{"ymdb_id":"YMDB00173","created_at":"2011-05-29T16:03:45.000Z","updated_at":"2016-09-08T18:35:08.000Z","name":"Myoinositol","cas":"87-89-8","state":"Solid","melting_point":"225 oC","description":"Myo-inositol is a cyclic polyalcohol. It is the most prominent form of inositol in nature. Myo-inositol plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells, including inositol phosphates, phosphatidylinositol (PI) and phosphatidylinositol phosphate (PIP) lipids. Inositol is almost tasteless, with a small amount of sweetness.","experimental_water_solubility":"143 mg/mL at 19 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"","location":"extracellular;cell envelope;mitochondrion;cytoplasm","synthesis_reference":"Iselin, Beat M. Synthesis of inositol-5-monophosphoric acid and scyllitol monophosphoric acid. Journal of the American Chemical Society (1949), 71 3822-5.","chebi_id":"17268","hmdb_id":"HMDB00211","kegg_id":"C00137","pubchem_id":"892","cs_id":"23203338","foodb_id":null,"wikipedia_link":"Inositol","biocyc_id":"MYO-INOSITOL","iupac":"(1R,2R,3r,4S,5S,6s)-cyclohexane-1,2,3,4,5,6-hexol","traditional_iupac":"L-inositol","logp":"-3.782009652","pka":"12.908097249605351","alogps_solubility":"4.85e+02 g/l","alogps_logp":"-2.59","alogps_logs":"0.43","acceptor_count":"6","donor_count":"6","rotatable_bond_count":"0","polar_surface_area":"121.38000000000001","refractivity":"35.77499999999999","polarizability":"16.141745963720343","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-3.645759838065448","pka_strongest_acidic":"12.285497953856298","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["cis-1,2,3,5-trans-4,6-Cyclohexanehexol","i-Inositol","iso-Inositol","Meat sugar","meso-Inositol","MI","Myo-Inositol","Myoinosite","Myoinositol","Phaseomannite","Rat antispectacled eye factor"],"pathways":[{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10844654,"citation":"Murray, M., Greenberg, M. L. (2000). \"Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate.\" Mol Microbiol 36:651-661."},{"pubmed_id":9370330,"citation":"Nikawa, J., Yamashita, S. (1997). \"Phosphatidylinositol synthase from yeast.\" Biochim Biophys Acta 1348:173-178."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-27T03:08:19.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"CDP-diacylglycerol--inositol 3-phosphatidyltransferase","uniprot_id":"P06197","uniprot_name":"PIS_YEAST","enzyme":true,"transporter":false,"gene_name":"PIS1","num_residues":220,"molecular_weight":"24823.5","theoretical_pi":"8.87","general_function":"Involved in phosphotransferase activity, for other substituted phosphate groups","specific_function":"CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol","reactions":[{"id":1852,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1853,"direction":"\u003c\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2706,"direction":"\u003e","locations":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane","altext":"CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"21-41;46-66;76-96;99-119;146-166;171-191","pdb_id":null,"cellular_location":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane","genbank_gene_id":"J02697","genbank_protein_id":"172173","gene_card_id":"PIS1","chromosome_location":"chromosome 16","locus":"YPR113W","synonyms":["Phosphatidylinositol synthase","PI synthase","PtdIns synthase"],"enzyme_classes":["2.7.8.11"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CDP-OH_P_transf","identifier":"PF01066"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGAGTTCGAATTCAACACCAGAAAAGGTTACTGCAGAACACGTTCTGTGGTATATTCCCAATAAGATCGGTTATGTTCGTGTTATCACCGCCGCCCTTTCTTTTTTCGTTATGAAGAATCATCCTACGGCCTTTACATGGTTGTATAGTACATCATGTCTACTGGATGCGCTAGACGGAACCATGGCAAGAAAGTACAATCAGGTTTCCAGTCTGGGTGCCGTTCTGGACATGGTTACCGACAGATCCAGTACCGCTGGCTTGATGTGTTTCCTTTGTGTGCAGTATCCCCAATGGTGCGTTTTCTTCCAATTAATGCTGGGCTTGGATATTACTAGTCACTACATGCATATGTATGCCAGTTTAAGTGCTGGTAAGACTTCTCATAAAAGTGTGGGCGAGGGTGAGTCCAGATTGTTACACCTGTACTACACGAGAAGAGACGTACTGTTCACTATCTGTGCGTTTAACGAACTATTTTATGCTGGATTGTACTTGCAGTTGTTCTCAAATTCTGCAACCTTTGGTAAATGGACTACAATCATAAGTTTCCCTGGTTACGTGTTCAAGCAGACCGCAAACGTTGTCCAGCTAAAAAGGGCAGCCTTGATTTTAGCAGACAACGATGCCAAGAATGCCAACGAGAAGAACAAGACTTACTGA","protein_sequence":"MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCVQYPQWCVFFQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLFTICAFNELFYAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNKTY"},{"created_at":"2011-05-27T03:09:16.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Myo-inositol transporter 1","uniprot_id":"P30605","uniprot_name":"ITR1_YEAST","enzyme":false,"transporter":true,"gene_name":"ITR1","num_residues":584,"molecular_weight":"63569.10156","theoretical_pi":"6.51","general_function":"Involved in transmembrane transporter activity","specific_function":"Major transporter for myo-inositol","reactions":[],"signal_regions":"None","transmembrane_regions":"82-102;130-150;164-184;187-207;216-236;247-267;350-370;377-397;401-421;442-462;487-507;511-531","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"D90352","genbank_protein_id":"218437","gene_card_id":"ITR1","chromosome_location":"chromosome 4","locus":"YDR497C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Sugar_tr","identifier":"PF00083"}],"pathways":[],"gene_sequence":"ATGGGAATACACATACCATATCTCACGTCAAAGACATCGCAATCAAATGTTGGTGATGCCGTTGGCAACGCTGATAGTGTAGAGTTCAACAGTGAGCATGACTCACCTTCAAAGAGAGGTAAAATTCACATTGAGTCACATGAAATACAGAGGGCTCCCGCTAGCGATGATGAAGATAGGATTCAAATTAAACCCGTGAACGACGAGGATGACACGTCGGTCATGATCACTTTTAACCAATCTCTTTCGCCCTTCATCATCACTCTGACTTTTGTCGCATCCATATCCGGTTTCATGTTTGGTTACGACACTGGTTATATATCCAGTGCGCTGATCTCGATCGGCACAGATCTGGACCACAAGGTACTTACTTATGGGGAGAAGGAAATTGTCACTGCGGCTACCTCTCTGGGAGCTTTGATTACCAGTATTTTCGCCGGTACTGCAGCTGACATATTTGGTAGGAAACGTTGTTTAATGGGTTCGAATCTGATGTTTGTCATTGGCGCAATCTTACAGGTCTCCGCACACACATTCTGGCAAATGGCTGTTGGTAGACTGATCATGGGTTTCGGTGTCGGTATCGGCTCCTTGATCGCGCCACTTTTCATCAGTGAAATTGCTCCCAAAATGATCAGAGGGAGACTAACTGTCATCAATTCCTTATGGTTGACTGGTGGTCAATTAGTCGCTTACGGTTGCGGTGCTGGGTTAAACTACGTCAACAATGGTTGGAGAATTCTTGTTGGATTGTCACTAATTCCCACTGCTGTGCAATTCACATGCCTGTGCTTTTTACCTGACACTCCAAGATACTACGTTATGAAGGGCGACTTGGCAAGGGCTACTGAGGTGTTGAAGAGAAGTTACACTGACACTTCGGAGGAAATCATTGAACGTAAGGTGGAAGAACTTGTTACTTTGAATCAATCTATTCCTGGTAAGAATGTCCCTGAAAAAGTCTGGAATACCATCAAAGAATTGCACACAGTACCATCTAATCTAAGGGCTTTGATCATTGGTTGTGGTTTACAAGCAATTCAACAGTTTACCGGTTGGAATTCGTTGATGTATTTCTCTGGTACCATCTTCGAAACTGTCGGTTTCAAAAATTCTTCCGCTGTTTCAATCATCGTGTCCGGTACCAATTTTATTTTCACTTTAGTTGCCTTTTTTTCCATTGACAAAATAGGCCGTAGAACCATATTATTGATTGGATTACCAGGCATGACCATGGCTTTAGTCGTGTGCTCTATTGCTTTCCATTTTCTAGGTATTAAGTTTGATGGCGCTGTCGCTGTGGTGGTTTCCTCCGGTTTCTCCTCTTGGGGTATTGTGATCATCGTATTTATTATCGTATTTGCTGCGTTCTACGCTCTTGGTATCGGTACTGTTCCATGGCAACAATCGGAACTATTCCCCCAAAACGTGAGAGGTATTGGGACTTCATATGCAACTGCTACAAACTGGGCTGGTTCACTGGTTATTGCATCCACATTTTTGACCATGTTACAGAATATCACTCCTGCAGGTACATTTGCCTTTTTCGCGGGATTGTCGTGCTTATCAACCATTTTCTGCTACTTCTGTTATCCAGAATTATCGGGATTGGAGTTAGAAGAGGTACAAACTATTTTGAAGGACGGGTTCAACATCAAAGCCTCGAAAGCTTTGGCCAAGAAGAGAAAACAGCAAGTTGCCAGAGTTCATGAATTGAAATATGAACCAACTCAAGAGATTATAGAGGATATATAG","protein_sequence":"MGIHIPYLTSKTSQSNVGDAVGNADSVEFNSEHDSPSKRGKITLESHEIQRAPASDDEDRIQIKPVNDEDDTSVMITFNQSLSPFIITLTFVASISGFMFGYDTGYISSALISIGTDLDHKVLTYGEKEIVTAATSLGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLKRSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPWQQSELFPQNVRGIGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLELEEVQTILKDGFNIKASKALAKKRKQQVARVHELKYEPTQEIIEDI"},{"created_at":"2011-05-27T03:10:02.000Z","updated_at":"2011-05-27T03:10:02.000Z","name":"Transposon Ty1-OL Gag-Pol polyprotein","uniprot_id":"Q12273","uniprot_name":"YO11B_YEAST","enzyme":false,"transporter":true,"gene_name":"TY1B-OL","num_residues":1755,"molecular_weight":"198613.0","theoretical_pi":"8.27","general_function":"Involved in DNA binding","specific_function":"Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome","reactions":[{"id":2707,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z74845","genbank_protein_id":"1419960","gene_card_id":"TY1B-OL","chromosome_location":null,"locus":"YOL103W-B","synonyms":["Gag-Pol-p199","TY1A-TY1B","Transposon Ty1 TYA-TYB polyprotein","p190","Capsid protein","CA","Gag-p45","p54","Ty1 protease","PR","Pol-p20","p23","Integrase","IN","Pol-p71","p84","p90","Reverse transcriptase/ribonuclease H","RT","RT-RH","Pol-p63","p60"],"enzyme_classes":["3.4.23.-","2.7.7.49","2.7.7.7","3.1.26.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" DNA binding"},{"category":"Function","description":" peptidase activity"},{"category":"Function","description":" peptidase activity, acting on L-amino acid peptides"},{"category":"Function","description":" endopeptidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aspartic-type endopeptidase activity"},{"category":"Process","description":" DNA integration"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" DNA metabolic process"},{"category":"Process","description":" protein metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" proteolysis"},{"category":"Process","description":" macromolecule metabolic process"}],"pfams":[{"name":"rve","identifier":"PF00665"},{"name":"RVT_2","identifier":"PF07727"},{"name":"TYA","identifier":"PF01021"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGGAATCCCAACAATTATCTAATTACCCACAAATTTCTCATGGTAGCGCCTGTGCTTCGGTTACTTCTAAGGAAGTCCACACAAATCAAGATCCGTTAGACGTTTCAGCTTCCAAAACAGAAGAATGTGAGAAGGCTTCCACTAAGGCTAACTCTCAACAGACAACAACACCTGCTTCATCAGCTGTTCCAGAGAACCCCCATCATGCCTCTCCTCAACCTGCTTCAGTACCACCTCCACAGAATGGGCCGTACCCACAGCAGTGCATGATGACCCAAAACCAAGCCAATCCATCTGGTTGGTCATTTTACGGACACCCATCTATGATTCCGTATACACCTTATCAAATGTCGCCTATGTACTTTCCACCTGGGCCACAATCACAGTTTCCGCAGTATCCATCATCAGTTGGAACGCCTCTGAGCACTCCATCACCTGAGTCAGGTAATACATTTACTGATTCATCCTCAGCGGACTCTGATATGACATCCACTAAAAAATATGTCAGACCACCACCAATGTTAACCTCACCTAATGACTTTCCAAATTGGGTTAAAACATACATCAAATTTTTACAAAACTCGAATCTCGGTGGTATTATTCCGACAGTAAACGGAAAACCCGTACGTCAGATCACTGATGATGAACTCACCTTCTTGTATAACACTTTTCAAATATTTGCTCCCTCTCAATTCCTACCTACCTGGGTCAAAGACATCCTATCCGTTGATTATACGGATATCATGAAAATTCTTTCCAAAAGTATTGAAAAAATGCAATCTGATACCCAAGAGGCAAACGACATTGTGACCCTGGCAAATTTGCAATATAATGGCAGTACACCTGCAGATGCATTTGAAACAAAAGTCACAAACATTATCAACAGACTGAACAATAATGGCATTCATATCAATAACAAGGTCGCATGCCAATTAATTATGAGAGGTCTATCTGGCGAATATAAATTTTTACGCTACACACGTCATCGACATCTAAATATGACAGTCGCTGAACTGTTCTTAGATATCCATGCTATTTATGAAGAACAACAGGGATCGAGAAACAGCAAACCTAATTACAGGAGAAATCTGAGTGATGAGAAGAATGATTCTCGCAGCTATACGAATACAACCAAACCCAAAGTTATAGCTCGGAATCCTCAAAAAACAAATAATTCGAAATCGAAAACAGCCAGGGCTCACAATGTATCCACATCTAATAACTCTCCCAGCACGGACAACGATTCCATCAGTAAATCAACTACTGAACCGATTCAATTGAACAATAAGCACGACCTTCACCTTGGCCAGGAACTTACTGAATCTACGGTAAATCACACTAATCATTCTGATGATGAACTCCCTGGACACCTCCTTCTCGATTCAGGAGCATCACGAACCCTTATAAGATCTGCTCATCACATACACTCAGCATCATCTAATCCTGACATAAACGTAGTTGATGCTCAAAAAAGAAATATACCAATTAACGCTATTGGTGACCTACAATTTCACTTCCAGGACAACACCAAAACATCAATAAAGGTATTGCACACTCCTAACATAGCCTATGACTTACTCAGTTTGAATGAATTGGCTGCAGTAGATATCACAGCATGCTTTACCAAAAACGTCTTAGAACGATCTGACGGCACTGTACTTGCACCTATCGTAAAATATGGAGACTTTTACTGGGTATCTAAAAAGTACTTGCTTCCATCAAATATCTCCGTACCCACCATCAATAATGTCCATACAAGTGAAAGTACACGCAAATATCCTTATCCTTTCATTCATCGAATGCTTGCACATGCCAATGCACAGACAATTCGATACTCACTTAAAAATAACACCATCACGTATTTTAACGAATCAGATGTCGACTGGTCTAGTGCTATTGACTATCAATGTCCTGATTGTTTAATCGGCAAAAGCACCAAACACAGACATATCAAAGGTTCACGACTAAAATACCAAAATTCATACGAACCCTTTCAATACCTACATACTGACATATTTGGTCCAGTTCACAACCTACCAAAAAGTGCACCATCCTATTTCATCTCATTTACTGATGAGACAACAAAATTCCGTTGGGTTTATCCATTACACGACCGTCGCGAGGACTCTATCCTCGATGTTTTTACTACGATACTAGCTTTTATTAAGAACCAGTTTCAGGCCAGTGTCTTGGTTATACAAATGGACCGTGGTTCTGAGTATACTAACAGAACTCTCCATAAATTCCTTGAAAAAAATGGTATAACTCCATGCTATACAACCACAGCGGATTCCCGAGCACATGGAGTCGCTGAACGGCTCAACCGTACCTTATTAGATGACTGCCGTACTCAACTGCAATGTAGTGGTTTACCGAACCATTTATGGTTCTCTGCAATCGAATTTTCTACTATTGTGAGAAATTCACTAGCTTCACCTAAAAGCAAAAAATCTGCAAGACAACATGCTGGCTTGGCAGGACTTGATATCAGTACTTTGTTACCTTTCGGTCAACCTGTTATCGTCAATGATCACAACCCTAACTCCAAAATACATCCTCGTGGCATCCCAGGCTACGCTCTACATCCGTCTCGAAACTCTTATGGATATATCATCTATCTTCCATCCTTAAAGAAGACAGTAGATACAACTAACTATGTTATTCTTCAGGGCAAGGAATCCAGATTAGATCAATTCAATTACGACGCACTCACTTTCGATGAAGACTTAAACCGTTTAACTGCTTCATATCAATCGTTCATTGCGTCAAATGAGATCCAACAATCCGATGATCTTAACATAGAATCTGACCATGACTTCCAATCTGACATCGAACTACATCCTGAGCAACCGAGAAATGTCCTTTCAAAAGCTGTGAGTCCAACCGATTCCACACCTCCGTCAACTCATACTGAAGATTCGAAACGTGTTTCTAAAACCAATATTCGCGCACCCAGAGAAGTTGACCCCAACATATCTGAATCTAATATTCTTCCATCAAAGAAGAGATCTAGCACCCCCCAAATTTCCAATATCGAGAGTACCGGTTCGGGTGGTATGCATAAATTAAATGTTCCTTTACTTGCTCCCATGTCCCAATCTAACACACATGAGTCGTCGCACGCCAGTAAATCTAAAGATTTCAGACACTCAGACTCGTACAGTGAAAATGAGACTAATCATACAAACGTACCAATATCCAGTACGGGTGGTACCAACAACAAAACTGTTCCGCAGATAAGTGACCAAGAGACTGAGAAAAGGATTATACACCGTTCACCTTCAATCGATGCTTCTCCACCGGAAAATAATTCATCGCACAATATTGTTCCTATCAAAACGCCAACTACTGTTTCTGAACAGAATACCGAGGAATCTATCATCGCTGATCTCCCACTCCCTGATCTACCTCCAGAATCTCCTACCGAATTCCCTGACCCATTTAAAGAACTCCCACCGATAAATTCTCATCAAACTAATTCCAGTTTGGGTGGTATTGGTGACTCTAATGCCTATACTACTATCAACAGTAAGAAAAGATCATTAGAAGATAATGAAACTGAAATTAAGGTATCACGAGACACATGGAATACTAAGAATATGCGTAGTTTAGAACCTCCGAGATCGAAGAAACGAATTCACCTGATTGCAGCTGTAAAAGCAGTAAAATCAATCAAACCAATACGGACAACCTTACGATACGATGAGGCAATCACCTATAATAAAGATATTAAAGAAAAAGAAAAATATATCGAGGCATACCACAAAGAAGTCAATCAACTGTTGAAGATGAAAACTTGGGACACTGACGAATATTATGACAGAAAAGAAATAGACCCTAAAAGAGTAATAAACTCAATGTTTATCTTCAACAAGAAACGTGACGGTACTCATAAAGCTAGATTTGTTGCAAGAGGTGATATTCAGCATCCTGACACTTACGACTCAGGCATGCAATCCAATACCGTACATCACTATGCATTAATGACATCCCTGTCACTTGCATTAGACAATAACTACTATATTACACAATTAGACATATCTTCGGCATATTTGTATGCAGACATCAAAGAAGAATTATACATAAGACCTCCACCACATTTAGGAATGAATGATAAGTTGATACGTTTGAAGAAATCACTTTATGGATTGAAACAAAGTGGAGCGAACTGGTACGAAACTATCAAATCATACCTGATAAAACAGTGTGGTATGGAAGAAGTTCGTGGATGGTCATGCGTATTTAAGAATAGTCAAGTAACAATATGTTTATTTGTTGACGACATGATTTTATTCAGCAAAGACTTAAATGCAAATAAGAAAATCATAACAACACTCAAGAAACAATACGATACAAAGATAATAAATCTGGGTGAAAGTGATAACGAAATTCAGTACGACATACTTGGCTTAGAAATCAAATATCAAAGAGGTAAATACATGAAATTAGGTATGGAAAACTCATTAACTGAGAAAATACCCAAATTAAACGTACCTTTGAATCCAAAAGGAAGAAAACTTAGCGCTCCAGGTCAACCAGGTCTTTATATAGACCAGGATGAACTAGAAATAGATGAAGATGAATACAAAGAGAAGGTACATGAAATGCAAAAGTTGATTGGTCTAGCTTCATATGTTGGATATAAATTTAGATTTGACTTACTATACTACATCAACACACTTGCTCAACATATACTATTCCCCTCTAGGCAAGTTTTAGACATGACATATGAGTTGATACAATTCATGTGGGACACTAGAGATAAACAACTGATATGGCACAAAAACAAACCTACCGAGCCAGATAATAAACTAGTCGCAATAAGTGATGCTTCGTATGGCAACCAACCGTATTATAAATCACAAATTGGCAACATATATTTACTTAATGGAAAGGTAATTGGAGGAAAGTCCACCAAGGCTTCATTAACATGTACTTCAACTACGGAAGCAGAAATACACGCGATAAGTGAATCTGTCCCATTATTAAATAATCTAAGTTACCTGATACAAGAACTTAACAAGAAACCAATTATTAAAGGCTTACTTACTGATAGTAGATCAACGATCAGTATAATTAAGTCTACAAATGAAGAGAAATTTAGAAACAGATTTTTTGGCACAAAGGCAATGAGACTTAGAGATGAAGTATCAGGTAATAATTTATACGTATACTACATCGAGACCAAGAAGAACATTGCTGATGTGATGACAAAACCTCTTCCGATAAAAACATTCAAACTATTAACAAACAAATGGATTCATTAG","protein_sequence":"MESQQLSNYPQISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIINRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH"},{"created_at":"2011-05-27T03:10:33.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Inositol monophosphatase 2","uniprot_id":"Q05533","uniprot_name":"INM2_YEAST","enzyme":true,"transporter":false,"gene_name":"INM2","num_residues":292,"molecular_weight":"32092.40039","theoretical_pi":"5.4","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling","reactions":[{"id":1749,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2708,"direction":"\u003e","locations":"Cytoplasm. 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Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"INM1","chromosome_location":"chromosome 8","locus":"YHR046C","synonyms":["IMP 1","IMPase 1","Inositol-1(or 4)-monophosphatase 1"],"enzyme_classes":["3.1.3.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Inositol_P","identifier":"PF00459"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACCATTGATCTAGCTTCTATCGAGAAATTCCTCTGTGAACTGGCTACTGAAAAAGTAGGACCAATCATCAAATCCAAGTCCGGCACTCAAAAGGATTATGACTTGAAGACTGGCTCCAGGAGCGTTGATATTGTAACTGCTATCGATAAACAGGTCGAAAAGTTAATTTGGGAATCGGTAAAAACCCAATATCCAACTTTCAAGTTTATTGGAGAGGAAAGTTATGTGAAAGGGGAGACCGTGATTACTGATGATCCTACCTTTATTATTGATCCAATTGATGGGACTACAAACTTTGTTCATGATTTCCCATTTAGCTGTACCTCTCTTGGGCTCACAGTAAACAAAGAGCCCGTAGTAGGCGTTATATATAATCCTCACATTAATCTTCTGGTATCCGCTTCTAAAGGAAATGGGATGAGAGTTAACAACAAGGACTATGACTATAAATCAAAATTGGAATCTATGGGTTCTCTAATACTAAATAAATCCGTAGTGGCATTACAGCCAGGTTCCGCTAGAGAGGGAAAGAATTTTCAGACAAAAATGGCCACATATGAAAAATTACTATCATGTGATTACGGTTTTGTTCATGGATTCAGAAATTTAGGATCATCTGCAATGACAATGGCATATATTGCTATGGGGTACCTTGATAGTTATTGGGATGGTGGTTGCTATTCGTGGGACGTGTGTGCTGGATGGTGTATTTTGAAAGAAGTGGGCGGTCGTGTAGTAGGTGCCAATCCAGGTGAATGGAGTATTGATGTCGACAATAGGACATATTTGGCTGTGAGGGGAACAATTAATAACGAAAGTGACGAACAAACAAAATATATCACAGACTTTTGGAACTGTGTTGATGGCCATTTGAAATATGACTGA","protein_sequence":"MTIDLASIEKFLCELATEKVGPIIKSKSGTQKDYDLKTGSRSVDIVTAIDKQVEKLIWESVKTQYPTFKFIGEESYVKGETVITDDPTFIIDPIDGTTNFVHDFPFSCTSLGLTVNKEPVVGVIYNPHINLLVSASKGNGMRVNNKDYDYKSKLESMGSLILNKSVVALQPGSAREGKNFQTKMATYEKLLSCDYGFVHGFRNLGSSAMTMAYIAMGYLDSYWDGGCYSWDVCAGWCILKEVGGRVVGANPGEWSIDVDNRTYLAVRGTINNESDEQTKYITDFWNCVDGHLKYD"}]}