{"ymdb_id":"YMDB00703","created_at":"2011-05-29T18:44:50.000Z","updated_at":"2016-09-08T18:35:48.000Z","name":"N(pros)-methyl-L-histidine","cas":"368-16-1","state":"Solid","melting_point":null,"description":"3-Methylhistidine is a methylated derivative of the amino acid histidine.","experimental_water_solubility":"200 mg/mL at 25 oC [BEILSTEIN]","experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Ohba, Masashi; Mukaihira, Takafumi; Fujii, Tozo. Preparatory study for the synthesis of the starfish alkaloid imbricatine. Syntheses of 5-arylthio-3-methyl-L-histidines. Chemical \u0026 Pharmaceutical Bulletin (1994), 42(9), 1784-90.","chebi_id":"27596","hmdb_id":"HMDB00479","kegg_id":"C01152","pubchem_id":"64969","cs_id":"58494","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid","traditional_iupac":"3,methylhistidine","logp":"-3.3952407273413714","pka":null,"alogps_solubility":"6.93e+00 g/l","alogps_logp":"-2.89","alogps_logs":"-1.39","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"81.14","refractivity":"42.9557","polarizability":"16.579381016239893","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.428858911874197","pka_strongest_acidic":"1.960164078727427","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoate","(2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid","1-Methylhistidine","3-methyl-L-histidine","3-methylhistidine","3-N-Methyl-L-histidine","l-3-methylhistidine","L-Histidine, 3-methyl-","N-pros-Methyl-L-histidine","N(pai)-Methyl-L-histidine","N(pi)-methyl-l-histidine","N3-Methyl-L-histidine","pi-Methyl-L-histidine","Tau-Methyl-L-histidine","Tau-methylhistidine"],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8647869,"citation":"Gary, J. D., Lin, W. J., Yang, M. C., Herschman, H. R., Clarke, S. (1996). \"The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae.\" J Biol Chem 271:12585-12594."}],"proteins":[{"created_at":"2011-05-27T03:36:30.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"HNRNP arginine N-methyltransferase","uniprot_id":"P38074","uniprot_name":"HMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"HMT1","num_residues":348,"molecular_weight":"39785.80078","theoretical_pi":"5.15","general_function":"Involved in protein methyltransferase activity","specific_function":"Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation","reactions":[{"id":1634,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1G6Q","cellular_location":null,"genbank_gene_id":"AY557869","genbank_protein_id":"45269629","gene_card_id":"HMT1","chromosome_location":"chromosome 2","locus":"YBR034C","synonyms":["Protein ODP1"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" post-translational protein modification"},{"category":"Process","description":" protein amino acid alkylation"},{"category":"Process","description":" protein amino acid methylation"}],"pfams":[{"name":"PrmA","identifier":"PF06325"}],"pathways":[],"gene_sequence":"ATGAGCAAGACAGCCGTGAAAGATTCTGCTACAGAAAAAACCAAGCTAAGTGAAAGCGAACAGCACTACTTCAATTCGTACGATCACTATGGTATTCACGAAGAGATGCTTCAAGATACTGTTCGTACCTTATCTTACAGAAACGCAATTATCCAAAATAAGGATCTTTTTAAGGACAAGATTGTTTTAGACGTCGGTTGCGGTACCGGTATTTTATCCATGTTTGCCGCTAAACACGGTGCGAAGCATGTTATCGGTGTTGATATGTCAAGCATTATTGAGATGGCGAAGGAATTGGTAGAGTTGAACGGATTCAGCGACAAGATCACCTTGCTAAGAGGCAAGTTGGAGGACGTTCATTTACCCTTTCCTAAAGTTGACATCATAATTTCTGAATGGATGGGTTACTTTCTACTATACGAGTCCATGATGGACACCGTTCTTTACGCTAGAGACCACTATTTGGTAGAAGGCGGTCTGATCTTTCCCGACAAGTGCTCCATTCATTTGGCCGGTTTGGAAGACTCTCAGTATAAAGACGAGAAGTTGAACTACTGGCAAGACGTTTACGGGTTTGATTATTCGCCATTTGTTCCGTTGGTCTTACACGAGCCCATCGTCGACACCGTGGAAAGAAACAATGTCAACACCACCTCAGACAAATTGATCGAATTTGATTTAAATACAGTAAAAATATCAGATCTAGCGTTTAAGAGTAACTTTAAATTGACGGCCAAGAGACAAGATATGATTAATGGTATAGTCACCTGGTTCGACATTGTTTTCCCTGCACCAAAGGGTAAGAGACCTGTTGAGTTCTCCACTGGTCCTCATGCTCCATACACTCACTGGAAGCAAACAATATTTTATTTCCCTGATGATCTAGATGCTGAAACTGGTGACACCATTGAAGGTGAATTGGTTTGCTCTCCAAACGAGAAGAATAACAGAGATCTAAATATCAAAATTTCTTACAAGTTCGAATCGAATGGCATCGACGGTAATTCAAGAAGCAGAAAAAACGAAGGTTCTTATTTAATGCATTAA","protein_sequence":"MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH"}]}