{"ymdb_id":"YMDB00004","created_at":"2011-05-29T15:47:35.000Z","updated_at":"2016-09-08T18:34:53.000Z","name":"Galactose 1-phosphate","cas":"2255-14-3","state":"Solid","melting_point":"","description":"Galactose-1-phosphate is an intermediate in the intraconversion of glucose and galactose. It is formed from galactose by galactokinase.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Chen Jie; Yager Claire; Reynolds Robert; Palmieri Michael; Segal Stanton  Erythrocyte galactose 1-phosphate quantified by isotope-dilution gas chromatography-mass spectrometry.    Clinical chemistry  (2002),  48(4),  604-12. ","chebi_id":"17973","hmdb_id":"HMDB00645","kegg_id":"C00446","pubchem_id":"439995","cs_id":"24604707","foodb_id":null,"wikipedia_link":"Galactose_1-phosphate","biocyc_id":"GALACTOSE-1P","iupac":"{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid","traditional_iupac":"galactose 1 phosphate","logp":"-3.056105249333333","pka":"6.218893458242332","alogps_solubility":"3.23e+01 g/l","alogps_logp":"-2.00","alogps_logs":"-0.91","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"3","polar_surface_area":"156.91","refractivity":"46.796299999999995","polarizability":"20.62028301430712","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.9810995814615806","pka_strongest_acidic":"1.1553718480897146","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-(dihydrogen phosphate) Galactitol","1-O-phosphono-a-D-Galactopyranose","1-O-phosphono-alpha-D-Galactopyranose","1-O-phosphono-α-D-galactopyranose","1-phosphate a-D-Galactopyranose","a-D-1-(dihydrogen phosphate) Galactopyranose","a-D-Gal-1-P","a-D-Galactopyranose 1-phosphate","a-D-Galactopyranose 1-phosphoric acid","a-D-Galactopyranose, 1-(dihydrogen phosphate)","a-D-Galactopyranose, 1-(dihydrogen phosphoric acid)","a-D-Galactopyranosyl phosphate","a-D-Galactopyranosyl phosphoric acid","a-D-Galactose 1-phosphate","a-D-Galactosyl phosphate","a-D-Galactosyl phosphoric acid","alpha-D-1-(dihydrogen phosphate) Galactopyranose","alpha-D-Gal-1-P","alpha-D-Galactopyranose 1-phosphate","alpha-D-Galactopyranose 1-phosphoric acid","alpha-D-Galactopyranose, 1-(dihydrogen phosphate)","alpha-D-Galactopyranose, 1-(dihydrogen phosphoric acid)","alpha-D-Galactopyranosyl phosphate","alpha-D-Galactopyranosyl phosphoric acid","alpha-D-Galactose 1-phosphate","alpha-D-Galactosyl phosphate","alpha-D-Galactosyl phosphoric acid","D-Galactose 1-phosphate","Galactopyranose 1-phosphate","Galactose 1-phosphate","Galactose 1-phosphic acid","Galactose 1-phosphoric acid","Galactose-1-phosphate","Galactose-1-phosphate, (beta-D-gal)-isomer","Galactose-1-phosphate, (beta-L-gal)-isomer","Galactose-1-phosphate, 14C-labeled","Galactose-1-phosphate, disilver (+1) salt, (D-gal)-isomer","Galactose-1-phosphate, sodium salt","Galactose-1-phosphoric acid","α-D-gal-1-P","α-D-galactopyranose 1-phosphate","α-D-galactopyranose 1-phosphoric acid","α-D-galactopyranose, 1-(dihydrogen phosphate)","α-D-galactopyranose, 1-(dihydrogen phosphoric acid)","α-D-galactopyranosyl phosphate","α-D-galactopyranosyl phosphoric acid","α-D-galactosyl phosphate","α-D-galactosyl phosphoric acid"],"pathways":[{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Leloir Pathway","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":14158615,"citation":"DOUGLAS, H. C., HAWTHORNE, D. C. (1964). \"ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCES.\" Genetics 49:837-844."}],"proteins":[{"created_at":"2011-05-24T19:45:53.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Galactokinase","uniprot_id":"P04385","uniprot_name":"GAL1_YEAST","enzyme":true,"transporter":false,"gene_name":"GAL1","num_residues":528,"molecular_weight":"57943.80078","theoretical_pi":"6.72","general_function":"Involved in galactokinase activity","specific_function":"ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate","reactions":[{"id":1558,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2270,"direction":"\u003e","locations":null,"altext":"ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3835,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006359","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01609","genbank_protein_id":"171567","gene_card_id":"GAL1","chromosome_location":"chromosome 2","locus":"YBR020W","synonyms":["Galactose kinase"],"enzyme_classes":["2.7.1.6"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" galactokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" carbohydrate phosphorylation"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" galactose metabolic process"},{"category":"Process","description":" phosphorus metabolic process"}],"pfams":[{"name":"GalKase_gal_bdg","identifier":"PF10509"},{"name":"GHMP_kinases_C","identifier":"PF08544"},{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGACTAAATCTCATTCAGAAGAAGTGATTGTACCTGAGTTCAATTCTAGCGCAAAGGAATTACCAAGACCATTGGCCGAAAAGTGCCCGAGCATAATTAAGAAATTTATAAGCGCTTATGATGCTAAACCGGATTTTGTTGCTAGATCGCCTGGTAGAGTCAATCTAATTGGTGAACATATTGATTATTGTGACTTCTCGGTTTTACCTTTAGCTATTGATTTTGATATGCTTTGCGCCGTCAAAGTTTTGAACGAGAAAAATCCATCCATTACCTTAATAAATGCTGATCCCAAATTTGCTCAAAGGAAGTTCGATTTGCCGTTGGACGGTTCTTATGTCACAATTGATCCTTCTGTGTCGGACTGGTCTAATTACTTTAAATGTGGTCTCCATGTTGCTCACTCTTTTCTAAAGAAACTTGCACCGGAAAGGTTTGCCAGTGCTCCTCTGGCCGGGCTGCAAGTCTTCTGTGAGGGTGATATACCAACTGGCAGTGGATTGTCTTCTTCGGCCGCATTCATTTGTGCCGTTGCTTTAGCTGTTGTTAAAGCGAATATGGGCCCTGGTTATCATATGTCCAAGCAAAATTTAATGCGTATCACGGTCGTTGCAGACATTATGTTGGTGTTAACAATGGCGGTATGGATCAGGCTGCCTCTGTTTGCGGTGAGGAAGATCATGCTCTATACGTTGAGTTCAAACGCAGTTGAGGCTACCCCGTTTAAATTTCCGCAATTAAAAAACCATGAAATTAGCTTTGTTATTGCGAACACCCTTGTTGTATCTAACAAGTTTGAAACCGCCCCAACCAACTATAATTTAAGAGTGGTAGAAGTCACTACAGCTGCAAATGTTTTAGCTGCCACGTACGGTGTTGTTTTACCTTCTGGAAAAGAAGGATCGAGCACGAATAAAGGTAATCTAAGAGATTTCATGAACGTTTATTATGCCAGATATCACAACATTTCCACACCCTGGAACGGCGATATTGAATCCGGCATCGAACGGTTAACAAAGATGCTAGTATTAGTTGAAGAGTCTCTCGCCAATAAGAAACAGGGCTTTAGTGTTGACGATGTCGCACAATCCTTGAATTGTTCTCGCGAAGAATTCACAAGAGACTACTTAACAACATCTCCAGTGAGATTTCAAGTCTTAAAGCTATATCAGAGGGCTAAGCATGTGTATTCTGAATCTTTAAGAGTCTTGAAGGCTGTGAAATTAATGACTACCGCGAGCTTTACTGCCGACGAAGACTTTTTCAAGCAATTTGGTGTCTTGATGAACGAGTCTCAAGCTTCTTGCGATAAACTTTACGAATGTTCTTGTCCAGAGATTGACAAAATTTGTTCCATTGCTTTGTCAAATGGATCATATGGTTCCCGTTTGACTGGAGCTGGCTGGGGTGGTTGTACTGTTCACTTGGTTCCAGGGGGCCCAAATAACGGCAACATAGAAAAGGTAAAAGAAGCCCTTGCCAATGAGTTCTACAAGGTCAAGTACCCTAAGATCACTGATGCTGAGCTAGAAAATGCTATCATCGTCTCTAAACCAGCATTGGGCAGCTGTCTATATGAATTATAA","protein_sequence":"MTKSHSEEVIVPEFNSSAKELPRPLAEKCPSIIKKFISAYDAKPDFVARSPGRVNLIGEHIDYCDFSVLPLAIDFDMLCAVKVLNEKNPSITLINADPKFAQRKFDLPLDGSYVTIDPSVSDWSNYFKCGLHVAHSFLKKLAPERFASAPLAGLQVFCEGDVPTGSGLSSSAAFICAVALAVVKANMGPGYHMSKQNLMRITVVAEHYVGVNNGGMDQAASVCGEEDHALYVEFKPQLKATPFKFPQLKNHEISFVIANTLVVSNKFETAPTNYNLRVVEVTTAANVLAATYGVVLLSGKEGSSTNKGNLRDFMNVYYARYHNISTPWNGDIESGIERLTKMLVLVEESLANKKQGFSVDDVAQSLNCSREEFTRDYLTTSPVRFQVLKLYQRAKHVYSESLRVLKAVKLMTTASFTADEDFFKQFGALMNESQASCDKLYECSCPEIDKICSIALSNGSYGSRLTGAGWGGCTVHLVPGGPNGNIEKVKEALANEFYKVKYPKITDAELENAIIVSKPALGSCLYEL"},{"created_at":"2011-05-24T19:46:41.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Galactose-1-phosphate uridylyltransferase","uniprot_id":"P08431","uniprot_name":"GAL7_YEAST","enzyme":true,"transporter":false,"gene_name":"GAL7","num_residues":366,"molecular_weight":"42384.69922","theoretical_pi":"7.64","general_function":"Involved in UDP-glucose:hexose-1-phosphate uridylyltransferase activity","specific_function":"UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose","reactions":[{"id":1559,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2032,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2271,"direction":"\u003e","locations":null,"altext":"UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.","export":false,"pw_reaction_id":null,"source":null},{"id":3836,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006360","source":"Smpdb"},{"id":3837,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006438","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X81324","genbank_protein_id":"587574","gene_card_id":"GAL7","chromosome_location":"chromosome 2","locus":"YBR018C","synonyms":["Gal-1-P uridylyltransferase","UDP-glucose--hexose-1-phosphate uridylyltransferase"],"enzyme_classes":["2.7.7.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" UDP-glucose:hexose-1-phosphate uridylyltransferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" uridylyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" galactose metabolic process"}],"pfams":[{"name":"GalP_UDP_tr_C","identifier":"PF02744"},{"name":"GalP_UDP_transf","identifier":"PF01087"}],"pathways":[{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGACTGCTGAAGAATTTGATTTTTCTAGCCATTCCCATAGACGTTACAATCCACTAACCGATTCATGGATCTTAGTTTCTCCACACAGAGCTAAAAGACCTTGGTTAGGTCAACAGGAGGCTGCTTACAAGCCCACAGCTCCATTGTATGATCCAAAATGCTATCTATGTCCTGGTAACAAAAGAGCTACTGGTAACCTAAACCCAAGATATGAATCAACGTATATTTTCCCCAATGATTATGCTGCCGTTAGGCTCGATCAACCTATTTTACCACAGAATGATTCCAATGAGGATAATCTTAAAAATAGGCTGCTTAAAGTGCAATCTGTGAGAGGCAATTGTTTCGTCATATGTTTTAGCCCCAATCATAATCTAACCATTCCACAAATGAAACAATCAGATCTGGTTCATATTGTTAATTCTTGGCAAGCATTGACTGACGATCTCTCCAGAGAAGCAAGAGAAAATCATAAGCCTTTCAAATATGTCCAAATATTTGAAAACAAAGGTACAGCCATGGGTTGTTCCAACTTACATCCACATGGCCAAGCTTGGTGCTTAGAATCCATCCCTAGTGAAGTTTCGCAAGAATTGAAATCTTTTGATAAATATAAACGTGAACACAATACTGATTTGTTTGCCGATTACGTCAAATTAGAATCAAGAGAGAAGTCAAGAGTCGTAGTGGAGAATGAATCCTTTATTGTTGTTGTTCCATACTGGGCCATCTGGCCATTTGAGACCTTGGTCATTTCAAAGAAGAAGCTTGCCTCAATTAGCCAATTTAACCAAATGGTGAAGGAGGACCTCGCCTCGATTTTAAAGCAACTAACTATTAAGTATGATAATTTATTTGAAACGAGTTTCCCATACTCAATGGGTATCCATCAGGCTCCTTTGAATGCGACTGGTGATGAATTGAGTAATAGTTGGTTTCACATGCATTTCTACCCACCTTTACTGAGATCAGCTACTGTTCGGAAATTCTTGGTTGGTTTTGAATTGTTAGGTGAGCCTCAAAGAGATTTAACTTCGGAACAAGCTGCTGAAAAACTAAGAAATTTAGATGGTCAGATTCATTATCTACAAAGACTGTAA","protein_sequence":"MTAEEFDFSSHSHRRYNPLTDSWILVSPHRAKRPWLGQQEAAYKPTAPLYDPKCYLCPGNKRATGNLNPRYESTYIFPNDYAAVRLDQPILPQNDSNEDNLKNRLLKVQSVRGNCFVICFSPNHNLTIPQMKQSDLVHIVNSWQALTDDLSREARENHKPFKYVQIFENKGTAMGCSNLHPHGQAWCLESIPSEVSQELKSFDKYKREHNTDLFADYVKLESREKSRVVVENESFIVVVPYWAIWPFETLVISKKKLASISQFNQMVKEDLASILKQLTIKYDNLFETSFPYSMGIHQAPLNATGDELSNSWFHMHFYPPLLRSATVRKFLVGFELLGEPQRDLTSEQAAEKLRNLDGQIHYLQRL"}]}