTTGTCTAATGGGTTATGTTTATGCTGTAGACAAAGTTAAGGATAAGATAACAGCAGCAGAGGGTTCTATTTATAGTGAATGGTGTGATACTTGCGCGTCTTCATTTTGCTACCAAGCTGTGCTTGAAGGTGAAAGGCTCATGAATCACATCTTGGAAACATATCCTCCAGATCAACTTGATTCTTTGGTGACGATCTTTGCAAGAGGTTGTGAATTAGAAACTAATTTCTGGACCGCCGCCATGGAATACGAATGA","protein_sequence":"MVIILLGLCTLGFPRTAFCPSIMTNSTVSINTPPPYLTLACNEKLPTVMSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAHNIPKKMVSQILDANLQDMKCNVIKTGMLTVDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPTGKDVVSLIIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNILVKGGHIPCDDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLARGYSLSQSVYGGIEYVQNAIAIGCDVTKKAVKVGPINHVYAVEIPLEKMLTDECFTASDAVPKKPIEGSLDKIPGGSFFNYLINHPKVKPHWDAYVNHEFVKRVADGTLERKKFQFFIEQDYLYLIDYVRVCCVTGSKSPTLEDLEKDLVIADCARNELNEHERRLREEFGVKDPDYLQKIKRGPALRAYCRYLIDISRRGNWQEIVVALNPCLMGYVYAVDKVKDKITAAEGSIYSEWCDTCASSFCYQAVLEGERLMNHILETYPPDQLDSLVTIFARGCELETNFWTAAMEYE"},{"created_at":"2011-05-27T03:22:51.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Nicotinate phosphoribosyltransferase","uniprot_id":"P39683","uniprot_name":"NPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"NPT1","num_residues":429,"molecular_weight":"49018.19922","theoretical_pi":"6.92","general_function":"Involved in nicotinate phosphoribosyltransferase activity","specific_function":"Essential for growth under anaerobic conditions","reactions":[{"id":1768,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2722,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4193,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006492","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1VLP","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z75117","genbank_protein_id":"1420489","gene_card_id":"NPT1","chromosome_location":"chromosome 15","locus":"YOR209C","synonyms":["NAPRTase"],"enzyme_classes":["2.4.2.11"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" nicotinate phosphoribosyltransferase activity"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" nucleotide biosynthetic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nicotinate nucleotide biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"}],"pfams":[{"name":"NAPRTase","identifier":"PF04095"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAGAACCAGTGATAAAGTCTCTTTTGGACACAGACATGTACAAGATTACGATGCATGCTGCTGTCTTCACTAATTTTCCAGATGTTACAGTTACTTATAAATATACCAACAGGTCGTCCCAATTGACCTTCAATAAGGAAGCCATTAATTGGTTGAAAGAGCAATTTTCGTATTTGGGAAATTTGAGGTTCACAGAAGAGGAAATTGAATACTTAAAACAGGAAATCCCATATTTGCCATCGGCATATATTAAGTATATTAGCAGTTCTAATTACAAACTACACCCTGAAGAGCAGATTTCCTTCACTTCAGAAGAAATCGAGGGCAAGCCCACCCACTACAAATTGAAAATTTTAGTCAGTGGTAGTTGGAAGGATACTATCCTTTATGAGATCCCCTTACTGTCCCTAATATCAGAAGCGTATTTTAAATTTGTTGACATCGACTGGGACTACGAAAACCAATTAGAACAAGCTGAGAAGAAGGCGGAAACTTTGTTTGATAATGGTATTAGATTCAGTGAATTTGGTACAAGACGTCGTAGATCTCTGAAGGCTCAAGATCTAATTATGCAAGGAATCATGAAAGCTGTGAACGGTAACCCAGACAGAAACAAATCGCTATTATTAGGCACATCAAATATTTTATTTGCCAAGAAATATGGAGTCAAGCCAATCGGTACTGTGGCTCACGAGTGGGTTATGGGAGTCGCTTCTATTAGTGAAGATTATTTGCATGCCAATAAAAATGCAATGGATTGTTGGATCAATACTTTTGGTGCAAAAAATGCTGGTTTAGCATTAACGGATACTTTTGGAACTGATGACTTTTTAAAATCATTCCGTCCACCATATTCTGATGCTTACGTCGGTGTTAGACAAGATTCTGGAGACCCAGTTGAGTATACCAAAAAGATTTCCCACCATTACCATGACGTGTTGAAATTGCCTAAATTCTCGAAGATTATCTGTTATTCCGATTCTTTGAACGTCGAAAAGGCAATAACTTACTCCCATGCAGCTAAAGAGAATGGAATGCTAGCCACATTCGGTATTGGCACAAACTTTACTAATGATTTTCGTAAGAAGTCAGAACCCCAGGTTAAAAGTGAGCCGTTAAACATCGTTATCAAACTATTAGAAGTAAATGGTAATCACGCTATCAAAATTTCTGATAACTTAGGTAAAAATATGGGAGATCCTGCCACTGTGAAGAGAGTGAAAGAGGAATTGGGATATACTGAACGAAGTTGGAGTGGTGATAACGAAGCGCACAGATGGACCTAA","protein_sequence":"MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT"},{"created_at":"2011-05-27T06:30:19.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 2","uniprot_id":"P50942","uniprot_name":"INP52_YEAST","enzyme":true,"transporter":false,"gene_name":"INP52","num_residues":1183,"molecular_weight":"133330.0","theoretical_pi":"8.89","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell 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phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z71382","genbank_protein_id":"1302022","gene_card_id":"INP52","chromosome_location":"chromosome 14","locus":"YNL106C","synonyms":["Synaptojanin-like protein 2"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol 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binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"ABC_membrane","identifier":"PF00664"},{"name":"ABC_tran","identifier":"PF00005"}],"pathways":[],"gene_sequence":"ATGCATCACGTACTCAATTCAACGAGACCTGACCATCGGTTTTGGTTTTACGATGACGTAACTCAGTACGGCAGAACAAAGTACCTTAATTATTATACTCCCTTAGTGCTTTTAATATTCACGGTGTTGTTCATAACTTATAACATATGGAAACATTATTACTACTATGACGTTCTACACTTGAAGCAAAAAAATCCAATTGATGAACTTTTATACTCATCTACCGACGAAGACGAACAGAGTCCGTTGATAAATAATAACACCATCACAACTAATTACGTGGACAATAATTGTACAAAAGACGCACTAAAAAATAGACACTTTTCTCTGGAAAAGCTGAAATCAGTTAAGGTAAATGGAGAACCTCATGGTACACCTGAAATAGTTAGAAGAGGCTTCATTGAAAAATCAAGAATTATCCTTGAATTTTTTTTGGTACTTTCTCAAGTTATAATACATTCTTTTATACTATTACACTATGTCAATAAAAACCCAGAGTTCACCCAACAAGGTACGATTACTGGTTTGGTAGAATGGTGTGCATTGTTTATCATTGTCTCTTTACGTTTAGCAAATGTCAACCAAAATTTCAAATTCATAAACAAATATCCCGGAAATCTATGGTCGGTATCGTTCATAAACTATTTGGCCTTGTTTATCTCTATGATTTTACCCTTTCGTTCCATTTTCATTCACCATATAAACAGTCCTATTTCGAGAAAGTATTACATTTCACAAATATCGATTAACCTTGCCCTTTTCTTGCTACTCTTTTTTGCGAGGATAAGAAATAATTTTGCCATCATCTATAAAACTGACAGCTGGATTACTCCATCTCCAGAACCAGTCACTTCTATTGCTGGATTCATATGCTGGGCTTGGTTAGACAGTTTTGTTTGGAAAGCACACAAAGTTAGTATCAAAGTTAAGGATATTTGGGGATTGATGATGCAAGATTATTCTTTCTTTGTAGTGAAAAAATTCAGATATTTTGTTGACCATAAGGTTAAAAGGAAGCGTATTTTTTCACTAAACCTTTTCTTTTTCTTTTCGAATTATTTGGTACTACAATGCTTTTGGGCATTTTTAGGCAGCGTCCTTTCTTTTATTCCAACAGTTTTACTAAAAAGGATCCTGGAATATGTTGAAGATCAGTCATCTGCTCCCTCAAATTTAGCTTGGTTTTACGTCACTGTCATGTTTGTAGGTAGGATATTAGTGGCTATTTGTCAAGCACAGGCACTATTCTTTGGAAGGAGAGTTTGTATCAGAATGAAAAGTATTATAATCTCTGAGATTTATACTAAAGCTTTGAGAAGAAAGATTTCCACCAACAAGACTAAACCTTCTAATGAGGATCCACAGGAAATTAATGATCAAAAAAGTATCAACGGCGATGAGGAGTCCACTTCTTCTGCCAACCTTGGAGCGATTATTAATCTCATGGCTATTGACGCTTTCAAGGTTTCTGAAATTTGTGGTTACCTTCATTCATTTTTGGAGGCTTTTGTTATGACTGTTGTCGCACTGGCGCTGTTATACCGTCTGCTGGGTTTTGCTGCGATTGTGGGTGTCTTAATCATTGTCGCAATGCTTCCACTGAATTATAAGCTTGCCAAGTACATCGGCGATTTGCAAAAGAAAAACTTGGCTGTCACAGATAATCGTATTCAAAAGTTGAATGAAGCTTTTCAAGCTATCAGAATCATCAAATACTTTTCATGGGAGGAGAATTTTGAAAAAGATATCAATACTATTAGAGAAAATGAATTATCTCTACTGCTAATGAGATCCATTGTTTGGTCTATCAGTTCCTTTCTTTGGTTTGTTACCCCAACTATTGTAACAGCCGCCTCATTTGCTTACTACATTTACGTTCAAGGCGAGGTATTAACCACTCCGGTTGCCTTTACTGCACTTTCTTTATTCACGTTATTAAGAGATCCTTTGGATCGTTTGTCTGATATGTTAAGTTTTGTCGTTCAATCAAAGGTCTCGTTAGATAGAGTTCAGGATTTCTTAAATGAAAATGATACAAAGAAATACGATCAACTGACCATAGATCCAAATGGAAACAGATTTGCCTTTGAGAATTCCACCATCTCTTGGGATAAGGACAATCAAGATTTCAAATTGAAAGACTTGAACATTGAATTCAAAACTGGTAAACTAAATGTCGTTATTGGCCCCACTGGTTCTGGTAAGACATCCCTACTAATGGCATTATTAGGTGAAATGTATCTACTCAATGGTAAGGTTGTCGTCCCAGCTCTAGAACCAAGGCAGGAACTAATAGTAGATGCGAATGGAACCACTAACTCTATCGCTTATTGTTCTCAGGCCGCTTGGCTTCTAAATGATACTGTAAAAAACAACATTTTATTCAATAGTCCATTCAATGAGGCAAGATATAAAGCTGTTGTCGAAGCATGCGGATTGAAACGTGATTTTGAGATCTTGAAAGCCGGTGACCTAACAGAAATCGGTGAGAAGGGTATTACTTTATCCGGTGGTCAAAAGCAGAGAGTCTCCCTTGCTAGAGCCTTGTATTCCAATGCTAGGCATGTCCTTTTGGATGATTGTTTAAGTGCAGTTGATTCACATACTGCATCTTGGATTTACGATAATTGTATTACTGGACCATTAATGGAAGATAGGACATGTATTTTGGTTTCACACAACATCGCCTTGACCTTGAGAAATGCTGAATTGGTAGTCTTACTAGAAGATGGTAGGGTTAAAGACCAAGGTGATCCAATAGACATGTTACAGAAGGGTTTGTTTGGTGAAGACGAGTTAGTGAAAAGTAGTATCTTATCGCGTGCAAACTCTTCTGCTAACTTAGCCGCAAAAAGTAGCACAAGCTTAAGTAACCTACCCGCTGTCAAAGAACAACAAGTTAGCGTGAACAACAACTCCTCCCACTTTGAAGCCAAGAAACTTCAAAAATCATTGAGGACAGAAGCTGAACGCACTGAAGATGGTAAATTAATAAAAGAGGAAACAAAAGAAGAAGGTGTGGTTGGTCTGGATGTCTATAAATGGTATTTGAAAATTTTTGGTGGTTGGAAGATTGTTTCATTTTTAGCTTCCTTGTTCTTGATAGCCCAACTTTTGTATATCGGACAATCATGGTGGGTTCGTGCCTGGGCGTCACACAATGTCATTGCTAAAATTATTCCCAGAGCACAACGCGCTATTGCATTTATCTCCAAGAAGGCTAGTCATCTAATTGATTGGAGGGGCTCGTCCCAAATCAGTATGGCGTCAGCTGAAAACCAACCTTCCAGTGGACACTCTACAATGTATTATCTGGTTTTGTACCTAATCATTGGTTTTGCTCAGGCTTTATTGGGAGCTGGTAAAACTATTTTAAATTTCGTTGCTGGTATCAACGCGTCAAGAAAGATATTTAATATGATTCTAAACAAGGTTTTACACTCCAAGATAAGATTTTTTGATGCTACTCCAACAGGTAGAATTATGAACAGGTTTTCCAAGGATATCGAAGCTATTGATCAGGAACTGACACCTTATATACAAGGCGCCTTCTATTCGCTTATTGAATGTTTATCCACCGTCATACTGATTACATTTATTACTCCACAGTTCTTATCTGTTGCTATAGTTGTTTCAATATTGTATTATTTTGTTGGGTATTTCTACATGGCAGGTTCTCGTGAATTGAAAAGATTTGAATCTATTTCTAGATCACCGATCTATCAACATTTTTCCGAGACTCTTGTCGGTGTTACCACCATTCGTGCGTTTGGTGATGAAGGGAGGTTTATGCAAGAGAATTTACACAAAATTGATGAAAATAATAAACCATTCTTCTACTTGTGGGTTGCTAATCGTTGGTTGGCCTTTAGGATAGATATGATTGGATCCTTGGTCATTTTTGGAGCTGGTTTGTTCATTCTATTCAATATTAATAATCTGGATTCGGGTATGGCTGGTATATCTTTGACGTATGCTATTTCCTTCACTGAAGGGGCATTGTGGTTGGTAAGATTGTACTCTGAAGTGGAGATGAATATGAATTCTGTTGAAAGAGTCAAAGAATATATGGAAATTGAGCAAGAGCCATACAACGAACACAAAGAAATACCGCCACCACAATGGCCACAAGACGGTAAAATCGAGGTTAATGATTTATCATTACGGTATGCTCCAAATCTACCTAGAGTAATTAAAAATGTTTCATTTTCTGTCGACGCTCAGTCTAAGATCGGTATTGTTGGTAGAACCGGTGCCGGTAAATCAACTATTATTACCGCCTTGTTCAGATTTTTGGAACCTGAGACAGGCCATATCAAAATTGATAATATCGATATTTCCGGTGTTGATTTACAAAGACTGCGTCGTTCTATAACTATTATTCCACAAGATCCAACACTATTCTCAGGGACGATTAAAACAAACCTAGACCCATATGATGAATTTAGTGACAGACAGATCTTTGAAGCTTTGAAACGTGTAAATCTAATTAGTGAAGAACAATTACAACAAGGCGCCACAAGAGAAACAAGCAATGAGGCTTCGTCGACTAACTCCGAAAATGTTAATAAATTCTTGGATTTAAGTAGTGAAATTAGCGAAGGTGGATCCAATTTGTCTCAAGGACAGCGCCAATTGATGTGCCTTGCTAGATCTTTACTGAGGAGTCCAAAGATCATATTGCTGGACGAAGCTACAGCGTCCATCGACTACAGTTCCGATGCGAAGATCCAAGAAACCATAAGAAAAGAGTTCCAAGGTAGTACAATTTTGACAATTGCACATAGGTTGAGATCTGTTATCGATTATGATAAAATTTTGGTGATGGATGCAGGTGAGGTAAAAGAGTATGATCACCCATATTCTTTGTTACTTAACAAACAAAGTGCCTTTTATAGCATGTGTGAGCATAGTGGAGAATTGGATATCCTAATTGAATTGGCTAAAAAAGCCTTTGTGGAAAAATTGAACTCTAAAAAGGACTAG","protein_sequence":"MHHVLNSTRPDHRFWFYDDVTQYGRTKYLNYYTPLVLLIFTVLFITYNIWKHYYYYDVLHLKQKNPIDELLYSSTDEDEQSPLINNNTITTNYVDNNCTKDALKNRHFSLEKLKSVKVNGEPHGTPEIVRRGFIEKSRIILEFFLVLSQVIIHSFILLHYVNKNPEFTQQGTITGLVEWCALFIIVSLRLANVNQNFKFINKYPGNLWSVSFINYLALFISMILPFRSIFIHHINSPISRKYYISQISINLALFLLLFFARIRNNFAIIYKTDSWITPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVKRKRIFSLNLFFFFSNYLVLQCFWAFLGSVLSFIPTVLLKRILEYVEDQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGLFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCEHSGELDILIELAKKAFVEKLNSKKD"},{"created_at":"2011-05-27T07:35:34.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"ADP,ATP carrier protein 1","uniprot_id":"P04710","uniprot_name":"ADT1_YEAST","enzyme":false,"transporter":true,"gene_name":"AAC1","num_residues":309,"molecular_weight":"34120.19922","theoretical_pi":"10.16","general_function":"Involved in transporter activity","specific_function":"Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"10-44;81-105;114-148;183-210;215-249;278-303","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"M12514","genbank_protein_id":"172134","gene_card_id":"AAC1","chromosome_location":"chromosome 13","locus":"YMR056C","synonyms":["ADP/ATP translocase 1","Adenine nucleotide translocator 1","ANT 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCTCACACAGAAACACAGACTCAGCAGTCACACTTCGGTGTGGACTTCCTTATGGGCGGCGTTTCTGCTGCCATTGCGAAGACGGGTGCCGCTCCCATTGAACGGGTGAAACTGTTGATGCAGAATCAAGAAGAGATGCTTAAACAGGGCTCGTTGGATACACGGTACAAGGGAATTTTAGATTGCTTCAAGAGGACTGCGACTCATGAAGGTATTGTGTCGTTCTGGAGGGGTAACACCGCCAATGTTCTCCGGTATTTCCCCACGCAGGCGCTGAATTTTGCCTTCAAAGACAAAATTAAGTCGTTGTTGAGTTACGACAGAGAGCGCGATGGGTATGCCAAGTGGTTTGCTGGAAATCTTTTCTCTGGTGGAGCGGCTGGTGGTTTGTCGCTTCTATTTGTATATTCCTTGGACTACGCAAGGACGCGGCTTGCAGCGGATGCTAGGGGTTCTAAGTCAACCTCGCAAAGACAGTTTAATGGATTGCTAGACGTGTATAAGAAGACACTGAAAACGGACGGGTTGTTGGGTCTGTACCGTGGGTTTGTGCCCTCAGTTCTGGGTATCATTGTCTACAGAGGTCTGTACTTTGGCTTGTACGATTCTTTCAAGCCTGTGCTGTTGACGGGGGCTCTAGAGGGGTCCTTTGTTGCCTCTTTCCTATTAGGTTGGGTCATTACCATGGGTGCTTCCACTGCGTCGTATCCCTTGGATACGGTAAGAAGAAGGATGATGATGACTTCGGGCCAGACCATCAAGTACGACGGTGCTCTGGACTGTTTGAGAAAGATTGTTCAGAAAGAGGGCGCGTATTCCTTGTTCAAGGGCTGTGGTGCCAACATATTTAGAGGAGTCGCTGCAGCTGGTGTCATCTCATTGTACGATCAGTTGCAACTCATAATGTTTGGCAAAAAATTCAAGTGA","protein_sequence":"MSHTETQTQQSHFGVDFLMGGVSAAIAKTGAAPIERVKLLMQNQEEMLKQGSLDTRYKGILDCFKRTATHEGIVSFWRGNTANVLRYFPTQALNFAFKDKIKSLLSYDRERDGYAKWFAGNLFSGGAAGGLSLLFVYSLDYARTRLAADARGSKSTSQRQFNGLLDVYKKTLKTDGLLGLYRGFVPSVLGIIVYRGLYFGLYDSFKPVLLTGALEGSFVASFLLGWVITMGASTASYPLDTVRRRMMMTSGQTIKYDGALDCLRKIVQKEGAYSLFKGCGANIFRGVAAAGVISLYDQLQLIMFGKKFK"},{"created_at":"2011-05-27T07:42:55.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"ADP,ATP carrier protein 3","uniprot_id":"P18238","uniprot_name":"ADT3_YEAST","enzyme":false,"transporter":true,"gene_name":"AAC3","num_residues":307,"molecular_weight":"33312.60156","theoretical_pi":"10.38","general_function":"Involved in transporter activity","specific_function":"Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"9-43;80-104;112-146;181-208;213-247;276-301","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"M34076","genbank_protein_id":"170960","gene_card_id":"AAC3","chromosome_location":"chromosome 2","locus":"YBR085W","synonyms":["ADP/ATP translocase 3","Adenine nucleotide translocator 3","ANT 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner 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transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGAGTAGCGACGCTAAGCAACAAGAAACAAACTTTGCCATTAATTTCTTAATGGGTGGTGTGAGTGCGGCCATCGCTAAAACTGCTGCCTCACCAATCGAAAGAGTCAAGATCTTGATCCAAAATCAAGATGAAATGATCAAGCAAGGAACTTTAGATAAAAAGTATTCCGGTATCGTGGATTGTTTCAAGAGAACTGCAAAGCAAGAGGGACTAATATCCTTTTGGCGAGGAAATACTGCCAATGTTATTCGTTATTTTCCCACTCAAGCTTTGAACTTCGCCTTCAAAGATAAGATTAAGTTGATGTTTGGTTTCAAGAAAGAGGAAGGCTATGGTAAATGGTTTGCAGGTAATCTGGCTTCTGGTGGTGCAGCTGGTGCTCTTTCGTTATTATTTGTTTATTCTTTAGATTTTGCCAGAACCAGACTTGCTGCTGATGCAAAATCGTCGAAAAAGGGTGGCGCTCGCCAATTCAATGGGTTGACTGATGTTTATAAAAAGACCTTGAAATCGGATGGTATCGCAGGATTATACAGAGGATTCATGCCATCAGTAGTGGGTATCGTGGTTTATAGAGGACTATATTTCGGTATGTTTGATTCTCTCAAGCCACTGGTGCTAACTGGTTCATTAGATGGTTCATTCTTGGCTTCATTTTTATTGGGATGGGTGGTCACTACAGGTGCCTCAACATGTTCTTATCCATTAGACACAGTGAGAAGAAGAATGATGATGACTTCAGGTCAAGCAGTAAAGTACAACGGTGCTATAGATTGTCTCAAAAAAATCGTAGCTTCTGAAGGTGTAGGGTCATTGTTCAAAGGCTGCGGGGCAAATATCTTGAGAAGTGTTGCTGGAGCTGGTGTTATTTCCATGTATGACCAGTTGCAAATGATATTGTTCGGTAAAAAATTCAAATGA","protein_sequence":"MSSDAKQQETNFAINFLMGGVSAAIAKTAASPIERVKILIQNQDEMIKQGTLDKKYSGIVDCFKRTAKQEGLISFWRGNTANVIRYFPTQALNFAFKDKIKLMFGFKKEEGYGKWFAGNLASGGAAGALSLLFVYSLDFARTRLAADAKSSKKGGARQFNGLTDVYKKTLKSDGIAGLYRGFMPSVVGIVVYRGLYFGMFDSLKPLVLTGSLDGSFLASFLLGWVVTTGASTCSYPLDTVRRRMMMTSGQAVKYNGAIDCLKKIVASEGVGSLFKGCGANILRSVAGAGVISMYDQLQMILFGKKFK"},{"created_at":"2011-05-27T07:43:28.000Z","updated_at":"2011-05-27T07:43:28.000Z","name":"ADP,ATP carrier protein 2","uniprot_id":"P18239","uniprot_name":"ADT2_YEAST","enzyme":false,"transporter":true,"gene_name":"AAC2","num_residues":318,"molecular_weight":"34425.89844","theoretical_pi":"10.33","general_function":"Involved in transporter activity","specific_function":"Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"20-54;91-115;123-157;192-219;224-258;287-312","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"J04021","genbank_protein_id":"170958","gene_card_id":"AAC2","chromosome_location":null,"locus":"YBL030C","synonyms":["ADP/ATP translocase 2","Adenine nucleotide translocator 2","ANT 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner 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transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCTTCTAACGCCCAAGTCAAAACCCCACTACCTCCAGCCCCAGCTCCAAAGAAGGAATCTAACTTTTTGATTGATTTCTTAATGGGTGGTGTCAGTGCCGCTGTCGCCAAAACTGCTGCATCTCCCATCGAAAGAGTTAAGCTTTTGATCCAAAACCAAGATGAAATGTTAAAACAAGGTACTTTGGACAGAAAATACGCAGGTATCTTAGACTGTTTCAAGAGAACCGCTACACAGGAAGGTGTTATCTCATTCTGGAGAGGTAACACTGCTAACGTTATCCGTTATTTCCCCACTCAAGCTTTGAATTTCGCCTTCAAGGACAAGATCAAGGCCATGTTTGGTTTCAAGAAGGAAGAAGGTTACGCCAAATGGTTTGCCGGTAACTTGGCATCTGGTGGTGCTGCTGGTGCCTTGTCATTACTATTTGTTTACTCTTTGGATTATGCAAGAACTAGATTGGCTGCTGACTCCAAGTCCTCTAAAAAGGGTGGTGCTCGTCAATTCAACGGTTTGATCGATGTCTACAAGAAGACCTTAAAATCTGATGGTGTTGCTGGTCTTTACAGAGGTTTCTTACCTTCTGTCGTTGGTATTGTTGTCTACAGAGGTCTATACTTCGGTATGTACGATTCTTTGAAGCCTCTATTGTTGACTGGTTCTTTGGAAGGTTCATTCTTGGCTTCATTCTTGTTGGGTTGGGTTGTTACTACTGGTGCTTCTACATGTTCTTACCCATTGGATACCGTTAGAAGAAGAATGATGATGACCTCCGGTCAAGCTGTTAAGTACGACGGTGCCTTTGACTGTTTGAGGAAGATTGTTGCTGCTGAAGGTGTTGGTTCTCTATTCAAGGGTTGTGGTGCTAACATCCTAAGAGGTGTCGCAGGTGCTGGTGTTATCTCAATGTACGACCAACTGCAAATGATCTTGTTTGGTAAGAAGTTCAAATAA","protein_sequence":"MSSNAQVKTPLPPAPAPKKESNFLIDFLMGGVSAAVAKTAASPIERVKLLIQNQDEMLKQGTLDRKYAGILDCFKRTATQEGVISFWRGNTANVIRYFPTQALNFAFKDKIKAMFGFKKEEGYAKWFAGNLASGGAAGALSLLFVYSLDYARTRLAADSKSSKKGGARQFNGLIDVYKKTLKSDGVAGLYRGFLPSVVGIVVYRGLYFGMYDSLKPLLLTGSLEGSFLASFLLGWVVTTGASTCSYPLDTVRRRMMMTSGQAVKYDGAFDCLRKIVAAEGVGSLFKGCGANILRGVAGAGVISMYDQLQMILFGKKFK"},{"created_at":"2011-05-27T08:03:53.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Peroxisomal long-chain fatty acid import protein 1","uniprot_id":"P34230","uniprot_name":"PXA2_YEAST","enzyme":false,"transporter":true,"gene_name":"PXA2","num_residues":853,"molecular_weight":"97125.29688","theoretical_pi":"9.25","general_function":"Involved in transport","specific_function":"Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix","reactions":[],"signal_regions":"None","transmembrane_regions":"122-142;166-186;269-289;364-384","pdb_id":null,"cellular_location":"Peroxisome membrane; Multi-pass membrane protein","genbank_gene_id":"U93584","genbank_protein_id":"1931633","gene_card_id":"PXA2","chromosome_location":"chromosome 11","locus":"YKL188C","synonyms":["Peroxisomal ABC transporter 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" primary active transmembrane transporter activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" P-P-bond-hydrolysis-driven transmembrane transporter activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of substances"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"ABC_tran","identifier":"PF00005"},{"name":"ABC_membrane_2","identifier":"PF06472"}],"pathways":[],"gene_sequence":"ATGATCTCAACAGCTTCTGCATTTTATCAGAAGCATAGAGTAAATTTACTGCGTTCTTCATACATAATATTGTTGCTAGCCACGCTTTACAATTCAAATTCCAGTTCTAGTAACAACAAAACTGATAAGAAGGATTCTGAGTCAACGGTTTTAGAAAATAAGAAAATTGAAGAGGGAAAAGAAACCGCAGTAGATAGAGAGGAAGATGAAAGTAGCAAAGAAGAGTTAACGATAGTCTCCAAACATAGCACAGATTCAGAAGATGGTGCAATAATAATTGATAAAGAAAGCAAGACTAATCATAAGGGGGGAGAGCGAAAAGGAAAGGTAGATTTTTTGTTCAAACTTTTGCTTCATGATAAGAAGTGCCTCATTTTATTTATTACACAGGCTATTCTTCTGAACATCAGAACATTGCTGTCTCTTCGTGTGGCTACTTTAGATGGTCAATTAGTGTCCACACTAGTAAGAGCTCAATACGCAAACTTCACAAAGATATTGTTGGGGAAATGGATGATCCTTGGAATTCCCGCCAGTTTTATTAATTCACTGATCAGTTACACGACAAAACTTTGTGCTGTCACTATTAATAGGAAAGTTTCAGACTTTCTACTCTCAAAGTATCTATCTAATCACCATACTTTCTATTCCGTAGCTTCTGCTGAATCTGTTTCAGAAATTCAGGATAATTTGACAAAAGATATTTACACATTTTCAATGAACTCGTCATTATTACTGAATCAGCTATTAAAGCCAATGCTGGATTTGATCCTCTGTTCATTCAAATTATTAACCTCAAACACTAGTGTTATGGGTGAAGGAACTTTGGCACTGGGCTTAATTGTCTACGCCTCCAATTCATTACTAAAATTGATTCAACCGAATTTCACTAGGTTAACTATGGCAAGCGCATCTTTGGAAAGTTGGTTCAGATCTTTACACTCGAATCTACATTCAAGCAATGAAGAAATTGCACTGCTAAGAGGGCAAAAGAGGGAACTAGAAAACGTTGATTATTCATTTTACCGTTTGGTGCTATTTTTAAACAGAGAAATAAAGGCAAGAGCTATTTATGATGTTGCTACTGCATTTGTCATTAAATATACTTGGGGCGCAGCTGGCTTGGTACTATGCTCGATTCCAATATTTTTCAAAAACAAACCTAGTGAAGACACCTTACAGCTTAAGGAACCCGGGAATGATATGACGGCTGATTTCATCACAAATAGAAGATTATTAGTCACTGCATCTAGCTCTATCGGAAGATTTGTGGAACTGAAGAGAAATATACAACAATTACGCGGTATCAGATTGAGATTGAACAAGTTCAATGATTTGTTGGATGCTAATAAAGGTGATGACGAAAAAGAACCAAGAGATGAAAGGTGTATAGTGGAATATGATGATTCAAGGATAAAGTTTGAAAATATTCCTTTAATAACACCTGCCAATCAAGTTCTAGTACCGGAGCTAAGTTTTGATCTGAAGCATGGAAATCATCTACTAATTATTGGGCCCAACGGTTGCGGTAAATCTTCATTATTTCGTATTCTAGGCGGGCTTTGGCCGATAAGGGCGACTCCCAATAAAAATCATCAATCCAAGTTAATAATGCCGCGTAGAACTGTGGATAGAGATTGCGCAATATTTTATTTACCCCAAAGGCCGTATATGGGCAATAGGTCGACATTCAGGGAACAGATTATTTATCCAGACAGTATTGAACAATTCAAAGAAAGATATCACAATGATTATGATCTAGGCGATGCAGATTTAATAAAAATTCTGCAATTATTAGATTTGGAGGATTTAGTCACTGAAAATATGTCACTTCTGCTGGCGCAAAGGACTTCCAAAAATGATTCACAGCAGTTGTCGACGGAAGACAATCAGTCACCATGCGCCATTAAAGTTCGTGATGCATTCAGTATAGTAAGAAATTGGTCCGAAGAATTAACAATTGGTGTCCAACAAAGGTTAGCTATGGCAAGGATGTACTATCATAAACCCAAGTTTGCTGTGCTCGACGAATGTACATCTGCAGTAGCCCCAGAAATGGAACAAAGGATGTACGAAAATGCGCAAAATTTTGGTATCTCGTTAATATCAGTTTGCCACAGGACAAGTTTATGGCATTTTCATAACTATCTGTTAAAATTTGATGGTAAAGGCGGATACCAATTTGGACCGTTTAACCCGAAGGAAAGGTTATGTAATGAAGAAAAACTTCTTGAACTAAATGCCATCTTGGATCAACAGGTGCCACTTTGGGAGCGGAAGTTGAAAGATCTGACAATTGCTAAAGAATCCAACATCATTCGTAAATCAGAAACTAACCTGAATCTTTTTGAAAAGATCGAAGATCCAAAAACGTCCAAATCTAATGCATTGTTTAATGCAAATAAAGGGCAGCGAATCACATCACCTACAGGGCAGGAGACTAGTAAGAGATTACCACTATTTTCCCAACCATCTAGTTCAGCATCATCAAATTTACTAAGAAACAATAAAAGCTTGAACAAAAAAGTTAAAACAAAAAAGGAAGAAGGAAAGGAGAGGTAA","protein_sequence":"MISTASAFYQKHRVNLLRSSYIILLLATLYNSNSSSSNNKTDKKDSESTVLENKKIEEGKETAVDREEDESSKEELTIVSKHSTDSEDGAIIIDKESKTNHKGGERKGKVDFLFKLLLHDKKCLILFITQAILLNIRTLLSLRVATLDGQLVSTLVRAQYANFTKILLGKWMILGIPASFINSLISYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAESVSEIQDNLTKDIYTFSMNSSLLLNQLLKPMLDLILCSFKLLTSNTSVMGEGTLALGLIVYASNSLLKLIQPNFTRLTMASASLESWFRSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDVATAFVIKYTWGAAGLVLCSIPIFFKNKPSEDTLQLKEPGNDMTADFITNRRLLVTASSSIGRFVELKRNIQQLRGIRLRLNKFNDLLDANKGDDEKEPRDERCIVEYDDSRIKFENIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLIMPRRTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLDLEDLVTENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYYHKPKFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQFGPFNPKERLCNEEKLLELNAILDQQVPLWERKLKDLTIAKESNIIRKSETNLNLFEKIEDPKTSKSNALFNANKGQRITSPTGQETSKRLPLFSQPSSSASSNLLRNNKSLNKKVKTKKEEGKER"},{"created_at":"2011-05-27T17:52:41.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Folylpolyglutamate 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Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"AY692818","genbank_protein_id":"51013087","gene_card_id":"MET7","chromosome_location":"chromosome 15","locus":"YOR241W","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"}],"pfams":[],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGCATAAAGGAAAAAAAAATTACCCTAATTTGATTACTTCGTTTCGGATGAATTTGAAAAAAATCATATTGAACCATGACCGATTTAGCCATCCAGAAAGATGGAAAACAAACGCACTCTTAAGGTTCACCTTCGTGTATATAAAATTTCTCTTCGACTTGATGATAATCAAAAATCCATTAAGGATGGTTGGAAAAACTTATCGAGACGCTGTTACTGCGCTAAACTCTTTGCAGTCCAATTATGCCAACATCATGGCTATCCGTCAAACTGGTGATCGTAAAAACACTATGACATTATTGGAAATGCATGAATGGTCTCGAAGAATTGGTTACTCTGCATCGGATTTCAATAAATTAAATATTGTTCATATCACTGGAACAAAAGGTAAAGGTTCTACTGCCGCATTTACTTCATCAATTCTAGGACAATATAAAGAACAATTACCACGTATCGGGCTATATACGTCTCCACATCTTAAGTCAGTGAGAGAAAGAATAAGAATAAATGGGGAGCCAATTTCTGAAGAAAAATTTGCGAAGTACTTCTTTGAGGTTTGGGACCGTCTAGATAGTACAACCTCTTCTTTGGATAAATTCCCGCACATGATCCCGGGAAGTAAGCCTGGCTATTTCAAGTTCCTCACATTGCTTTCATTTCACACTTTTATACAAGAGGACTGCAAAAGCTGTGTCTACGAAGTCGGCGTCGGAGGTGAATTGGATAGCACTAATATAATTGAAAAGCCAATTGTCTGCGGTGTTACACTATTAGGAATAGACCATACTTTCATGCTTGGTGATACTATTGAAGAAATTGCTTGGAATAAGGGAGGAATTTTCAAATCTGGAGCACCAGCATTCACCGTTGAGAAACAACCTCCTCAGGGATTAACAATATTGAAAGAAAGAGCTGAGGAGCGCAAAACAACGCTAACAGAAGTACCCCCATTTAAACAGTTGGAAAATGTCAAGCTTGGAATTGCTGGCGAGTTTCAAAAAAGTAACGCCTCCCTTGCCGTTATGCTGGCTTCTGAGATCTTGCATACGTCCAATATATTGGAGGAGAAGATCAAATGCAGTTCGAATGCATCGATTCCAGAAAAATTCATAATCGGTCTACAAAATACTAAGTGGGAAGGCAGATGTCAAGTACTAGAAAAGGGAAAAAACGTTTGGTACATTGATGGTGCTCACACCAAAGATAGTATGGTAGCTGCATCAACATGGTTCAGAGATATGGTTCGATTGTCGAAGAGAAAGAAGATCTTGCTCTTCAACCAACAAAGCAGAGATGCCAACGCTCTTGTGAATAACCTGTACTCATCTGTTTCGCCAGAAATAACGTTCGATGATGTGATATTTACTACTAATGTCACTTGGAAATCAGGCTCATACAGCGCTGACCTCGTTTCCATGAACACTTCTCAAGAAGATGTAGAAAAATTGAAAGTCCAGGAGTCATTAGTCAAGAATTGGAACAAAATAGACGATAATCGTGCTAAAACGCATGTAACGGCTAGTATAGAGGAAGCAAATGAATTGATTGAAACGCTATACGATGAACCTGCTGATATATTTGTAACTGGTTCATTACATCTTGTTGGCGGATTATTGGTCGTTTTTGATAGAATAGATGTAAAGTAA","protein_sequence":"MHKGKKNYPNLITSFRMNLKKIILNHDRFSHPERWKTNALLRFTFVYIKFLFDLMIIKNPLRMVGKTYRDAVTALNSLQSNYANIMAIRQTGDRKNTMTLLEMHEWSRRIGYSASDFNKLNIVHITGTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKYFFEVWDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNIIEKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAEERKTTLTEVPPFKQLENVKLGIAGEFQKSNASLAVMLASEILHTSNILEEKIKCSSNASIPEKFIIGLQNTKWEGRCQVLEKGKNVWYIDGAHTKDSMVAASTWFRDMVRLSKRKKILLFNQQSRDANALVNNLYSSVSPEITFDDVIFTTNVTWKSGSYSADLVSMNTSQEDVEKLKVQESLVKNWNKIDDNRAKTHVTASIEEANELIETLYDEPADIFVTGSLHLVGGLLVVFDRIDVK"},{"created_at":"2011-05-29T04:06:34.000Z","updated_at":"2011-05-29T04:06:34.000Z","name":"Ribonucleoside-diphosphate reductase large chain 2","uniprot_id":"P21672","uniprot_name":"RIR3_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR3","num_residues":869,"molecular_weight":"97513.79688","theoretical_pi":"5.86","general_function":"Involved in oxidation-reduction process","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"RNR3","chromosome_location":null,"locus":null,"synonyms":["Ribonucleotide reductase DNA damage-inducible regulatory subunit 2","Ribonucleotide reductase R1 subunit 2","Ribonucleotide reductase large subunit 2"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" ribonucleoside-diphosphate reductase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" DNA metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" DNA replication"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ATP-cone","identifier":"PF03477"},{"name":"Ribonuc_red_lgC","identifier":"PF02867"},{"name":"Ribonuc_red_lgN","identifier":"PF00317"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTACGTTATTAAAAGAGACGGCCGCAAAGAGCCCGTTCAATTCGATAAAATTACCTCCCGTATCACCCGTTTGTCATACGGTTTAGACCCAAACCGTATTGATGCTGTTAAGGTAACCCAACGTATTATTTCTGGTGTGTACTCCGGTGTTACTACCGTTGAGCTGGACAATCTTGCAGCTGAAACATGTGCATACATGACCACTGTGCACCCTGATTATGCCACTCTAGCCGCTAGAATCGCCATCTCTAACTTACATAAGCAAACCACAAAGCAATTCTCCAAAGTTATTGAGGATTTACACGACTGGATTAACCCAGCTACTGGAAAGCATGCTCCTATGATTTCGGACGAAATTTACAACATTGTCATGGAAAACAAAGATACTTTGAACTCGGCCATCGTGTACGATAGGGATTTCCAGTATACGTATTTCGGATTCAAGACACTGGAGCGTTCGTACTTGCTAAGACTGAACGGTGAAGTGGCAGAACGTCCTCAGCATTTGGTAATGCGTGTGGCGCTAGGTATCCATGGTAGCGATATCGAATCTGTGCTGAAGACTTATAATTTGATGTCGTTAAGATACTTCACTCACGCTTCCCCAACTTTATTCAACGCTGGTACGCCACATCCTCAAATGTCTTCATGTTTCTTAATTGCCATGAAGGATGACTCTATCGAAGGTATTTATGATACTTTGAAAGAATGTGCTATGATTTCCAAAACTGCAGGTGGTGTTGGTCTTCATATCAACAACATCCGTTCCACAGGTTCTTATATCGCTGGTACCAACGGTACTTCAAACGGGTTGATTCCTATGATTCGTGTTTTCAATAATACTGCCCGTTATGTGGACCAGGGTGGTAACAAGAGACCTGGTGCTTTCGCCCTTTTCTTGGAGCCATGGCATGCAGATATCTTCGACTTTGTCGATATCAGAAAAACACATGGTAAGGAAGAAATTCGTGCAAGAGATTTGTTCCCTGCTCTATGGATCCCTGATCTTTTCATGAAACGTGTTCAAGAGGATGGGCCTTGGACTTTGTTTTCGCCCAGTGCTGCCCCAGGTTTAGATGATGTGTGGGGTGATGAATTTGAAGAACTATATACTCGTTACGAAAGAGAAGGTCGTGGTAAAACAATTAAAGCCCAAAAGTTGTGGTATGCCATTTTGCAAGCACAGACAGAAACAGGTACACCTTTCATGGTTTATAAGGACGCATGTAACAGGAAGACAAACCAACAGAACTTAGGTACTATCAAATCATCTAATTTATGTTGTGAAATCGTCGAATATTCCTCCCCGGATGAAACTGCAGTTTGTAATTTAGCTTCTATTGCCCTACCAGCATTCGTTGAGGTTTCAGAAGATGGTAAAACTGCAAGCTATAATTTCGAGAGATTACACGAGATTGCTAAAGTCATTACTCACAACTTGAACAGAGTTATCGACCGTAATTACTATCCAGTTCCCGAGGCTAGAAATTCAAATATGAAGCATAGACCTATTGCTCTTGGTGTCCAGGGTTTGGCCGATACTTATATGATGTTGCGTCTACCCTTTGAATCGGAAGAAGCTCAAACTCTAAACAAACAAATCTTCGAAACTATTTACCATGCTACTCTTGAAGCCTCCTGTGAATTGGCCCAAAAAGAAGGTAAATATTCTACTTTTGAAGGTTCTCCAGCTTCTAAGGGTATTTTACAATTCGATATGTGGAACGCTAAACCATTTGGCATGTGGGATTGGGAAACCTTAAGAAAGGACATTGTTAAACATGGGTTAAGAAACTCTTTGACTATGGCACCAATGCCAACCGCCTCAACTTCCCAAATTCTTGGTTATAATGAATGCTTCGAACCAGTGACCTCAAACATGTACTCTCGTCGTGTCCTGTCTGGTGAATTCCAAGTTGTTAATCCATATTTACTACGTGATTTAGTCGACCTGGGTATTTGGGATGATAGTATGAAACAATATCTAATTACACAAAATGGTTCTATTCAAGGCTTACCAAATGTGCCACAAGAATTGAAGGAATTATACAAAACCGTCTGGGAAATCTCTCAAAAGACCATTATCAATATGGCTGCTGATCGTGCCATCTACATCGATCAGTCTCATTCCTTGAATCTTTTCTTGCAAGCACCATCAATGGGTAAGATTACTAGTATGCATTTCTACGGTTGGAAGAAGGGTTTAAAAACTGGTATGTACTACTTAAGAACGCAAGCCGCCTCCGCTGCTATTCAATTTACCATTGATCAAGAGGTTGCCGATCAAGCCGCTACACATATTGCTTCCGTCTCAGAATTGGATCGTCCAGTTTATGTTCCAAAGGGTACAAAATTCTCTGAACAAAAGGCGGCATCTGCGCTTACCGAAAGCTCAGATAATGAGAAGGATGCATCTCCAGTTCCATCCGAACAATCATCGGTGTCGAGTGCCATGTCAAATGTGAAATTGGAAGATAGTGTTGCCCCAGCAGTTCCAACGGAAACAATAAAAGAAGATTCCGACGAGAAGAAATGTGACATTTACAATGAAAAGGTGATTGCTTGTACTGCTCCTACTCCAGAAGCTTGTGAGTCATGTTCCGGTTGA","protein_sequence":"MYVIKRDGRKEPVQFDKITSRITRLSYGLDPNRIDAVKVTQRIISGVYSGVTTVELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVIEDLHDWINPATGKHAPMISDEIYNIVMENKDTLNSAIVYDRDFQYTYFGFKTLERSYLLRLNGEVAERPQHLVMRVALGIHGSDIESVLKTYNLMSLRYFTHASPTLFNAGTPHPQMSSCFLIAMKDDSIEGIYDTLKECAMISKTAGGVGLHINNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALFLEPWHADIFDFVDIRKTHGKEEIRARDLFPALWIPDLFMKRVQEDGPWTLFSPSAAPGLDDVWGDEFEELYTRYEREGRGKTIKAQKLWYAILQAQTETGTPFMVYKDACNRKTNQQNLGTIKSSNLCCEIVEYSSPDETAVCNLASIALPAFVEVSEDGKTASYNFERLHEIAKVITHNLNRVIDRNYYPVPEARNSNMKHRPIALGVQGLADTYMMLRLPFESEEAQTLNKQIFETIYHATLEASCELAQKEGKYSTFEGSPASKGILQFDMWNAKPFGMWDWETLRKDIVKHGLRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDDSMKQYLITQNGSIQGLPNVPQELKELYKTVWEISQKTIINMAADRAIYIDQSHSLNLFLQAPSMGKITSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQEVADQAATHIASVSELDRPVYVPKGTKFSEQKAASALTESSDNEKDASPVPSEQSSVSSAMSNVKLEDSVAPAVPTETIKEDSDEKKCDIYNEKVIACTAPTPEACESCSG"},{"created_at":"2011-07-22T05:45:54.000Z","updated_at":"2011-07-22T05:45:54.000Z","name":"Alkylphosphocholine 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membrane","reactions":[{"id":34386,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000206","source":"Smpdb"},{"id":34387,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000207","source":"Smpdb"},{"id":34388,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000208","source":"Smpdb"},{"id":34390,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000210","source":"Smpdb"},{"id":34392,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000212","source":"Smpdb"},{"id":34394,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_RCT000214","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"75-95;373-393","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z46259","genbank_protein_id":"633662","gene_card_id":"LEM3","chromosome_location":null,"locus":null,"synonyms":["Brefeldin-A sensitivity protein 3","Ro-sensitive 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":"cell part"},{"category":"Component","description":"membrane"}],"pfams":[{"name":"CDC50","identifier":"PF03381"}],"pathways":[{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGGTAAATTTCGATTTGGGCCAAGTTGGTGAAGTATTCCGTAGAAAGGACAAAGGAGCTATAGTGTCCGGAGACAACCCAGAAGAAGAAGAAGACGTCGATGCTTCTGAGTTTGAAGAGGATGAAGTAAAGCCTGTGCGTACAAAGAACAGAAGACCCAAAGAGGATGCATTCACTCAACAAAGATTAGCGGCTATAAACCCGGTGTTAACGCCGAGGACAGTTTTGCCTCTTTATCTGTTAATTGCTGTTGTATTTGTTATTGTAGGAGGGTGCATATTAGCACAGAACTCCAAAGTGGATGAAGTAACCATATATTACCAGGACTGTATGACTAACGCAACCTCATCATGGAGCGACATCCCTTCTGAACATTGGCAATTTGTATTTCACAAATATAAAACATATAATACTGCACCACAATGGAGGTTTGTGGATGATGAATCAGATGACTTCACAAAACAAAGAGGTACATGCCAAATCAGGTTCACTACTCCAAGTGATATGAAAAATAACGTATATTTGAATTATGTGCTGGAAAAATTTGCTGCCAATCACAGAAGATATGTACTATCTTTTAGCGAAGATCAGATACGTGGGGAGGACGCCTCTTATGAGACGGTGCATGATGCAACCGGTATAAATTGTAAGCCACTATCTAAGAACGCCGATGGTAAAATATACTATCCATGTGGCCTAATTGCGAACTCAATGTTCAACGACACGTTCCCCCTGCAGTTAACAAATGTAGGGGATACGTCTAACAACTATTCATTGACAAATAAAGGAATCAATTGGGAATCTGATAAAAAAAGGTACAAAAAAACCAAATACAATTATACACAGATAGCACCTCCACCATATTGGGAAAAGATGTATCCAGATGGATACAACGAGACGAATATTCCTGATATTCAGGATTGGGAAGAGTTCCAAAACTGGATGAGGCCAGGTGCTTTTGATAAAATTACAAAACTGATCAGAATCAATAAAAACGATACTTTGCCAGCGGGTGAATACCAGTTGGATATCGGTCTGCATTGGCCAGTATTGGAGTTTAATGGTAAGAAGGGAATCTACTTGACTCACGGTTCTCACCTTGGCGGTAGAAATCCATTTTTAGGTATAGTTTACCTGATTGGAGGCTGTATTTGTGCTGCCATGGCATTGATATTATTAACGTTTTGGCTCTTCGGCGGTAGAAAGATTGCTGATGCATCAAGTTTGTCATGGAATATGAAATAG","protein_sequence":"MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK"},{"created_at":"2016-09-09T22:38:10.000Z","updated_at":"2016-09-09T22:38:10.000Z","name":"Adenylate kinase","uniprot_id":"B3LG61","uniprot_name":null,"enzyme":false,"transporter":false,"gene_name":null,"num_residues":null,"molecular_weight":null,"theoretical_pi":null,"general_function":null,"specific_function":null,"reactions":[{"id":14311,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006810","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["ATP-AMP transphosphorylase","ATP:AMP phosphotransferase","Adenylate kinase cytosolic and mitochondrial","Adenylate monophosphate kinase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"mitochondrial intermembrane space"},{"category":"Function","description":"adenylate kinase activity"},{"category":"Function","description":"ADP biosynthetic process"},{"category":"Function","description":"AMP metabolic process"},{"category":"Function","description":"ATP metabolic process"},{"category":"Function","description":"ATP binding"},{"category":"Function","description":"cytosol"}],"pfams":[],"pathways":[{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"gene_sequence":null,"protein_sequence":null},{"created_at":"2016-09-09T22:41:19.000Z","updated_at":"2016-09-09T22:41:21.000Z","name":"Serine/threonine-protein kinase VPS15","uniprot_id":"P22219","uniprot_name":"VPS15","enzyme":true,"transporter":true,"gene_name":"VPS15","num_residues":1454,"molecular_weight":"166370.295","theoretical_pi":null,"general_function":"vacuole inheritance","specific_function":"Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.","reactions":[{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"3GRE","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Golgi-retention defective mutant protein 8","Vacuolar protein sorting-associated protein 15"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"endosome membrane"},{"category":"Function","description":"Golgi apparatus"},{"category":"Function","description":"protein phosphorylation"},{"category":"Function","description":"late endosome"},{"category":"Function","description":"nucleus-vacuole junction"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type I"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type II"},{"category":"Function","description":"ubiquitin binding"},{"category":"Function","description":"inositol lipid-mediated signaling"},{"category":"Function","description":"late endosome to vacuole transport"},{"category":"Function","description":"macroautophagy"},{"category":"Function","description":"pexophagy"},{"category":"Function","description":"positive regulation of transcription elongation from RNA polymerase II promoter"},{"category":"Function","description":"protein retention in Golgi apparatus"},{"category":"Function","description":"ATP binding"},{"category":"Function","description":"protein targeting to vacuole"},{"category":"Function","description":"protein serine/threonine kinase activity"},{"category":"Function","description":"vacuole inheritance"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGGGCACAATTATCACTAGTGGTCCAAGCATCACCTTCCATAGCCATTTTTTCATATATCGATGTCTTAGAGGAAGTACACTACGTTTCACAGTTAAACTCATCAAGATTCTTAAAAACATGCAAGGCACTGGACCCTAACGGCGAAATTGTTATCAAAGTGTTTATTAAACCAAAAGACCAATATAGCTTACGACCTTTTCTCCAACGTATAAGGGCTCAATCGTTTAAGTTGGGACAACTACCGCACGTTTTAAACTACAGTAAATTGATCGAGACAAATAGAGCCGGCTACATGATACGGCAGCACTTAAAAAATAATTTATATGACAGATTGAGTTTGAGACCTTACTTACAAGACATTGAACTGAAATTCATTGCTTTCCAGTTGTTAAATGCATTAAAGGACATTCATAATCTGAATATTGTCCATGGTGATATAAAGACAGAAAATATCCTAGTAACAAGTTGGAATTGGTGTATATTGACAGATTTTGCTGCATTTATCAAACCCGTATATTTGCCTGAAGATAATCCAGGTGAATTTTTATTCTACTTCGACACCTCGAAGAGAAGAACCTGTTATCTAGCCCCGGAGAGGTTTAACTCTAAACTTTACCAAGATGGAAAATCTAACAATGGTAGGCTAACTAAAGAAATGGACATATTTAGTCTTGGATGTGTTATTGCAGAAATATTTGCTGAAGGAAGACCCATCTTCAACTTATCACAGCTATTCAAATATAAAAGTAATTCATATGACGTAAACAGGGAATTTCTCATGGAGGAAATGAATTCTACCGATTTAAGGAACTTGGTTCTAGACATGATTCAACTAGATCCATCCAAAAGACTTTCATGTGATGAACTACTGAATAAATATCGTGGCATTTTCTTCCCCGATTATTTCTACACTTTCATTTATGATTATTTCAGAAATTTGGTTACTATGACAACAAGCACACCGATATCAGATAACACTTGCACCAATAGTACCTTGGAAGACAATGTAAAACTTTTAGATGAAACTACGGAAAAAATATACAGAGATTTTTCCCAAATATGTCATTGTTTGGACTTTCCTTTAATAAAAGACGGGGGTGAGATTGGTTCAGACCCCCCAATTTTGGAATCTTACAAAATAGAGATAGAAATTAGTCGGTTTTTAAACACAAACTTATATTTCCCCCAAAATTACCATTTAGTCTTACAGCAGTTTACCAAAGTATCCGAAAAGATAAAATCAGTTAAAGAGGAATGTGCCTTACTCTTTATCTCTTATTTGTCTCATAGTATAAGAAGTATTGTTTCGACTGCTACGAAACTTAAAAATTTAGAACTATTAGCAGTATTTGCACAATTCGTTTCTGATGAAAATAAAATTGATCGAGTCGTACCTTATTTCGTATGTTGTTTTGAAGATAGTGACCAGGACGTCCAGGCCCTATCTTTGTTAACATTAATCCAGGTACTCACCTCTGTAAGAAAATTGAATCAATTGAACGAGAATATATTTGTGGACTACTTACTTCCGAGACTGAAAAGATTACTTATTTCCAATAGGCAGAATACCAATTATTTAAGGATTGTGTTTGCTAATTGTTTGAGCGACTTGGCCATTATCATTAATAGATTTCAAGAATTTACATTTGCTCAGCACTGCAATGATAACTCAATGGATAACAACACGGAAATCATGGAAAGCAGTACCAAGTATTCAGCAAAATTGATCCAAAGTGTCGAAGATTTAACTGTCTCTTTTTTAACAGATAATGATACTTATGTAAAGATGGCACTTTTGCAAAACATTCTTCCACTTTGTAAATTTTTTGGTAGGGAAAGAACAAACGATATTATACTGAGTCATTTAATAACCTACCTTAATGATAAGGACCCAGCATTGCGAGTTTCCTTAATTCAAACAATATCCGGAATATCAATTCTTTTGGGTACCGTTACATTAGAACAGTATATTTTACCATTGTTAATCCAGACCATCACTGATTCGGAAGAATTAGTAGTGATCAGTGTTTTACAAAGCTTAAAATCTTTGTTCAAGACTGGGTTGATTAGGAAAAAATATTATATTGATATATCAAAAACAACATCTCCCTTGTTGTTGCATCCTAATAATTGGATAAGACAGTTTACTTTGATGATAATTATAGAAATTATTAATAAGTTATCAAAAGCCGAAGTGTACTGCATTCTCTATCCAATAATAAGGCCTTTCTTCGAATTTGACGTTGAGTTCAACTTCAAATCAATGATAAGCTGTTGCAAGCAACCAGTGTCAAGATCGGTTTACAATCTATTGTGTAGTTGGTCTGTTAGAGCGTCAAAATCTTTATTTTGGAAAAAAATCATCACAAATCATGTAGATTCATTCGGAAATAATAGAATCGAATTTATAACAAAAAATTACTCAAGTAAAAATTATGGATTTAATAAAAGAGATACGAAATCAAGTTCCTCGCTGAAGGGTATTAAAACATCATCCACCGTCTATTCACATGACAACAAGGAAATTCCCTTAACTGCTGAAGACAGAAATTGGATTGATAAGTTCCACATTATTGGGCTAACAGAAAAAGATATTTGGAAAATTGTGGCTTTGAGGGGTTATGTAATAAGGACAGCGAGAGTTATGGCAGCGAACCCTGATTTTCCATATAATAATAGTAATTACCGTCCATTAGTACAGAACTCACCACCTAACCTAAACCTTACGAATATTATGCCAAGAAACATTTTCTTTGATGTAGAGTTTGCTGAAGAGTCGACAAGTGAGGGACAAGATTCTAACTTAGAGAACCAACAGATATATAAATATGATGAAAGTGAGAAAGATAGCAATAAGCTAAATATTAACGGTAGCAAACAGCTATCTACCGTCATGGACATAAATGGATCACTAATATTCAAAAATAAGTCCATTGCCACTACTACTTCTAATTTGAAGAACGTTTTTGTTCAGTTAGAACCAACGTCCTATCACATGCATTCTCCAAATCATGGCTTGAAAGATAATGCAAATGTTAAACCAGAAAGGAAGGTAGTCGTCAGCAACAGCTATGAAGGCGACGTTGAAAGCATAGAAAAATTCCTATCGACTTTCAAAATTTTACCTCCTCTGAGAGATTATAAGGAGTTTGGGCCTATTCAAGAGATTGTACGGAGTCCAAACATGGGTAATTTGAGGGGCAAGTTGATAGCTACTTTGATGGAAAACGAACCCAATTCTATTACGTCTTCTGCTGTTTCTCCAGGAGAAACACCCTATTTAATAACAGGTTCAGATCAAGGTGTAATCAAGATTTGGAACCTGAAAGAGATTATCGTGGGCGAGGTTTACTCTTCTTCTTTAACTTATGACTGCTCCTCTACCGTAACTCAGATAACCATGATTCCTAACTTTGACGCGTTTGCCGTTTCCAGTAAAGATGGACAAATAATTGTATTAAAGGTTAATCATTACCAACAAGAAAGTGAAGTCAAATTTTTGAATTGCGAATGCATCAGGAAAATTAACTTGAAGAATTTTGGTAAAAATGAATACGCAGTGAGAATGAGAGCATTTGTGAATGAGGAAAAATCTCTACTAGTAGCATTGACGAATTTGTCAAGGGTTATTATATTTGATATTAGAACCCTGGAGAGGTTACAAATTATAGAGAATTCTCCAAGGCATGGTGCCGTTTCAAGCATCTGTATCGATGAAGAGTGTTGTGTCCTAATTTTGGGGACGACTAGAGGTATTATTGATATATGGGATATCCGTTTCAACGTGCTGATAAGGAGTTGGTCCTTTGGGGACCACGCACCAATCACGCATGTGGAGGTTTGTCAGTTTTATGGAAAGAATTCTGTAATTGTTGTAGGAGGTAGTTCAAAAACATTTCTAACAATATGGAATTTTGTTAAGGGGCATTGTCAGTATGCTTTCATAAATTCTGATGAACAGCCATCTATGGAGCACTTTTTACCAATTGAGAAAGGCTTAGAAGAATTAAATTTTTGTGGAATCAGGTCTTTAAACGCACTAAGCACTATCTCAGTATCTAATGATAAAATTCTTCTTACCGATGAAGCAACAAGTTCCATTGTTATGTTTAGCCTAAATGAGCTTTCTTCTTCTAAAGCAGTAATAAGTCCTTCAAGATTCAGTGACGTTTTTATTCCTACACAAGTTACGGCAAATCTCACAATGTTATTGAGAAAAATGAAACGTACTAGCACTCATTCAGTAGATGATTCTCTATATCATCATGATATTATAAATTCTATATCTACATGTGAAGTTGATGAGACACCTTTGCTGGTTGCTTGTGATAACTCAGGGCTTATTGGAATCTTCCAATAA","protein_sequence":"MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNALKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFFPDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLDFPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEECALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLMIIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRASKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHDNKEIPLTAEDRNWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPLVQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGSKQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKVVVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNFGKNEYAVRMRAFVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRGIIDIWDIRFNVLIRSWSFGDHAPITHVEVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSDEQPSMEHFLPIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSSIVMFSLNELSSSKAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDDSLYHHDIINSISTCEVDETPLLVACDNSGLIGIFQ"},{"created_at":"2016-09-09T22:47:03.000Z","updated_at":"2016-09-09T22:47:03.000Z","name":"Probable ATP-dependent kinase TDA10","uniprot_id":"P42938","uniprot_name":"TDA10","enzyme":false,"transporter":false,"gene_name":"TDA10","num_residues":290,"molecular_weight":"33336.605","theoretical_pi":null,"general_function":"kinase activity","specific_function":"ATP-dependent kinase whose specificity is not yet known.","reactions":[{"id":3908,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006419","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"1ODF","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Topoisomerase I damage affected protein 10"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"nucleus"},{"category":"Function","description":"kinase activity"},{"category":"Function","description":"ATP binding"},{"category":"Function","description":"cytosol"}],"pfams":[],"pathways":[{"name":"Glycerol metabolism","kegg_map_id":null}],"gene_sequence":"ATGTGTGATAAGTCAAAAACGGTATTGGACTACACGATAGAATTCTTGGATAAATATATACCTGAATGGTTTGAGACGGGAAATAAATGCCCCTTGTTCATTTTCTTCTCGGGCCCACAAGGCTCAGGCAAAAGTTTTACAAGTATCCAAATCTATAACCATTTGATGGAAAAATATGGGGGTGAAAAATCTATCGGTTACGCCTCAATTGATGATTTTTATTTAACTCACGAGGACCAATTGAAACTCAATGAGCAATTCAAGAACAATAAGCTGTTACAAGGACGTGGTTTACCAGGTACTCATGATATGAAATTGTTGCAAGAGGTATTGAACACCATCTTCAATAATAATGAACATCCGGATCAAGATACTGTCGTACTACCCAAGTACGATAAATCCCAATTTAAAGGAGAAGGGGACCGTTGCCCCACTGGTCAAAAAATCAAGCTACCAGTCGATATTTTTATCTTAGAAGGTTGGTTCCTCGGGTTCAACCCCATTTTGCAAGGAATTGAGAATAATGATCTTCTTACTGGGGACATGGTTGATGTCAATGCCAAGCTCTTCTTCTATAGCGACTTGTTGTGGCGCAACCCAGAAATCAAATCTTTAGGGATAGTATTCACCACCGATAACATTAACAATGTTTATGGCTGGAGACTACAACAGGAGCATGAACTAATATCAAAGGTCGGAAAGGGGATGACCGACGAACAAGTGCATGCTTTTGTGGATAGATACATGCCCTCCTATAAACTTTATTTGAACGACTTTGTCCGGAGTGAAAGTTTAGGTTCCATTGCTACATTGACGTTAGGAATCGACTCCAACAGGAATGTATATTCTACGAAAACGAGATGTATTGAATAG","protein_sequence":"MCDKSKTVLDYTIEFLDKYIPEWFETGNKCPLFIFFSGPQGSGKSFTSIQIYNHLMEKYGGEKSIGYASIDDFYLTHEDQLKLNEQFKNNKLLQGRGLPGTHDMKLLQEVLNTIFNNNEHPDQDTVVLPKYDKSQFKGEGDRCPTGQKIKLPVDIFILEGWFLGFNPILQGIENNDLLTGDMVDVNAKLFFYSDLLWRNPEIKSLGIVFTTDNINNVYGWRLQQEHELISKVGKGMTDEQVHAFVDRYMPSYKLYLNDFVRSESLGSIATLTLGIDSNRNVYSTKTRCIE"},{"created_at":"2016-09-09T22:48:58.000Z","updated_at":"2016-09-09T22:48:59.000Z","name":"Vacuolar protein sorting-associated protein 30","uniprot_id":"Q02948","uniprot_name":"VPS30","enzyme":false,"transporter":true,"gene_name":"VPS30","num_residues":557,"molecular_weight":"63260.22","theoretical_pi":null,"general_function":"retrograde transport, endosome to Golgi","specific_function":"Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.","reactions":[{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"3VP7","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Autophagy-related protein 6"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"endosome membrane"},{"category":"Function","description":"piecemeal microautophagy of nucleus"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type I"},{"category":"Function","description":"retrograde transport, endosome to Golgi"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type II"},{"category":"Function","description":"late endosome to vacuole transport"},{"category":"Function","description":"macroautophagy"},{"category":"Function","description":"pexophagy"},{"category":"Function","description":"protein targeting to vacuole"},{"category":"Function","description":"extrinsic component of membrane"},{"category":"Function","description":"cytoplasmic, membrane-bounded vesicle"},{"category":"Function","description":"pre-autophagosomal structure"},{"category":"Function","description":"pre-autophagosomal structure membrane"},{"category":"Function","description":"autophagosome assembly"},{"category":"Function","description":"autophagy"},{"category":"Function","description":"cellular response to nitrogen starvation"},{"category":"Function","description":"cytosol"},{"category":"Function","description":"CVT pathway"},{"category":"Function","description":"cytoplasm"},{"category":"Function","description":"phosphatidylinositol biosynthetic process"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGTGCCAAACATGTCACTTACCCCTGCAACTAGACCCATCTTTAGAAGGTCTTAGTTTAACCCAAAGAAATTTGCTACTTTCAAATAATTCAATTATCACTGCAACGAATGAAAATGTCATCAGCAACAAGGGCATCGAAGCCGCAGATAATTGTGGGCCTCAAATACCGAAGGAGAGGCTGAGGCGATTAGGGGAGATTCAGAACATAAAAGACTTGAATTTAAAAGATGATAAATTAATCACTGATTCGTTTGTTTTTCTTAATCACGATGATGATGATAATGCTAATATTACGAGTAATAGCAGAGAGGACCAGCGTTATGGAAATGCCAACGGAAATGATAATAAAAAAGCTAATAGTGATACTTCCGATGGAACCAGTACCTTTCGAGATCATGACGAAGAGGAACAAGAAGCTACGGATGAGGACGAAAACCAACAAATACAATTGAATTCCAAGACTTTGTCCACACAAGTCAACGCAATGACTAATGTATTTAACATTCTATCTTCTCAAACAAACATAGACTTTCCTATCTGTCAGGACTGCTGTAACATCTTGATAAACAGACTAAAAAGTGAGTATGATGATGCAATAAAAGAGAGAGATACTTACGCTCAATTTTTATCGAAGTTAGAGAGTCAAAACAAAGAAATATCAGAAAGCAATAAAGAAAAGCAGTATTCCCATAATCTTTCGGAAAAAGAAAATTTGAAAAAGGAAGAGGAAAGACTCTTGGATCAATTATTACGTTTGGAAATGACAGATGATGACTTAGATGGAGAACTAGTTCGTTTACAAGAAAAGAAAGTTCAACTGGAAAATGAGAAACTCCAAAAACTGAGTGATCAGAATTTAATGGATTTAAATAACATTCAATTCAACAAAAATTTACAGTCATTAAAACTGCAATACGAATTATCCTTGAATCAATTAGATAAGTTGAGGAAAATCAATATTTTCAATGCTACATTCAAAATCTCACATAGCGGCCCCTTTGCCACTATAAATGGATTGAGATTAGGCAGTATACCAGAATCAGTGGTACCTTGGAAGGAAATCAATGCAGCACTGGGCCAATTGATTCTTTTACTGGCTACCATAAACAAAAACCTGAAGATAAATTTAGTAGACTACGAATTACAACCGATGGGTTCATTTTCCAAAATCAAGAAAAGAATGGTTAACAGTGTCGAATATAATAATTCCACTACGAACGCTCCCGGTGATTGGTTGATTCTGCCTGTCTACTATGATGAGAATTTCAATTTGGGGAGAATCTTCCGCAAGGAAACGAAGTTTGATAAATCATTAGAAACAACATTAGAAATAATAAGCGAAATCACTCGGCAGCTTTCTACGATAGCGTCATCATATTCATCTCAAACACTCACAACAAGCCAAGATGAATCTTCAATGAATAACGCAAATGACGTTGAAAATAGTACTTCCATTCTCGAGCTACCCTATATCATGAATAAGGACAAGATTAATGGATTATCCGTCAAATTGCATGGTAGCAGTCCCAACCTTGAATGGACAACGGCTATGAAATTTTTATTAACCAATGTAAAGTGGTTGTTAGCGTTTTCTTCCAATTTACTATCCAAGTCAATTACCTTAAGCCCTACAGTGAATTACAATGATAAGACCATCAGCGGAAACTAA","protein_sequence":"MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN"},{"created_at":"2016-09-09T22:50:12.000Z","updated_at":"2016-09-09T22:50:13.000Z","name":"Vacuole morphology and inheritance protein 14","uniprot_id":"Q06708","uniprot_name":"VAC14","enzyme":false,"transporter":false,"gene_name":"VAC14","num_residues":880,"molecular_weight":"99771.325","theoretical_pi":null,"general_function":"regulation of lipid kinase activity","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity.","reactions":[{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Swollen vacuole phenotype 2 protein"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"phosphatidylinositol biosynthetic process"},{"category":"Function","description":"extrinsic component of vacuolar membrane"},{"category":"Function","description":"PAS complex"},{"category":"Function","description":"protein binding, bridging"},{"category":"Function","description":"positive regulation of kinase activity"},{"category":"Function","description":"protein transport"},{"category":"Function","description":"regulation of lipid kinase activity"},{"category":"Function","description":"identical protein binding"},{"category":"Function","description":"fungal-type vacuole membrane"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAAAAATCGATTGCCAAAGGTTTAAGCGACAAACTATACGAAAAACGGAAGGCTGCCGCCTTGGAGTTGGAAAAGTTGGTCAAACAATGCGTTCTAGAAGGGGACTATGATCGTATTGACAAGATAATAGACGAACTATGCAGAGACTATGCATACGCTTTGCATCAGCCCATGGCTAGAAATGCAGGATTAATGGGCTTGGCTGCCACAGCAATTGCTTTAGGAATAAACGATGTTGGCCGTTACTTGAGGAATATTCTTCCTCCAGTTCTCGCATGTTTTGGCGACCAGAATGACCAAGTAAGATTTTATGCGTGTGAGAGTTTGTACAATATTGCAAAGATTGCGAAGGGTGAAATACTGGTCTATTTCAATGAAATATTTGACGTACTCTGTAAAATTAGTGCTGATACAGAAAACTCGGTCCGAGGAGCAGCTGAACTATTAGATCGGTTGATAAAAGATATTGTTGCTGAAAGAGCATCCAATTACATAAGCATTGTAAATAATGGATCGCATGGTTTGCTTCCAGCCATAAAAACGGATCCAATCAGCGGGGATGTCTACCAAGAAGAATATGAGCAAGATAATCAATTGGCGTTCTCTTTACCAAAATTTATTCCTTTATTAACAGAGAGAATTTACGCCATTAACCCTGATACGCGTGTTTTTTTAGTTGACTGGCTTAAAGTCTTGCTCAATACCCCAGGACTAGAGCTCATATCGTATCTACCATCATTTCTTGGCGGGTTATTCACGTTCTTGGGCGATTCTCATAAAGATGTCAGAACAGTTACACACACCCTTATGGACTCACTACTTCACGAAGTCGACCGCATTTCAAAATTACAAACTGAAATTAAAATGAAGAGACTGGAAAGACTGAAAATGCTGGAAGATAAATACAATAACAGTTCTACTCCAACGAAAAAGGCCGATGGTGCACTTATTGCTGAAAAGAAGAAAACTTTAATGACTGCATTAGGTGGGTTATCCAAACCTCTGAGTATGGAGACTGATGATACCAAATTATCTAATACTAATGAGACAGATGATGAAAGACACTTGACAAGCCAGGAGCAGCTGCTAGATAGCGAGGCAACTAGCCAAGAACCTCTTCGCGATGGCGAAGAATATATACCTGGTCAAGATATCAACCTCAATTTCCCAGAGGTTATTACCGTTCTTGTGAACAATTTGGCATCATCTGAGGCAGAGATTCAATTGATTGCATTACACTGGATTCAGGTTATTTTATCCATTTCTCCAAATGTGTTTATCCCCTTCCTTTCAAAAATTCTTTCTGTGCTTTTAAAGCTATTGAGCGATTCGGATCCGCATATTACTGAAATTGCTCAGCTGGTGAACGGTCAATTACTCTCATTGTGCAGCTCATATGTGGGAAAAGAGACAGACGGGAAAATTGCATACGGGCCAATCGTTAATAGCTTAACTCTACAGTTTTTCGATAGTAGGATTGATGCCAAGATTGCCTGCTTGGATTGGCTCATCTTAATTTATCACAAGGCTCCAAACCAAATCTTGAAACATAACGACAGCATGTTCCTAACTTTGTTGAAGTCATTATCAAATAGAGACTCGGTGCTAATCGAGAAAGCTTTAAGTCTCTTACAGAGTTTATGTTCTGACTCAAATGATAATTATTTACGTCAGTTTCTTCAAGATTTATTAACTTTATTCAAGAGAGATACCAAATTGGTGAAAACTAGAGCAAACTTTATCATGAGACAGATATCTTCCCGTTTATCACCAGAACGTGTTTATAAAGTAATTTCTTCGATATTGGACAATTATAACGACACAACGTTTGTGAAAATGATGATTCAGATTTTAAGTACAAACTTAATAACTTCACCGGAGATGTCGTCGTTAAGAAACAAACTTAGAACTTGTGAAGACGGTATGTTTTTCAATAGTTTATTCAAATCTTGGTGTCCCAACCCCGTGTCCGTGATATCCTTATGTTTTGTAGCAGAAAATTATGAGTTAGCTTACACAGTGTTACAAACTTACGCGAACTACGAGTTGAAGTTAAATGATCTAGTGCAGTTGGATATTTTGATTCAGTTGTTCGAATCACCCGTTTTCACAAGGATGCGGTTGCAACTTTTAGAACAACAGAAACATCCGTTTCTGCATAAGTGTCTATTTGGTATACTGATGATTATACCACAGTCAAAGGCATTTGAAACATTGAACCGCAGATTGAATAGTTTGAACATATGGACATCCCAATCTTATGTCATGAACAACTATATAAGACAAAGGGAGAATAGTAACTTTTGTGATTCCAATTCTGATATCTCGCAAAGGTCCGTTAGCCAAAGTAAACTACATTTCCAGGAACTAATTAATCATTTTAAGGCCGTTTCAGAAGAAGATGAATATTCATCAGATATGATAAGGCTTGACCATGGTGCTAACAATAAATCACTTCTGCTTGGAAGTTTTTTGGACGGTATTGACGAAGATAAACAAGAAATTGTCACACCAATCTCGCCCATGAATGAAGCTATTAACGAGGAGATGGAATCTCCCAACGATAATAGTTCTGTCATATTAAAAGATAGTGGCAGTCTGCCATTCAACCGCAATGTATCCGATAAATTAAAAAAATAA","protein_sequence":"MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMARNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGEILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAIKTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLELISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLEDKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQEQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVILSISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGPIVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEKALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVISSILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVISLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFLHKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRSVSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPISPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK"}]}