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Identification
YMDB IDYMDB00275
NameDihydroxyacetone phosphate acyl ester
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionDihydroxyacetone Phosphate Acyl Ester, also known as 1-acyl-glycerone 3-phosphate, belongs to the class of organic compounds known as o-acylglycerone-phosphates. These are glycerone-3-phosphates carrying an acyl substituent at the 1-position. Dihydroxyacetone Phosphate Acyl Ester is an extremely weak basic (essentially neutral) compound (based on its pKa). Dihydroxyacetone Phosphate Acyl Ester exists in all eukaryotes, ranging from yeast to humans.
Structure
Thumb
Synonyms
  • 1-acyl-glycerone 3-phosphate
  • 1-acylglycerone 3-phosphate
  • 1-acylglycerone 3-phosphates
  • Acylglycerone phosphate
  • Dihydroxyacetone phosphoric acid acyl ester
  • [3-(Formyloxy)-2-oxopropoxy]phosphonate
CAS numberNot Available
WeightAverage: 198.0679
Monoisotopic: 197.99293909
InChI KeyIWFZHMQFZRLGDQ-UHFFFAOYSA-N
InChIInChI=1S/C4H7O7P/c5-3-10-1-4(6)2-11-12(7,8)9/h3H,1-2H2,(H2,7,8,9)
IUPAC Name[3-(formyloxy)-2-oxopropoxy]phosphonic acid
Traditional IUPAC Name3-(formyloxy)-2-oxopropoxyphosphonic acid
Chemical FormulaC4H7O7P
SMILES[H]OP(=O)(O[H])OC([H])([H])C(=O)C([H])([H])OC([H])=O
Chemical Taxonomy
Description belongs to the class of organic compounds known as o-acylglycerone-phosphates. These are glycerone-3-phosphates carrying an acyl substituent at the 1-position.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbonyl compounds
Direct ParentO-acylglycerone-phosphates
Alternative Parents
Substituents
  • O-acylglycerone-phosphate
  • Monosaccharide phosphate
  • Alpha-acyloxy ketone
  • Monoalkyl phosphate
  • Alkyl phosphate
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Monosaccharide
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water Solubility14 mg/mL [Predicted by ALOGPS]PhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility14 g/LALOGPS
logP-1.2ALOGPS
logP-1.3ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)1.19ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area110.13 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity35.13 m³·mol⁻¹ChemAxon
Polarizability14.72 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular LocationsNot Available
Organoleptic PropertiesNot Available
SMPDB Pathways
Ether lipid metabolismPW002492 ThumbThumb?image type=greyscaleThumb?image type=simple
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Ether lipid metabolismec00565 Map00565
Glycerophospholipid metabolismec00564 Map00564
SMPDB ReactionsNot Available
KEGG Reactions
acyl-CoA + Dihydroxyacetone phosphateCoenzyme A + Dihydroxyacetone phosphate acyl ester
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI ID15835
HMDB IDHMDB11750
Pubchem Compound ID6857386
Kegg IDC03372
ChemSpider ID5256726
FOODB IDFDB028422
Wikipedia IDNot Available
BioCyc ID1-ACYL-GLYCERONE-3-PHOSPHATE

Enzymes

General function:
Involved in acyltransferase activity
Specific function:
G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase
Gene Name:
GPT1
Uniprot ID:
P32784
Molecular weight:
85693.5
Reactions
Acyl-CoA + sn-glycerol 3-phosphate → CoA + 1-acyl-sn-glycerol 3-phosphate.
Acyl-CoA + glycerone phosphate → CoA + acylglycerone phosphate.
General function:
Involved in acyltransferase activity
Specific function:
G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase
Gene Name:
GPT2
Uniprot ID:
P36148
Molecular weight:
83644.0
Reactions
Acyl-CoA + sn-glycerol 3-phosphate → CoA + 1-acyl-sn-glycerol 3-phosphate.
Acyl-CoA + glycerone phosphate → CoA + acylglycerone phosphate.