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Nameurea-1-carboxylic acid
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionUrea-1-carboxylic acid, also known as urea-1-carboxylic acid or urea-1-carboxylic acid, belongs to the class of organic compounds known as ureas. Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group. Urea-1-carboxylic acid is possibly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Urea-1-carboxylic acid exists in both E.coli (prokaryote) and yeast (eukaryote). Urea-1-carboxylic acid participates in a number of enzymatic reactions, within yeast. In particular, Urea-1-carboxylic acid can be biosynthesized from carbonic acid and urea through the action of the enzyme urea carboxylase / urea-1-carboxylic acid hydrolase. In addition, Urea-1-carboxylic acid can be converted into ammonium; which is mediated by the enzyme urea carboxylase / urea-1-carboxylic acid hydrolase. In yeast, urea-1-carboxylic acid is involved in the metabolic pathway called the arginine and proline metabolism pathway.
  • Allophanate
  • Allophanic acid
  • Urea-1-carboxylate
  • Urea-1-carboxylic acid
CAS number625-78-5
WeightAverage: 104.0648
Monoisotopic: 104.022192004
IUPAC Namecarbamoylcarbamic acid
Traditional IUPAC Nameallophanic acid
Chemical FormulaC2H4N2O3
Chemical Taxonomy
Description belongs to the class of organic compounds known as ureas. Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassUreas
Direct ParentUreas
Alternative Parents
  • Urea
  • Carbamic acid derivative
  • Carbamic acid
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateNot Available
Melting pointNot Available
Experimental Properties
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
Water Solubility72 g/LALOGPS
pKa (Strongest Acidic)3.2ChemAxon
pKa (Strongest Basic)-9.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.42 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity19.56 m³·mol⁻¹ChemAxon
Polarizability8.04 ųChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB PathwaysNot Available
KEGG Pathways
Arginine and proline metabolismec00330 Map00330
SMPDB ReactionsNot Available
KEGG Reactions
water + hydron + urea-1-carboxylic acidCarbon dioxide + Ammonium
Carbonic acid + Adenosine triphosphate + Ureaphosphate + hydron + ADP + urea-1-carboxylic acid
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Whitney, P. A., Cooper, T. (1973). "Urea carboxylase from Saccharomyces cerevisiae. Evidence for a minimal two-step reaction sequence." J Biol Chem 248:325-330.4571226
  • Whitney, P. A., Cooper, T. G. (1972). "Urea carboxylase and allophanate hydrolase. Two components of adenosine triphosphate:urea amido-lyase in Saccharomyces cerevisiae." J Biol Chem 247:1349-1353.4551940
Synthesis Reference:Not Available
External Links:
HMDB IDNot Available
Pubchem Compound ID150833
Kegg IDC01010
ChemSpider ID132943
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDNot Available


General function:
Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:
Hydrolysis of urea to ammonia and CO(2)
Gene Name:
Uniprot ID:
Molecular weight:
ATP + urea + HCO(3)(-) → ADP + phosphate + urea-1-carboxylate.
Urea-1-carboxylate + H(2)O → 2 CO(2) + 2 NH(3).