{"ymdb_id":"YMDB00262","created_at":"2011-05-29T17:59:56.000Z","updated_at":"2016-09-08T18:35:15.000Z","name":"Lanosterin","cas":"79-63-0","state":"Solid","melting_point":"140.5 oC","description":"Lanosterol (lanosterin) is a tetracyclic triterpenoid. It is synthesized from acetyl-CoA in the HMG-CoA reductase pathway. It is the compound from which all steroids are derived.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"extracellular;endoplasmic reticulum;cytoplasm","synthesis_reference":"Maienthal, Millard; Franklin, Philip J. Preparation of lanosterol from bromolanosterol. Journal of Organic Chemistry (1955), 20 1627-30.","chebi_id":"16521","hmdb_id":"HMDB01251","kegg_id":"C01724","pubchem_id":"246983","cs_id":"23253432","foodb_id":null,"wikipedia_link":"Lanosterol","biocyc_id":"LANOSTEROL","iupac":"(2S,5S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-ol","traditional_iupac":"(2S,5S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-ol","logp":"7.706672521","pka":null,"alogps_solubility":"3.76e-04 g/l","alogps_logp":"7.72","alogps_logs":"-6.06","acceptor_count":"1","donor_count":"1","rotatable_bond_count":"4","polar_surface_area":"20.23","refractivity":"134.5447","polarizability":"55.05559169383237","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-0.806973642323843","pka_strongest_acidic":"19.553786825962863","bioavailability":"1","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["(3 beta)-Lanosta-8,24-dien-3-ol","(3alpha)-4,4,14-trimethyl-Cholesta-8,24-dien-3-ol","(3beta,5alpha)-4,4,14-trimethyl-Cholesta-8,24-dien-3-ol","(3beta,5alpha)-4,4,14-trimethylcholesta-8,24-dien-3-ol","(3beta)-Lanosta-8,24-dien-3-ol","4,4',14alpha-Trimethyl-5alpha-cholesta-8,24-dien-3beta-ol","Lanosta-8,24-dien-3-ol","Lanosta-8,24-dien-3-ol, (3.beta.)-","Lanosta-8,24-dien-3-ol, (3beta)-","Lanosta-8,24-dien-3.beta.-ol","Lanosta-8,24-dien-3beta-ol","Lanosta-8,24-dienol","Lanosterin","Lanosterol","Lanster"],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7896706,"citation":"Loubbardi, A., Marcireau, C., Karst, F., Guilloton, M. (1995). \"Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase.\" J Bacteriol 177:1817-1823."},{"pubmed_id":12077145,"citation":"Wilcox, L. J., Balderes, D. A., Wharton, B., Tinkelenberg, A. H., Rao, G., Sturley, S. L. (2002). \"Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.\" J Biol Chem 277:32466-32472."},{"pubmed_id":10622712,"citation":"Lamb, D. C., Kelly, D. E., Manning, N. J., Kaderbhai, M. A., Kelly, S. L. (1999). \"Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.\" FEBS Lett 462:283-288."},{"pubmed_id":10672016,"citation":"Zweytick, D., Leitner, E., Kohlwein, S. D., Yu, C., Rothblatt, J., Daum, G. (2000). \"Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae.\" Eur J Biochem 267:1075-1082."}],"proteins":[{"created_at":"2011-05-24T20:03:33.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Lanosterol 14-alpha demethylase","uniprot_id":"P10614","uniprot_name":"CP51_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG11","num_residues":530,"molecular_weight":"60719.80078","theoretical_pi":"8.95","general_function":"Involved in iron ion binding","specific_function":"Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol","reactions":[{"id":2295,"direction":"\u003e","locations":"Membrane; Single-pass membrane protein","altext":"Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14387,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006897","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"21-41","pdb_id":null,"cellular_location":"Membrane; Single-pass membrane protein","genbank_gene_id":"M18109","genbank_protein_id":"170946","gene_card_id":"ERG11","chromosome_location":"chromosome 8","locus":"YHR007C","synonyms":["CYPLI","Cytochrome P450 51","Cytochrome P450-14DM","Cytochrome P450-LIA1","Sterol 14-alpha demethylase"],"enzyme_classes":["1.14.13.70"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" monooxygenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"p450","identifier":"PF00067"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCTGCTACCAAGTCAATCGTTGGAGAGGCATTGGAATACGTAAACATTGGTTTAAGTCATTTCTTGGCTTTACCATTGGCCCAAAGAATCTCTTTGATCATAATAATTCCTTTCATTTACAATATTGTATGGCAATTACTATATTCTTTGAGAAAGGACCGTCCACCTCTAGTGTTTTACTGGATTCCATGGGTCGGTAGTGCTGTTGTGTACGGTATGAAGCCATACGAGTTTTTCGAAGAATGTCAAAAGAAATACGGTGATATTTTTTCATTCGTTTTGTTAGGAAGAGTCATGACTGTGTATTTAGGACCAAAGGGTCACGAATTTGTCTTCAACGCTAAGTTGGCAGATGTTTCAGCAGAAGCTGCTTACGCTCATTTGACTACTCCAGTTTTCGGTAAAGGTGTTATTTACGATTGTCCAAATTCTAGATTGATGGAGCAAAAGAAGTTTGTTAAGGGTGCTCTAACCAAAGAAGCCTTCAAGAGCTACGTTCCATTGATTGCTGAAGAAGTGTACAAGTACTTCAGAGACTCCAAAAACTTCCGTTTGAATGAAAGAACTACTGGTACTATTGACGTGATGGTTACTCAACCTGAAATGACTATTTTCACCGCTTCAAGATCATTATTGGGTAAGGAAATGAGAGCAAAATTGGATACCGATTTTGCTTACTTGTACAGTGATTTGGATAAGGGTTTCACTCCAATCAACTTCGTCTTCCCTAACTTACCATTGGAACACTATAGAAAGAGAGATCACGCTCAAAAGGCTATCTCCGGTACTTACATGTCTTTGATTAAGGAAAGAAGAAAGAACAACGACATTCAAGACAGAGATTTGATCGATTCCTTGATGAAGAACTCTACCTACAAGGATGGTGTGAAGATGACTGATCAAGAAATCGCTAACTTGTTAATTGGTGTCTTAATGGGTGGTCAACATACTTCTGCTGCCACTTCTGCTTGGATTTTGTTGCACTTGGCTGAAAGACCAGATGTCCAACAAGAATTGTACGAAGAACAAATGCGTGTTTTGGATGGTGGTAAGAAGGAATTGACCTACGATTTATTACAAGAAATGCCATTGTTGAACCAAACTATTAAGGAAACTCTAAGAATGCACCATCCATTGCACTCTTTGTTCCGTAAGGTTATGAAAGATATGCACGTTCCAAACACTTCTTATGTCATCCCAGCAGGTTATCACGTTTTGGTTTCTCCAGGTTACACTCATTTAAGAGACGAATACTTCCCTAATGCTCACCAATTCAACATTCACCGTTGGAACAAAGATTCTGCCTCCTCTTATTCCGTCGGTGAAGAAGTCGATTACGGTTTCGGTGCCATTTCTAAGGGTGTCAGCTCTCCATACTTACCTTTCGGTGGTGGTAGACACAGATGTATCGGTGAACACTTTGCTTACTGTCAGCTAGGTGTTCTAATGTCCATTTTTATCAGAACATTAAAATGGCATTACCCAGAGGGTAAGACCGTTCCACCTCCTGACTTTACATCTATGGTTACTCTTCCAACCGGTCCAGCCAAGATCATCTGGGAAAAGAGAAATCCAGAACAAAAGATCTAA","protein_sequence":"MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI"},{"created_at":"2011-05-26T16:23:25.000Z","updated_at":"2011-07-22T17:53:58.000Z","name":"Sterol O-acyltransferase 1","uniprot_id":"P25628","uniprot_name":"ARE1_YEAST","enzyme":true,"transporter":false,"gene_name":"ARE1","num_residues":610,"molecular_weight":"71612.5","theoretical_pi":"8.38","general_function":"Involved in O-acyltransferase activity","specific_function":"Acyl-CoA + cholesterol = CoA + cholesterol ester","reactions":[{"id":1255,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1256,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1257,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1258,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1259,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1260,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1261,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1262,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1263,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1264,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2413,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + cholesterol = CoA + cholesterol ester.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"182-202;229-249;264-284;371-391;409-429;535-555;590-610","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY692921","genbank_protein_id":"51013293","gene_card_id":"ARE1","chromosome_location":"chromosome 3","locus":"YCR048W","synonyms":["Sterol-ester synthase 1"],"enzyme_classes":["2.3.1.26"],"go_classes":[],"pfams":[{"name":"MBOAT","identifier":"PF03062"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"}],"gene_sequence":"ATGACGGAGACTAAGGATTTGTTGCAAGACGAAGAGTTTCTTAAGATCCGCAGACTCAATTCCGCAGAAGCCAACAAACGGCATTCGGTCACGTACGATAACGTGATCCTGCCACAGGAGTCCATGGAGGTTTCGCCACGGTCGTCTACCACGTCGCTGGTGGAGCCAGTGGAGTCGACTGAAGGAGTGGAGTCGACTGAGGCGGAACGTGTGGCAGGGAAGCAGGAGCAGGAGGAGGAGTACCCTGTGGACGCCCACATGCAAAAGTACCTTTCACACCTGAAGAGCAAGTCTCGGTCGAGGTTCCACCGAAAGGATGCTAGCAAGTATGTGTCGTTTTTTGGGGACGTGAGTTTTGATCCTCGCCCCACGCTCCTGGACAGCGCCATCAACGTGCCCTTCCAGACGACTTTCAAAGGTCCGGTGCTGGAGAAACAGCTCAAAAATTTACAGTTGACAAAGACCAAGACCAAGGCCACGGTGAAGACTACGGTGAAGACTACGGAGAAAACGGACAAGGCAGATGCCCCCCCAGGAGAAAAACTGGAGTCGAACTTTTCAGGGATCTACGTGTTCGCATGGATGTTCTTGGGCTGGATAGCCATCAGGTGCTGCACAGATTACTATGCGTCGTACGGCAGTGCATGGAATAAGCTGGAAATCGTGCAGTACATGACAACGGACTTGTTCACGATCGCAATGTTGGACTTGGCAATGTTCCTGTGCACTTTCTTCGTGGTTTTCGTGCACTGGCTGGTGAAAAAGCGGATCATCAACTGGAAGTGGACTGGGTTCGTTGCAGTGAGCATCTTCGAGTTGGCTTTCATCCCCGTGACGTTCCCCATTTACGTCTACTACTTTGATTTCAACTGGGTCACGAGAATCTTCCTGTTCCTGCACTCCGTGGTGTTTGTTATGAAGAGCCACTCGTTTGCCTTTTACAACGGGTATCTTTGGGACATAAAGCAGGAACTCGAGTACTCTTCCAAACAGTTGCAAAAATACAAGGAATCTTTGTCCCCAGAGACCCGCGAGATTCTGCAAAAAAGTTGCGACTTTTGCCTTTTCGAATTGAACTACCAGACCAAGGATAACGACTTCCCCAACAACATCAGTTGCAGCAATTTCTTCATGTTCTGTTTGTTCCCCGTCCTCGTGTACCAGATCAACTACCCAAGAACGTCGCGCATCAGATGGAGGTATGTGTTGGAGAAGGTGTGCGCCATCATTGGCACCATCTTCCTCATGATGGTCACGGCACAGTTCTTCATGCACCCGGTGGCCATGCGCTGTATCCAGTTCCACAACACGCCCACCTTCGGCGGCTGGATCCCCGCCACGCAAGAGTGGTTCCACCTGCTCTTCGACATGATTCCGGGCTTCACTGTTCTGTACATGCTCACGTTTTACATGATATGGGACGCTTTATTGAATTGCGTGGCGGAGTTGACCAGGTTTGCGGACAGATATTTCTACGGCGACTGGTGGAATTGCGTTTCGTTTGAAGAGTTTAGCAGAATCTGGAACGTCCCCGTTCACAAATTTTTACTAAGACACGTGTACCACAGCTCCATGGGCGCATTGCATTTGAGCAAGAGCCAAGCTACATTATTTACTTTTTTCTTGAGTGCCGTGTTCCACGAAATGGCCATGTTCGCCATTTTCAGAAGGGTTAGAGGATATCTGTTCATGTTCCAACTGTCGCAGTTTGTGTGGACTGCTTTGAGCAACACCAAGTTTCTACGGGCAAGACCGCAGTTGTCCAACGTTGTCTTTTCGTTTGGTGTCTGTTCAGGGCCCAGTATCATTATGACGTTGTACCTGACCTTATGA","protein_sequence":"MTETKDLLQDEEFLKIRRLNSAEANKRHSVTYDNVILPQESMEVSPRSSTTSLVEPVESTEGVESTEAERVAGKQEQEEEYPVDAHMQKYLSHLKSKSRSRFHRKDASKYVSFFGDVSFDPRPTLLDSAINVPFQTTFKGPVLEKQLKNLQLTKTKTKATVKTTVKTTEKTDKADAPPGEKLESNFSGIYVFAWMFLGWIAIRCCTDYYASYGSAWNKLEIVQYMTTDLFTIAMLDLAMFLCTFFVVFVHWLVKKRIINWKWTGFVAVSIFELAFIPVTFPIYVYYFDFNWVTRIFLFLHSVVFVMKSHSFAFYNGYLWDIKQELEYSSKQLQKYKESLSPETREILQKSCDFCLFELNYQTKDNDFPNNISCSNFFMFCLFPVLVYQINYPRTSRIRWRYVLEKVCAIIGTIFLMMVTAQFFMHPVAMRCIQFHNTPTFGGWIPATQEWFHLLFDMIPGFTVLYMLTFYMIWDALLNCVAELTRFADRYFYGDWWNCVSFEEFSRIWNVPVHKFLLRHVYHSSMGALHLSKSQATLFTFFLSAVFHEMAMFAIFRRVRGYLFMFQLSQFVWTALSNTKFLRARPQLSNVVFSFGVCSGPSIIMTLYLTL"},{"created_at":"2011-05-27T05:41:32.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Lanosterol synthase","uniprot_id":"P38604","uniprot_name":"ERG7_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG7","num_residues":731,"molecular_weight":"83460.70313","theoretical_pi":"6.51","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus","reactions":[{"id":1711,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2779,"direction":"\u003e","locations":"Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.","altext":"(S)-2,3-epoxysqualene = lanosterol.","export":false,"pw_reaction_id":null,"source":null},{"id":14380,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006895","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.","genbank_gene_id":"AY693043","genbank_protein_id":"51013537","gene_card_id":"ERG7","chromosome_location":"chromosome 8","locus":"YHR072W","synonyms":["2,3-epoxysqualene--lanosterol cyclase","Oxidosqualene--lanosterol cyclase","OSC"],"enzyme_classes":["5.4.99.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGACAGAATTTTATTCTGACACAATCGGTCTACCAAAGACAGATCCACGTCTTTGGAGACTGAGAACTGATGAGCTAGGCCGAGAAAGCTGGGAATATTTAACCCCTCAGCAAGCCGCAAACGACCCACCATCCACTTTCACGCAGTGGCTTCTTCAAGATCCCAAATTTCCTCAACCTCATCCAGAAAGAAATAAGCATTCACCAGATTTTTCAGCCTTCGATGCGTGTCATAATGGTGCATCTTTTTTCAAACTGCTTCAAGAGCCTGACTCAGGTATTTTTCCGTGTCAATATAAAGGACCCATGTTCATGACAATCGGTTACGTAGCCGTAAACTATATCGCCGGTATTGAAATTCCTGAGCATGAGAGAATAGAATTAATTAGATACATCGTCAATACAGCACATCCGGTTGATGGTGGCTGGGGTCTACATTCTGTTGACAAATCCACCGTGTTTGGTACAGTATTGAACTATGTAATCTTACGTTTATTGGGTCTACCCAAGGACCACCCGGTTTGCGCCAAGGCAAGAAGCACATTGTTAAGGTTAGGCGGTGCTATTGGATCCCCTCACTGGGGAAAAATTTGGCTAAGTGCACTAAACTTGTATAAATGGGAAGGTGTGAACCCTGCCCCTCCTGAAACTTGGTTACTTCCATATTCACTGCCCATGCATCCGGGGAGATGGTGGGTTCATACTAGAGGTGTTTACATTCCGGTCAGTTACCTGTCATTGGTCAAATTTTCTTGCCCAATGACTCCTCTTCTTGAAGAACTGAGGAATGAAATTTACACTAAACCGTTTGACAAGATTAACTTCTCCAAGAACAGGAATACCGTATGTGGAGTAGACCTATATTACCCCCATTCTACTACTTTGAATATTGCGAACAGCCTTGTAGTATTTTACGAAAAATACCTAAGAAACCGGTTCATTTACTCTCTATCCAAGAAGAAGGTTTATGATCTAATCAAAACGGAGTTACAGAATACTGATTCCTTGTGTATAGCACCTGTTAACCAGGCGTTTTGCGCACTTGTCACTCTTATTGAAGAAGGGGTAGACTCGGAAGCGTTCCAGCGTCTCCAATATAGGTTCAAGGATGCATTGTTCCATGGTCCACAGGGTATGACCATTATGGGAACAAATGGTGTGCAAACCTGGGATTGTGCGTTTGCCATTCAATACTTTTTCGTCGCAGGCCTCGCAGAAAGACCTGAATTCTATAACACAATTGTCTCTGCCTATAAATTCTTGTGTCATGCTCAATTTGACACCGAGTGCGTTCCAGGTAGTTATAGGGATAAGAGAAAGGGGGCTTGGGGCTTCTCAACAAAAACACAGGGCTATACAGTGGCAGATTGCACTGCAGAAGCAATTAAAGCCATCATCATGGTGAAAAACTCTCCCGTCTTTAGTGAAGTACACCATATGATTAGCAGTGAACGTTTATTTGAAGGCATTGATGTGTTATTGAACCTACAAAACATCGGATCTTTTGAATATGGTTCCTTTGCAACCTATGAAAAAATCAAGGCCCCACTAGCAATGGAAACCTTGAATCCTGCTGAAGTTTTTGGTAACATAATGGTAGAATACCCATACGTGGAATGTACTGATTCATCCGTTCTGGGGTTGACATATTTTCACAAGTACTTCGACTATAGGAAAGAGGAAATACGTACACGCATCAGAATCGCCATCGAATTCATAAAAAAATCTCAATTACCAGATGGAAGTTGGTATGGAAGCTGGGGTATTTGTTTTACATATGCCGGTATGTTTGCATTGGAGGCATTACACACCGTGGGGGAGACCTATGAGAATTCCTCAACGGTAAGAAAAGGTTGCGACTTCTTGGTCAGTAAACAGATGAAGGATGGCGGTTGGGGGGAATCAATGAAGTCCAGTGAATTACATAGTTATGTGGATAGTGAAAAATCGCTAGTCGTTCAAACCGCATGGGCGCTAATTGCACTTCTTTTCGCTGAATATCCTAATAAAGAAGTCATCGACCGCGGTATTGACCTTTTAAAAAATAGACAAGAAGAATCCGGGGAATGGAAATTTGAAAGTGTAGAAGGTGTTTTCAACCACTCTTGTGCAATTGAATACCCAAGTTATCGATTCTTATTCCCTATTAAGGCATTAGGTATGTACAGCAGGGCATATGAAACACATACGCTTTAA","protein_sequence":"MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGDIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL"},{"created_at":"2011-05-27T08:55:29.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"ATP-dependent permease AUS1","uniprot_id":"Q08409","uniprot_name":"AUS1_YEAST","enzyme":false,"transporter":true,"gene_name":"AUS1","num_residues":1394,"molecular_weight":"157750.0","theoretical_pi":"7.2","general_function":"Involved in ATP binding","specific_function":"Transporter involved in the uptake of sterol","reactions":[],"signal_regions":"None","transmembrane_regions":"421-443;468-490;497-519;529-551;558-575;636-658;1081-1103;1107-1129;1156-1178;1193-1215;1224-1246;1346-1368","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"Z74919","genbank_protein_id":"1420108","gene_card_id":"AUS1","chromosome_location":"chromosome 15","locus":"YOR011W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to 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activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" primary active transmembrane transporter activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" P-P-bond-hydrolysis-driven transmembrane transporter activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"ABC_tran","identifier":"PF00005"},{"name":"ABC2_membrane","identifier":"PF01061"},{"name":"PDR_CDR","identifier":"PF06422"}],"pathways":[],"gene_sequence":"ATGTCAATTTCAAAGTACTTCACTCCCGTTGCTGACGGGTCACTCACTTTCAATGGCGCGAACATTCAATTTGGCGCCGATGCTCAAGGCGAGTCAAAAAAGAGTTATGACGCTGAGGACAGCATGCCGAATCCGGCAAATCAACTAAATGACATAACCTTCCAAGCAGAGGCTGGTGAAATGGTTTTGGTTTTGGGTTATCCCACATCCACTCTATTTAAGACTTTGTTTCATGGTAAAACTAGTTTGTCATACTCTCCTCCAGGCTCGATTAAATTTAAAAATAATGAGTTTAAGAGCTTTTCCGAAAAATGTCCCCACCAAATCATTTACAATAATGAACAAGATGTGCATTTCCCATTTCTAACGGTAGAACAAACAATTGATTTTGCCTTGAGTTGTAAGTTCGATATTCCAAAAGGTGAGCGCGATCAAATAAGAAATGAACTTCTAAGAGAATTCGGCCTGTCTCATGTATTGAAAACTATTGTAGGAAATGATTTTTTCCGTGGTGTTTCTGGTGGTGAGCGTAAACGTATTTCTATTATTGAAACGTTTATTGCTAATGGTTCCGTTTATCTATGGGATAATTCTACTAAAGGTTTAGATTCCGCCACAGCTCTCGATTTTTTGGAAATTCTTAGAAAAATGGCAAAAGCTACTCGTTCTGTAAACTTAGTCAGAATTTCCCAGGCAAGTGATAAAATTGTTGATAAGTTTGACAAGATTCTTATGCTATCCGATTCCTACCAGCTTTTCTATGGTACGGTCGATGAGTGTTTGACTTATTTTCGTGACACTTTAGGTATTGAGAAAGATCCTAACGATTGTATTATTGAATATCTGACCTCTATCTTAAATTTTCAGTTCAAAAATAAAAATTTGGGGAATTTATCAAATTCATCATCTGCTAGCGTTCTCAAAACCGCAACAGGGGAAGTCACTAAGTATACTTATAATTCTGATTTCGATTTATATGATCAATGGAAACATTCTTCGTACTATAGAAATATAAAGCAGCAAATCCAGGGGTCTTCAATTGATGACTCCATTAAGGAAGTGGATCCCTCTGATGTCTCACCTATTTTTAATATTCCGTTGAAGAAACAATTATTATTTTGCACAAAAAGAGCTTTTCAACGAAGTTTGGGTGATAAAGCTTATATGACGGCACAATTTATTTCTGTCGTTATTCAATCTTTGGTCATTGGTTCACTGTTTTACGAAATTCCGTTGACTACCATTGGTTCATACTCAAGAGGTTCTTTAACCTTTTTCTCCATTCTTTTCTTCACTTTTCTTTCTCTTGCAGATATGCCTATTGCCTTCCAAAGACAACCCGTCGTTAAAAAGCAATCCCAACTTCACTTCTATACTAACTGGGTTGAAACCCTTTCAACAACAGTGTTCGACTACTGCTTTAAACTTTGTTTGGTAATTGTATTCAGTATCATCCTATACTTCCTTGCTCACCTGCAATACAAGGCTGCAAGATTTTTCATTTTCCTCCTGTTCCTTTCCTTTTACAATTTCTGTATGGTGTCCTTATTCGCTTTGACGACACTAGTTGCTCCAACCATTTCAGTTGCAAATTTATTTGCAGGTATTCTGCTACTAGCTATAGCAATGTATGCTTCTTACGTCATCTACCTGAAAAATATGCATCCTTGGTTTGTATGGATTGCTTATCTAAATCCTGCAATGTACGCTATGGAGGCAATACTGTCTAATGAGCTTTACAATTTGAAGCTGGATTGTAGTGAGACAATTGTTCCAAGAGGTCCTACTTACAACGATGTTCCATTTTCCCATAAGGCCTGTGCTTGGCAAGGTGCTACTCTGGGTAATGATTACGTTAGAGGCCGTGATTACTTGAAGCAAGGTTTATCCTACACGTATCATCATGTGTGGAGAAACTTTGGTATTATCATTGGTTTCCTAGTATTCTTTATTGCCTGTACTCTGTTTGCATCTCAATATATTAAGCCTTATTTCAATAAGGATGAAATAGAGCGCAACAATAGTCGTTTGACAAGATGGCTACCATTTTTGAATAAAAAGAGAGGTACCAGGTCCTCTGCAAGAAATGACAGTAAGTATGTTGGTATCCCAAAGTCGCACTCCGTTTCGTCTTCCTCGTCTAGCCTGTCGGCTGTTCCATATCAGATATCACCCTCAAATAAGGAAATGGCTCTAAACGATTATAACGAGCAACCTATCACGGAAACAGTAGAGACTCAAAAGCATATCATCTCTTGGAAAAATATCAACTACACAGTTGGTACAAAGAAACTGATTAATAATGCATCCGGTTTCATCAGTTCTGGTTTGACCGCCTTAATGGGTGAGTCCGGTGCAGGTAAAACTACTTTGCTGAATGTCTTATCACAAAGAGTTGAGACAGGTGTTGTTAGCGGCGAAATTTTGATCGATGGCCACCCATTGACAGATGAGGACGCGTTTAAGAGAAGTATTGGTTTTGTTCAACAACAGGATTTGCATCTAGATTTGCTGTCTGTGAAAGAATCTCTGGAAATATCATGTCTTTTGAGAGGTGATGGTGACAGGGCATACTTAGACACTGTTTCAAATTTACTGAAATTGCCATCTGACATTTTAGTCGCTGATTTAAACCCGACTCAAAGGAAGCTTTTATCTATCGGTGTTGAACTTGTTACTAAGCCTTCACTTTTATTATTCCTAGACGAACCAACCTCTGGGCTGGACGCTGAGGCTGCACTAACAATCGTCAAATTTTTAAAACAACTTTCTTTACAGGGTCAGGCTATTTTTTGTACCATTCATCAGCCTAGTAAAAGTGTCATCAGCCATTTTGACAATATTTTCTTATTGAAAAGGGGTGGTGAATGTGTCTTCTTTGGACCAATGGACGATGCCTGCGGCTATTTCATGTCTCATGACAACACGCTCGTTTACGATAAAGAACATGATAACCCTGCAGATTTCGTCATTGATGCAGTAGGTAACAGTAACTCCTCGGCAGGGAAAGATACAGCGGAGGAAGCTCTTACTTTGAACAAAGAAGCCATAGATTGGAGTGCATTATGGGAATCTTCTGTAGAAAAGAAACTAGTTAAAAAAGAAACAGCTAGGTTAGAAGATGATGCTCGTGCGTCTGGTGTTGATTACACAACCTCATTGTGGAAGCAGCCTTCCTACTTACAGCAATTAGCTCTTATTACAAGAAGACAATATATTTGTACGAAAAGAGACATGACTTATGTCATGGCCAAGTACTGTTTGAATGGTGGCGCTGGTTTGTTTATCGGTTTCTCATTTTGGCACATTAAGCATAATATTATCGGTTTGCAGGATAGTATCTTCTTCTGTTTCATGGCTCTTTGTGTTTCATCTCCATTGATCAATCAAATTCAGGACAAAGCCTTGAAAACAAAGGAAGTTTATGTTGCTAGGGAGGCGAGATCTAACACTTATCACTGGACTGTTCTTCTTTTGTCACAGTCAATTATTGAACTACCACTGGCACTTACAAGTTCCACACTATTTTTCGTCTGTGCCTTTTTCTCTTGTGGATTTAACAACGCTGGCTGGAGTGCCGGTGTTTTCTTTTTAAACTATATGCTTTTCGCTGCTTATTACTCGACTCTTGGTTTATGGCTGATCTATACTGCTCCTAATCTACAAACTGCTGCTGTTTTTGTTGCGTTTATTTACAGTTTTACAGCATCATTCTGTGGTGTTATGCAACCATACTCTTTGTTTCCAACTTTTTGGAAATTCATGTACAGGGTTTCGCCATACACATATTTTGTGGAAACTTTTGTTAGTATTCTATTGCATAACTGGGAAATCAAGTGTGACATGTCGGAGATGGTTCCTGGTCAACCTCTGACGGGGCAATCTTGTGGCCAATTTATGGAAGCTTTCATAGAAGAATACGGTGGCTATCTACATAATAAGAACACTTTCACAGTCTGCGCTTATTGTACGTACACTGTTGGCGATGACTTCCTGAAAAATGAGAATATGAGTTACGACCACGTTTGGAGGAACTTTGGTATTGAATGGGCTTTTGTTGGTTTCAATTTCTTTGCGATGTTTGCTGGTTACTACTTAACTTACGTGGCAAGAATATGGCCAAAGGTCTTTAAAATTATCACCAAAGTAATTCCACACAGAGGGAAGAAGCCTGTACAGAACTAA","protein_sequence":"MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKIITKVIPHRGKKPVQN"},{"created_at":"2011-05-29T04:31:24.000Z","updated_at":"2011-06-07T17:03:16.000Z","name":"ATP-dependent permease PDR11","uniprot_id":"P40550","uniprot_name":"PDR11_YEAST","enzyme":false,"transporter":true,"gene_name":"PDR11","num_residues":1411,"molecular_weight":"160536.0","theoretical_pi":"6.86","general_function":"Involved in ATP binding","specific_function":"Transporter involved in the uptake of sterol","reactions":[],"signal_regions":"None","transmembrane_regions":"389-409;419-439;472-492;495-515;525-545;637-657;1091-1111;1118-1138;1176-1196;1205-1225;1231-1251;1356-1376","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"PDR11","chromosome_location":"chromosome 9","locus":"YIL013C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to 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activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" primary active transmembrane transporter activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" P-P-bond-hydrolysis-driven transmembrane transporter activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"ABC_tran","identifier":"PF00005"},{"name":"ABC2_membrane","identifier":"PF01061"},{"name":"PDR_CDR","identifier":"PF06422"}],"pathways":[],"gene_sequence":"ATGTCTCTTTCCAAATATTTTAATCCAATTCCTGACGCTTCAGTCACCTTTGATGGGGCTACCGTTCAATTGGAAGAATCCCTCGGTGCTGTTCAGAACGATGAAGAGTCCGCATCGGAATTCAAAAACGTAGGCCATTTAGAAATTAGTGATATCACTTTTCGTGCTAATGAAGGTGAAGTCGTCTTAGTACTGGGAAACCCAACATCAGCGCTCTTCAAAGGTCTATTCCATGGTCACAAGCATCTGAAATACTCGCCTGAAGGGTCTATTAGATTCAAAGACAATGAGTACAAACAGTTTGCTTCCAAATGCCCCCATCAGATCATTTATAATAACGAACAAGATATTCACTTCCCGTATCTGACGGTGGAGCAAACCATTGATTTTGCGTTGAGTTGTAAGTTTCACATTCCCAAGCAAGAGCGTATTGAAATGAGAGACGAGTTATTAAAAGAGTTCGGACTGTCGCACGTAAAGAAGACGTATGTGGGTAATGACTACGTTCGTGGTGTTTCTGGAGGTGAAAGGAAACGTATCTCCATTATAGAAACGTTTATTGCCAATGGGTCTGTTTACTTATGGGACAACTCGACGAAGGGTTTGGACTCTGCCACCGCCCTAGAATTTCTTTCCATTACCCAAAAGATGGCAAAAGCTACAAGATCGGTGAATTTTGTTAAAATTTCTCAAGCAAGCGACAAAATTGTCAGCAAGTTTGACAAGATTCTTATGTTAGGTGATTCCTTCCAGGTGTTTTACGGAACCATGGAGGAGTGTTTAACCCATTTTCATGACACCTTACAGATAAAAAAAAACCCTAACGATTGTATTATTGAATATTTAACATCAATCTTAAATTTTAAGTTCAAGGAAACGTCTAATTCCATTGTTGGTCTTGACACTCCATCTGTTGTTTCTGAAGAAAATCAAGCTTTAAACATCAATAATGAAACAGATTTGCATACATTATGGATTCAGTCTCCATACTATAAACACTGGAAGGCCATCACTTCAAAAACAGTGCAAGAATGCACCAGAAAAGATGTTAATCCGGATGATATCTCCCCCATTTTTAGTATTCCGCTAAAGACGCAACTGAAAACGTGCACTGTAAGAGCTTTCGAAAGAATCATTGGTGACAGAAACTACTTGATTTCTCAATTTGTTTCTGTTGTGGTGCAGTCTTTGGTTATTGGGTCCCTTTTTTATAACATTCCCCTGACAACAATTGGTTCGTTTTCTAGAGGATCTTTAACTTTCTTTTCCATCCTATTCTTTACATTTCTTTCTCTCGCCGACATGCCTGCTTCCTTTCAAAGGCAACCCGTCGTTCGTAAACATGTCCAGCTCCATTTTTATTATAATTGGGTGGAAACTTTAGCAACAAATTTTTTCGATTGCTGCTCTAAATTTATACTGGTGGTTATTTTTACAATCATACTTTACTTTTTGGCCCATTTACAGTACAATGCAGCTAGGTTTTTCATCTTTTTGCTTTTCCTTTCCGTCTATAATTTTTGCATGGTGTCACTATTTGCATTAACTGCTTTGATCGCTCCAACTCTATCAATGGCAAACCTATTGGCCGGTATCTTACTGTTAGCCATTGCCATGTACGCGTCCTATGTTATTTATATGAAAGATATGCATCCATGGTTCATATGGATTGCATATTTGAATCCTGCTATGTTTGCCATGGAAGCCATTTTGAGTAACGAATTGTTTAACCTGAAACTAGACTGTCATGAAAGTATTATTCCCAGAGGTGAATATTATGACAATATTTCATTCAGTCATAAAGCTTGTGCCTGGCAAGGCGCTACCCTAGGTAACGATTACGTCAGAGGCCGTGATTATTTAAAAAGTGGATTGAAATACACTTACCATCACGTGTGGAGAAATTTCGGTATTATCATTGGGTTTCTGTGTTTCTTCCTATTTTGCTCTTTACTAGCAGCGGAATATATCACGCCTCTGTTTACTAGAGAAAATTTATTGCGCTGGAATAACTATCTCAAAAGATACTGTCCCTTTCTGAATAGCCAAAAAAAGAATAATAAAAGCGCTATTACCAACAACGATGGCGTATGTACTCCCAAGACCCCGATAGCCAATTTTTCCACTTCATCCTCTTCTGTTCCATCAGTCTCGCATCAATACGATACTGATTACAATATTAAACATCCAGATGAAACTGTTAACAATCATACTAAGGAATCCGTAGCTATGGAAACGCAAAAGCACGTCATCTCCTGGAAAAATATCAATTATACCATTGGAGACAAAAAATTGATCAACGACGCTTCTGGATATATAAGTTCCGGATTAACTGCCCTAATGGGTGAATCTGGTGCTGGTAAGACAACTTTGTTGAATGTCTTGTCTCAAAGGACCGAAAGCGGGGTTGTTACCGGTGAATTATTAATCGATGGACAGCCCTTAACGAATATTGATGCATTCAGAAGAAGTATAGGGTTCGTTCAACAGCAAGATGTTCATTTAGAGCTCTTAACTGTGAGAGAGTCTTTGGAAATTTCCTGCGTCCTAAGAGGTGATGGGGATAGAGACTATTTAGGAGTTGTTAGCAACCTATTAAGATTGCCTTCGGAAAAACTGGTTGCTGATTTATCTCCAACTCAAAGAAAATTATTATCTATTGGTGTTGAATTGGTCACTAAGCCTTCTCTGTTGTTATTCCTAGATGAACCTACTTCAGGGCTAGACGCCGAAGCAGCTTTAACCATCGTGCAATTTCTGAAAAAGCTTTCGATGCAAGGTCAGGCTATCTTATGTACTATTCATCAGCCTAGCAAAAGTGTCATCAGCTATTTTGATAACATCTATTTACTAAAAAGAGGTGGTGAGTGTGTCTATTTTGGTTCATTACCTAATGCCTGTGACTATTTTGTAGCTCACGATAGACGCCTAACATTTGACAGAGAAATGGATAATCCGGCTGATTTCGTTATTGACGTTGTTGGTAGCGGAAGTACAAATATTCCAATGGATGATGCAGAGAAGCCAACCTCAAGCAAAATTGATGAGCCAGTATCTTACCATAAGCAATCTGATTCAATTAACTGGGCAGAACTCTGGCAATCCTCTCCAGAAAAAGTGCGGGTTGCTGATGATTTGCTTTTATTAGAAGAAGAAGCCCGGAAATCTGGTGTTGATTTCACTACGTCCGTATGGAGTCCGCCTTCGTATATGGAACAAATAAAGTTAATCACAAAGAGACAGTACATTTGTACCAAGAGAGACATGACCTATGTTTTCGCTAAATATGCTTTGAATGCTGGCGCTGGACTATTCATTGGATTTTCATTTTGGAGGACAAAGCATAATATCAACGGTCTGCAAGATGCTATTTTCTTGTGCTTCATGATGCTTTGTGTTTCCTCCCCTTTGATCAATCAGGTTCAAGATAAGGCTTTGCAATCTAAAGAAGTATATATCGCCAGGGAAGCGAGATCTAATACTTATCATTGGACCGTTCTTTTGATTGCTCAAACTATTGTTGAATTACCATTAGCCATTTCCAGTTCTACCTTATTTTTCCTGTGTTGCTACTTCTGTTGCGGTTTCGAAACCTCTGCCCGTGTAGCTGGTGTCTTTTACTTGAATTATATTTTATTTTCCATGTATTATTTGTCATTTGGGTTGTGGCTTCTATATTCTGCCCCCGATTTACAAACTGCCGCTGTCTTTGTTGCCTTCCTCTATAGTTTCACAGCTTCATTCTGTGGCGTTATGCAACCATACTCGTTATTCCCAAGATTTTGGACATTCATGTACAGGGTTTCACCATACACGTATTTCATTGAAACTTTCGTAAGCTTACTTCTCCATGACAGAGAAGTAAACTGCTCGACAAGTGAAATGGTACCAAGCCAACCTGTAATGGGTCAAACCTGCGGTCAGTTTATGAAACCCTTTATTGATGAATTTGGTGGGAAACTGCACATCAATAACACATACACCGTCTGCGCCTACTGCATGTACACTGTTGGGGATGACTTCCTTGCTCAAGAAAATATGAGTTATCATCACAGATGGAGAAATTTTGGTTTTGAATGGGTTTTCGTTTGCTTTAACATTGCCGCCATGTTTGTGGGCTTCTACCTAACCTACATCAAAAAAATTTGGCCTTCTGTGATTGATGGTATAAAGAAGTGTATCCCATCAATGAGGCGGTCCAAAACATCTCATAATCCAAACGAACAAAGCGTATAA","protein_sequence":"MSLSKYFNPIPDASVTFDGATVQLEESLGAVQNDEESASEFKNVGHLEISDITFRANEGEVVLVLGNPTSALFKGLFHGHKHLKYSPEGSIRFKDNEYKQFASKCPHQIIYNNEQDIHFPYLTVEQTIDFALSCKFHIPKQERIEMRDELLKEFGLSHVKKTYVGNDYVRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALEFLSITQKMAKATRSVNFVKISQASDKIVSKFDKILMLGDSFQVFYGTMEECLTHFHDTLQIKKNPNDCIIEYLTSILNFKFKETSNSIVGLDTPSVVSEENQALNINNETDLHTLWIQSPYYKHWKAITSKTVQECTRKDVNPDDISPIFSIPLKTQLKTCTVRAFERIIGDRNYLISQFVSVVVQSLVIGSLFYNIPLTTIGSFSRGSLTFFSILFFTFLSLADMPASFQRQPVVRKHVQLHFYYNWVETLATNFFDCCSKFILVVIFTIILYFLAHLQYNAARFFIFLLFLSVYNFCMVSLFALTALIAPTLSMANLLAGILLLAIAMYASYVIYMKDMHPWFIWIAYLNPAMFAMEAILSNELFNLKLDCHESIIPRGEYYDNISFSHKACAWQGATLGNDYVRGRDYLKSGLKYTYHHVWRNFGIIIGFLCFFLFCSLLAAEYITPLFTRENLLRWNNYLKRYCPFLNSQKKNNKSAITNNDGVCTPKTPIANFSTSSSSVPSVSHQYDTDYNIKHPDETVNNHTKESVAMETQKHVISWKNINYTIGDKKLINDASGYISSGLTALMGESGAGKTTLLNVLSQRTESGVVTGELLIDGQPLTNIDAFRRSIGFVQQQDVHLELLTVRESLEISCVLRGDGDRDYLGVVSNLLRLPSEKLVADLSPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVQFLKKLSMQGQAILCTIHQPSKSVISYFDNIYLLKRGGECVYFGSLPNACDYFVAHDRRLTFDREMDNPADFVIDVVGSGSTNIPMDDAEKPTSSKIDEPVSYHKQSDSINWAELWQSSPEKVRVADDLLLLEEEARKSGVDFTTSVWSPPSYMEQIKLITKRQYICTKRDMTYVFAKYALNAGAGLFIGFSFWRTKHNINGLQDAIFLCFMMLCVSSPLINQVQDKALQSKEVYIAREARSNTYHWTVLLIAQTIVELPLAISSSTLFFLCCYFCCGFETSARVAGVFYLNYILFSMYYLSFGLWLLYSAPDLQTAAVFVAFLYSFTASFCGVMQPYSLFPRFWTFMYRVSPYTYFIETFVSLLLHDREVNCSTSEMVPSQPVMGQTCGQFMKPFIDEFGGKLHINNTYTVCAYCMYTVGDDFLAQENMSYHHRWRNFGFEWVFVCFNIAAMFVGFYLTYIKKIWPSVIDGIKKCIPSMRRSKTSHNPNEQSV"}]}