{"ymdb_id":"YMDB00830","created_at":"2011-05-29T18:56:30.000Z","updated_at":"2016-10-18T17:11:37.000Z","name":"D-mannitol","cas":"69-65-8","state":"Solid","melting_point":"166 oC","description":"Mannitol is a six-carbon sugar alcohol. It is one of the most abundant energy and carbon storage molecules in nature, produced by a plethora of organisms, including bacteria, yeasts, fungi, algae, lichens, and many plants. A fructose to mannitol metabolic pathway, known as the mannitol cycle in fungi, has been discovered in a type of red algae (Caloglossa leprieurii), and it is highly possible that other microorganisms employ similar such pathways.","experimental_water_solubility":"216 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.10 [HANSCH,C ET AL. (1995)]","location":null,"synthesis_reference":"Zhang, Chaohui; Wang, Jianping; He, Junlin.  Preparation of mannitol from sucrose with high yield.    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2005),     11 pp.","chebi_id":"16899","hmdb_id":"HMDB00765","kegg_id":"C00392","pubchem_id":"6251","cs_id":"6015","foodb_id":null,"wikipedia_link":"Mannitol","biocyc_id":null,"iupac":"(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol","traditional_iupac":"mannitol","logp":"-3.7300188486666666","pka":"13.37874915684328","alogps_solubility":"2.29e+02 g/l","alogps_logp":"-2.68","alogps_logs":"0.10","acceptor_count":"6","donor_count":"6","rotatable_bond_count":"5","polar_surface_area":"121.38000000000001","refractivity":"38.40359999999999","polarizability":"17.040202393955006","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.974211614825128","pka_strongest_acidic":"12.585200956788803","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexaol","(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol","1,2,3,4,5,6-Hexanehexol","Cordycepate","Cordycepic acid","D-(-)-Mannitol","D-mannite","D-mannitol","D(-)-Mannitol","Diosmol","Hexahydroxyhexane","Hexanhexol","Hexitol","Invenex","Isotol","Manicol","manita","Maniton-s","Manna sugar","Mannazucker","Mannidex","Mannigen","Mannistol","Mannit","Mannit p","Mannite","Mannitol","Mannitol, D-","Mushroom sugar","Osmitrol","Osmofundin","Osmosal","Resectisol","SORBITOL-MANNITOL"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"}],"growth_conditions":[{"growth_media":"YEB media with 0.5 mM glucose","concentration":"1020.0","concentration_units":"\u0026#181;M","error":"51.0"}],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":3117965,"citation":"Quain, D. E., Boulton, C. A. (1987). \"Growth and metabolism of mannitol by strains of Saccharomyces cerevisiae.\" J Gen Microbiol 133:1675-1684."}],"proteins":[{"created_at":"2011-05-27T02:36:31.000Z","updated_at":"2011-05-29T14:01:22.000Z","name":"Mannitol dehydrogenase DSF1","uniprot_id":"P39941","uniprot_name":"DSF1_YEAST","enzyme":true,"transporter":false,"gene_name":"DSF1","num_residues":502,"molecular_weight":"56469.69922","theoretical_pi":"6.07","general_function":"Involved in oxidoreductase activity","specific_function":null,"reactions":[{"id":2681,"direction":"\u003e","locations":null,"altext":"D-mannitol + NAD+ = D-fructose + NADH + H+","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18795","genbank_protein_id":"603248","gene_card_id":"DSF1","chromosome_location":"chromosome 5","locus":"YEL070W","synonyms":["Deletion suppressor of MPT5 mutation protein 1"],"enzyme_classes":["1.1.1.-","1.1.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" coenzyme binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Mannitol_dh","identifier":"PF01232"},{"name":"Mannitol_dh_C","identifier":"PF08125"}],"pathways":[],"gene_sequence":"ATGACAAAATCAGACGAAACAACAGCTACCAGCTTGAATGCTAAAACTCTAAAGAGTTTTGAATCAACTCTTCCAATACCAACTTACCCAAGAGAAGGTGTTAAACAAGGTATTGTTCATCTGGGAGTCGGTGCATTCCACCGTTCCCATTTAGCTGTTTTCATGCACCGTCTGATGCAGGAGCACCACTTAAAGGACTGGTCCATATGTGGTGTTGGTTTAATGAAGGCAGATGCACTTATGCGCGATGCCATGAAGGCCCAAGATTGCCTATACACCCTTGTGGAGCGTGGTATCAAGGACACTAACGCTTATATCGTCGGTTCCATTACTGCTTACATGTACGCTCCCGATGATCCAAGAGCTGTTATTGAAAAGATGGCCAATCCAGACACACACATTGTTTCTTTGACGGTCACAGAAAACGGTTACTACCACAGTGAAGCAACAAACTCCTTAATGACAGATGCTCCCGAGATTATCAATGATTTGAACCACCCAGAAAAGCCAGATACTCTGTATGGGTACCTATATGAAGCCCTGTTGTTGCGTTACAAGAGAGGTCTTACCCCATTCACTATTATGTCATGTGACAACATGCCCCAAAATGGTGTCACAGTAAAGACCATGCTTGTTGCATTTGCCAAGTTAAAGAAGGATGAGAAATTCGCCGCCTGGATTGAAGACAAGGTTACTTCTCCTAACAGCATGGTGGACCGTGTGACCCCACGTTGTACCGATAAAGAGCGTAAATACGTTGCTGACACCTGGGGAATCAAAGATCAATGTCCCGTTGTCGCAGAACCTTTCATCCAATGGGTTCTTGAAGACAACTTCTCCGATGGCCGTCCTCCATGGGAACTTGTTGGTGTTCAGGTCGTCAAGGATGTCGATTCCTACGAATTGATGAAGTTGCGTCTACTTAACGGTGGACATTCTGCTATGGGATATTTGGGATACTTGGCAGGCTACACCTATATACATGAGGTTGTCAACGACCCAACTATCAACAAGTATATCCGTGTTTTGATGCGTGAGGAAGTTATCCCATTATTGCCTAAAGTGCCAGGTGTTGATTTCGAAGAGTACACTGCATCAGTGTTGGAAAGATTCTCCAATCCAGCAATTCAGGACACTGTCGCACGTATTTGTTTGATGGGCTCTGGTAAGATGCCTAAGTATGTTTTGCCATCAATTTACGAGCAGTTGCGTAAACCAGATGGTAAGTACAAGTTGTTGGCAGTATGTGTTGCTGGCTGGTTCCGTTACCTGACTGGTGTAGACATGAATGGGAAGCCATTCGAAATCGAGGATCCTATGGCACCAACCTTGAAGGCAGCCGCAGTTAAGGGCGGTAAAGATCCTCACGAACTGCTTAACATTGAGGTGCTTTTCAGTCCTGAGATTCGTGACAACAAAGAATTCGTTGCACAATTGACCCACTCCCTAGAAACAGTTTACGATAAAGGGCCAATTGCCGCTATTAAGGAAATTTTAGACCAAGTGTGA","protein_sequence":"MTKSDETTATSLNAKTLKSFESTLPIPTYPREGVKQGIVHLGVGAFHRSHLAVFMHRLMQEHHLKDWSICGVGLMKADALMRDAMKAQDCLYTLVERGIKDTNAYIVGSITAYMYAPDDPRAVIEKMANPDTHIVSLTVTENGYYHSEATNSLMTDAPEIINDLNHPEKPDTLYGYLYEALLLRYKRGLTPFTIMSCDNMPQNGVTVKTMLVAFAKLKKDEKFAAWIEDKVTSPNSMVDRVTPRCTDKERKYVADTWGIKDQCPVVAEPFIQWVLEDNFSDGRPPWELVGVQVVKDVDSYELMKLRLLNGGHSAMGYLGYLAGYTYIHEVVNDPTINKYIRVLMREEVIPLLPKVPGVDFEEYTASVLERFSNPAIQDTVARICLMGSGKMPKYVLPSIYEQLRKPDGKYKLLAVCVAGWFRYLTGVDMNGKPFEIEDPMAPTLKAAAVKGGKDPHELLNIEVLFSPEIRDNKEFVAQLTHSLETVYDKGPIAAIKEILDQV"}]}