{"ymdb_id":"YMDB00378","created_at":"2011-05-29T18:11:04.000Z","updated_at":"2016-10-18T17:11:28.000Z","name":"L-Proline","cas":"147-85-3","state":"Solid","melting_point":"221 oC","description":"Proline (abbreviated as Pro or P) is an alpha-amino acid or more technically an iminio acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a polar amino acid, because of the hydrophilic nature of its cycloalkyl side chain.  It is unique among the 20 protein-forming amino acids in that the alpha-amino group is secondary.  The distinctive cyclic structure of proline's side chain locks its φ backbone dihedral angle at approximately −75°, giving proline an exceptional conformational rigidity compared to other amino acids. Proline is biosynthetically derived from the amino acid L-glutamate and its immediate precursor is the imino acid (S)-1-pyrroline-5-carboxylate (P5C). Enzymes involved in a typical biosynthesis include: Glutamate kinase; Glutamate dehydrogenase and Pyrroline-5-carboxylate reductase. Proline and its derivatives are often used as asymmetric catalysts in organic reactions. The CBS reduction and proline catalysed aldol condensation are prominent examples.  In brewing, proteins rich in proline combine with polyphenols to produce haze (turbidity). Proline is typically the most abundant amino acid found in wine. During fermentation of wine most of the amino acids are practically depleted from the grape juice/ grape must (the juice component including skins, seeds and stems) by the time the first 30 g of sugar have been fermented. Yeast make use of alanine and argnine acids and ammonium (slightly) after the depletion of the other amino acids. Yeast then assimilate arginine only after the disappearance of ammonium from the grape must/juice. Yeasts do not utilize proline during fermentation although it is one of the principle amino acids found in must. During fermentation, yeasts assimilate between 1 and 2 g/L of amino acids. Towards the end of fermentation, yeasts excrete significant but variable amounts of different amino acids. Finally at the end of alcoholic fermentation, a few hundred mg/L of amino acids remain with proline generally represents half.","experimental_water_solubility":"162 mg/mL at 25 oC [MERCK INDEX (1996)]","experimental_logp_hydrophobicity":"-2.54 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":" Itoh, Tamio. Synthesis of L-proline from L-glutamine. Bulletin of the Chemical Society of Japan (1963), 36(1), 25-9","chebi_id":"17203","hmdb_id":"HMDB00162","kegg_id":"C00148","pubchem_id":"145742","cs_id":"128566","foodb_id":null,"wikipedia_link":"Proline","biocyc_id":"PRO","iupac":"(2S)-pyrrolidine-2-carboxylic acid","traditional_iupac":"L-proline","logp":"-2.568638276039985","pka":null,"alogps_solubility":"3.65e+02 g/l","alogps_logp":"-2.71","alogps_logs":"0.50","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"1","polar_surface_area":"49.33","refractivity":"28.064299999999996","polarizability":"11.50403298353395","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"11.332026115136207","pka_strongest_acidic":"1.9406707712827913","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-(S)-Proline","(-)-2-Pyrrolidinecarboxylate","(-)-2-Pyrrolidinecarboxylic acid","(-)-Proline","(S)-(-)-Proline","(S)-(-)-Pyrrolidine-2-carboxylate","(S)-(-)-Pyrrolidine-2-carboxylic acid","(S)-2-Carboxypyrrolidine","(S)-2-Pyrralidinecarboxylate","(S)-2-Pyrralidinecarboxylic acid","(S)-2-Pyrrolidinecarboxylate","(S)-2-Pyrrolidinecarboxylic acid","(S)-Proline","2-Pyrrolidinecarboxylate","2-Pyrrolidinecarboxylic acid","Proline"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YEB media with 0.5 mM glucose","concentration":"1075.0","concentration_units":"\u0026#181;M","error":"54.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"3.9","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T20:08:32.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Proline-specific permease","uniprot_id":"P15380","uniprot_name":"PUT4_YEAST","enzyme":false,"transporter":true,"gene_name":"PUT4","num_residues":627,"molecular_weight":"68786.79688","theoretical_pi":"7.59","general_function":"Involved in transport","specific_function":"Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also function as non- specific GABA permease. Can also transport alanine and glycine","reactions":[],"signal_regions":"None","transmembrane_regions":"115-136;142-162;191-210;229-247;262-281;306-326;351-370;408-427;455-473;483-503;522-542;558-578","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"M30583","genbank_protein_id":"172307","gene_card_id":"PUT4","chromosome_location":"chromosome 15","locus":"YOR348C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGTAAATATACTGCCCTTCCACAAGAACAATAGACACAGCGCGGGAGTCGTCACCTGCGCGGACGATGTTAGCGGCGACGGTAGCGGCGGCGACACCAAGAAGGAGGAGAATGTTGTCCAGGTAACGGAATCACCATCGTCCGGGTCGCGCAATAATCATCGCAGCGACAATGAAAAAGATGACGCCATCCGTATGGAGAAAATATCTAAGAACCAGTCCGCGTCGTCCAACGGCACCATCCGCGAGGATTTGATTATGGACGTGGACTTGGAGAAATCGCCCTCCGTCGATGGCGATAGCGAGCCGCACAAACTAAAACAAGGTTTGCAGTCGCGCCATGTGCAACTGATCGCGCTGGGCGGCGCCATCGGTACCGGTTTGCTGGTGGGGACTTCATCCACGCTTCATACGTGCGGTCCCGCGGGGCTGTTCATATCGTACATTATTATTTCCGCGGTGATCTACCCGATCATGTGCGCGCTGGGCGAAATGGTGTGCTTTTTGCCCGGTGATGGTTCTGACAGTGCCGGGTCGACGGCCAATCTGGTCACTAGGTACGTTGACCCTTCGTTGGGCTTCGCCACTGGGTGGAATTACTTCTACTGCTACGTCATTTTAGTGGCCGCCGAGTGTACGGCGGCATCCGGTGTGGTCGAATACTGGACCACCGCGGTTCCCAAGGGCGTTTGGATCACGATCTTTCTATGCGTGGTTGTTATACTAAACTTTTCCGCGGTCAAAGTGTACGGCGAATCCGAGTTTTGGTTCGCGTCTATCAAGATATTATGCATTGTGGGACTGATCATTCTGTCCTTTATTTTGTTTTGGGGTGGTGGCCCCAACCATGACCGTCTTGGCTTCAGATACTGGCAACATCCGGGCGCTTTTGCGCATCACCTCACGGGCGGATCGCTGGGTAACTTCACAGATATCTACACTGGGATTATCAAGGGCGCCTTCGCCTTCATTCTTGGTCCGGAACTGGTGTGCATGACTTCCGCGGAATGCGCGGACCAGCGTAGAAATATCGCTAAGGCTTCGCGCCGCTTTGTATGGAGACTGATCTTCTTCTACGTTCTGGGGACGCTGGCCATCTCCGTTATTGTTCCATATAATGACCCAACATTGGTAAATGCGCTGGCGCAGGGCAAACCGGGAGCCGGCTCGTCACCCTTTGTGATCGGAATTCAAAACGCCGGGATTAAGGTTCTTCCCCACATTATCAATGGGTGTATCTTGACCAGCGCGTGGTCTGCCGCCAATGCGTTTATGTTTGCGAGCACAAGATCCCTGTTGACCATGGCGCAAACGGGACAGGCACCCAAATGTTTGGGCAGAATCAACAAATGGGGTGTTCCATACGTGGCTGTGGGTGTTTCCTTCTTGTGTTCTTGTTTGGCATATCTGAACGTGTCTTCATCCACGGCAGACGTGTTCAATTGGTTTTCCAATATCAGCACCATTTCCGGGTTTCTGGGCTGGATGTGCGGCTGCATCGCGTACCTGAGATTCCGCAAGGCTATTTTCTACAATGGCCTCTACGACAGATTGCCTTTCAAGACGTGGGGACAGCCTTACACCGTGTGGTTCTCTCTCATTGTTATAGGCATCATCACCATTACCAACGGGTATGCCATTTTCATCCCTAAGTACTGGAGAGTAGCAGATTTCATAGCTGCCTACATCACCCTACCCATCTTCCTGGTTTTGTGGTTCGGCCATAAGCTGTATACTCGGACGTGGAGACAATGGTGGCTCCCTGTGTCCGAGATCGATGTTACTACAGGGCTAGTCGAGATCGAAGAGAAATCAAGAGAAATTGAGGAGATGAGATTACCCCCCACCGGTTTCAAAGACAAGTTCTTGGACGCCTTGTTGTAA","protein_sequence":"MVNILPFHKNNRHSAGVVTCADDVSGDGSGGDTKKEEDVVQVTESPSSGSRNNHRSDNEKDDAIRMEKISKNQSASSNGTIREDLIMDVDLEKSPSVDGDSEPHKLKQGLQSRHVQLIALGGAIGTGLLVGTSSTLHTCGPAGLFISYIIISAVIYPIMCALGEMVCFLPGDGSDSAGSTANLVTRYVDPSLGFATGWNYFYCYVILVAAECTAASGVVEYWTTAVPKGVWITIFLCVVVILNFSAVKVYGESEFWFASIKILCIVGLIILSFILFWGGGPNHDRLGFRYWQHPGAFAHHLTGGSLGNFTDIYTGIIKGAFAFILGPELVCMTSAECADQRRNIAKASRRFVWRLIFFYVLGTLAISVIVPYNDPTLVNALAQGKPGAGSSPFVIGIQNAGIKVLPHIINGCILTSAWSAANAFMFASTRSLLTMAQTGQAPKCLGRINKWGVPYVAVGVSFLCSCLAYLNVSSSTADVFNWFSNISTISGFLGWMCGCIAYLRFRKAIFYNGLYDRLPFKTWGQPYTVWFSLIVIGIITITNGYAIFIPKYWRVADFIAAYITLPIFLVLWFGHKLYTRTWRQWWLPVSEIDVTTGLVEIEEKSREIEEMRLPPTGFKDKFLDALL"},{"created_at":"2011-05-26T18:26:09.000Z","updated_at":"2011-05-27T15:01:04.000Z","name":"Probable prolyl-tRNA synthetase, mitochondrial","uniprot_id":"P39965","uniprot_name":"SYPM_YEAST","enzyme":true,"transporter":false,"gene_name":"AIM10","num_residues":576,"molecular_weight":"65879.70313","theoretical_pi":"7.45","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)","reactions":[{"id":2533,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18839","genbank_protein_id":"603324","gene_card_id":"AIM10","chromosome_location":"chromosome 5","locus":"YER087W","synonyms":["Altered inheritance rate of mitochondria protein 10","Proline--tRNA ligase","ProRS"],"enzyme_classes":["6.1.1.15"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" proline-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" prolyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" macromolecule metabolic process"}],"pfams":[{"name":"tRNA-synt_2b","identifier":"PF00587"}],"pathways":[],"gene_sequence":"ATGTCAGCTACTCTACTAAAGCAACCATTATGTACGGTTGTTCGGCAAGGTAAACAGTCCAAAGTGTCTGGATTGAACCTTTTGAGACTAAAGGCTCATTTGCACAGACAACACCTGTCACCTTCCTTGATAAAACTACACTCTGAATTGAAATTGGATGAGCTGCAAACTGATAACACCCCTGATTACGTCCGTTTAGTTTTAAGGTCCTCTGTATACGATGTTATTAATGAATCTCCAATCTCTCAAGGTGTAGGTTTGTCTTCCCGTCTAAACACGAATGTCATCTTGAAAAGAGAAGATCTATTGCCTGTTTTCTCTTTCAAGCTTCGTGGTGCCTATAACATGATTGCCAAGTTGGACGATTCTCAAAGAAACCAGGGTGTTATTGCCTGTTCAGCTGGGAATCATGCCCAAGGTGTGGCCTTTGCTGCTAAACACTTGAAAATACCTGCTACTATCGTTATGCCTGTTTGTACACCATCTATTAAGTATCAAAATGTCTCGAGATTAGGGTCTCAAGTCGTCCTATATGGTAACGATTTTGACGAGGCTAAGGCTGAATGTGCCAAATTGGCTGAAGAGCGTGGCTTGACGAACATTCCTCCTTTCGATCATCCTTATGTCATTGCCGGTCAAGGTACTGTAGCTATGGAAATCCTAAGACAAGTACGTACCGCTAATAAGATCGGTGCTGTCTTTGTTCCCGTCGGCGGTGGTGGTTTAATTGCTGGTATTGGTGCTTATTTGAAAAGGGTTGCTCCTCATATCAAAATCATTGGTGTTGAAACTTACGATGCGGCCACTTTACATAATTCCTTGCAACGCAACCAGAGAACTCCTTTACCTGTGGTGGGTACTTTTGCCGATGGTACGTCTGTGCGTATGATTGGTGAAGAAACATTTAGAGTCGCCCAACAAGTGGTTGATGAAGTTGTTCTTGTTAACACTGACGAAATCTGTGCTGCAGTAAAGGATATTTTTGAAGATACTAGAAGTATTGTAGAACCATCTGGTGCCCTTTCAGTAGCCGGTATGAAGAAATACATCTCTACCGTACATCCAGAAATTGACCACACTAAAAACACCTATGTTCCCATCCTTTCTGGTGCTAACATGAACTTTGATAGATTAAGATTTGTTTCCGAACGTGCTGTTCTTGGTGAAGGAAAGGAAGTCTTCATGTTAGTTACTTTACCCGACGTCCCTGGTGCGTTCAAGAAAATGCAAAAGATCATCCACCCAAGATCTGTCACTGAATTCTCTTACCGTTACAATGAACATCGTCATGAGTCCTCTAGTGAAGTGCCCAAGGCTTACATTTACACTTCTTTCAGCGTCGTTGACAGAGAAAAGGAAATCAAGCAAGTTATGCAACAGTTGAATGCTTTAGGTTTTGAAGCTGTGGATATCTCCGATAACGAATTGGCTAAATCTCATGGTAGATACTTGGTTGGTGGTGCTTCTAAGGTTCCTAATGAAAGAATTATTTCATTTGAATTCCCTGAAAGACCAGGTGCCTTGACTAGGTTCCTTGGAGGCCTAAGCGATTCTTGGAATCTTACTTTATTCCATTATAGAAACCATGGTGCCGATATCGGTAAGGTTTTAGCTGGTATTTCCGTTCCTCCAAGGGAAAACTTAACCTTCCAAAAATTCTTGGAAGATTTAGGCTACACTTATCATGATGAAACTGATAACACTGTTTATCAAAAATTCTTGAAATATTAA","protein_sequence":"MLKYRTLSRSCHIFHPKSLSNNTLKSETTQELLQTVGFVRRSQVGLFQWLPLGLRSLNKVSNAIRNRMDSDGGAIEVSLSAISSKALWQATDRWNNSELFKLKDSKGKQYCLTATCEEDITDLMKNYIASYKDMPITIYQMTRKYRDEIRPRGGILRGREFLMKDAYSFASNEEDAFASFQKLDDTYNKIFKDLKIPFVSAWADSGDIGGEFSKEFHLIHESGEDTLMSCKHCGDISTLDMSQSYPEKDGQYSGDVDCKYALTKDHSTLICFYYPKDRQLNWNLALNAMDKDIDLTLRNKPNDHVLQVYEKDNEDIMFSKILRVMDCRLNSKSNFPDFPLKKYLKNNFGQISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNVKFVDKENKNETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWPAIMAPYKVSICTGPNNPENSQRLQDVKSELLNDPTMQNLQNDILDQFNEKLGIGARIKLSHAMGIPLCVIVGSKSWPNVEIEVRGIRWGEKDLWRKQFEKRCSELQWKCTKNEHGIEKHTVPIQHLAEVIGVLLKDM"},{"created_at":"2011-05-26T19:09:25.000Z","updated_at":"2011-05-26T19:09:25.000Z","name":"Putative prolyl-tRNA synthetase YHR020W","uniprot_id":"P38708","uniprot_name":"YHI0_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":688,"molecular_weight":"77385.70313","theoretical_pi":"6.35","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)","reactions":[{"id":1912,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2533,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U10399","genbank_protein_id":"500692","gene_card_id":null,"chromosome_location":null,"locus":"YHR020W","synonyms":["Proline--tRNA ligase","ProRS"],"enzyme_classes":["6.1.1.15"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" proline-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" prolyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" macromolecule metabolic process"}],"pfams":[{"name":"HGTP_anticodon","identifier":"PF03129"},{"name":"tRNA-synt_2b","identifier":"PF00587"},{"name":"ProRS-C_1","identifier":"PF09180"}],"pathways":[],"gene_sequence":"ATGCCTGTTTCGGAAGCGTTTGCCAAGTTGTGTGTGAATGAGAAGCCTCCTGCTGAATCTGCCGTTGCGGTGAAGTCTTTGGTCTTCAAACCAAAGACTCCAAAGTCCGCCACCCCTGTTCCTATCGTTGTGGTGGCTTTGCAATCTACTACTACTCCTTCTGCGTTGATTGCCAACGCTACGTCCAGTAAGGATCCAAGATTGGCTCGCGATGATTTGGTCAAGCAAGCGTTCCAATCTGAATCCGCTAGAGCTTTTATCTTGGGGGATTTGGCTAACGCCACGTCCAATTTTCACTTGCTAATTGATCACGAGTTGGGTACTGTTGACGGTGACACTATCTTGCAGTTAAACGACAGTACTTATATGAAGAAATCTGACATGATGAAATTTCTAAACAATTTTGAGGATAGTCAAAAAGTGGTTGATTTCTCCCAAGAGGTGTCTAAGGAAACCGCTACAGAAGGCAAGAAACAACAGAAAAAGCAGCAACCTTCTAAGGCAGGCACTGCAGCAGCAGCAGCAGCAGCAGCTTTGGAAGACGCCAAACTTATTGGTATCACCGTAGACAAAGCGTTGGATTTCCCAGGCTGGTACCAACAAATCTTGACCAAGGGTGAAATGTTGGACTACTACGATGTTTCTGGCTGTTACATCTTAAGACCTCCTTCTTATGCGATCTGGGAAAACATTCAGAAATGGTTCGACGACAAGATCAAGGCCATTGGTGTACAAAATGCCTATTTCCCAATGTTTGTTTCCTCACGTGTGTTGGAAAAGGAAAAGGACCATGTTGAAGGCTTTGCTCCAGAAGTTGCCTGGGTCACCAGAGCTGGCTCCTCTGAATTGGAAGAACCAATCGCCATTAGACCAACTTCTGAAACTGTCATGTATCCTTACTACGCAAAATGGGTCCAGTCTTACAGAGATTTACCATTGAAACTAAACCAATGGAATTCTGTGGTTAGATGGGAATTCAAGCATCCTCAGCCCTTTTTAAGAACCAGAGAATTCTTGTGGCAAGAAGGTCATACTGCTCACTTGACTGCTAAGGATGCCGAAGAGGAGGTTTTGCAAATCTTAGATTTCTACGCTGGGGTTTACGAAGAGTTATTAGCTGTTCCAGTGGTTAAGGGTAGAAAGACCGAAAAGGAAAAATTTGCTGGTGGTGACTTCACCACAACTTGTGAAGGCTATATTCCACAAACCGGTCGTGGTATTCAAGGTGCCACCTCTCACCATTTGGGCCAAAACTTTTCTAAGATGTTCAATTTGTCTGTGGAGAACCCACTAGGTTCTGATCATCCAAAGATCTTTGCGTACCAAAATTCATGGGGTTTATCCACTCGTGTCATTGGTGTCATGGTCATGATCCACTCTGACAACAAGGGTTTGGTTATCCCACCAAGAGTGTCCCAATTCCAATCCGTTGTCATTCCAGTGGGCATCACAAAGAAGACCTCTGAGGAACAGCGTAAACACATTCATGAAACAGCCAGAAGTGTGGAATCCCGTTTGAAAAAGGTTGGCATTAGAGCCTTTGGTGACTATAACGATAATTACACACCAGGTTGGAAATTTTCCCAATACGAGCTAAAGGGTATTCCAATCCGTATTGAATTAGGTCCTAAGGATATTGAAAAAAACCAAGTCGTTGTCGTTCGTAGAAATGACTCCAAGAAATACGTCGTTTCTTTCGACGAATTGGAAGCCCGTATCCCAGAAATCTTAGAAGAAATGCAAGGAGATTTGTTCAAAAAAGCCAAGGAGCTATTCGACACCCACAGAGTTATCGTTAATGAATGGAGTGGTTTTGTTCCAGCATTGAACAAGAAGAACGTTATCTTAGCACCATGGTGTGGTGTGATGGAATGTGAAGAAGATATCAAGGAATCTTCTGCAAAGAAAGACGATGGTGAAGAATTCGAGGAAGATGACAAGGCACCAAGTATGGGTGCCAAATCTTTATGTATCCCATTCGACCAACCTGTATTGAATGAAGGTCAAAAATGTATCAAGTGTGAACGTATTGCTGTCAATTACTGTATGTTCGGTCGTTCTTATTAG","protein_sequence":"MPVSEAFAKLCVNEKPPAESAVAVKSLVFKPKTPKSATPVPIVVVALQSTTTPSALIANATSSKDPRLARDDLVKQAFQSESARAFILGDLANATSNFHLLIDHELGTVDGDTILQLNDSTYMKKSDMMKFLNNFEDSQKVVDFSQEVSKETATEGKKQQKKQQPSKAGTAAAAAAAALEDAKLIGITVDKALDFPGWYQQILTKGEMLDYYDVSGCYILRPPSYAIWENIQKWFDDKIKAIGVQNAYFPMFVSSRVLEKEKDHVEGFAPEVAWVTRAGSSELEEPIAIRPTSETVMYPYYAKWVQSYRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLTAKDAEEEVLQILDFYAGVYEELLAVPVVKGRKTEKEKFAGGDFTTTCEGYIPQTGRGIQGATSHHLGQNFSKMFNLSVENPLGSDHPKIFAYQNSWGLSTRVIGVMVMIHSDNKGLVIPPRVSQFQSVVIPVGITKKTSEEQRKHIHETARSVESRLKKVGIRAFGDYNDNYTPGWKFSQYELKGIPIRIELGPKDIEKNQVVVVRRNDSKKYVVSFDELEARIPEILEEMQGDLFKKAKELFDTHRVIVNEWSGFVPALNKKNVILAPWCGVMECEEDIKESSAKKDDGEEFEEDDKAPSMGAKSLCIPFDQPVLNEGQKCIKCERIAVNYCMFGRSY"},{"created_at":"2011-05-27T02:30:51.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Proline dehydrogenase, mitochondrial","uniprot_id":"P09368","uniprot_name":"PUT1_YEAST","enzyme":true,"transporter":false,"gene_name":"PUT1","num_residues":476,"molecular_weight":"53270.89844","theoretical_pi":"9.31","general_function":"Involved in proline dehydrogenase activity","specific_function":"Converts proline to delta-1-pyrroline-5-carboxylate","reactions":[{"id":1911,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2677,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY692906","genbank_protein_id":"51013263","gene_card_id":"PUT1","chromosome_location":"chromosome 12","locus":"YLR142W","synonyms":["Proline oxidase"],"enzyme_classes":["1.5.99.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" proline dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" glutamate metabolic process"},{"category":"Process","description":" glutamate biosynthetic process"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline catabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Pro_dh","identifier":"PF01619"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGATAGCTTCCAAAAGCTCCTTATTAGTTACTAAATCGCGCATACCCTCTCTATGCTTTCCTTTGATAAAGAGGTCCTATGTGTCAAAGACTCCGACACACTCTAACACGGCTGCTAATCTGATGGTTGAAACTCCGGCCGCCAATGCCAACGGCAATAGTGTGATGGCACCTCCTAACTCAATCAATTTTCTACAGACACTTCCCAAGAAGGAACTATTCCAACTGGGATTCATCGGTATTGCGACCTTGAACAGCTTCTTCCTGAACACGATCATTAAGTTGTTCCCTTACATCCCCATCCCAGTAATAAAATTCTTCGTCTCTTCTTTATACTGTGGCGGTGAGAACTTTAAAGAGGTCATCGAATGCGGCAAACGTCTGCAGAAGAGAGGTATATCGAACATGATGCTTTCATTAACTATTGAAAATTCCGAAGGTACAAAGAGTTTGTCCAGTACTCCAGTAGACCAAATTGTCAAGGAAACAATCAGCTCTGTCCACAACATCCTACTGCCCAATATTATTGGCCAGCTGGAATCTAAGCCAATCAATGACATTGCTCCAGGTTATATCGCTCTAAAACCCTCTGCTTTGGTCGATAACCCTCACGAGGTTCTGTACAATTTCAGTAATCCCGCCTACAAGGCTCAAAGGGATCAGCTGATCGAGAACTGCTCTAAGATTACAAAAGAGATTTTTGAACTAAATCAATCTTTGTTAAAGAAGTACCCTGAAAGAAAGGCCCCATTTATGGTTTCCACTATTGACGCTGAGAAGTATGATTTGCAGGAGAATGGTGTTTACGAATTACAGAGAATCTTATTTCAAAAATTCAATCCCACTTCATCTAAACTGATATCATGTGTCGGTACTTGGCAGTTGTACCTAAGGGACTCTGGTGACCATATTTTGCACGAATTGAAGCTGGCCCAAGAAAACGGCTATAAGCTTGGGCTGAAACTGGTTCGTGGTGCTTATATTCATTCTGAAAAAAACCGTAACCAAATTATCTTTGGCGATAAAACGGGCACTGACGAAAATTACGATCGTATCATCACTCAAGTTGTCAATGATTTAATCATCAATGGCGAGGATTCTTATTTTGGTCACTTGGTTGTCGCCTCTCATAATTACCAATCCCAAATGCTCGTTACTAATTTGCTAAAATCTACCCAAGACAACTCTTATGCCAAATCGAACATTGTGTTGGGGCAATTACTAGGTATGGCAGATAATGTTACCTATGACCTAATTACCAACCATGGCGCTAAAAACATAATCAAGTATGTCCCATGGGGCCCACCATTGGAAACTAAAGATTATCTTTTGAGAAGATTGCAAGAAAACGGGGATGCTGTGAGATCTGATAATGGCTGGCCATTAATCAAGGCCATAGCAAAGTCGATTCCAAAAAGAGTAGGCCTATGA","protein_sequence":"MIASKSSLLVTKSRIPSLCFPLIKRSYVSKTPTHSNTAANLMVETPAANANGNSVMAPPNSINFLQTLPKKELFQLGFIGIATLNSFFLNTIIKLFPYIPIPVIKFFVSSLYCGGENFKEVIECGKRLQKRGISNMMLSLTIENSEGTKSLSSTPVDQIVKETISSVHNILLPNIIGQLESKPINDIAPGYIALKPSALVDNPHEVLYNFSNPAYKAQRDQLIENCSKITKEIFELNQSLLKKYPERKAPFMVSTIDAEKYDLQENGVYELQRILFQKFNPTSSKLISCVGTWQLYLRDSGDHILHELKLAQENGYKLGLKLVRGAYIHSEKNRNQIIFGDKTGTDENYDRIITQVVNDLIINGEDSYFGHLVVASHNYQSQMLVTNLLKSTQDNSYAKSNIVLGQLLGMADNVTYDLITNHGAKNIIKYVPWGPPLETKDYLLRRLQENGDAVRSDNGWPLIKAIAKSIPKRVGL"},{"created_at":"2011-05-27T02:32:56.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Pyrroline-5-carboxylate reductase","uniprot_id":"P32263","uniprot_name":"P5CR_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO3","num_residues":286,"molecular_weight":"30131.59961","theoretical_pi":"5.17","general_function":"Involved in oxidoreductase activity","specific_function":"L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H","reactions":[{"id":1700,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1701,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1931,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2679,"direction":"\u003e","locations":null,"altext":"L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3718,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006234","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M57886","genbank_protein_id":"172243","gene_card_id":"PRO3","chromosome_location":"chromosome 5","locus":"YER023W","synonyms":["P5C reductase","P5CR"],"enzyme_classes":["1.5.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" pyrroline-5-carboxylate reductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"F420_oxidored","identifier":"PF03807"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTACACATTGGCAATTTTAGGCTGCGGTGTTATGGGCCAAGCACTTCTTTCCGCCATTTATAATGCTCCAAAGGCGGCTGATGAAACTGCTGCTGCATTTTACCCTTCCAAAATTATCACATGTAACCATGATGAACCTAGTGCACAACAAGTTACCGATCTAGTTGAGACATTCGACGAATCTCCTAACGGTATTAAAGTCGAAAGCACTTACGGTCACAACGTGAGCGCTGTCGAAGAAGCTTCTGTAGTTCTTCTTGGTACCAAGCCATTTTTGGCCGAAGAAGTGTTGAATGGTGTGAAGAGCGTCATTGGGGGAAAGCTACTTATTTCCCTGGCTGCTGGCTGGACAATTGACCAATTGAGTCAATACACTAGCACTGTTTGCCGTGTTATGACGAACACACCTGCCAAGTACGGATATGGTTGTGCGGTGGTGTCCTACTCAGCTGATGTTTCCAAAGAGCAAAAGCCACTGGTCAACGAATTGATTAGCCAAGTTGGTAAATACGTTGAGCTTCCAGAAAAGAACATGGATGCTGCTACGGCTTTAGTCGGTTCAGGCCCCGCTTTTGTTCTCTTGATGTTAGAATCCTTGATGGAGAGTGGGTTGAAATTGGGAATCCCATTACAAGAGAGTAAGGAGTGTGCCATGAAAGTTCTAGAAGGAACAGTGAAGATGGTTGAGAAAAGCGGTGCTCATCCATCCGTTTTAAAGCATCAAGTTTGCACACCAGGTGGTACAACTATTGCCGGGTTGTGCGTAATGGAAGAAAAGGGCGTCAAGAGCGGTATTATCAATGGTGTTGAAGAGGCAGCCCGTGTTGCGTCACAATTAGGCCAAAAGAAGAAATAG","protein_sequence":"MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK"},{"created_at":"2016-09-09T22:43:43.000Z","updated_at":"2016-09-09T22:43:43.000Z","name":"Aldehyde dehydrogenase 2, mitochondrial","uniprot_id":"P32872","uniprot_name":null,"enzyme":false,"transporter":false,"gene_name":null,"num_residues":null,"molecular_weight":null,"theoretical_pi":null,"general_function":null,"specific_function":null,"reactions":[{"id":3719,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006235","source":"Smpdb"},{"id":3720,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006236","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"cellular aldehyde metabolic process"},{"category":"Function","description":"ethanol catabolic process"},{"category":"Function","description":"mitochondrial matrix"},{"category":"Function","description":"aldehyde dehydrogenase (NAD) activity"},{"category":"Function","description":"aldehyde dehydrogenase [NAD(P)+] activity"}],"pfams":[],"pathways":[{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":null,"protein_sequence":null}]}