{"ymdb_id":"YMDB00510","created_at":"2011-05-29T18:25:01.000Z","updated_at":"2016-09-08T18:35:33.000Z","name":"Inosine","cas":"58-63-9","state":"Solid","melting_point":"218 oC","description":"Inosine is a purine nucleoside. It is formed by a molecule of hypoxanthine attached to a ribose sugar molecule. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.","experimental_water_solubility":"15.8 mg/mL at 20 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-2.10 [HANSCH,C ET AL. (1995)]","location":"extracellular;cytoplasm","synthesis_reference":"Shi, Qingshan; Qiu, Yutang; Li, Liangqiu; Lin, Xiaoping.  New inosine-producing bacterium and method for producing inosine.    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2003),     6 pp. ","chebi_id":"17596","hmdb_id":"HMDB00195","kegg_id":"C00294","pubchem_id":"6021","cs_id":"5799","foodb_id":null,"wikipedia_link":"Inosine","biocyc_id":"INOSINE","iupac":"9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one","traditional_iupac":"inosine","logp":"-1.9609272363333337","pka":"12.456472643760424","alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"8","donor_count":"4","rotatable_bond_count":"2","polar_surface_area":"129.20000000000002","refractivity":"60.898399999999995","polarizability":"24.603674083841288","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"2.7357381933005236","pka_strongest_acidic":"6.941792414582618","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-Inosine","1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one","1,9-Dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one","1,9-Dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one","9-b-D-ribofuranosyl-Hypoxanthine","9-b-D-Ribofuranosylhypoxanthine","9-beta-D-ribofuranosyl-Hypoxanthine","9-beta-D-Ribofuranosylhypoxanthine","9-beta-delta-ribofuranosyl-Hypoxanthine","9-beta-delta-Ribofuranosylhypoxanthine","9beta-D-Ribofuranosylhypoxanthine","9beta-delta-Ribofuranosylhypoxanthine","Atorel","beta-D-Ribofuranoside hypoxanthine-9","beta-delta-Ribofuranoside hypoxanthine-9","beta-Inosine","HXR","Hypoxanthine 9-beta-D-ribofuranoside","Hypoxanthine 9-beta-delta-ribofuranoside","Hypoxanthine D-riboside","Hypoxanthine nucleoside","Hypoxanthine ribonucleoside","Hypoxanthine riboside","hypoxanthine-9 beta-D-Ribofuranoside","hypoxanthine-9 beta-delta-Ribofuranoside","Hypoxanthine-9-beta-D-ribofuranoside","Hypoxanthine-9-beta-delta-ribofuranoside","Hypoxanthine-9-D-ribofuranoside","Hypoxanthine-9-delta-ribofuranoside","hypoxanthine-ribose","Hypoxanthosine","Indole-3-carboxaldehyde","Ino","Inosie","iso-prinosine","Oxiamin","Panholic-L","Pantholic-L","Ribonosine","Selfer","Trophicardyl"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12735798,"citation":"Itoh, R., Saint-Marc, C., Chaignepain, S., Katahira, R., Schmitter, J. M., Daignan-Fornier, B. (2003). \"The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.\" BMC Biochem 4:4."}],"proteins":[{"created_at":"2011-05-24T20:49:32.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Purine nucleoside phosphorylase","uniprot_id":"Q05788","uniprot_name":"PNPH_YEAST","enzyme":true,"transporter":false,"gene_name":"PNP1","num_residues":311,"molecular_weight":"33754.60156","theoretical_pi":"7.31","general_function":"Involved in purine-nucleoside phosphorylase activity","specific_function":"Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules","reactions":[{"id":1447,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1915,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1916,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1917,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1918,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1919,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1920,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1921,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2012,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2349,"direction":"\u003e","locations":null,"altext":"Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557950","genbank_protein_id":"45269792","gene_card_id":"PNP1","chromosome_location":"chromosome 12","locus":"YLR209C","synonyms":["PNP","Inosine phosphorylase"],"enzyme_classes":["2.4.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" purine-nucleoside phosphorylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" nucleoside metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"PNP_UDP_1","identifier":"PF01048"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGAGTGATATCTTGAACGTAAGTCAACAACGTGAAGCAATTACCAAGGCCGCTGCGTATATTTCTGCTATTTTAGAACCACATTTCAAAAATACAACAAATTTCGAGCCTCCGAGAACTTTGATTATATGTGGTTCAGGGCTTGGTGGAATATCTACCAAGCTGTCTAGAGACAATCCACCCCCGGTAACAGTCCCATACCAAGACATCCCAGGATTCAAGAAAAGTACGGTTCCAGGTCATTCCGGTACACTAATGTTCGGATCTATGAATGGTTCACCAGTAGTATTAATGAATGGTCGTCTTCATGGATATGAAGGCAACACATTGTTTGAGACTACTTTTCCTATTAGAGTGCTTAACCACATGGGTCATGTTCGTAATTTAATTGTCACTAATGCCGCTGGTGGTATAAACGCGAAATATCAAGCCTGCGATTTGATGTGCATTTATGATCATTTAAATATCCCTGGCCTTGCTGGCCAGCACCCATTGAGAGGTCCTAACTTGGATGAAGATGGACCTCGTTTTTTAGCCTTGAGTGATGCATATGATCTGGAGTTGAGGAAGCTTTTATTTAAGAAATGGAAAGAGCTCAAGATTCAAAGGCCACTGCATGAAGGTACTTATACTTTTGTATCTGGACCCACTTTCGAAACAAGAGCAGAATCCAAAATGATAAGGATGTTGGGAGGAGATGCTGTCGGAATGAGTACTGTTCCCGAAGTCATTGTTGCAAGACATTGCGGATGGAGGGTTTTGGCCTTAAGTTTGATTACCAATACTTGCGTGGTGGATAGCCCTGCCAGTGCGTTGGACGAATCACCTGTACCCTTAGAAAAAGGCAAAGCGACTCACGCTGAAGTACTGGAGAATGGTAAAATCGCCTCTAATGACGTGCAAAACTTAATTGCTGCCGTAATGGGGGAATTATAA","protein_sequence":"MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL"},{"created_at":"2011-05-26T16:49:15.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Adenosine deaminase","uniprot_id":"P53909","uniprot_name":"ADA_YEAST","enzyme":true,"transporter":false,"gene_name":"AAH1","num_residues":347,"molecular_weight":"39634.69922","theoretical_pi":"5.07","general_function":"Involved in deaminase activity","specific_function":"Adenosine + H(2)O = inosine + NH(3)","reactions":[{"id":1266,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1268,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1440,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2446,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Adenosine + H(2)O = inosine + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z46843","genbank_protein_id":"854497","gene_card_id":"AAH1","chromosome_location":"chromosome 14","locus":"YNL141W","synonyms":["Adenosine aminohydrolase"],"enzyme_classes":["3.5.4.4","3.5.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenosine deaminase activity"},{"category":"Function","description":" deaminase activity"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"}],"pfams":[{"name":"A_deaminase","identifier":"PF00962"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGTTTCTGTGGAGTTTTTACAGGAGTTACCAAAATGTGAGCATCACTTGCATTTGGAAGGTACTCTAGAACCTGACCTATTGTTCCCATTAGCTAAAAGAAACGATATAATTCTACCTGAAGGTTTTCCTAAATCGGTCGAGGAATTAAACGAAAAGTATAAGAAGTTTCGTGATCTGCAGGATTTCTTAGATTACTATTATATTGGTACTAATGTCTTGATTAGTGAACAAGATTTCTTTGATTTGGCGTGGGCCTATTTTAAAAAAGTTCACAAACAAGGCTTGGTCCATGCTGAAGTGTTTTACGACCCTCAGTCACATACATCTAGGGGCATCTCCATAGAAACAGTCACTAAAGGTTTCCAAAGAGCTTGTGACAAAGCCTTCTCTGAATTTGGTATTACATCCAAGCTAATTATGTGTCTGTTAAGACACATTGAACCAGAGGAATGTTTGAAAACTATCGAAGAAGCTACCCCATTTATTAAAGATGGTACTATCTCTGCCTTAGGATTAGATTCTGCTGAGAAACCATTTCCCCCACATTTATTTGTTGAATGTTACGGAAAGGCCGCCTCATTGAATAAAGATTTAAAACTAACTGCACACGCAGGTGAAGAAGGCCCCGCTCAATTCGTCTCGGATGCTTTAGACTTGTTGCAAGTAACAAGAATCGATCACGGTATCAACAGTCAATACGACGAGGAGTTATTGGATAGGTTGTCGCGCGACCAGACCATGCTAACTATTTGTCCTCTCTCCAACGTGAAGCTACAAGTAGTCCAATCCGTTTCAGAGTTACCACTACAAAAGTTTCTTGACAGAGATGTTCCATTTTCTTTAAATTCTGATGACCCCGCCTATTTTGGTGGTTATATCTTAGATGTCTACACTCAAGTTTCGAAAGATTTCCCACACTGGGACCATGAAACATGGGGTCGTATCGCTAAGAACGCCATTAAAGGTTCATGGTGTGACGATAAAAGAAAGAACGGTTTGTTAAGTAGAGTGGACGAAGTAGTCACTAAATATTCGCATTAG","protein_sequence":"MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFPKSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVFYDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEATPFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDALDLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDRDVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGLLSRVDEVVTKYSH"},{"created_at":"2011-05-27T07:02:22.000Z","updated_at":"2011-07-22T17:53:50.000Z","name":"IMP-specific 5'-nucleotidase 1","uniprot_id":"Q99312","uniprot_name":"ISN1_YEAST","enzyme":true,"transporter":false,"gene_name":"ISN1","num_residues":450,"molecular_weight":"51329.5","theoretical_pi":"5.07","general_function":"Involved in magnesium ion binding","specific_function":"IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation","reactions":[{"id":1209,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"Z75063","genbank_protein_id":"1420387","gene_card_id":"ISN1","chromosome_location":"chromosome 15","locus":"YOR155C","synonyms":[],"enzyme_classes":["3.1.3.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"}],"pfams":[{"name":"ISN1","identifier":"PF06437"}],"pathways":[],"gene_sequence":"ATGTCCTCAAGATATAGAGTGGAATATCATTTGAAGAGCCACCGCAAGGATGAGTTTATAGATTGGGTAAAGGGGCTACTGGCCTCACCTTTTGTTCTACATGCCGTCTCTCATGAAGGTGACTACAATGACGACTTAGCAACAACTCAACGTGTAAGGTCGCAGTATGCTGATATCTTTAAAGACATTGAAGGGCTGATTAAAGATAAAATAGAATTTGACTCAAGAAACATGAGCCAAGACGAAATTGAAGATGGCGCCTCTTCTCAATCTCTGAATATATTAGGACAATCGCGTTTAAATCTTTTGGTTCCATCAATTGGAACATTCTTTACGGAACTTCCATTGGAACAAGCTTTTCTATGGGAAGACTCACAACGGGCCATTTCGGCGCGTAGAATGGTAGCACCCAGTTTTAATGATATCAGGCATATCCTGAATACTGCACAGATATTTCACTTTAAGAAACAGGAGAACTTACATAATGGTAAGGTTTTGAGATTAGTGACTTTTGATGGAGATGTGACGCTGTATGAAGATGGTGGCTCCCTGGTTTACACTAATCCTGTAATTCCTTATATTCTCAAGCTGTTGCGGTGCGGTATCAATGTGGGAATAGTCACTGCGGCCGGATATGATGAAGCTGGAACCTATGAGAACAGATTGAAAGGATTAATTGTTGCATTACATGATTCAACTGATATACCAGTTTCTCAAAAGCAGAATTTAACAATAATGGGTGGTGAGTCGAGTTACCTTTTCCGTTACTATGAAGACCCGGAGGAAGATAACTTTGGCTTTAGACAAATTGACAAAGAGGAATGGCTATTGCCTAGAATGAAGGCTTGGTCCCTCGAGGACGTGGAAAAGACTTTGGACTTTGCCGAGAGAACTCTTAACAGGTTAAGAAAAAGACTAAACCTACCTTCAGAGATTTCTATTATCCGTAAAGTCAGGGCAGTGGGTATCGTCCCAGGCGAACGGTACGATGAAGCTTCTAAAAGACAAGTTCCTGTTAAGCTTGATAGGGAACAACTGGAGGAAATAGTTTTAACCCTTCAAAACACTTTAGAGTCTTTTGCCCCATCTAGAAGAATTCAATTTAGTTGTTTTGATGGTGGTAGTGATGTCTGGTGTGATATTGGGGGGAAAGATCTTGGTGTTCGTTCATTGCAACAATTTTATAACCCTGAATCTCCTATCCAACCCTCTGAAACCTTACACGTAGGCGATCAGTTTGCACCGGTGGGATCAGCAAATGATTTTAAGGCAAGGCTAGCTGGATGTACCCTCTGGATAGCATCCCCTCAAGAAACAGTGAATTATCTTCATAGATTATTAGAAACTGATTAA","protein_sequence":"MSSRYRVEYHLKSHRKDEFIDWVKGLLASPFVLHAVSHEGDYNDDLATTQRVRSQYADIFKDIEGLIKDKIEFDSRNMSQDEIEDGASSQSLNILGQSRLNLLVPSIGTFFTELPLEQAFLWEDSQRAISARRMVAPSFNDIRHILNTAQIFHFKKQENLHNGKVLRLVTFDGDVTLYEDGGSLVYTNPVIPYILKLLRCGINVGIVTAAGYDEAGTYENRLKGLIVALHDSTDIPVSQKQNLTIMGGESSYLFRYYEDPEEDNFGFRQIDKEEWLLPRMKAWSLEDVEKTLDFAERTLNRLRKRLNLPSEISIIRKVRAVGIVPGERYDEASKRQVPVKLDREQLEEIVLTLQNTLESFAPSRRIQFSCFDGGSDVWCDIGGKDLGVRSLQQFYNPESPIQPSETLHVGDQFAPVGSANDFKARLAGCTLWIASPQETVNYLHRLLETD"}]}