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Identification
YMDB IDYMDB00456
Name2-Hydroxy-3-oxobutyl phosphate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
Description1-Deoxy-L-glycero-tetrulose 4-phosphate, also known as 3,4-dihydroxy-2-butanone 4-phosphate or 2-hydroxy-3-oxobutyl phosphate, belongs to the class of organic compounds known as monoalkyl phosphates. These are organic compounds containing a phosphate group that is linked to exactly one alkyl chain. 1-Deoxy-L-glycero-tetrulose 4-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). 1-Deoxy-L-glycero-tetrulose 4-phosphate exists in both E. coli (prokaryote) and yeast (eukaryote). Within yeast, 1-deoxy-L-glycero-tetrulose 4-phosphate participates in a number of enzymatic reactions. In particular, formic acid and 1-deoxy-L-glycero-tetrulose 4-phosphate can be biosynthesized from D-ribulose 5-phosphate; which is catalyzed by the enzyme 3,4-dihydroxy 2-butanone 4-phosphate synthase. In addition, 1-deoxy-L-glycero-tetrulose 4-phosphate and 5-amino-6-ribitylamino uracil can be converted into 6,7-dimethyl-8-(D-ribityl)lumazine through the action of the enzyme 6,7-dimethyl-8-ribityllumazine synthase. In yeast, 1-deoxy-L-glycero-tetrulose 4-phosphate is involved in the metabolic pathway called the riboflavin metabolism pathway.
Structure
Thumb
Synonyms
  • 1-Deoxy-L-glycero-tetrulose 4-phosphate
  • 3,4-Dihydroxy-2-butanone 4-phosphate
  • L-3,4-Dihydroxybutan-2-one 4-phosphate
  • 2-Hydroxy-3-oxobutyl phosphate
  • 3,4-Dihydroxy-2-butanone 4-phosphoric acid
  • 2-Hydroxy-3-oxobutyl phosphoric acid
  • 1-Deoxy-L-glycero-tetrulose 4-phosphoric acid
  • L-3,4-Dihydroxybutan-2-one 4-phosphoric acid
CAS numberNot Available
WeightAverage: 184.0844
Monoisotopic: 184.013674532
InChI KeyOKYHYXLCTGGOLM-UHFFFAOYSA-N
InChIInChI=1S/C4H9O6P/c1-3(5)4(6)2-10-11(7,8)9/h4,6H,2H2,1H3,(H2,7,8,9)
IUPAC Name(2-hydroxy-3-oxobutoxy)phosphonic acid
Traditional IUPAC Name2-hydroxy-3-oxobutyl phosphate
Chemical FormulaC4H9O6P
SMILESCC(=O)C(O)COP(O)(O)=O
Chemical Taxonomy
Description belongs to the class of organic compounds known as monoalkyl phosphates. These are organic compounds containing a phosphate group that is linked to exactly one alkyl chain.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic phosphoric acids and derivatives
Sub ClassPhosphate esters
Direct ParentMonoalkyl phosphates
Alternative Parents
Substituents
  • Monoalkyl phosphate
  • Monosaccharide
  • Acyloin
  • Alpha-hydroxy ketone
  • Secondary alcohol
  • Ketone
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateNot Available
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility24.9 g/LALOGPS
logP-1.6ALOGPS
logP-1.3ChemAxon
logS-0.87ALOGPS
pKa (Strongest Acidic)1.39ChemAxon
pKa (Strongest Basic)-3.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area104.06 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity34.81 m³·mol⁻¹ChemAxon
Polarizability14.38 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB Pathways
Riboflavin metabolismPW002443 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Riboflavin metabolismec00740 Map00740
SMPDB Reactions
D-ribulose 5-phosphateFormic acid + 2-Hydroxy-3-oxobutyl phosphate
2-Hydroxy-3-oxobutyl phosphate + 5-Amino-6-ribitylamino uracil6,7-Dimethyl-8-(1-D-ribityl)lumazine
KEGG Reactions
D-ribulose 5-phosphateFormic acid + 2-Hydroxy-3-oxobutyl phosphate + hydron
5-Amino-6-ribitylamino uracil + 2-Hydroxy-3-oxobutyl phosphatewater + 6,7-Dimethyl-8-(1-D-ribityl)lumazine + phosphate
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0007-9400000000-971962d1d681055c1e3cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00kr-3900000000-a3d7948fc05904e06862JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014s-9500000000-31ec6e7cea40d06a6892JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014r-9000000000-beb8708b4dc7d349cdeaJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-003r-5900000000-9e4612499bf4e2f07fc5JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9100000000-425643565aa835d01981JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-0ef89293cd43e0a1a071JSpectraViewer
References
References:
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Jin, C., Barrientos, A., Tzagoloff, A. (2003). "Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration." J Biol Chem 278:14698-14703.12595523
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI ID50606
HMDB IDNot Available
Pubchem Compound ID669
Kegg IDC15556
ChemSpider ID649
FOODB IDFDB030244
Wikipedia IDNot Available
BioCyc IDNot Available

Enzymes

General function:
Involved in riboflavin biosynthetic process
Specific function:
Condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydroxy-2-butanone 4- phosphate to produce 6,7-dimethyl-8-(1-D-ribityl)lumazine
Gene Name:
RIB4
Uniprot ID:
P50861
Molecular weight:
18555.40039
Reactions
2 6,7-dimethyl-8-(1-D-ribityl)lumazine → riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
General function:
Involved in 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Specific function:
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Gene Name:
RIB3
Uniprot ID:
Q99258
Molecular weight:
22567.40039
Reactions
D-ribulose 5-phosphate → formate + L-3,4-dihydroxybutan-2-one 4-phosphate.