{"ymdb_id":"YMDB00258","created_at":"2011-05-29T17:59:27.000Z","updated_at":"2016-09-08T18:35:15.000Z","name":"O-Phosphohomoserine","cas":"4210-66-6","state":"Solid","melting_point":"","description":"O-Phosphohomoserine is a naturally occurring analogue of phosphonate amino acids. It is the final intermediate in the production of threonine. Threonine synthase hydrolyzes O-Phosphohomoserine into threonine and phosphate.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"-3.82","location":"cytoplasm","synthesis_reference":null,"chebi_id":"15961","hmdb_id":"HMDB03484","kegg_id":"C01102","pubchem_id":"151187","cs_id":"133252","foodb_id":null,"wikipedia_link":null,"biocyc_id":"O-PHOSPHO-L-HOMOSERINE","iupac":"(2S)-2-amino-4-(phosphonooxy)butanoic acid","traditional_iupac":"O-phosphohomoserine","logp":"-3.160008943226651","pka":"2.279284969740528","alogps_solubility":"1.81e+01 g/l","alogps_logp":"-2.34","alogps_logs":"-1.04","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"130.08","refractivity":"37.779300000000006","polarizability":"15.862376851424528","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"9.460891275706492","pka_strongest_acidic":"1.5192579618572903","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-amino-4-hydroxy-Butyric acid phosphate","Homoserine phosphate","L-2-amino-4-hydroxy-Butyric acid dihydrogen phosphate (ester)","O-Phospho-homoserine","O-Phospho-L-homoserine"],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"threonine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8973190,"citation":"Huo, X., Viola, R. E. (1996). \"Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli.\" Biochemistry 35:16180-16185."},{"pubmed_id":8082795,"citation":"Ramos, C., Calderon, I. L. (1994). \"Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase.\" FEBS Lett 351:357-359."}],"proteins":[{"created_at":"2011-05-26T19:28:04.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Homoserine kinase","uniprot_id":"P17423","uniprot_name":"KHSE_YEAST","enzyme":true,"transporter":false,"gene_name":"THR1","num_residues":357,"molecular_weight":"38712.0","theoretical_pi":"5.05","general_function":"Involved in ATP binding","specific_function":"Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate","reactions":[{"id":1641,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2569,"direction":"\u003e","locations":null,"altext":"ATP + L-homoserine = ADP + O-phospho-L-homoserine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M37692","genbank_protein_id":"172978","gene_card_id":"THR1","chromosome_location":"chromosome 8","locus":"YHR025W","synonyms":["HK","HSK"],"enzyme_classes":["2.7.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" homoserine kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" phosphorus metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"}],"gene_sequence":"ATGGTTCGTGCCTTCAAAATTAAAGTTCCAGCTTCTTCCGCCAATATCGGCCCTGGTTATGATGTTCTTGGTGTCGGTCTTTCTCTATTCTTGGAGTTAGATGTCACCATCGACTCCAGCCAAGCTCAGGAAACAAACGACGATCCCAACAACTGCAAGCTGTCTTACACTAAAGAAAGTGAAGGCTATTCTACGGTCCCATTGCGTTCTGATGCTAACCTGATTACCAGGACTGCGTTATATGTGTTGCGTTGCAACAATATTAGAAACTTCCCCTCCGGAACCAAAGTTCACGTCTCCAACCCAATCCCACTTGGCCGTGGATTGGGTTCCTCTGGTGCAGCAGTTGTGGCAGGTGTTATTTTAGGTAACGAAGTGGCCCAATTGGGTTTCTCTAAGCAACGTATGTTGGACTACTGTTTGATGATTGAACGTCATCCAGACAACATAACCGCTGCTATGATGGGAGGCTTTTGCGGTTCATTCCTAAGGGACTTGACCCCACAAGAGGTGGAAAGACGTGAGATTCCATTGGCTGAGGTGCTTCCAGAACCTTCTGGTGGTGAAGATACCGGTCTGGTTCCCCCATTACCTCCCACCGATATCGGTAGACATGTCAAATACCAATGGAACCCCGCCATTAAATGTATTGCGATCATCCCACAGTTCGAGTTGTCCACCGCCGACTCCAGAGGCGTTCTTCCAAAAGCCTACCCAACCCAGGACTTGGTTTTCAATCTACAAAGATTGGCCGTCTTGACCACAGCTTTGACCATGGACCCACCTAATGCCGACTTAATCTACCCTGCTATGCAAGATCGTGTCCACCAACCTTATAGAAAGACATTGATCCCAGGTCTCACGGAAATCTTATCATGTGTCACCCCATCCACATACCCTGGCCTATTGGGTATCTGCTTGTCAGGTGCAGGCCCAACTATCTTGGCTTTGGCCACTGAGAATTTCGAAGAAATCTCTCAAGAAATTATCAACAGGTTCGCCAAAAACGGCATCAAGTGCTCCTGGAAACTACTGGAGCCTGCCTACGATGGTGCTAGCGTCGAACAGCAATGA","protein_sequence":"MVRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSQAQETNDDPNNCKLSYTKESEGYSTVPLRSDANLITRTALYVLRCNNIRNFPSGTKVHVSNPIPLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGFCGSFLRDLTPQEVERREIPLAEVLPEPSGGEDTGLVPPLPPTDIGRHVKYQWNPAIKCIAIIPQFELSTADSRGVLPKAYPTQDLVFNLQRLAVLTTALTMDPPNADLIYPAMQDRVHQPYRKTLIPGLTEILSCVTPSTYPGLLGICLSGAGPTILALATENFEEISQEIINRFAKNGIKCSWKLLEPAYDGASVEQQ"},{"created_at":"2011-05-27T04:03:47.000Z","updated_at":"2011-07-22T17:53:49.000Z","name":"Threonine synthase","uniprot_id":"P16120","uniprot_name":"THRC_YEAST","enzyme":true,"transporter":false,"gene_name":"THR4","num_residues":514,"molecular_weight":"57473.69922","theoretical_pi":"5.3","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine","reactions":[{"id":1193,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2009,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2755,"direction":"\u003e","locations":null,"altext":"O-phospho-L-homoserine + H(2)O = L-threonine + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006379","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1KL7","cellular_location":null,"genbank_gene_id":"X17256","genbank_protein_id":"4616","gene_card_id":"THR4","chromosome_location":"chromosome 3","locus":"YCR053W","synonyms":["TS"],"enzyme_classes":["4.2.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" carbon-oxygen lyase activity, acting on phosphates"},{"category":"Function","description":" threonine synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"},{"category":"Process","description":" threonine biosynthetic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTAACGCTTCCCAAGTTTACAGATCTACCAGATCCAGCTCTCCAAAGACAATCTCTTTTGAAGAGGCTATCATTCAAGGTCTGGCCACTGACGGTGGTCTTTTCATTCCACCAACTATTCCACAAGTGGACCAAGCCACTCTTTTCAATGATTGGTCAAAGCTCTCCTTCCAAGACTTAGCCTTTGCTATCATGAGACTATACATTGCCCAAGAAGAGATTCCAGATGCTGATCTAAAGGACTTGATCAAGAGATCTTATTCTACTTTCCGTTCTGATGAAGTCACCCCCTTGGTGCAAAACGTCACTGGTGACAAGGAGAATTTGCACATTTTAGAATTATTCCACGGTCCTACCTACGCTTTCAAAGACGTTGCTTTACAATTTGTCGGTAATCTTTTTGAATACTTCTTACAAAGAACCAACGCCAATTTACCTGAAGGCGAGAAAAAGCAAATCACTGTGGTCGGTGCTACTTCCGGTGACACTGGTTCTGCAGCCATCTACGGTTTAAGAGGCAAAAAGGACGTTTCCGTTTTCATCTTATATCCAACCGGTAGAATTTCCCCAATTCAAGAAGAACAAATGACCACCGTTCCAGATGAAAACGTCCAGACTTTGTCTGTTACCGGTACTTTCGACAACTGTCAAGATATCGTCAAAGCTATTTTCGGTGACAAAGAATTCAACTCTAAACACAACGTCGGTGCTGTTAACTCCATCAACTGGGCAAGAATCTTGGCCCAAATGACCTATTACTTTTATTCATTCTTCCAAGCCACCAACGGTAAGGACTCCAAGAAGGTCAAGTTCGTTGTGCCAAGTGGGAACTTCGGTGATATATTGGCCGGTTATTTTGCCAAGAAAATGGGTTTGCCTATTGAAAAACTGGCCATCGCTACCAATGAAAACGACATTTTGGACAGATTTTTGAAATCTGGTCTATACGAAAGATCAGACAAGGTTGCTGCTACTTTATCCCCAGCAATGGATATCTTAATCTCTTCTAACTTTGAAAGACTACTATGGTACCTAGCTCGTGAATACCTAGCTAATGGTGATGATTTGAAAGCCGGTGAAATCGTCAACAATTGGTTCCAGGAATTGAAGACCAACGGTAAGTTCCAAGTTGACAAATCCATCATTGAAGGCGCATCAAAGGACTTTACATCAGAAAGAGTTTCCAATGAAGAAACATCTGAAACAATCAAGAAGATCTACGAATCATCTGTAAATCCAAAACATTACATCTTAGATCCTCACACAGCTGTCGGTGTTTGCGCCACAGAAAGATTGATTGCAAAAGATAATGACAAGTCCATCCAATACATTTCTCTATCTACCGCTCACCCAGCTAAATTTGCCGATGCTGTAAACAATGCATTGTCTGGATTTTCCAATTATTCATTTGAAAAGGATGTTTTGCCTGAGGAATTGAAGAAACTATCCACATTAAAGAAGAAATTAAAATTCATCGAAAGAGCTGACGTTGAATTGGTCAAAAACGCTATTGAAGAAGAACTTGCTAAAATGAAATTATAA","protein_sequence":"MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQATLFNDWSKLSFQDLAFAIMRLYIAQEEIPDADLKDLIKRSYSTFRSDEVTPLVQNVTGDKENLHILELFHGPTYAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVNSINWARILAQMTYYFYSFFQATNGKDSKKVKFVVPSGNFGDILAGYFAKKMGLPIEKLAIATNENDILDRFLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDDLKAGEIVNNWFQELKTNGKFQVDKSIIEGASKDFTSERVSNEETSETIKKIYESSVNPKHYILDPHTAVGVCATERLIAKDNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEELKKLSTLKKKLKFIERADVELVKNAIEEELAKMKL"}]}