{"ymdb_id":"YMDB00261","created_at":"2011-05-29T17:59:49.000Z","updated_at":"2016-09-08T18:35:15.000Z","name":"Guanosine monophosphate","cas":"85-32-5","state":"Solid","melting_point":"","description":"Guanosine 5'-monophosphate (GMP) is a guanine nucleotide containing one phosphate group esterified to a sugar moiety. It is found in RNA.","experimental_water_solubility":"369 mg/mL [sodium salt, HMP experimental]","experimental_logp_hydrophobicity":"","location":"mitochondrion;Golgi;cytoplasm","synthesis_reference":"Sato, Katsuaki; Matsui, Hiroshi; Ei, Hitoshi; Takinami, Koichi.  Guanosine-5'-monophosphate.    Jpn. Kokai Tokkyo Koho  (1979),     3 pp.","chebi_id":"17345","hmdb_id":"HMDB01397","kegg_id":"C00144","pubchem_id":"6804","cs_id":"6545","foodb_id":null,"wikipedia_link":"Guanosine_monophosphate","biocyc_id":"GMP","iupac":"{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"guanylate","logp":"-3.1266968802741064","pka":"6.250470034590121","alogps_solubility":"3.56e+00 g/l","alogps_logp":"-1.99","alogps_logs":"-2.01","acceptor_count":"10","donor_count":"6","rotatable_bond_count":"4","polar_surface_area":"201.74999999999994","refractivity":"75.49399999999999","polarizability":"30.69674158026033","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"0.3777087267091779","pka_strongest_acidic":"1.291332123072766","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["5'-GMP","GMP","Guanidine monophosphate","Guanosine 5'-monophosphate","Guanosine 5'-phosphate","Guanosine 5'-phosphorate","Guanosine 5'-phosphoric acid","guanosine monophosphate","guanosine-5'-monophosphate","guanosine-5'-phosphate","guanosine-phosphate","guanylate","guanylic acid"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":10409709,"citation":"Gao, X. D., Kaigorodov, V., Jigami, Y. (1999). \"YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae.\" J Biol Chem 274:21450-21456."}],"proteins":[{"created_at":"2011-05-24T19:35:15.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"GMP synthase [glutamine-hydrolyzing]","uniprot_id":"P38625","uniprot_name":"GUAA_YEAST","enzyme":true,"transporter":false,"gene_name":"GUA1","num_residues":525,"molecular_weight":"58481.80078","theoretical_pi":"6.47","general_function":"Involved in catalytic activity","specific_function":"ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate","reactions":[{"id":1608,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2260,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X70397","genbank_protein_id":"460064","gene_card_id":"GUA1","chromosome_location":"chromosome 13","locus":"YMR217W","synonyms":["GMP synthetase","Glutamine amidotransferase"],"enzyme_classes":["6.3.5.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" GMP synthase (glutamine-hydrolyzing) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" GMP biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"GMP_synt_C","identifier":"PF00958"},{"name":"NAD_synthase","identifier":"PF02540"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGCTGCCGGTGAACAAGTTTCTAACATGTTTGACACTATCTTAGTGTTAGACTTTGGTTCTCAATACTCTCATTTGATTACCAGAAGATTAAGAGAGTTTAACATCTATGCTGAGATGTTGCCATGCACTCAGAAGATCTCTGAGTTGGGCTGGACTCCAAAGGGTGTCATTCTTTCTGGTGGTCCATATTCCGTATACGCTGAAGACGCTCCACACGTAGACCATGCTATCTTTGATTTGAACGTTCCAATCCTGGGTATCTGTTACGGTATGCAAGAATTGGCTTGGATTAATGGTAAACAAGTTGGTCGTGGTGACAAGAGAGAGTACGGTCCTGCCACTTTGAAGGTGATTGACGATTCCAACTCTCTATTCAAAGGTATGAACGACTCTACTGTCTGGATGTCTCACGGTGATAAATTGCACGGCTTGCCAACTGGTTACAAGACCATTGCCACCTCCGATAACTCCCCATACTGTGGTATTGTCCACGAAACTAAGCCAATCTATGGTATCCAATTCCACCCAGAAGTTACACATTCTACCCAAGGTAAGACTCTTTTGAAAAACTTCGCCGTTGATTTGTGTCACGCTAAGCAAAACTGGACTATGGAAAACTTTATCGACACTGAAATAAACAGAATCAGAAAACTGGTCGGTCCAACTGCTGAAGTCATTGGTGCTGTTTCCGGTGGTGTTGATTCTACTGTTGCATCCAAATTGATGACAGAAGCCATCGGTGATAGATTCCATGCCATTTTGGTCGATAACGGTGTTTTAAGATTAAATGAAGCTGCTAACGTTAAAAAGACTCTTGTCGAAGGTTTAGGTATCAACTTGATGGTTGTCGATGCTTCCGAAGAATTTTTAAGCAAATTGAAGGGTGTCACTGACCCAGAAAAGAAGAGAAAGATTATTGGTAACACATTTATCCACGTCTTTGAAAGAGAAGCTGAAAAAATTAAGCCAAGAGATGGTAAGGAGATTCAATTCCTGTTACAAGGTACTCTTTATCCAGATGTCATCGAATCCATTTCTTTCAAAGGTCCTTCTCAAACCATTAAAACTCATCACAACGTCGGTGGTTTACTAGAGAACATGAAATTAAAGCTAATTGAACCATTGAGAGAACTGTTCAAAGACGAAGTCAGGCATCTAGGTGAATTATTAGGAATCCCTCATGATCTAGTCTGGAGACACCCTTTCCCTGGTCCAGGTATTGCTATTCGTGTTCTAGGTGAAGTTACTAAGGAACAAGTCGAAATAGCAAGAAAAGCTGACAACATTTACATTGAAGAAATCAAGAAGGCCGGCTTATACAACCAAATTTCCCAAGCCTTTGCCTGTTTGTTGCCCGTTAAATCCGTTGGTGTTATGGGTGACCAAAGAACCTATGATCAAGTTATTGCTTTGAGGGCCATTGAAACTACTGATTTCATGACTGCTGACTGGTTCCCATTCGAACACAGTTTCTTGAAGAAAGTCGCCTCAAGAATTGTCAATGAAGTCGATGGGGTTGCTAGGGTCACTTACGATATAACTTCCAAACCTCCTGCAACTGTTGAATGGGAATGA","protein_sequence":"MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE"},{"created_at":"2011-05-26T16:36:32.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Ectonucleotide pyrophosphatase/phosphodiesterase 1","uniprot_id":"P25353","uniprot_name":"NPP1_YEAST","enzyme":true,"transporter":false,"gene_name":"NPP1","num_residues":742,"molecular_weight":"84733.20313","theoretical_pi":"4.24","general_function":"Involved in catalytic activity","specific_function":"Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5","reactions":[{"id":2432,"direction":"\u003e","locations":"Membrane; Single-pass type II membrane protein (Potential)","altext":"A dinucleotide + H(2)O = 2 mononucleotides.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"114-134","pdb_id":null,"cellular_location":"Membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"X59720","genbank_protein_id":"14588938","gene_card_id":"NPP1","chromosome_location":"chromosome 3","locus":"YCR026C","synonyms":["E-NPP 1","Alkaline phosphodiesterase 1","Nucleotide pyrophosphatase","NPPase"],"enzyme_classes":["3.1.4.1","3.6.1.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Phosphodiest","identifier":"PF01663"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"gene_sequence":"ATGGAACTTCAGAATGATTTAGAGTCGCTCGATAACGAGCTGAATGATTTTAGTGAAGATCCATTTCGTGATGATTTCATAACGGATGAAGATGCTGTAAGATCGGGGTGGCGATCTGCGTGGACCAGGATGAAATATTGGTTTTATAAGAATAGACTGAAGTGGACAAACAATCCCATAGTGATTGGCGACGCGAAAGATAGTAGGGATGGTTCTAACTTTAGAAGGGGTATACCGCTATATGAATTAGACGCGAATGGTCAACCCATTGATACTGAACTTGTTGATGAGAATGAACTTTCTTTTGGAACGGGATTTCATTCCAAAGTGCCTTTTAAAATAATATTTCGCACATTGTTTGGCTCGCTGGTGTTTGCCATTTTTTTAATTCTGATGATTAACATAGCAAAACCCCATCACTCCACGAGAGTGCTATCGCACTTTGGCAGTCCTGAATTTGACCCTTACGTGAAGTATTTTAACGGTACGCATGAATTTTTCCCCTTAACGATAGTAATTTCACTAGACGGTTTCCATCCTTCACTCATATCTAAGAGGAACACACCGTTTTTACATGACTTATATGAATTGAAATATGATGGAGGTATGAATATCACGTCCACACCTTTTATGGTACCCAGCTTCCCTACGGAGACCTTTCCCAACCATTGGACGTTGGTTACTGGACAATACCCAATACACCACGGTATAGTCTCTAACGTATTTTGGGATCCTGATCTTAATGAGGAATTCCATCCAGGTGTATTGGACCCTCGAATATGGAACAATAATGATACAGAACCAATATGGCAAACTGTTCAGTCTGCATTTGACGGTGATATACCATTCAAAGCTGCTACCCATATGTGGCCAGGTAGCGATGTGAATTATACCAAGTATAATGAAGAGAAACTACAACCTGAACATAAAAATCCTATTGCTAGAGAGAGAACTCCATTTTACTTCGACGAATTCAATGCTAAAGAACCACTTTCGCAAAAATTATCCAAGATTATTGAATATGTGGATATGAGTACACTGAACGAAAGACCACAGCTAATTCTCGGTTATGTACCGAACGTAGATGCCTTTGGACATAAGCATGGATATCCGTCAGAGTCGGAATACTATTATGAAGACTTCACTGAAACACTGGGGGAAGTAGATACATTTCTGAAGCAACTAGTGGAATCGCTGCAAGAAAGAAATTTAACCAGCTTTACTAATTTGGTCATTGTTAGCGATCATGGTATGAGCGATATCGTAGTTCCCTCAAATGTTATTATATGGGAAGACTTACTGGACGAAAAATTGAGGAAGGATTATGTATCGCACGCATATCTAGAGGGTCCGATGATGGCTATATCGTTGAAAGATTCCGGAAACATCAATGAGGTTTACCACAATTTAAAGACTTCTATAGATGAAGACAAGTATACGGTTTACGTTAATGGAAATTTCCCCAAAGAATGGAACTTTAATGATGGAAAAAATCATCACATGGCGTCAATCTGGATTGTGCCCGAGCCTGGGTATGCAGTGATGAAGAAAGAACAATTGAAGAAGGTGGCAAAAGGTGATCATAAGGACAAAAACGAAGACAATGTGTTCACGATTGGATCACATGGATACGACAATAACGCGATCGATATGAGATCTGTATTTATTGGTATGGGGCCATATTTTCCACAGGGATACATTGAGCCGTTCCAAAATACCGAAATTTACAACCTTTTGTGTGATATTTGCGGTGTGGCAGAAAAGGACAGAAATTCCAATGATGGGACTGGGATGCTTATGAACCAACTCCGCGAACCCCAGAGCAGCGAAGAAGTAGAGATTGAAGATGACTTTGATTATTTGGTCAGTAAGTTTGGTGAATTCAGCACTTATAATATAATTTGGGGCGGGTACCCCGAAGAGACAGAACAAGACAATGTTGACAATGATAATGATGACAACGACGATGGAAACACTGATGAAATAGCCGCTATGCCATCTTCGTCATTAACGATAAAACTAGAAATGACAACTTCAATACCATCAGCAACTGAGACTCTACTGGGCGAAACATCACCATCATCAAGAAGCAGCAGCAGCAGCAGCATACAAGCTAGCGCTACTGCTAGCACAGTGGGGGATTGGCTTCAAGACATAATCAACGACGCAAAAGATCTCATTGACGACATAATTGACAGCATCGACGATTTAGTCGATTCTGATACCTAA","protein_sequence":"MELQNDLESLDNELNDFSEDPFRDDFITDEDAVRSGWRSAWTRMKYWFYKNRLKWTNNPIVIGDAKDSRDGSNFRRGIPLYELDANGQPIDTELVDENELSFGTGFHSKVPFKIIFRTLFGSLVFAIFLILMINIAKPHHSTRVLSHFGSPEFDPYVKYFNGTHEFFPLTIVISLDGFHPSLISKRNTPFLHDLYELKYDGGMNITSTPFMVPSFPTETFPNHWTLVTGQYPIHHGIVSNVFWDPDLNEEFHPGVLDPRIWNNNDTEPIWQTVQSAFDGDIPFKAATHMWPGSDVNYTKYNEEKLQPEHKNPIARERTPFYFDEFNAKEPLSQKLSKIIEYVDMSTLNERPQLILGYVPNVDAFGHKHGYPSESEYYYEDFTETLGEVDTFLKQLVESLQERNLTSFTNLVIVSDHGMSDIVVPSNVIIWEDLLDEKLRKDYVSHAYLEGPMMAISLKDSGNINEVYHNLKTSIDEDKYTVYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIGSHGYDNNAIDMRSVFIGMGPYFPQGYIEPFQNTEIYNLLCDICGVAEKDRNSNDGTGMLMNQLREPQSSEEVEIEDDFDYLVSKFGEFSTYNIIWGGYPEETEQDNVDNDNDDNDDGNTDEIAAMPSSSLTIKLEMTTSIPSATETLLGETSPSSRSSSSSSIQASATASTVGDWLQDIINDAKDLIDDIIDSIDDLVDSDT"},{"created_at":"2011-05-26T16:38:22.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Golgi apyrase","uniprot_id":"P40009","uniprot_name":"YND1_YEAST","enzyme":true,"transporter":false,"gene_name":"YND1","num_residues":630,"molecular_weight":"71851.20313","theoretical_pi":"6.18","general_function":"Involved in hydrolase activity","specific_function":"Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis","reactions":[{"id":1341,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1618,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1782,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1784,"direction":"\u003e","locations":"Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1785,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2043,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2435,"direction":"\u003e","locations":"Golgi apparatus. Membrane; Single-pass membrane protein (Potential)","altext":"ATP + 2 H(2)O = AMP + 2 phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"501-517","pdb_id":null,"cellular_location":"Golgi apparatus. Membrane; Single-pass membrane protein (Potential)","genbank_gene_id":"AF203695","genbank_protein_id":"6573161","gene_card_id":"YND1","chromosome_location":"chromosome 5","locus":"YER005W","synonyms":["ATP-diphosphatase","ATP-diphosphohydrolase","Adenosine diphosphatase","ADPase","Golgi nucleoside diphosphatase","Yeast nucleoside diphosphatase 1"],"enzyme_classes":["3.6.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"GDA1_CD39","identifier":"PF01150"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGCTCATAGAAAACACTAATGATCGGTTTGGTATCGTCATAGATGCAGGGTCTTCGGGTTCGAGAATCCATGTGTTTAAGTGGCAGGACACGGAATCGCTTCTTCATGCAACAAACCAGGACTCACAGTCCATATTACAATCAGTACCTCATATTCATCAAGAAAAAGACTGGACTTTTAAGCTGAATCCAGGCTTGTCGAGTTTTGAAAAAAAACCTCAAGATGCGTACAAATCTCACATCAAGCCGTTACTAGATTTTGCTAAGAATATTATCCCTGAATCACATTGGTCGAGTTGTCCCGTTTTTATTCAAGCAACCGCGGGCATGCGCCTTTTACCTCAAGACATACAATCTTCCATTTTGGATGGTTTGTGTCAGGGGCTCAAACACCCTGCAGAATTTTTGGTTGAGGATTGCTCAGCACAAATTCAAGTCATTGATGGTGAAACCGAAGGTTTATATGGCTGGCTTGGCTTAAACTATCTATATGGACACTTTAATGACTATAATCCAGAGGTCTCTGACCATTTTACATTTGGGTTTATGGACATGGGCGGTGCCTCTACTCAGATTGCGTTTGCACCGCATGATTCAGGAGAAATAGCTAGACATAGAGATGACATCGCCACCATCTTCTTGAGGAGTGTTAACGGAGATTTGCAGAAATGGGACGTTTTTGTTAGTACGTGGTTAGGGTTTGGTGCCAATCAGGCTAGAAGAAGGTACTTGGCTCAGTTGATCAATACCCTTCCAGAAAACACAAATGATTACGAAAATGATGACTTCTCTACAAGGAACTTGAATGATCCATGTATGCCGCGAGGAAGCAGCACGGATTTTGAATTTAAAGATACCATATTTCACATCGCGGGTTCTGGGAATTACGAACAATGTACAAAATCTATTTATCCGTTACTTTTAAAGAACATGCCTTGTGATGACGAGCCGTGCTTGTTTAATGGTGTTCATGCTCCTCGAATAGACTTTGCCAATGACAAATTTATAGGTACTTCTGAGTACTGGTACACTGCCAACGACGTATTCAAACTTGGGGGCGAATACAACTTTGACAAATTTAGCAAAAGCCTAAGGGAGTTTTGCAATTCCAATTGGACGCAAATATTAGCGAACAGTGATAAAGGCGTGTATAATTCTATTCCGGAGAATTTTTTGAAAGATGCATGCTTTAAGGGCAATTGGGTCCTTAATATACTTCATGAAGGGTTTGATATGCCTCGAATAGATGTCGACGCAGAAAATGTCAATGACAGGCCCTTATTTCAAAGTGTGGAAAAAGTCGAAGAACGAGAGTTATCGTGGACACTAGGCAGAATTTTACTTTATGCCTCAGGTAGCATATTGGCAGGTAATGATGACTTCATGGTGGGTATTGCGCCCAGTGAAAGAAGAACTAAGCTCACTGGTAAGAAATTCATACCTGGCAAGTTACTGGAGTCTGATCAACTACGCAAGCAAAGTTCCAGCCTTTCTAATAAAGGATTTTTGATGTGGTTCGCAATTATTTGTTGCATATTTTACTTGATCTTTCATAGGTCACACATAATCAGAAGACGTTTTTCCGGTCTGTACAACATTACCAAGGACTTTAAGACAGGCATAAGGAGAAGGTTGAAATTTCTAAGGAGATCAGATCCATTTTCCAGATTGGAGGAAGGTGAACTTGGAACAGACGTAGATGGCTTCAAAGATGTGTACAGGATGAAGAGTAGCAGTATGTTTGATCTTGGTAAGAGTTCAGCCACAATGCAAAGGGAGCACGAACCACAAAGGACAGCAAGTCAGTCCGCTAATCTCGCTCCGTCAAACTTACGACCTGCGTTTTCTATGGCTGATTTTTCCAAATTTAAGGACAGTAGGCTATATGAT","protein_sequence":"MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD"},{"created_at":"2011-05-26T16:38:48.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Ectonucleotide pyrophosphatase/phosphodiesterase 2","uniprot_id":"P39997","uniprot_name":"NPP2_YEAST","enzyme":true,"transporter":false,"gene_name":"NPP2","num_residues":493,"molecular_weight":"57354.10156","theoretical_pi":"5.46","general_function":"Involved in catalytic activity","specific_function":"Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5","reactions":[{"id":2432,"direction":"\u003e","locations":"Membrane; Single-pass type II membrane protein (Potential)","altext":"A dinucleotide + H(2)O = 2 mononucleotides.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"29-45","pdb_id":null,"cellular_location":"Membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"AY692687","genbank_protein_id":"51012825","gene_card_id":"NPP2","chromosome_location":"chromosome 5","locus":"YEL016C","synonyms":["E-NPP 2","Alkaline phosphodiesterase 1","Nucleotide pyrophosphatase","NPPase"],"enzyme_classes":["3.1.4.1","3.6.1.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Phosphodiest","identifier":"PF01663"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"Pantothenate and CoA 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mitochondrial carrier YIL006W","uniprot_id":"P40556","uniprot_name":"YIA6_YEAST","enzyme":false,"transporter":true,"gene_name":null,"num_residues":373,"molecular_weight":"41954.0","theoretical_pi":"8.83","general_function":"Involved in binding","specific_function":null,"reactions":[],"signal_regions":"None","transmembrane_regions":"81-101;142-162;177-199;236-256;281-297;336-358","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"Z38113","genbank_protein_id":"558398","gene_card_id":null,"chromosome_location":null,"locus":"YIL006W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGACACAGACTGATAATCCTGTCCCCAACTGCGGTTTACTGCCCGAGCAGCAGTATTGCTCTGCAGACCATGAAGAGCCACTGTTGTTGCATGAAGAACAATTGATATTCCCTGATCATTCCTCCCAACTGTCCTCAGCAGATATCATCGAGCCCATCAAGATGAACAGCAGTACTGAGTCAATTATAGGGACAACGCTGCGAAAGAAATGGGTACCACTATCCTCAACTCAGATCACAGCTCTTTCCGGCGCATTTGCTGGATTCTTATCAGGTGTGGCAGTATGTCCCCTCGATGTTGCCAAAACGCGATTGCAAGCACAAGGACTACAAACTAGGTTCGAGAACCCCTACTATAGGGGGATAATGGGGACATTAAGTACTATAGTAAGAGACGAAGGCCCGCGGGGCCTCTACAAAGGGCTGGTACCGATTGTCCTGGGCTACTTCCCAACCTGGATGATATACTTCTCCGTGTATGAATTCAGCAAAAAGTTCTTTCACGGCATCTTCCCACAGTTTGATTTTGTTGCTCAGTCATGTGCTGCAATCACGGCAGGCGCTGCATCTACCACCTTGACCAACCCAATCTGGGTTGTGAAGACAAGACTTATGCTGCAATCAAACCTCGGTGAGCACCCCACACATTACAAAGGCACTTTCGATGCATTCAGAAAGCTATTTTATCAGGAAGGGTTTAAAGCATTATATGCGGGGCTGGTCCCCTCATTATTAGGGCTATTTCATGTGGCTATCCATTTCCCTATATACGAAGATTTGAAGGTAAGATTTCACTGCTATTCTCGGGAGAACAACACCAACTCCATCAACTTGCAACGGTTGATCATGGCATCGTCCGTCTCTAAGATGATTGCATCAGCAGTAACATATCCGCACGAAATTTTACGAACCAGAATGCAACTGAAATCAGATATACCAGATTCCATTCAACGACGTCTGTTCCCCCTCATTAAAGCAACTTATGCACAAGAGGGACTAAAGGGATTTTATTCTGGATTTACTACTAACCTAGTACGAACCATTCCGGCCTCGGCAATCACTCTAGTGTCCTTTGAGTATTTCAGAAACCGCCTAGAAAATATTAGCACTATGGTAATTTAA","protein_sequence":"MTQTDNPVPNCGLLPEQQYCSADHEEPLLLHEEQLIFPDHSSQLSSADIIEPIKMNSSTESIIGTTLRKKWVPLSSTQITALSGAFAGFLSGVAVCPLDVAKTRLQAQGLQTRFENPYYRGIMGTLSTIVRDEGPRGLYKGLVPIVLGYFPTWMIYFSVYEFSKKFFHGIFPQFDFVAQSCAAITAGAASTTLTNPIWVVKTRLMLQSNLGEHPTHYKGTFDAFRKLFYQEGFKALYAGLVPSLLGLFHVAIHFPIYEDLKVRFHCYSRENNTNSINLQRLIMASSVSKMIASAVTYPHEILRTRMQLKSDIPDSIQRRLFPLIKATYAQEGLKGFYSGFTTNLVRTIPASAITLVSFEYFRNRLENISTMVI"},{"created_at":"2011-05-26T19:20:47.000Z","updated_at":"2011-07-22T17:53:44.000Z","name":"3',5'-cyclic-nucleotide 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(PDE1)","reactions":[{"id":1155,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1156,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1157,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1158,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1159,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2564,"direction":"\u003e","locations":"Cytoplasmic","altext":"Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M14563","genbank_protein_id":"172106","gene_card_id":"PDE2","chromosome_location":"chromosome 15","locus":"YOR360C","synonyms":["PDEase 2","High-affinity cAMP phosphodiesterase"],"enzyme_classes":["3.1.4.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" cyclic-nucleotide phosphodiesterase activity"},{"category":"Function","description":" 3',5'-cyclic-nucleotide phosphodiesterase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"}],"pfams":[{"name":"PDEase_I","identifier":"PF00233"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCCACCCTTTTTCTGATTGGAATACACGAGATTGAGAAATCTCAAACAATTGTACAGAATGAACACTATTTTGATAGAGTGATTGAGCTTCAAGATTTGGATTCTCTGATGGTAGCATTGTATAAGGACAGAGTTTCGCCTTTTCCAAACGTCCATAACTTTGAAACGGGCGTATCTATAGTTCTTTATGACCCTTCAAAATTTCAATTATCTGTGCGACAATTGGATGTTCTATTCAAGGGATTTTTCCCATCTTTCAATATTTCTGCGATAGATCATACACGAGAGGAAAACCTGCAACGTCTGGAATGTGTTGAGCGTGAAAATAGCATCTGTCGTAATAGAATAACGAGAATTAACCACTGGATGTATCACCATCATGATGATACTCCAGACGGTATTAACAAAAACAGCTATGGTACTGTAAATGGGAATTCTGTCCCCACTCAAGCATGTGAAGCAAACATTTACACTTTATTATTGCATTTGAATGATTCCAAGGCACAACATTTACGAAAGGCATCAGTGCCAAGGCTAATTCGCAACATCGAGTTTATGTCTTTTTTGTCAGATCCAATAGAAAAAATTTCTCAAGAGGGATCACATTATTGGAACATTCTATCAACTTGGGACTTTTGTGCTTTATCATTAAGCACTCAAGAATTGATTTGGTGCGGGTTCACGCTTATCAAAAAATTATCTAAGGATGCAAAAGTACTCATTGCAGATAATAAGTTACTGCTACTACTATTTACTTTAGAATCATCCTATCATCAAGTTAACAAATTTCACAATTTTAGGCATGCCATCGATGTCATGCAAGCCACATGGCGATTGTGTACATATCTTCTTAAAGATAATCCTGTACAAACATTACTGTTGTGTATGGCTGCCATAGGTCATGATGTCGGTCATCCTGGGACTAACAATCAACTATTGTGCAACTGTGAATCAGAGGTTGCTCAAAATTTCAAAAATGTCTCTATCTTGGAGAATTTTCACAGGGAATTATTTCAACAATTGCTATCAGAGCATTGGCCTCTTAAGCTCTCTATCTCCAAAAAAAAATTTGATTTTATTTCCGAGGCTATTCTGGCCACAGATATGGCATTGCATTCTCAGTATGAGGATAGATTAATGCATGAAAACCCAATGAAACAAATCACTTTGATATCTCTAATTATTAAAGCTGCAGACATCTCTAATGTGACGAGAACCTTGTCAATATCAGCACGTTGGGCATACCTCATTACTCTCGAATTTAATGATTGCGCTCTTTTGGAAACATTTCATAAAGCTCACCGCCCAGAACAAGACTGTTTTGGCGATTCATACAAGAATGTTGATTCTCCGAAAGAAGATTTGGAATCAATTCAAAATATTTTGGTGAACGTAACAGACCCTGATGATATTATCAAAGACCATCCGCATATTCCAAACGGTCAAATATTTTTCATTAATACGTTTGCTGAAGTATTTTTCAACGCATTAAGTCAAAAATTCTCAGGATTAAAATTTTTAAGCGATAATGTCAAAATCAATAAAGAATACTGGATGAAACACAAGAAACCACAATAG","protein_sequence":"MSTLFLIGIHEIEKSQTIVQNEHYFDRVIELQDLDSLMVALYKDRVSPFPNVHNFETGVSIVLYDPSKFQLSVRQLDVLFKRFFPSFNISAIDHTREENLQRLECVERENSICRNRITRINHWMYHHHDDTPDGINKNSYGTVNGNSVPTQACEANIYTLLLHLNDSKAQHLRKASVPRLIRNIEFMSFLSDPIEKISQEGSHYWNILSTWDFCALSLSTQELIWCGFTLIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATWRLCTYLLKDNPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQLLSISKKKFDFISEAILATDMALHSQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFFNALSQKFSGLKFLSDNVKINKEYWMKHKKPQ"},{"created_at":"2011-05-26T21:50:14.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"5',5'''-P-1,P-4-tetraphosphate phosphorylase 2","uniprot_id":"P22108","uniprot_name":"APA2_YEAST","enzyme":true,"transporter":false,"gene_name":"APA2","num_residues":325,"molecular_weight":"36840.5","theoretical_pi":"5.23","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis","reactions":[{"id":1338,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M60265","genbank_protein_id":"171066","gene_card_id":"APA2","chromosome_location":"chromosome 4","locus":"YDR530C","synonyms":["ATP adenylyltransferase","Ap4A phosphorylase II","AP,A phosphorylase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP-4-A phosphorylase"],"enzyme_classes":["2.7.7.53"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGATTGAAGAGAATTTGAAACAGAAAATCCACGATAAGTTCGTTGCAGCCAAAAAGAATGGGCATCTGAAAGTAACGCATGCAGAATCCAAGAAGTTGAAAGATCCTCAAACGACGACACAATATTGGGTGACATTTGCTCCATCTTTGGCACTTAAGCCAGACGCTAACAAGAATAGCGATTCAAAGGCGGAGGACCCGTTCGCCAATCCCGACGAAGAACTAGTGGTGACTGAAGATCTAAATGGTGACGGAGAATATAAGCTGCTACTCAACAAATTTCCTGTGGTCCCTGAACATAGTCTCCTAGTGACAAGCGAGTTTAAAGACCAGAGATCTGCTTTGACGCCAAGTGACTTGATGACTGCTTATAATGTGCTCTGTTCTCTCCAAGGAGACAAGGACGATGATGTCACTTGTGAAAGGTATCTGGTCTTTTATAATTGTGGACCTCATAGCGGTTCCTCACAAGATCACAAACACTTGCAGATCATGCAAATGCCTGAAAAATTTATACCTTTTCAGGACGTATTGTGCAACGGAAAGGATCATTTCTTGCCCACCTTCAACGCAGAGCCATTACAAGATGATAAGGTTTCCTTTGCTCATTTCGTCTTGCCGCTGCCGGAATCGTCTGATCAAGTGGACGAAGATCTTCTTGCTATGTGTTACGTATCTTTGATGCAGAGAGCACTTACATTTTTCCAAGATTGGACCAATGAGTCTCCGGAGTTGACCAAGTCATACAATGTGCTACTGACCAAGAAATGGATCTGTGTAGTTCCAAGATCGCATGCCAAGAGTGGACCGCCATTGATGTTAAACATTAACTCCACGGGGTACTGTGGTATGATCCTCGTTAAAGACAGAGAAAAACTAGAGAACCTCACTGAAGATCCTCATCTTGTGGACAAGTCGTTACTGCAATGCGGTTTCCCCAACACAGCAGGCCAAAAACCAACAGAGTATCACTATTAA","protein_sequence":"MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY"},{"created_at":"2011-05-27T00:02:34.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Guanylate kinase","uniprot_id":"P15454","uniprot_name":"KGUA_YEAST","enzyme":true,"transporter":false,"gene_name":"GUK1","num_residues":187,"molecular_weight":"20637.19922","theoretical_pi":"7.34","general_function":"Involved in protein binding","specific_function":"Essential for recycling GMP and indirectly, cGMP","reactions":[{"id":1443,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1622,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1623,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2618,"direction":"\u003e","locations":null,"altext":"ATP + GMP = ADP + GDP.","export":false,"pw_reaction_id":null,"source":null},{"id":14313,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006812","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1EX7","cellular_location":null,"genbank_gene_id":"L04683","genbank_protein_id":"171625","gene_card_id":"GUK1","chromosome_location":"chromosome 4","locus":"YDR454C","synonyms":["GMP kinase"],"enzyme_classes":["2.7.4.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" guanylate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"}],"pfams":[{"name":"Guanylate_kin","identifier":"PF00625"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCGTCCTATCGTAATTTCTGGCCCAAGTGGTACAGGTAAATCTACACTGTTGAAGAAATTGTTCGCTGAATACCCAGATTCTTTCGGGTTTAGTGTTTCATCCACTACTAGAACCCCAAGAGCTGGCGAAGTAAACGGTAAGGACTATAACTTTGTCTCCGTAGATGAATTCAAATCTATGATTAAGAACAATGAATTCATTGAATGGGCGCAATTCTCCGGTAACTACTATGGTAGTACTGTCGCTTCCGTCAAACAAGTCAGTAAATCTGGTAAGACTTGTATTTTAGATATTGATATGCAGGGTGTCAAATCTGTCAAGGCTATCCCAGAGTTAAATGCCAGGTTTTTGTTTATTGCTCCACCATCGGTCGAGGATTTGAAAAAAAGATTAGAAGGTAGAGGTACGGAGACCGAAGAATCCATCAACAAGAGGTTAAGCGCCGCTCAAGCTGAATTGGCATATGCTGAGACAGGTGCCCATGACAAAGTTATTGTCAATGATGATTTGGACAAGGCCTACAAGGAATTGAAGGATTTTATCTTTGCAGAAAAATGA","protein_sequence":"MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK"},{"created_at":"2011-05-27T03:52:51.000Z","updated_at":"2011-06-05T01:52:11.000Z","name":"GDP-mannose transporter 1","uniprot_id":"P40107","uniprot_name":"GMT1_YEAST","enzyme":false,"transporter":true,"gene_name":"VRG4","num_residues":337,"molecular_weight":"37018.30078","theoretical_pi":"9.7","general_function":"Involved in transmembrane transport","specific_function":"Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity","reactions":[],"signal_regions":"None","transmembrane_regions":"17-37;52-72;93-113;120-140;145-165;181-201;216-236;253-273;280-300;305-325","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.","genbank_gene_id":"L33915","genbank_protein_id":"499894","gene_card_id":"VRG4","chromosome_location":"chromosome 7","locus":"YGL225W","synonyms":["GMT 1","Low dye-binding protein 3","Morphogenesis checkpoint-dependent protein 3","Vanadate resistance glycosylation protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" carbohydrate transmembrane transporter activity"},{"category":"Function","description":" nucleotide-sugar transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" carbohydrate transport"},{"category":"Process","description":" nucleotide-sugar transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"UAA","identifier":"PF08449"}],"pathways":[],"gene_sequence":"ATGTCTGAATTGAAAACAGGTCATGCAGGCCATAACCCTTGGGCTTCAGTTGCCAATTCCGGTCCGATCTCTATTTTATCCTACTGTGGTTCCTCTATTTTAATGACGGTGACTAACAAGTTCGTCGTCAATTTGAAGGATTTCAACATGAACTTTGTCATGCTTTTCGTGCAATCTTTGGTTTGTACTATAACCTTGATTATCCTACGTATACTGGGCTATGCGAAGTTCCGTTCATTAAACAAAACAGACGCCAAGAACTGGTTCCCTATTTCCTTTTTACTGGTCTTGATGATCTACACCTCTTCGAAGGCTTTACAATACTTGGCTGTTCCAATTTACACCATTTTCAAGAATTTGACTATTATCTTGATTGCTTATGGTGAGGTTCTCTTTTTTGGTGGCTCTGTCACCTCCATGGAATTGTCATCATTTTTGTTGATGGTCCTTTCTTCTGTCGTTGCAACTTGGGGTGACCAGCAAGCTGTGGCTGCCAAGGCTGCTTCATTGGCTGAAGGAGCAGCCGGTGCTGTTGCCTCCTTTAACCCAGGTTATTTCTGGATGTTCACCAACTGTATCACTTCTGCATTATTCGTTCTTATAATGAGAAAGAGAATTAAGTTAACTAACTTCAAGGATTTCGACACTATGTTTTACAACAATGTTTTGGCTCTACCTATTCTATTGCTGTTTTCTTTCTGTGTGGAAGATTGGTCTTCAGTTAATTTGACCAATAACTTTTCTAACGATTCGCTAACTGCTATGATCATCAGTGGTGTTGCATCCGTCGGTATTTCTTACTGTTCCGGTTGGTGTGTTCGTGTTACTTCGTCTACTACATATTCGATGGTAGGGGCTTTGAACAAGCTGCCAATTGCCTTGTCTGGTTTGATTTTCTTTGATGCTCCAAGAAACTTCTTATCTATTCTCTCCATTTTTATTGGTTTCCTATCAGGTATTATTTATGCTGTTGCCAAACAAAAGAAGCAACAAGCCCAACCTTTACGTAAATGA","protein_sequence":"MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGYAKFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK"},{"created_at":"2011-05-27T04:32:07.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Hypoxanthine-guanine phosphoribosyltransferase","uniprot_id":"Q04178","uniprot_name":"HPRT_YEAST","enzyme":true,"transporter":false,"gene_name":"HPT1","num_residues":221,"molecular_weight":"25190.5","theoretical_pi":"5.4","general_function":"Involved in nucleoside metabolic process","specific_function":"IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate","reactions":[{"id":1620,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1652,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2765,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2766,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U32274","genbank_protein_id":"927331","gene_card_id":"HPT1","chromosome_location":"chromosome 4","locus":"YDR399W","synonyms":["HGPRT","HGPRTase","Bypass of repression by adenine protein 6"],"enzyme_classes":["2.4.2.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside metabolic process"}],"pfams":[{"name":"Pribosyltran","identifier":"PF00156"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCGGCAAACGATAAGCAATACATCTCGTACAACAACGTACATCAACTATGTCAAGTATCCGCTGAGAGAATTAAGAATTTCAAGCCGGACTTAATCATTGCCATTGGTGGTGGTGGTTTCATTCCTGCTAGGATCCTACGTACGTTCCTAAAGGAGCCCGGCGTGCCAACCATCAGAATTTTTGCTATTATTTTGTCTTTGTACGAAGATTTGAACAGTGTAGGCTCAGAAGTTGAGGAAGTTGGTGTTAAGGTTAGCAGAACACAATGGATTGATTACGAGCAATGTAAATTAGATCTAGTCGGCAAGAACGTTCTTATCGTTGACGAAGTCGATGACACCCGTACCACACTTCATTACGCTTTGAGTGAATTGGAAAAGGATGCAGCTGAACAGGCAAAGGCTAAAGGTATCGATACTGAAAAGTCTCCAGAGATGAAAACAAACTTCGGGATTTTTGTTCTACACGATAAGCAAAAACCAAAGAAAGCAGATTTGCCTGCCGAAATGTTGAATGACAAGAACCGTTATTTTGCAGCTAAAACTGTTCCAGACAAGTGGTATGCATATCCATGGGAATCTACTGACATTGTTTTCCATACTAGAATGGCTATTGAACAGGGCAATGACATCTTTATTCCTGAGCAGGAACACAAGCAATGA","protein_sequence":"MSANDKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLNSVGSEVEEVGVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQEHKQ"},{"created_at":"2011-05-27T05:40:17.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Guanosine-diphosphatase","uniprot_id":"P32621","uniprot_name":"GDA1_YEAST","enzyme":true,"transporter":false,"gene_name":"GDA1","num_residues":518,"molecular_weight":"56821.0","theoretical_pi":"4.98","general_function":"Involved in hydrolase activity","specific_function":"After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol","reactions":[{"id":1784,"direction":"\u003e","locations":"Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2778,"direction":"\u003e","locations":"Golgi apparatus membrane; Single-pass type II membrane protein","altext":"GDP + H(2)O = GMP + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"10-24","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Single-pass type II membrane protein","genbank_gene_id":"AY723798","genbank_protein_id":"51830299","gene_card_id":"GDA1","chromosome_location":"chromosome 5","locus":"YEL042W","synonyms":["GDPase"],"enzyme_classes":["3.6.1.42"],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" Golgi membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" nucleoside-diphosphatase activity"},{"category":"Function","description":" guanosine-diphosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"GDA1_CD39","identifier":"PF01150"}],"pathways":[],"gene_sequence":"ATGGCGCCCATCTTTAGAAATTACCGGTTCGCTATCGGTGCTTTTGCCGTTATTATGCTCATTTTGTTGATTAAAACATCTTCCATCGGTCCACCTTCTATTGCACGTACAGTTACTCCTAATGCTAGTATTCCCAAAACTCCGGAGGACATCTCTATCTTGCCCGTCAATGATGAACCAGGTTACCTTCAAGATTCGAAGACTGAACAAAACTATCCTGAGCTTGCCGATGCTGTGAAGTCACAAACAAGTCAAACATGCAGCGAAGAACATAAGTATGTTATCATGATCGATGCCGGCTCTACCGGTTCCCGAGTACATATATACAAGTTTGACGTCTGTACCTCCCCACCTACATTACTTGATGAAAAATTCGACATGTTAGAGCCTGGTTTATCTTCTTTCGATACCGATTCCGTTGGTGCCGCTAACTCCCTTGACCCATTACTGAAAGTAGCAATGAACTATGTCCCTATTAAGGCAAGAAGTTGTACTCCCGTTGCGGTGAAAGCTACTGCAGGCCTAAGACTCTTGGGTGATGCCAAATCTTCAAAAATTTTGAGCGCTGTAAGGGATCATTTGGAGAAGGACTATCCTTTCCCAGTTGTCGAAGGTGATGGTGTTTCCATCATGGGCGGTGATGAAGAAGGTGTCTTCGCCTGGATTACTACAAACTACCTATTAGGTAATATCGGTGCTAATGGCCCCAAGTTACCTACTGCTGCCGTTTTTGACTTAGGCGGAGGGTCTACACAAATTGTTTTTGAGCCTACTTTCCCAATAAATGAAAAAATGGTCGATGGTGAGCATAAATTTGATTTGAAGTTTGGTGATGAAAATTACACCTTGTACCAATTTTCTCATCTAGGTTACGGCTTGAAGGAAGGAAGAAATAAAGTTAACTCTGTTCTTGTGGAAAATGCATTAAAAGACGGCAAAATATTGAAGGGTGATAACACTAAGACTCATCAATTGTCATCTCCATGCCTACCGCCTAAAGTTAATGCCACAAATGAAAAGGTTACATTAGAATCCAAGGAAACTTATACCATTGACTTTATAGGGCCGGACGAGCCAAGTGGTGCACAATGTAGATTTCTGACTGATGAAATTTTGAATAAAGATGCTCAGTGCCAGTCTCCACCATGCTCTTTCAATGGGGTTCACCAACCTTCTTTAGTTCGTACATTCAAAGAATCGAACGATATCTATATTTTCTCTTATTTCTACGACAGAACCCGTCCATTGGGTATGCCCTTGTCCTTTACTTTGAATGAATTGAACGATTTGGCAAGAATAGTGTGTAAAGGCGAAGAAACTTGGAATAGTGTCTTCAGTGGCATTGCGGGGTCCCTAGATGAATTGGAAAGTGACTCGCACTTCTGTTTGGACTTATCTTTTCAAGTGTCCTTATTACATACGGGATATGACATTCCATTACAAAGAGAATTGAGAACTGGAAAGAAAATTGCCAATAAAGAAATCGGTTGGTGTTTAGGTGCGTCATTACCATTGTTGAAAGCTGATAACTGGAAATGTAAAATTCAATCAGCTTGA","protein_sequence":"MAPIFRNYRFAIGAFAVIMLILLIKTSSIGPPSIARTVTPNASIPKTPEDISILPVNDEPGYLQDSKTEQNYPELADAVKSQTSQTCSEEHKYVIMIDAGSTGSRVHIYKFDVCTSPPTLLDEKFDMLEPGLSSFDTDSVGAANSLDPLLKVAMNYVPIKARSCTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSIMGGDEEGVFAWITTNYLLGNIGANGPKLPTAAVFDLGGGSTQIVFEPTFPINEKMVDGEHKFDLKFGDENYTLYQFSHLGYGLKEGRNKVNSVLVENALKDGKILKGDNTKTHQLSSPCLPPKVNATNEKVTLESKETYTIDFIGPDEPSGAQCRFLTDEILNKDAQCQSPPCSFNGVHQPSLVRTFKESNDIYIFSYFYDRTRPLGMPLSFTLNELNDLARIVCKGEETWNSVFSGIAGSLDELESDSHFCLDLSFQVSLLHTGYDIPLQRELRTGKKIANKEIGWCLGASLPLLKADNWKCKIQSA"}]}