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Identification
YMDB IDYMDB00009
NameEthanolamine
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionEthanolamine is an important head group for phospholipids, which are the major structural components of biological membranes. Ethanolamine is a precursor in the phosphatidylethanolamine biosynthesis pathway. It is also used for the biosynthesis of choline, which is an other important head group for phospholipids. [Biocyc PHOSLIPSYN2-PWY and PWY4FS-6 and PWY-3385]
Structure
Thumb
Synonyms
  • 1-Amino-2-hydroxyethane
  • 2 Aminoethanol
  • 2-Amino-1-ethanol
  • 2-amino-Ethanol
  • 2-Aminoethan-1-ol
  • 2-Aminoethanol
  • 2-Aminoethyl alcohol
  • 2-Ethanolamine
  • 2-Hydroxyethanamine
  • 2-Hydroxyethylamine
  • Aethanolamin
  • Aminoethanol
  • b-Aminoethanol
  • b-Aminoethyl alcohol
  • b-Ethanolamine
  • b-Hydroxyethylamine
  • beta-Aminoethanol
  • beta-Aminoethyl alcohol
  • beta-ethanolamine
  • beta-Hydroxyethylamine
  • Colamine
  • Envision conditioner PDD 9020
  • ETA
  • Ethanolamine
  • Ethylolamine
  • Glycinol
  • H-Glycinol
  • Hea
  • MEA
  • Monoaethanolamin
  • Monoethanolamine
  • Olamine
  • β-aminoethanol
  • β-aminoethyl alcohol
  • β-ethanolamine
  • β-hydroxyethylamine
  • Β-aminoethanol
  • Β-aminoethyl alcohol
  • Β-ethanolamine
  • Β-hydroxyethylamine
CAS number141-43-5
WeightAverage: 61.0831
Monoisotopic: 61.052763851
InChI KeyHZAXFHJVJLSVMW-UHFFFAOYSA-N
InChIInChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2
IUPAC Name2-aminoethan-1-ol
Traditional IUPAC Nameethanolamine
Chemical FormulaC2H7NO
SMILES[H]OC([H])([H])C([H])([H])N([H])[H]
Chemical Taxonomy
Description belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct Parent1,2-aminoalcohols
Alternative Parents
Substituents
  • 1,2-aminoalcohol
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Primary aliphatic amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateLiquid
Charge0
Melting point10.5 °C
Experimental Properties
PropertyValueReference
Water Solubility1000 mg/mL [RIDDICK,JA et al. (1986)]PhysProp
LogP-1.31 [HANSCH,C ET AL. (1995)]PhysProp
Predicted Properties
PropertyValueSource
Water Solubility849 g/LALOGPS
logP-1.5ALOGPS
logP-1.3ChemAxon
logS1.14ALOGPS
pKa (Strongest Acidic)15.61ChemAxon
pKa (Strongest Basic)9.55ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.25 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity16.21 m³·mol⁻¹ChemAxon
Polarizability6.63 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • extracellular
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB Pathways
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycerophospholipid metabolismec00564 Map00564
SMPDB Reactions
Ethanolamine + Adenosine triphosphateADP + hydron + O-Phosphoethanolamine
KEGG Reactions
Adenosine triphosphate + Ethanolaminehydron + ADP + O-Phosphoethanolamine
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Kersting, M. C., Carman, G. M. (2006). "Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion." J Biol Chem 281:13110-13116.16551612
  • Kim, K. H., Voelker, D. R., Flocco, M. T., Carman, G. M. (1998). "Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae." J Biol Chem 273:6844-6852.9506987
Synthesis Reference:Soucaille, Philippe. Ethanolamine production by fermentation of genetically modified Escherichia coli. PCT Int. Appl. (2007), 23pp.
External Links:
ResourceLink
CHEBI ID16000
HMDB IDHMDB00149
Pubchem Compound ID700
Kegg IDC00189
ChemSpider ID13835336
FOODB IDFDB030851
WikipediaEthanolamine
BioCyc IDETHANOL-AMINE

Enzymes

General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine
Gene Name:
EKI1
Uniprot ID:
Q03764
Molecular weight:
61656.39844
Reactions
ATP + ethanolamine → ADP + O-phosphoethanolamine.
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline
Gene Name:
CKI1
Uniprot ID:
P20485
Molecular weight:
66316.0
Reactions
ATP + choline → ADP + O-phosphocholine.