{"ymdb_id":"YMDB00027","created_at":"2011-05-29T15:49:44.000Z","updated_at":"2016-09-08T18:34:55.000Z","name":"Ureidosuccinic acid","cas":"13184-27-5","state":"Solid","melting_point":"174 - 175 oC","description":"N-Carbamoyl-L-aspartate is an intermediate in the uridine-5'-phosphate biosynthesis pathway. Uridine-5'-phosphate (UMP) is a pyrimidine used for the de novo biosynthesis of pyrimidine nucleotides. [Biocyc PWY-5686]","experimental_water_solubility":"3.7 mg/mL [BEILSTEIN]","experimental_logp_hydrophobicity":null,"location":"Cytoplasm;Extracellular","synthesis_reference":null,"chebi_id":"15859","hmdb_id":"HMDB00828","kegg_id":"C00438","pubchem_id":"93072","cs_id":"84022","foodb_id":null,"wikipedia_link":"","biocyc_id":"CARBAMYUL-L-ASPARTATE","iupac":"(2S)-2-(carbamoylamino)butanedioic acid","traditional_iupac":"carbamylaspartic acid","logp":"-1.7352221553333331","pka":"5.2526016307709105","alogps_solubility":"2.13e+01 g/l","alogps_logp":"-1.12","alogps_logs":"-0.92","acceptor_count":"5","donor_count":"4","rotatable_bond_count":"4","polar_surface_area":"129.72000000000003","refractivity":"34.653200000000005","polarizability":"14.723969618976081","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.589637248709309","pka_strongest_acidic":"3.333225520739885","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Ureidobutanedioate","2-Ureidobutanedioic acid","Aspartic acid, N-carbamoyl-","Aspartic acid, N-carbamoyl-, L-","Carbamoylaspartic acid","Carbamyl-L-aspartate","Carbamyl-l-aspartic acid","Carbamylaspartic acid","L-Aspartic acid, N-(aminocarbonyl)-","L-n-carbamoylaspartic acid","L-ureidosuccinate","L-ureidosuccinic acid","N-(Aminocarbonyl)-L-aspartate","N-(aminocarbonyl)-l-aspartic acid","N-(aminocarbonyl)aspartic acid","N-carbamoyl-l-aspartate","N-carbamoyl-l-aspartic acid","N-Carbamoyl-S-aspartate","N-carbamoyl-s-aspartic acid","N-carbamoylaspartate","N-carbamoylaspartic acid","NCD","Succinic acid, ureido-","Ureidosuccinate","Ureidosuccinic acid"],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":4550662,"citation":"Drillien, R., Lacroute, F. (1972). \"Ureidosuccinic acid uptake in yeast and some aspects of its regulation.\" J Bacteriol 109:203-208."},{"pubmed_id":2897615,"citation":"Guyonvarch, A., Nguyen-Juilleret, M., Hubert, J. C., Lacroute, F. (1988). \"Structure of the Saccharomyces cerevisiae URA4 gene encoding dihydroorotase.\" Mol Gen Genet 212:134-141."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:28:29.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Protein URA1","uniprot_id":"P07259","uniprot_name":"PYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"URA2","num_residues":2214,"molecular_weight":"245124.0","theoretical_pi":"5.64","general_function":"Involved in carboxyl- or carbamoyltransferase activity","specific_function":"This protein is a \"fusion\" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)","reactions":[{"id":1332,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1365,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2256,"direction":"\u003e","locations":null,"altext":"Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3739,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006264","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14249,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006733","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M27174","genbank_protein_id":"173146","gene_card_id":"URA2","chromosome_location":"chromosome 10","locus":"YJL130C","synonyms":["Glutamine-dependent carbamoyl-phosphate synthase","Aspartate carbamoyltransferase"],"enzyme_classes":["6.3.5.5","2.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" aspartate carbamoyltransferase activity"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" carboxyl- or carbamoyltransferase activity"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CPSase_sm_chain","identifier":"PF00988"},{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"CPSase_L_D3","identifier":"PF02787"},{"name":"MGS","identifier":"PF02142"},{"name":"OTCace","identifier":"PF00185"},{"name":"OTCace_N","identifier":"PF02729"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGGCCACTATTGCTCCCACTGCTCCAATCACCCCTCCAATGGAATCTACGGGTGACCGTCTGGTTACGTTGGAACTTAAGGACGGCACGGTCTTACAAGGTTATTCATTTGGTGCTGAGAAATCCGTCGCTGGTGAATTAGTTTTCCAAACTGGTATGGTTGGTTATCCTGAATCTGTGACCGATCCATCTTATGAAGGCCAGATCTTAGTCATCACTTACCCATTGGTAGGCAATTATGGTGTCCCAGATATGCACTTGAGAGATGAATTGGTCGAAGAATTGCCAAGATATTTTGAAAGTAATAGAATCCATATTGCCGGTTTAGTTATTTCTCACTATACCGACGAGTACTCTCATTATCTTGCTAAATCTTCCTTAGGTAAATGGTTACAAAATGAAGGGATCCCAGCTGTTTATGGTGTTGATACAAGATCATTGACCAAGCATTTGAGAGATGCAGGTTCAATGTTGGGTAGGTTGTCTTTGGAAAAAAGCGGCTCTGACAGAACCATCTCCAGATCTTCCTCTTGGAGAAGTGCGTTTGATGTTCCTGAATGGGTGGATCCAAATGTTCAAAACCTAGTTTCTAAGGTCTCCATCAATGAACCTAAATTGTACGTTCCTCCAGCAGACAATAAGCACATCGAATTGCAAACCGGACCCGATGGTAAAGTTTTAAGGATTCTAGCCATTGACGTGGGTATGAAATACAATCAAATTCGTTGTTTTATCAAAAGGGGTGTAGAATTGAAAGTTGTTCCATGGAACTACGATTTCACTAAAGAAGATTATGATGGTCTGTTTATTTCAAATGGTCCAGGTGATCCATCTGTTCTAGATGATCTATCTCAAAGATTGTCAAATGTCCTGGAGGCTAAAAAGACGCCAGTATTCGGTATTTGTCTCGGTCATCAATTGATAGCAAGAGCTGCCGGTGCATCCACCCTAAAACTAAAATTTGGTAACCGTGGTCATAACATACCTTGTACATCAACTATAAGTGGTCGTTGTTACATAACATCTCAAAACCATGGGTTCGCTGTGGATGTTGACACTCTAACTTCCGGATGGAAGCCATTGTTTGTTAACGCGAATGATGACTCTAACGAAGGTATCTATCATTCTGAATTACCTTATTTTTCCGTCCAATTCCATCCAGAATCCACACCTGGCCCAAGAGATACAGAATTCTTGTTTGACGTTTTTATCCAAGCAGTTAAAGAATTCAAGTATACACAAGTGTTGAAACCAATCGCTTTCCCAGGTGGCCTATTAGAGGATAACGTTAAGGCACACCCTAGAATCGAAGCGAAGAAGGTTCTAGTTCTCGGTTCTGGTGGTTTGTCCATCGGTCAAGCTGGTGAATTTGACTACTCTGGTTCTCAAGCCATCAAAGCTTTGAAAGAAGAAGGTATCTATACAATTTTAATTAATCCAAACATTGCTACCATCCAAACTTCGAAAGGGTTGGCTGATAAGGTTTATTTTGTTCCTGTTACTGCAGAGTTCGTGAGAAAAGTTATTTTACATGAAAGGCCGGACGCCATTTATGTGACATTTGGTGGACAAACTGCTTTATCTGTTGGTATAGCCATGAAAGATGAATTTGAGGCGTTAGGAGTTAAAGTATTGGGTACTCCAATCGATACTATTATTACCACGGAAGACCGTGAACTCTTCAGTAATGCCATTGACGAAATTAATGAAAAATGTGCGAAATCTCAAGCTGCTAATTCAGTGGACGAGGCATTGGCCGCTGTCAAGGAGATCGGTTTCCCAGTTATTGTACGTGCTGCATATGCATTGGGAGGTTTAGGTTCCGGTTTCGCTAATAATGAAAAAGAATTGGTTGATCTATGTAATGTTGCATTTTCATCCTCACCTCAAGTTTTAGTCGAGAAATCTATGAAAGGTTGGAAAGAAGTCGAATATGAAGTTGTTCGTGATGCTTTTGACAACTGTATTACTGTTTGTAATATGGAAAATTTTGATCCACTAGGTATTCACACCGGTGATTCCATCGTTGTAGCCCCATCTCAAACTTTATCTGATGAAGATTACAATATGTTAAGAACTACTGCTGTTAATGTTATTAGACACTTAGGTGTTGTTGGTGAATGTAATATCCAATATGCTTTAAATCCCGTTTCTAAGGATTATTGCATCATTGAAGTTAATGCGCGTTTGTCACGTTCCTCTGCTTTAGCTTCTAAGGCTACTGGTTACCCATTGGCCTACACTGCGGCTAAGTTAGGTTTGAATATCCCATTAAATGAAGTTAAGAATTCCGTCACAAAATCCACATGTGCTTGTTTTGAACCTTCTCTAGACTACTGTGTTGTCAAAATGCCAAGATGGGATTTGAAGAAGTTCACCAGAGTTTCTACCGAATTATCTTCATCAATGAAATCTGTTGGTGAAGTTATGAGCATCGGTAGAACCTTCGAAGAAGCTATTCAAAAAGCTATCAGATCCACAGAATATGCTAACCTCGGATTCAATGAGACAGATCTAGATATCGACATTGATTACGAGTTGAACAACCCTACGGATATGCGTGTCTTCGCCATTGCAAATGCTTTTGCTAAGAAGGGATATTCTGTTGATAAAGTCTGGGAAATGACTAGAATTGATAAGTGGTTTTTAAACAAACTGCACGATTTGGTCCAATTTGCTGAGAAAATTAGTTCATTTGGTACTAAAGAGGAATTACCTTCCTTAGTTTTAAGACAGGCTAAGCAGTTAGGTTTTGATGACAGACAGATTGCAAGATTTTTGGATTCCAACGAAGTTGCCATCCGTAGATTAAGAAAAGAATATGGAATTACACCATTTGTCAAACAAATTGATACAGTTGCCGCTGAATTCCCCGCTTACACGAACTATTTATACATGACATACAATGCTGACTCACACGATTTATCCTTTGATGACCACGGTGTTATGGTCTTGGGTTCTGGTGTTTACCGTATCGGTTCTTCTGTCGAATTTGATTGGTGTGCTGTTACTGCAGTTAGAACATTACGTGCCAACAATATCAAAACTATCATGGTCAACTATAATCCAGAAACTGTTTCCACAGATTATGATGAGGCTGATAGACTATACTTTGAAACCATCAACCTTGAAAGAGTTTTGGATATTTACGAGATTGAAAACTCAAGCGGTGTTGTCGTATCAATGGGTGGTCAAACTTCCAACAACATCGCCATGACTTTACATCGTGAAAATGTAAAGATTCTTGGTACATCCCCTGACATGATTGATTCTGCTGAAAACCGTTACAAGTTCTCTCGTATGTTGGATCAAATTGGTGTTGACCAACCAGCTTGGAAAGAATTGACATCCATGGACGAAGCTGAATCTTTTGCCGAAAAGGTGGGTTATCCAGTTTTGGTACGTCCATCTTATGTGTTATCCGGTGCCGCCATGAATACTGTTTATTCTAAAAACGATTTGGAATCCTACTTAAACCAAGCCGTCGAAGTTTCACGTGATTATCCTGTTGTTATCACTAAATATATTGAAAACGCAAAGGAGATTGAAATGGATGCAGTTGCAAGAAATGGTGAATTGGTTATGCATGTTGTCTCTGAGCATGTTGAAAATGCAGGTGTCCACTCGGGTGATGCAACATTAATCGTTCCACCTCAAGATTTGGCTCCTGAAACTGTGGATAGAATTGTTGTCGCCACTGCTAAAATTGGTAAGGCTTTGAAAATTACAGGTCCATACAACATCCAATTCATTGCAAAGGACAATGAAATCAAGGTCATAGAATGTAATGTTCGTGCTTCGAGATCTTTCCCATTCATTTCAAAGGTTGTTGGCGTCAATCTGATTGAATTGGCAACAAAGGCCATAATGGGTTTGCCTTTGACGCCTTATCCTGTTGAAAAATTACCAGATGATTATGTCGCCGTTAAAGTACCACAATTCTCTTTCCCACGTTTAGCAGGAGCTGATCCAGTCTTAGGTGTTGAAATGGCCTCTACTGGTGAAGTCGCTACTTTTGGCCACTCGAAGTATGAAGCATACTTAAAGTCTTTGTTGGCAACCGGCTTCAAACTTCCAAAGAAGAATATTTTATTGTCTATTGGTTCTTACAAGGAAAAACAAGAATTGCTTTCTTCCGTACAAAAACTATACAACATGGGATATAAATTATTTGCAACATCAGGTACTGCTGACTTTTTATCTGAACATGGTATTGCCGTCCAATATCTGGAGGTTTTAAACAAGGATGATGATGATCAAAAATCAGAATACTCACTTACTCAACATTTGGCTAATAATGAAATTGACCTTTACATCAACTTGCCTTCTGCCAACAGGTTCCGTCGTCCTGCATCCTATGTTTCAAAGGGGTATAAAACACGTCGTTTGGCTGTCGATTATTCGGTTCCGTTGGTTACTAACGTTAAATGTGCAAAATTGTTGATTGAAGCCATTTCAAGAAATATCACTTTAGATGTTTCTGAACGTGATGCACAAACTTCCCACAGAACTATTACCTTACCTGGTTTAATCAATATCGCAACTTATGTTCCGAATGCATCCCATGTTATCAAAGGCCCAGCTGAACTGAAGGAGACCACACGTCTATTTTTGGAATCCGGTTTTACATACTGTCAATTGATGCCCAGATCCATCAGCGGACCTGTTATTACTGACGTTGCATCCTTGAAGGCCGCAAACTCTGTTTCCCAAGATTCATCTTACACTGACTTTTCTTTCACTATTGCTGGTACAGCACACAATGCTCATAGTGTTACGCAATCTGCTAGCAAAGTGACAGCATTGTTTTTGCCCCTACGTGAATTAAAGAACAAGATCACAGCAGTAGCTGAACTTCTGAATCAGTGGCCAACTGAAAAGCAAGTGATTGCAGAAGCTAAAACTGCAGATTTGGCATCGGTTTTATTGTTAACCTCCCTTCAAAACAGATCTATTCACATTACTGGTGTTTCGAATAAGGAAGATTTAGCTTTGATCATGACGGTCAAGGCAAAAGACCCTAGAGTGACTTGTGATGTCAATATTTATTCTTTGTTTATTGCCCAAGATGACTATCCGGAGGCAGTTTTCTTGCCTACTAAGGAAGATCAAGAGTTTTTCTGGAACAACCTTGATAGTATCGATGCTTTCTCTGTCGGTGCTCTTCCTGTCGCCTTGGCAAATGTCACAGGTAACAAGGTTGATGTTGGTATGGGTATCAAAGATTCATTACCACTATTGTTGGCTGCTGTTGAAGAAGGTAAATTAACCATTGATGATATCGTCCTTCGTCTGCATGACAATCCCGCTAAAATTTTCAACATCCCTACTCAGGACTCAGTTGTCGAAATTGATTTGGATTATTCTTTCAGACGTAATAAGAGATGGTCACCATTCAACAAAGATATGAACGGTGGTATTGAGCGTGTTGTCTATAATGGCGAAACATTAGTTTTGAGCGGTGAATTAGTTTCACCAGGCGCCAAAGGAAAATGCATTGTTAATCCAAGTCCAGCTTCCATAACTGCTTCCGCAGAGCTCCAATCTACTAGTGCTAAAAGAAGGTTCTCGATCACGGAAGAAGCAATCGCTGATAATTTAGATGCCGCGGAGGATGCAATTCCAGAACAGCCTTTGGAACAAAAATTGATGTCTTCAAGGCCACCAAGAGAACTTGTTGCTCCAGGCGCCATCCAGAATTTGATCCGTAGTAACAATCCATTCCGCGGAAGACATATATTGTCTATCAAACAATTCAAACGTTCTGATTTCCATGTGTTGTTTGCTGTTGCACAAGAACTAAGGGCACGTGTCGCAAGAGAAGGTGTCTTAGATTTAATGAAAGGCCACGTTATTACTACAATTTTCTTTGAACCATCTACTCGTACTTGTTCTTCATTCATTGCTGCTATGGAACGTTTGGGTGGTAGAATTGTAAATGTTAATCCATTGGTGTCTTCTGTCAAGAAAGGTGAAACCCTTCAAGATACTATCAGAACTTTGGCTTGTTACAGTGATGCCATTGTCATGCGTCATTCAGAAGAAATGTCTGTTCATATCGCCGCTAAATATTCTCCTGTTCCAATTATTAATGGTGGTAATGGTTCTCGCGAGCATCCTACGCAGGCCTTCTTGGATTTGTTTACGATTCGTGAAGAAATCGGTACTGTTAATGGTATTACTGTTACTTTCATGGGTGATCTCAAACATGGTAGAACCGTACATTCATTGTGTCGTTTGTTAATGCACTATCAAGTCAGAATTAATCTTGTTTCTCCTCCGGAATTGAGGTTACCAGAAGGATTAAGAGAAGAGCTAAGAAAAGCTGGCTTACTTGGTGTTGAGAGCATTGAATTAACCCCTCATATCATCTCAAAGACCGATGTTCTGTATTGTACAAGGGTCCAAGAAGAAAGATTCAATAGCCCTGAAGAATATGCACGTCTGAAGGATACTTATATCGTGGACAACAAGATCTTGGCACACGCCAAAGAAAATATGGCTATCATGCATCCATTGCCTCGTGTAAATGAAATCAAAGAGGAAGTGGACTACGATCATCGTGCTGCTTACTTCAGACAAATGAAGTATGGTTTGTTCGTCAGAATGGCTTTGTTGGCCATGGTCATGGGTGTTGATATGTGA","protein_sequence":"MATIAPTAPITPPMESTGDRLVTLELKDGTVLQGYSFGAEKSVAGELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYGVPDMHLRDELVEELPRYFESNRIHIAGLVISHYTDEYSHYLRKSSLGKWLQNEGIPAVYGVDTRSLTKHLRDAGSMLGRLSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVPPADNKHIELQTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGPGDPSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTISGRCYITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPGPRDTEFLFDVFIQAVKEFKYTQVLKPIAFPGGLLEDNVKAHPRIEAKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTEDRELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKELVDLCNVAFSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDIDIDYELNNPTDMRVFAIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVLRQAKQLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADSHDLSFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETINLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRMLDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQAVEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDLAPETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNLIELATKAIMGLPLTPYPVEKLPDDYVAVKVPQFSFPRLAGADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKKNILLSIGSYKEKQELLSSVQKLYNMGYKLFATSGTADFLSEHGIAVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLPSANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISRNITLDVSERDAQTSHRTITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRELKNKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAKDPRVTCDVNIYSLFIAQDDYPEAVFLPTKEDQEFFWNNLDSIDAFSVGALPVALANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDLDYSFRRNKRWSPFNKDMNGGIERVVYNGETLVLSGELVSPGAKGKCIVNPSPASITASAELQSTSAKRRFSITEEAIADNLDAAEDAIPEQPLEQKLMSSRPPRELVAPGAIQNLIRSNNPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQVRINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEYARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALLAMVMGVDM"},{"created_at":"2011-05-24T20:43:50.000Z","updated_at":"2011-07-22T17:54:37.000Z","name":"Dihydroorotase","uniprot_id":"P20051","uniprot_name":"PYRC_YEAST","enzyme":true,"transporter":false,"gene_name":"URA4","num_residues":364,"molecular_weight":"40313.0","theoretical_pi":"6.51","general_function":"Involved in dihydroorotase activity","specific_function":"(S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate","reactions":[{"id":1460,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2337,"direction":"\u003e","locations":"Cytoplasmic","altext":"(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":14250,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006734","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U20162","genbank_protein_id":"632670","gene_card_id":"URA4","chromosome_location":"chromosome 12","locus":"YLR420W","synonyms":["DHOase"],"enzyme_classes":["3.5.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" dihydroorotase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"}],"pfams":[],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGGTACAAGAAATCGATTTAGGTTTGACATGTGATATGCATGTTCATGTAAGAGAGGGTGCGATGTGTGAACTAGTCACCCCCAAGATTAGAGATGGTGGGGTTTCAATTGCTTACATCATGCCAAATTTACAACCTCCAATTACCACACTAGATAGAGTGATTGAATACAAAAAGACACTGCAGAAACTAGCTCCTAAAACTACCTTCTTAATGAGTTTTTATCTTTCAAAAGACTTAACTCCAGATTTAATTCATGAAGCTGCCCAACAACATGCCATTCGTGGAGTAAAGTGTTATCCAGCGGGAGTAACAACAAATTCGGCTGCTGGGGTGGATCCAAATGACTTCAGCGCATTTTACCCAATTTTCAAGGCTATGCAAGAAGAGAACCTGGTATTAAATTTGCATGGGGAAAAACCTTCTGTCCATGATGGAGACAAAGAACCTATTCATGTATTGAATGCAGAGGAAGCCTTTTTGCCAGCCTTGAAAAAATTGCATAATGATTTCCCAAACCTGAAAATAATTCTGGAACACTGCACTAGCGAGTCGGCAATAAAGACAATCGAGGATATAAATAAGAACGTGAAGAAAGCCACTGACGTAAAGGTTGCTGCCACATTAACGGCTCATCACTTATTTTTAACAATTGATGATTGGGCCGGAAATCCGGTAAATTTTTGCAAACCTGTTGCGAAACTTCCAAATGACAAAAAGGCTCTAGTCAAAGCTGCTGTATCAGGGAAACCATATTTTTTCTTTGGATCTGATTCAGCACCTCATCCTGTACAAAATAAGGCCAATTACGAGGGTGTTTGCGCAGGAGTTTACTCACAATCTTTTGCGATCCCTTATATCGCCCAAGTTTTTGAAGAGCAAAATGCCTTGGAGAACTTAAAGGGCTTTGTTTCCGACTTCGGAATTTCCTTTTATGAGGTTAAAGATAGCGAAGTGGCTTCTTCAGATAAGGCAATATTATTCAAAAAAGAACAAGTTATCCCTCAGGTTATCAGCGATGGCAAAGACATAAGCATCATCCCATTTAAAGCAGGTGATAAACTAAGTTGGTCGGTGAGATGGGAACCTCGTTAA","protein_sequence":"MVQEIDLGLTCDMHVHVREGAMCELVTPKIRDGGVSIAYIMPNLQPPITTLDRVIEYKKTLQKLAPKTTFLMSFYLSKDLTPDLIHEAAQQHAIRGVKCYPAGVTTNSAAGVDPNDFSAFYPIFKAMQEENLVLNLHGEKPSVHDGDKEPIHVLNAEEAFLPALKKLHNDFPNLKIILEHCTSESAIKTIEDINKNVKKATDVKVAATLTAHHLFLTIDDWAGNPVNFCKPVAKLPNDKKALVKAAVSGKPYFFFGSDSAPHPVQNKANYEGVCAGVYSQSFAIPYIAQVFEEQNALENLKGFVSDFGISFYEVKDSEVASSDKAILFKKEQVIPQVISDGKDISIIPFKAGDKLSWSVRWEPR"}]}