{"ymdb_id":"YMDB00500","created_at":"2011-05-29T18:24:04.000Z","updated_at":"2016-09-08T18:35:32.000Z","name":"Myo-Inositol hexakisphosphate","cas":"83-86-3","state":"Solid","melting_point":"\u003c 25 oC","description":"1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate (phytic acid or IP6) is an intermediate in inositol pyrophosphates biosynthesis pathway. IP6 is one of the most prevalent forms of phosphorylated inositols in the eukaryotic cell. It is a strong chelator of important minerals such as calcium, magnesium, iron and zinc. The main function of IP6 in yeast is related to regulation of mRNA export from the nucleus. In plant cells IP6 serves as a storage form of myo-inositol, phosphate and mineral nutrients for utilization during seed germination and seedling growth. [Biocyc PWY-6369 and PWY-6361]","experimental_water_solubility":"1000 mg/mL [MERCK INDEX (1996)]","experimental_logp_hydrophobicity":null,"location":"nucleus;cytoplasm","synthesis_reference":"Mitsuhashi Naoto; Ohnishi Miwa; Sekiguchi Yoko; Kwon Yong-Uk; Chang Young-Tae; Chung Sung-Kee; Inoue Yoshinori; Reid Robert J; Yagisawa Hitoshi; Mimura Tetsuro  Phytic acid synthesis and vacuolar accumulation in suspension-cultured cells of Catharanthus r","chebi_id":"17401","hmdb_id":"HMDB03502","kegg_id":"C01204","pubchem_id":"890","cs_id":"25060692","foodb_id":null,"wikipedia_link":"Phytic_acid","biocyc_id":"MI-HEXAKISPHOSPHATE","iupac":"{[2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphonic acid","traditional_iupac":"phytic acid","logp":"-4.52340584","pka":"0.5855923317656591","alogps_solubility":"1.37e+01 g/l","alogps_logp":"0.11","alogps_logs":"-1.68","acceptor_count":"18","donor_count":"12","rotatable_bond_count":"12","polar_surface_area":"400.56000000000006","refractivity":"101.0124","polarizability":"42.7084109516151","formal_charge":"0","physiological_charge":"-12","pka_strongest_basic":null,"pka_strongest_acidic":"0.1432375060866935","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["[2,3,4,5,6-pentakis(phosphonatooxy)cyclohexyl] phosphate","1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate","1D-myo-inositol hexakisphosphate","D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate","Inositol 1,2,3,4,5,6-hexakisphosphate","myo-Inositol 1,2,3,4,5,6-hexakisphosphate","myo-Inositol hexakisphosphate","myo-Inositol hexakisphosphic acid","Phytate","Phytic acid"],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":17563356,"citation":"Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). \"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.\" Proc Natl Acad Sci U S A 104:10364-10369."},{"pubmed_id":17412958,"citation":"Mulugu, S., Bai, W., Fridy, P. C., Bastidas, R. J., Otto, J. C., Dollins, D. E., Haystead, T. A., Ribeiro, A. A., York, J. D. (2007). \"A conserved family of enzymes that phosphorylate inositol hexakisphosphate.\" Science 316:106-109."},{"pubmed_id":11956213,"citation":"Dubois, E., Scherens, B., Vierendeels, F., Ho, M. M., Messenguy, F., Shears, S. B. (2002). \"In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.\" J Biol Chem 277:23755-23763."},{"pubmed_id":17412959,"citation":"Lee, Y. S., Mulugu, S., York, J. D., O'Shea, E. K. (2007). \"Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.\" Science 316:109-112."},{"pubmed_id":15665377,"citation":"Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). \"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.\" Mol Cell Proteomics 4:310-327."},{"pubmed_id":18407956,"citation":"Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). \"A multidimensional chromatography technology for in-depth phosphoproteome analysis.\" Mol Cell Proteomics 7:1389-1396."},{"pubmed_id":14562095,"citation":"Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). \"Global analysis of protein localization in budding yeast.\" Nature 425:686-691."},{"pubmed_id":10960485,"citation":"Ives, E. B., Nichols, J., Wente, S. R., York, J. D. (2000). \"Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases.\" J Biol Chem 275:36575-36583."},{"pubmed_id":10419486,"citation":"Safrany, S. T., Ingram, S. W., Cartwright, J. L., Falck, J. R., McLennan, A. G., Barnes, L. D., Shears, S. B. (1999). \"The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.\" J Biol Chem 274:21735-21740."},{"pubmed_id":17330950,"citation":"Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). \"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.\" J Proteome Res 6:1190-1197."},{"pubmed_id":15459192,"citation":"Miller, A. L., Suntharalingam, M., Johnson, S. L., Audhya, A., Emr, S. D., Wente, S. R. (2004). \"Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.\" J Biol Chem 279:51022-51032."}],"proteins":[{"created_at":"2011-05-24T19:50:13.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Inositol polyphosphate multikinase","uniprot_id":"P07250","uniprot_name":"IPMK_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG82","num_residues":355,"molecular_weight":"40352.5","theoretical_pi":"4.33","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity","reactions":[{"id":1661,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1662,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1663,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1664,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2276,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2277,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14818,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007006","source":"Smpdb"},{"id":14819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007031","source":"Smpdb"},{"id":14820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007032","source":"Smpdb"},{"id":14821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007033","source":"Smpdb"},{"id":14822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007034","source":"Smpdb"},{"id":14823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007035","source":"Smpdb"},{"id":14824,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007036","source":"Smpdb"},{"id":14825,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007037","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X05328","genbank_protein_id":"3376","gene_card_id":"ARG82","chromosome_location":"chromosome 4","locus":"YDR173C","synonyms":["IPMK","Arginine metabolism regulation protein III"],"enzyme_classes":["2.7.1.151"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGGATACGGTAAACAATTATAGGGTTTTAGAGCATAAAGCTGCTGGCCACGACGGTACTCTAACAGACGGTGATGGATTGCTCATCTTTAAACCGGCCTTTCCGCAGGAACTGGAATTCTACAAAGCCATACAAGTGAGAGATGTGAGTCGAAGAAAGTCTTCGGCTGATGGAGATGCTCCCTTGTGCTCTTGGATGCCCACGTATCTTGGAGTCTTGAATGAAGGGGCAAAAATCGAGCAAAGTGGCGATGCTGCGCTTCTGAAGATAGATGAGCGGTTAAGTGATTCCACTGATAATCTTGATTCAATACCTGTAAAGTCTGAGAAGTCCAAGCAATACCTCGTTTTAGAAAATCTACTATATGGATTTAGTAAACCTAATATACTTGATATAAAATTAGGCAAAACTTTGTATGATTCGAAGGCATCATTGGAAAAAAGAGAGAGAATGAAAAGAGTCAGTGAGACGACGACTTCAGGATCTTTGGGTTTCAGGATATGTGGCATGAAAATACAGAAAAATCCCTCTGTGCTGAATCAGCTTTCGCTCGAATATTACGAAGAAGAAGCAGACAGTGATTATATCTTTATAAACAAATTGTATGGTCGTTCAAGAACCGATCAAAATGTTTCAGATGCAATTGAACTTTATTTTAACAATCCTCATCTGTCGGATGCGAGAAAGCATCAACTGAAGAAAACATTTTTGAAAAGATTGCAGTTGTTTTATAATACTATGCTAGAAGAAGAAGTTAGAATGATATCAAGTAGTCTTTTGTTTATTTACGAAGGAGACCCGGAGCGATGGGAATTACTAAATGATGTTGACAAACTTATGCGAGATGATTTTATAGACGATGATGACGACGATGATGATAATGATGATGATGATGATGATGATGCCGAGGGAAGCAGCGAAGGACCAAAGGACAAAAAAACAACTGGTTCTTTGAGTTCCATGTCACTAATAGATTTTGCACATTCTGAAATAACGCCGGGGAAGGGTTATGATGAAAACGTGATTGAAGGAGTTGAAACCTTGCTAGATATTTTTATGAAATTCTAG","protein_sequence":"MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF"},{"created_at":"2011-05-24T19:59:56.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Diphosphoinositol polyphosphate phosphohydrolase DDP1","uniprot_id":"Q99321","uniprot_name":"DDP1_YEAST","enzyme":true,"transporter":false,"gene_name":"DDP1","num_residues":188,"molecular_weight":"21572.30078","theoretical_pi":"8.32","general_function":"Involved in hydrolase activity","specific_function":"May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)","reactions":[{"id":1198,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1214,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1225,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1468,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2288,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY558436","genbank_protein_id":"45270762","gene_card_id":"DDP1","chromosome_location":"chromosome 15","locus":"YOR163W","synonyms":["Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase","AP6A hydrolase","Diadenosine and diphosphoinositol polyphosphate phosphohydrolase 1"],"enzyme_classes":["3.6.1.52","3.6.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"NUDIX","identifier":"PF00293"}],"pathways":[],"gene_sequence":"ATGGGCAAAACCGCGGATAATCATGGTCCAGTACGTTCTGAGACAGCACGTGAAGGAAGAGAAAACCAGGTTTACTCACCCGTTACAGGTGCAAGATTAGTTGCTGGCTGCATATGTTTAACACCCGACAAGAAGCAAGTTCTCATGATTACTTCTTCTGCACACAAGAAAAGATGGATTGTCCCCAAAGGTGGCGTTGAGAAAGACGAGCCTAATTACGAGACGACTGCCCAACGAGAAACTTGGGAGGAAGCTGGTTGCATAGGTAAAATTGTCGCCAATTTGGGTACAGTTGAAGACATGAGACCCCCTAAGGACTGGAACAAAGACATTAAGCAATTCGAGAACTCTCGAAAAGATTCAGAAGTAGCAAAGCACCCGCCAAGAACCGAATTTCATTTTTATGAATTAGAGATTGAAAATCTCCTTGATAAATTTCCGGAATGTCACAAAAGACATAGAAAGCTATACTCTTATACAGAAGCTAAACAAAACTTGATAGACGCCAAGAGGCCTGAATTGTTGGAGGCCCTTAATAGGTCTGCTATCATTAAAGACGACAAATAG","protein_sequence":"MGKTADNHGPVRSETAREGRENQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKDEPNYETTAQRETWEEAGCIGKIVANLGTVEDMRPPKDWNKDIKQFENSRKDSEVAKHPPRTEFHFYELEIENLLDKFPECHKRHRKLYSYTEAKQNLIDAKRPELLEALNRSAIIKDDK"},{"created_at":"2011-05-24T20:00:21.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Inositol hexakisphosphate kinase 1","uniprot_id":"Q12494","uniprot_name":"KCS1_YEAST","enzyme":true,"transporter":false,"gene_name":"KCS1","num_residues":1050,"molecular_weight":"119549.0","theoretical_pi":"6.78","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance","reactions":[{"id":1199,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1215,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1226,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1469,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1667,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"S81651","genbank_protein_id":"1478442","gene_card_id":"KCS1","chromosome_location":"chromosome 4","locus":"YDR017C","synonyms":["InsP6 kinase 1","InsP6 kinase KCS1","PKC1 suppressor protein 1"],"enzyme_classes":["2.7.4.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[],"gene_sequence":"ATGGATACCTCTCACGAAATTCATGATAAAATACCCGATACATTAAGAGAGCAGCAGCAGCATTTGCGCCAAAAAGAGTCGGAAGGGTGCATAACAACATTGAAAGATCTTAATGTACCTGAGACGAAGAAACTTTCCTCCGTCTTACATGGCAGAAAGGCGAGTACATATTTAAGAATTTTTAGAGATGATGAATGTTTAGCCGATAACAACAATGGTGTAGATAGCAATAATGGCGGGTCCGTGACATGCGCGGACAAAATAACAAGGTCAGAAGCAACTCCCAAATCGGTACCAGAAGGACTACAAGTTTCTGAAAAAAAGAATAACCCAGATACTTTGTCCTCTTCATTGTCAAGTTTCATTTTATCTAACCACGAGGAGCCGGCAATTAAGCCCAATAAACACGTGGCGCATAGAAATAATATTACTGAGACAGGTCAAGGCTCTGGTGAGGATATCGCAAAACAACAATCACACCAACCACAGGTGTTACACCACCAGACTTCTTTAAAGCCAATTCAGAATGTTGATGAGGGATGTATTTCGCCTAAGTCCACTTATCAGGAGAGCTTACATGGAATATCGGAGGACTTAACGTTAAAGCCTGTTTCTTCTGCAACATACTATCCTCACAAAAGTAAAGCAGATTCTGGTTATGAAGAAAAGGATAAAATGGAAAATGATATTGATACTATTCAGCCTGCCACCATAAATTGTGCCTCTGGTATAGCGACACTTCCTAGTTCATATAACCGACATACTTTCAAAGTTAAGACATATTCAACTTTATCACAATCCCTAAGGCAAGAAAACGTCAACAATCGTAGTAACGAAAAAAAACCTCAACAGTTTGTGCCACATAGCGAATCAATTAAAGAAAAACCCAATACGTTTGAACAAGATAAAGAAGGCGAGCAAGCGGACGAAGAAGAGGATGAAGGTGATAATGAACATAGGGAATATCCCCTAGCAGTTGAACTAAAACCATTTACGAATAGAGTTGGAGGTCACACTGCAATATTCAGATTTTCGAAGAGAGCGGTTTGTAAGGCTCTAGTGAATAGAGAAAACAGGTGGTATGAGAATATAGAGCTGTGCCATAAAGAATTATTGCAATTCATGCCACGTTATATTGGTGTCCTGAATGTTAGGCAACATTTTCAGTCAAAAGATGACTTTTTAAGCGATTTGGATCAAGAAAACAACGGTAAAAATGATACCAGTAATGAAAACAAAGACATAGAAGTCAATCATAACAATAACGACGATATTGCGCTTAATACAGAACCCACGGGGACCCCCTTAACACACATACATTCCTTCCCCTTGGAACATTCGTCGAGACAAGTACTTGAAAAAGAGCATCCTGAAATTGAGTCTGTCCATCCACACGTGAAAAGATCACTGTCAAGTTCCAACCAACCTTCCTTGTTGCCCGAGGTTGTATTAAATGATAACAGGCATATTATACCGGAATCTCTGTGGTACAAATATTCCGATTCTCCAAACTCGGCACCGAATGATTCGTACTTTTCGTCCTCCTCTTCTCATAACTCATGTTCGTTCGGTGAGCGTGGCAATACAAATAAATTAAAAAGACGCGATTCTGGGTCCACCATGATCAATACTGAATTGAAGAACCTAGTCATAAGGGAAGTATTTGCACCGAAATGTTTTAGAAGGAAAAGAAACTCTAATACGACTACAATGGGAAACCATAATGCGCGTTTGGGTTCCAGTCCATCTTTTTTAACACAAAAATCAAGAGCCTCGTCCCATGATGCATCGAATACGTCTATGAAGACTCTTGGTGATTCATCGTCACAAGCGAGTTTACAGATGGATGACTCGAAAGTCAATCCGAATTTGCAGGATCCTTTCTTGAAAAAATCGCTTCATGAAAAAATATCTAATGCTTTAGATGGCTCGCATTCAGTAATGGATTTGAAGCAATTCCACAAAAACGAACAAATAAAACATAAAAACTCTTTCTGCAACTCTTTATCACCCATTCTCACTGCAACCAATTCTAGAGATGATGGCGAATTTGCCACCTCCCCGAATTATATCAGCAACGCACAAGATGGTGTTTTTGATATGGATGAAGATACGGGAAACGAAACTATAAATATGGATAACCACGGCTGCCATCTTGACTCTGGTAAAAACATGATTATAAAGTCATTGGCGTATAATGTTTCAAATGACTATAGTCATCATGATATTGAATCAATTACGTTTGAGGAGACGTCCCACACCATTGTTTCAAAATTTATCTTATTGGAAGATTTGACAAGAAACATGAACAAGCCTTGTGCACTGGATCTAAAGATGGGGACAAGACAATATGGCGTAGACGCCAAAAGAGCCAAGCAACTGTCACAGCGTGCAAAGTGTTTAAAGACCACTTCTAGGCGTTTAGGCGTTAGAATCTGCGGATTAAAGGTTTGGAACAAAGATTATTATATCACAAGAGATAAATACTTTGGTAGAAGGGTTAAGGTTGGTTGGCAATTTGCTAGGGTACTTGCACGTTTTTTGTATGATGGTAAGACCATTGAAAGTTTAATCAGGCAAATTCCAAGGTTGATCAAGCAACTAGATACTTTGTATTCTGAAATTTTTAATTTGAAAGGTTACAGGCTATATGGCGCGTCTTTATTACTAATGTACGATGGAGATGCTAATAAATCAAATTCTAAAAGGAAAAAAGCTGCTAATGTTAAAGTCAACTTGATCGATTTTGCACGTTGTGTTACTAAAGAAGATGCAATGGAATGTATGGATAAATTTCGTATACCCCCAAAATCGCCAAATATAGAAGATAAAGGGTTCTTACGAGGTGTGAAGAGCTTGAGGTTTTATCTGTTATTAATCTGGAATTATCTGACTTCTGATATGCCGTTAATTTTCGATGAAGTAGAGATGAATGATATGATTAGCGAAGAAGCAGATTCGAATAGTTTCACCTCCGCCACCGGTTCGAAAATCAACTTCAACAGTAAGTGGGATTGGTTAGATGAATTTGACAAAGAAGACGAAGAAATGTATAATGATCCAAATAGTAAACTAAGACAAAAATGGAGAAAATACGAGCTTATTTTCGACGCTGAACCAAGATACAATGACGATGCTCAAGTTAGTGATTGA","protein_sequence":"MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD"},{"created_at":"2011-05-24T20:01:03.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase","uniprot_id":"Q06685","uniprot_name":"VIP1_YEAST","enzyme":true,"transporter":false,"gene_name":"VIP1","num_residues":1146,"molecular_weight":"129754.0","theoretical_pi":"9.01","general_function":"Involved in acid phosphatase activity","specific_function":"Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth","reactions":[{"id":1198,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1221,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1222,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1225,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null},{"id":2291,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton","altext":"ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Cytoplasm, cytoskeleton","genbank_gene_id":"U20162","genbank_protein_id":"632676","gene_card_id":"VIP1","chromosome_location":"chromosome 12","locus":"YLR410W","synonyms":["InsP6 and PP-IP5 kinase"],"enzyme_classes":["2.7.4.21","2.7.4.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"},{"name":"RimK","identifier":"PF08443"}],"pathways":[],"gene_sequence":"ATGAGTGGGATAAAGAAGGAACCGATTGAATCTGATGAGGTTCCTCAACAAGAGACAAAAAATAACTTACCTAGTGCACCTTCTGAGATGTCACCCCTTTTCCTAAACAAAAACACACAGAAGGCTATGCAATCTATTGCACCAATATTGGAGGGTTTCAGTCCTAAGACGTCAGCTAGCGAAAATATGTCTTTGAAATTGCCACCTCCCGGTATTCAAGATGATCACAGTGAAGAGAATCTCACCGTGCATGATACTCTGCAAAGAACCATAAGCACTGCACTAGGAAACGGAAACAACACCAATACAGTTACAACTTCCGGTTTAAAAAAGGCAGACAGTGAATCAAAGTCAGAAGCTGATCCTGAGGGGCTCAGCAATTCTAACATAGTCAATGATGCAGATAACATAAATTCCATCTCCAAGACCGGATCGCCCCATTTACCTCAAGGAACAATGGACGCTGAGCAGACTAACATGGGAACTAACTCTGTACCTACTTCATCAGCTTCTTCACGCAAATCCTCGACTAGTCATCCCAAACCTAGGCTACCCAAGGTAGGGAAGATTGGGGTATGTGCAATGGATGCAAAAGTCCTTTCAAAGCCAATGAGACACATTTTGAATCGTTTAATTGAACATGGTGAATTTGAAACTGTCATTTTTGGAGATAAGGTGATTCTAGATGAAAGAATAGAGAATTGGCCAACTTGCGACTTTTTGATATCTTTCTTTTCTTCAGGATTTCCCCTAGATAAAGCAATTAAATACGTCAAGTTACGCAAGCCTTTCATTATCAATGATTTAATAATGCAAAAGATTTTGTGGGACAGGAGATTATGTCTACAAGTATTAGAAGCCTACAACGTTCCAACACCTCCTAGACTGGAAATCAGTAGAGATGGTGGTCCCCGTGCCAACGAAGAATTAAGGGCAAAATTACGTGAGCATGGCGTAGAAGTTAAACCCGTTGAAGAACCGGAATGGAAAATGGTTGATGATGATACTTTAGAAGTTGATGGGAAAACCATGACTAAGCCCTTTGTTGAAAAGCCCGTTGATGGTGAAGACCACAACATTTATATATACTATCATTCTAAGAACGGAGGAGGCGGTCGTCGTCTATTCCGTAAAGTTGGTAACAAGTCTTCTGAGTTTGATCCTACTTTGGTTCATCCTCGTACGGAGGGGTCTTACATTTATGAGCAGTTTATGGATACCGATAATTTCGAAGATGTGAAGGCTTATACGATTGGTGAGAACTTTTGTCACGCTGAAACTAGGAAATCACCTGTGGTTGATGGTATAGTTAGAAGAAATACTCATGGTAAAGAAGTTAGATATATTACTGAGTTATCAGACGAAGAGAAAACCATTGCTGGGAAAGTTTCCAAAGCTTTTTCACAAATGATCTGTGGTTTCGATTTGCTTCGCGTTTCTGGTAAAAGTTACGTCATTGATGTTAACGGATTTTCTTTTGTAAAGGATAACAAAGCTTACTATGATTCATGCGCCAATATATTGAGAAGTACCTTCATTGAAGCCAAAAAGAAGATGGATATGGAAAAGAAGAATCTGCCCATTATTCGTGAAGAAAAGGAACAAAAGTGGGTATTCAAAGGACTGGCTATCATTATCCGTCACGCGGACAGAACACCAAAACAGAAATTCAAACATTCATTCACTTCGCCTATTTTTATATCGTTACTAAAAGGTCACAAAGAAGAAGTTGTCATTCGGAATGTAAATGATTTAAAGATTGTTCTTCAGGCCTTAAGAATTGCGTTAGATGAAAAAGCAGGAAATCCAGCTAAAATTAAAGTGTTAGCAAACGCTCTAGAAAAGAAACTGAATTTTCCCGGTACGAAAATACAATTGAAACCGGTTTTAAATAAAGAGAACGAAGTGGAAAAAGTTCAGTTTATTTTGAAATGGGGTGGTGAACCCACTCATTCTGCCAAATATCAGGCTACGGAACTCGGAGAGCAAATGAGACAAGATTTTGACCTATTGAATAAGAGCATTCTACAAAACATCAAGATATTTTCATCGTCTGAGAGACGTGTTCTTCATACGGCGCAGTACTGGACCAGAGCTCTTTTTGGGGCCGATGAATTAGGTAGCGATGAAATCAGTATTAGAAAGGATCTTTTAGATGACAGTAATGCCGCCAAAGATTTAATGGATAAGGTGAAAAAGAAGTTGAAGCCACTTTTAAGAGAGGGTAAGGAAGCTCCCCCACAATTTGCCTGGCCTTCAAAGATGCCGGAGCCATATTTAGTCATAAAGCGAGTGGTTGAATTGATGAATTACCATAAAAAAATTATGGATAACAACTTTGCTAAAAAGGATGTCAACTCGATGCAAACAAGATGGTGTACTTCTGAAGATCCTAGTTTGTTTAAGGAAAGGTGGGATAAACTTTTCAAAGAATTCAATAATGCTGAAAAAGTCGATCCTTCTAAAATTTCTGAATTGTATGATACTATGAAGTATGATGCTCTTCACAACAGGCAGTTCCTAGAGAACATATTTGACCCGGGTCTTCCAAATGAAGCTATCGCCGATGAACTCGGCAGTCATTCTTTAGTTGACCGATACCCAATTAACGTTCTCGCCAAAAATAATTTTAAGATAATAGACAGTCATAGCATGAACAATTCTGGAAAGAACAGTAGTAATAGTGTTGGGTCGTTAGGATGGGTTCTGGAAAGCGGAAAAACATCTACAGCAAGAAACCCCAAATCTTCTTCTCAATTCGATGAGCCACGCTTTATGCAGTTGCGGGAGCTGTATAAGCTGGCCAAAGTATTGTTTGATTTTATCTGCCCCAAAGAATATGGTATTTCAGATGCAGAGAAACTGGATATCGGTTTGTTAACTTCGTTGCCTTTGGCAAAGCAAATACTAAATGATATAGGAGACATGAAAAATAGAGAAACTCCAGCTTGTGTTGCGTACTTCACCAAAGAGTCCCATATTTACACTCTATTGAATATCATATACGAATCTGGTATTCCAATGAGAATCGCTAGAAATGCTTTACCAGAACTAGACTACTTGTCGCAGATCACTTTTGAACTTTATGAGAGTACGGATGCTTCTGGTCAAAAATCGCATTCCATTAGACTAAAAATGTCTCCTGGGTGTCATACTCAAGATCCGTTAGATGTTCAATTAGATGACAGGCATTATATTAGTTGTATTCCAAAGATTTCCCTGACGAAGCATTTGGATATGGACTATGTTCAACAGAAATTGAGAAACAAATTTACCAGGGTCATTATGCCTCCGAAATTTACACCAGTAAACATTACGAGCCCCAACTTGAGTTTCCAGAAACGCAAAACCAGAAGAAAGTCGGTATCTGTTGAGAAGTTGAAACGTCCTGCCTCGTCCGGATCTTCATCATCTACCTCCGTTAACAAGACATTAGATTAG","protein_sequence":"MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSASENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEADPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFETVIFGDKVILDERIENWPTCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSPVVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKDNKAYYDSCANILRSTFIEAKKKMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPKQKFKHSFTSPIFISLLKGHKEEVVIRNVNDLKIVLQALRIALDEKAGNPAKIKVLANALEKKLNFPGTKIQLKPVLNKENEVEKVQFILKWGGEPTHSAKYQATELGEQMRQDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKEFNNAEKVDPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDIGDMKNRETPACVAYFTKESHIYTLLNIIYESGIPMRIARNALPELDYLSQITFELYESTDASGQKSHSIRLKMSPGCHTQDPLDVQLDDRHYISCIPKISLTKHLDMDYVQQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASSGSSSSTSVNKTLD"},{"created_at":"2011-05-26T19:29:06.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Inositol-pentakisphosphate 2-kinase","uniprot_id":"Q06667","uniprot_name":"IPK1_YEAST","enzyme":true,"transporter":false,"gene_name":"IPK1","num_residues":281,"molecular_weight":"32917.69922","theoretical_pi":"7.95","general_function":"Involved in ATP binding","specific_function":"Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate","reactions":[{"id":1660,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2570,"direction":"\u003e","locations":"Nucleus","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14853,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007030","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"AY557740","genbank_protein_id":"45269371","gene_card_id":"IPK1","chromosome_location":"chromosome 4","locus":"YDR315C","synonyms":["Inositol-1,3,4,5,6-pentakisphosphate 2-kinase","Ins(1,3,4,5,6)P5 2-kinase","InsP5 2-kinase"],"enzyme_classes":["2.7.1.158"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol pentakisphosphate 2-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ins_P5_2-kin","identifier":"PF06090"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGCAAGTCATCGGACGTGGTGGGGCAAATATACTGATTGATTATGGGGATCCTACGTGGTTGTGGCGATGCTGCATCCGTTGGCCCGATCTGTTATCATCAAATAATTCTTATACAATCAAAAACATCAGTTATATTAAAGATTATGTAGAACCTCTTCTACATGGCTTGCTTTGCCCGATGTATCTGATTGACGTCGATATAGAAGCTATAAGGCCAATTCTCAGTGACTTTATTCTAAATTTAGACGATAAGGTAGTCAAAGTTATCAAAATTAAAAATCTCACCAATAATACCTCAAATCTGATATTAAATAACCACTTTTTAAAATCTTATTGTTCACAAAATCTGCAAACAGTTATTTTAGAATTGAAGCCTAAATGGTTATACTATGATACAGATTACTGTAGGAACTGTACTCATAATGCATTTAAGGGTAGAGGCACTAAGTACTGTTACAATCAATTACTAATGAATCCAGCACACTTGGAATTAATATTTGGAGAATGTAATATATTTCCGGTTAAGTTTAAAGATGCCATGCATGAGTACTTGCGCAATGACAATAACATTTTCAAGATCCTTTATGATTTACAGAAAAAACTTACAAAGAACACAACTCCAATAAGTGACATAAAATCAATCAACGATGTAAACGATGAGCATCTGCTACTCATGACACTCAGAGACGTGACATGTTTCATTGAATGGAACAGTGCTGAAAATGCGTTGCACGTGAATATAATAGATGTAGATCTAAAGCCGAAAGAAAAATGGACCCATTGGACAAAAACTTACAGCCAGTTGACATCAAGCCAAAAAATTTATCATACTTCAAATAAATAA","protein_sequence":"MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK"}]}