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1D-myo-inositol 3-phosphate (YMDB00715)

Identification
YMDB IDYMDB00715
Name1D-myo-inositol 3-phosphate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionMyo-inositol 1-phosphate, also known as inositol 3-phosphoric acid, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. Myo-inositol 1-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Myo-inositol 1-phosphate exists in all living species, ranging from bacteria to humans. myo-inositol 1-phosphate can be converted into myo-inositol through the action of the enzyme inositol monophosphatase 1. In yeast, myo-inositol 1-phosphate is involved in the metabolic pathway called the inositol phosphate metabolism pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
  • 1D-myo-Inositol 3-monophosphate
  • 1L-myo-Inositol 1-phosphate
  • D-myo-Inositol 3-monophosphate
  • D-myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
  • Inositol 3-phosphate
  • L-myo-Inositol 1-phosphate
  • myo-Inositol 3-monophosphate
  • myo-Inositol 3-phosphate
  • Myoinositol 3-phosphate
  • 1D-Myo-inositol 3-monophosphoric acid
  • 1l-Myo-inositol 1-phosphoric acid
  • D-Myo-inositol 3-monophosphoric acid
  • D-Myo-inositol 3-phosphoric acid
  • Inositol 3-phosphoric acid
  • L-Myo-inositol 1-phosphoric acid
  • Myoinositol 3-phosphoric acid
  • Myo-inositol 3-phosphoric acid
  • Myo-inositol 3-monophosphoric acid
  • Inositol 3-monophosphoric acid
  • Myo-inositol 1-phosphoric acid
  • 1-(Dihydrogen phosphate) DL-myo-inositol
  • 1-(Dihydrogen phosphate) myo-inositol
  • DL-Myo-inositol 1-phosphate
  • Myo-inositol 1-monophosphate
  • Myo-inositol-1-phosphate
  • Myoinositol 1-phosphate
  • 1D-Myo-inositol 1-phosphoric acid
CAS number2831-74-5
WeightAverage: 260.1358
Monoisotopic: 260.029718526
InChI KeyINAPMGSXUVUWAF-PTQMNWPWSA-N
InChIInChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/t1-,2-,3+,4-,5-,6-/m0/s1
IUPAC Name{[(1R,2S,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid
Traditional IUPAC Namemyo-inositol 1-phosphate
Chemical FormulaC6H13O9P
SMILESO[C@H]1[C@H](O)[C@H](O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1O
Chemical Taxonomy
Description belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassAlcohols and polyols
Direct ParentInositol phosphates
Alternative Parents
Substituents
  • Inositol phosphate
  • Monoalkyl phosphate
  • Cyclohexanol
  • Alkyl phosphate
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Secondary alcohol
  • Polyol
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External Descriptors
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility39.5 g/LALOGPS
logP-2ALOGPS
logP-3.9ChemAxon
logS-0.82ALOGPS
pKa (Strongest Acidic)1.16ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area167.91 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity46.65 m³·mol⁻¹ChemAxon
Polarizability20.63 ųChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • mitochondrion
  • endoplasmic reticulum
Organoleptic PropertiesNot Available
SMPDB Pathways
Inositol MetabolismPW002498 ThumbThumb?image type=greyscaleThumb?image type=simple
Inositol phosphate metabolismPW002495 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Inositol phosphate metabolismec00562 Map00562
SMPDB Reactions
1D-myo-inositol 3-phosphate + water → Myoinositol + phosphate
1D-myo-inositol 3-phosphate + water → Myoinositol + phosphate
1D-Myo-inositol 3,4-bisphosphate + water → 1D-myo-inositol 3-phosphate + phosphate
Glucose 6-phosphate → 1D-myo-inositol 3-phosphate
Glucose 6-phosphate → 1D-myo-inositol 3-phosphate
KEGG Reactions
water + inositol phosphoceramide ↔ 1D-myo-inositol 3-phosphate + ceramides
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Nunez, L. R., Henry, S. A. (2006). "Regulation of 1D-myo-inositol-3-phosphate synthase in yeast." Subcell Biochem 39:135-156.17121274
  • Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). "Growth control of the eukaryote cell: a systems biology study in yeast." J Biol 6:4.17439666
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI ID18169
HMDB IDHMDB06814
Pubchem Compound ID440194
Kegg IDC04006
ChemSpider ID24808130
FOODB IDFDB021907
Wikipedia IDInositol phosphate
BioCyc IDNot Available

Enzymes

Protein Details
1. Inositol phosphosphingolipids phospholipase C
General function:
Involved in metal ion binding
Specific function:
Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C). Also active on sphingomyelin, but this activity is probably not physiologically relevant
Gene Name:
ISC1
Uniprot ID:
P40015
Molecular weight:
53939.89844
Reactions
Protein Details
2. Inositol-3-phosphate synthase
General function:
Involved in inositol-3-phosphate synthase activity
Specific function:
D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate
Gene Name:
INO1
Uniprot ID:
P11986
Molecular weight:
59641.60156
Reactions
D-glucose 6-phosphate → 1D-myo-inositol 3-phosphate.
Protein Details
3. Inositol monophosphatase 1
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides
Gene Name:
INM1
Uniprot ID:
P38710
Molecular weight:
32823.0
Reactions
Myo-inositol phosphate + H(2)O → myo-inositol + phosphate.