{"ymdb_id":"YMDB00206","created_at":"2011-05-29T16:06:53.000Z","updated_at":"2016-09-08T18:35:10.000Z","name":"dCMP","cas":"1032-65-1","state":"Solid","melting_point":"","description":"Deoxycytidine monophosphate (dCMP) is a deoxyribonucleotide found in DNA. dCMP consists of a phosphate group, the sugar deoxy-ribose, and the nucleobase cytidine. When found in DNA the cytidine portion of dCMP pairs with the guanosine portion of dGMP.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Tanaka, Toshiki; Yamada, Yasuki; Ikehara, Morio. Chemical synthesis of deoxyribonucleotide with a 5'-phosphoryl group on a polystyrene polymer support by the phosphotriester method. Chemical \u0026 Pharmaceutical Bulletin (1987), 35(7), 2726-33.","chebi_id":"15918","hmdb_id":"HMDB01202","kegg_id":"C00239","pubchem_id":"13945","cs_id":"25057310","foodb_id":null,"wikipedia_link":"Deoxycytidine_monophosphate","biocyc_id":"DCMP","iupac":"{[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"dCMP","logp":"-2.283034970573228","pka":"6.2585739758421095","alogps_solubility":"1.09e+01 g/l","alogps_logp":"-2.13","alogps_logs":"-1.45","acceptor_count":"8","donor_count":"4","rotatable_bond_count":"4","polar_surface_area":"154.91","refractivity":"63.907000000000004","polarizability":"26.195129069085244","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"0.16099958039925","pka_strongest_acidic":"1.279165528098246","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2'-Deoxycytidine 5'-monophosphate","2'-Deoxycytidine-3'-monophosphate","2'-Deoxycytidine-5'-monophosphate","2'-Deoxycytidine-5'-monophosphorate","2'-Deoxycytidine-5'-monophosphoric acid","2'-deoxycytidine-5'-phosphate","dCMP","deoxycytidine monophosphate","deoxycytidine-phosphate","Deoxycytidylate","deoxycytidylic acid"],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."}],"proteins":[{"created_at":"2011-05-26T18:17:59.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Deoxycytidylate deaminase","uniprot_id":"P06773","uniprot_name":"DCTD_YEAST","enzyme":true,"transporter":false,"gene_name":"DCD1","num_residues":312,"molecular_weight":"35645.69922","theoretical_pi":"7.95","general_function":"Involved in zinc ion binding","specific_function":"Supplies the nucleotide substrate for thymidylate synthetase","reactions":[{"id":1438,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1439,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2522,"direction":"\u003e","locations":"Cytoplasmic","altext":"dCMP + H(2)O = dUMP + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M13010","genbank_protein_id":"171384","gene_card_id":"DCD1","chromosome_location":"chromosome 8","locus":"YHR144C","synonyms":["dCMP deaminase"],"enzyme_classes":["3.5.4.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"dCMP_cyt_deam_1","identifier":"PF00383"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTTAATTGGTGTAAGTGGTACGAAATTTTGCGGATGCGAAGATGTTATTAACATGTTGGTTGATCATTTTCATTTTGAATTACTCAATCACCTAGATAATCCAGAGGAGATATTAGATTATGCTACGAAAAATTACACAAAAAATTCAGTTATATTCCTAGAAAAATTATCATTACTGGAGAAACTGGAAAAGAGACCATTTTTTGTTCATCTTTCTATCGACGCTCCTGCTACTACAAGGGTAGCATTATACAGGAAAACGACTCAAGCAGAAAGCTTATCATTAGAACAAATAATACAAGCCATTGATCAACATGACTTTCAGCCTGAAGGCATCAAATTAAGGGAGAAATCCCATTTGAGATTTAAAATAGTTAATGAGGACCGCAGAGGAAGGAGACAGAGCTTGATTAATAACATTACCACACAATTAAAGATTCTCGATGACAAAGAGAAACAAATGGCTCCATTAATGAGGCCTAGTTGGGATAGCTATTTTATGAAGTTAGCCACACTAGCAGCATCTCGTTCCAATTGCATGAAACGTAGAGTTGGTTGCGTGATTGTGAGAGAATGCAGAGTGATTGCTACTGGCTATAATGGGACTCCTCGACATTTAACAAATTGTTTCAATGGCGGTTGCCCACGTTGCAATGACGGTGATTCTAGAAATCTGCACACTTGCTTATGCTTACATGCAGAAGAGAATGCACTACTGGAAGCTGGCAGGGATCGTGTAGGTCAAAATGCGACCTTATACTGTGATACTTGCCCTTGCTTAACATGTTCTGTAAAGATTGTTCAAACAGGCATCAGTGAAGTAGTTTATAGCCAAAGTTATAGAATGGACGAGGAAAGTTTCAAGGTCTTGAAGAATGCGGGAATAACCGTCCGGCAATTCAGCTTTACGGAAGAACCAAGAATTGTGATGATTTAA","protein_sequence":"MLIGVSGTKFCGCEDVINMLVDHFHFELLNHLDNPEEILDYATKNYTKNSVIFLEKLSLLEKLEKRPFFVHLSIDAPVTTRVALYRKTTQAESLSLEQIIQAIDQHDFQPEGIKLREKSHLRFKIVNEDRRGRRQSLINNITTQLKILDDKEKQMAPLMRPSWDSYFMKLATLAASRSNCMKRRVGCVIVRECRVIATGYNGTPRHLTNCFNGGCPRCNDGDSRNLHTCLCLHAEENALLEAGRDRVGQNATLYCDTCPCLTCSVKIVQTGISEVVYSQSYRMDEESFKVLKNAGITVRQFSFTEEPRIVMI"}]}